TMED1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMED1_HUMAN
• UniProt AC: Q13445
• Protein Name: Transmembrane emp24 domain-containing protein 1
• Gene Name: TMED1
• Organism: Homo sapiens (Human).
• Sequence Length: 227
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Golgi apparatus, cis-Golgi network membrane ; Single-pass type I membrane protein . Endoplasmic reticulum-Golgi intermediate compa
• Protein Description: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side..
• Protein Sequence: MMAAGAALALALWLLMPPVEVGGAGPPPIQDGEFTFLLPAGRKQCFYQSAPANASLETEYQVIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVEPTEAGDYKLCFDNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLERSIQMLTLLRAFEARDRNLQEGNLERVNFWSAVNVAVLLLVAVLQVCTLKRFFQDKRPVPT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Ubiquitination	EYQVIGGAGLDVDFT EEEEECCCCCEEEEE	15.34	21963094
88	Ubiquitination	LLVSESRKADGVHTV EEEECCCCCCCCEEC	61.17	29967540
103	Phosphorylation	EPTEAGDYKLCFDNS CCCCCCCEEEEECCC	12.63	-
104	Ubiquitination	PTEAGDYKLCFDNSF CCCCCCEEEEECCCC	43.44	21963094
112	Ubiquitination	LCFDNSFSTISEKLV EEECCCCCCHHHHHH	25.34	22817900
117	Ubiquitination	SFSTISEKLVFFELI CCCCHHHHHHHHHHH	43.06	21963094
150	Ubiquitination	PEEMLDVKMEDIKES HHHHHCCCHHHHHHH	35.92	22817900
155	Ubiquitination	DVKMEDIKESIETMR CCCHHHHHHHHHHHH	58.70	21963094
157	Phosphorylation	KMEDIKESIETMRTR CHHHHHHHHHHHHHH	22.26	29083192
168	Phosphorylation	MRTRLERSIQMLTLL HHHHHHHHHHHHHHH	14.06	-
173	Phosphorylation	ERSIQMLTLLRAFEA HHHHHHHHHHHHHHH	20.57	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMED1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMED1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMED1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TMED1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.