TMED4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMED4_HUMAN
• UniProt AC: Q7Z7H5
• Protein Name: Transmembrane emp24 domain-containing protein 4
• Gene Name: TMED4
• Organism: Homo sapiens (Human).
• Sequence Length: 227
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
• Protein Description: Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity)..
• Protein Sequence: MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Glutathionylation	IGETEKRCFIEEIPD CCCCCCEEEEEECCC	6.28	22555962
63	Ubiquitination	YRTQMWDKQKEVFLP CCCCCHHCCCCEECC	47.99	-
65	Ubiquitination	TQMWDKQKEVFLPST CCCHHCCCCEECCCC	62.68	-
71	Phosphorylation	QKEVFLPSTPGLGMH CCCEECCCCCCCCEE	49.75	25278378
71	O-linked_Glycosylation	QKEVFLPSTPGLGMH CCCEECCCCCCCCEE	49.75	OGP
72	Phosphorylation	KEVFLPSTPGLGMHV CCEECCCCCCCCEEE	21.31	25278378
82	Ubiquitination	LGMHVEVKDPDGKVV CCEEEEEECCCCCEE	50.46	-
87	Ubiquitination	EVKDPDGKVVLSRQY EEECCCCCEEEEEEE	36.23	-
91	Phosphorylation	PDGKVVLSRQYGSEG CCCCEEEEEEECCCC	13.01	25278378
117	N-linked_Glycosylation	HQICLHSNSTRMALF CEEEEECCCCEEEEE	36.33	19159218
128	Ubiquitination	MALFAGGKLRVHLDI EEEEECCEEEEEEEE	32.00	-
128	Acetylation	MALFAGGKLRVHLDI EEEEECCEEEEEEEE	32.00	25953088
136 (in isoform 2)	Ubiquitination	-	36.51	21890473
150	Ubiquitination	NYPEIAAKDKLTELQ CCHHHHHHCHHHHHH	46.50	-
152 (in isoform 3)	Ubiquitination	-	57.51	21890473
152 (in isoform 1)	Ubiquitination	-	57.51	21890473
152	Ubiquitination	PEIAAKDKLTELQLR HHHHHHCHHHHHHHH	57.51	21890473
154	Phosphorylation	IAAKDKLTELQLRAR HHHHCHHHHHHHHHH	40.15	21406692
156 (in isoform 2)	Ubiquitination	-	4.97	21890473
172 (in isoform 3)	Ubiquitination	-	60.00	21890473
172 (in isoform 1)	Ubiquitination	-	60.00	21890473
172	Ubiquitination	DQVEQIQKEQDYQRY HHHHHHHHHHHHHHH	60.00	21906983
172	Acetylation	DQVEQIQKEQDYQRY HHHHHHHHHHHHHHH	60.00	26051181
199	Phosphorylation	NQRVLWWSIAQTVIL CHHHHHHHHHHHHHH	9.10	20068231
218	Ubiquitination	IWQMRHLKSFFEAKK HHHHHHHHHHHHHHH	38.81	21890473
218	Acetylation	IWQMRHLKSFFEAKK HHHHHHHHHHHHHHH	38.81	25825284
224	Ubiquitination	LKSFFEAKKLV---- HHHHHHHHHCC----	39.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMED4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMED4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMED4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TMED4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-117, AND MASSSPECTROMETRY.
PubMed: 19159218