DHB12_HUMAN - dbPTM
DHB12_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DHB12_HUMAN
UniProt AC Q53GQ0
Protein Name Very-long-chain 3-oxoacyl-CoA reductase {ECO:0000305}
Gene Name HSD17B12 {ECO:0000312|HGNC:HGNC:18646}
Organism Homo sapiens (Human).
Sequence Length 312
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation..
Protein Sequence MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLAKIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSIISNLPSWIYLKIVMNMNKSTRAHYLKKTKKN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10UbiquitinationSALPAAGFLYWVGAG
CCCCCCCEEEECCHH		3.9722817900
12UbiquitinationLPAAGFLYWVGAGTV
CCCCCEEEECCHHHH		8.8621890473
12PhosphorylationLPAAGFLYWVGAGTV
CCCCCEEEECCHHHH		8.86-
21UbiquitinationVGAGTVAYLALRISY
CCHHHHHHHHHHHHH		6.5422817900
23UbiquitinationAGTVAYLALRISYSL
HHHHHHHHHHHHHHH		5.1122817900
25UbiquitinationTVAYLALRISYSLFT
HHHHHHHHHHHHHHH		15.3622817900
27PhosphorylationAYLALRISYSLFTAL
HHHHHHHHHHHHHHH		11.3921406692
28PhosphorylationYLALRISYSLFTALR
HHHHHHHHHHHHHHH		13.6621406692
29PhosphorylationLALRISYSLFTALRV
HHHHHHHHHHHHHHH		15.3721406692
32PhosphorylationRISYSLFTALRVWGV
HHHHHHHHHHHHHCC		30.0321406692
43UbiquitinationVWGVGNEAGVGPGLG
HHCCCCCCCCCCCCC		23.2122817900
45UbiquitinationGVGNEAGVGPGLGEW
CCCCCCCCCCCCCCE		12.3222817900
52UbiquitinationVGPGLGEWAVVTGST
CCCCCCCEEEEECCC		7.8022817900
54UbiquitinationPGLGEWAVVTGSTDG
CCCCCEEEEECCCCC		4.0821890473
63UbiquitinationTGSTDGIGKSYAEEL
ECCCCCCCHHHHHHH		20.5622817900
65UbiquitinationSTDGIGKSYAEELAK
CCCCCCHHHHHHHHH		25.1022817900
66PhosphorylationTDGIGKSYAEELAKH
CCCCCHHHHHHHHHC		22.86-
67UbiquitinationDGIGKSYAEELAKHG
CCCCHHHHHHHHHCC		15.7522817900
72AcetylationSYAEELAKHGMKVVL
HHHHHHHHCCCEEEE		54.0026822725
81PhosphorylationGMKVVLISRSKDKLD
CCEEEEEECCHHHHH		26.7529514088
83PhosphorylationKVVLISRSKDKLDQV
EEEEEECCHHHHHHH		38.1129514088
84MalonylationVVLISRSKDKLDQVS
EEEEECCHHHHHHHC		58.7426320211
84UbiquitinationVVLISRSKDKLDQVS
EEEEECCHHHHHHHC		58.7421906983
85UbiquitinationVLISRSKDKLDQVSS
EEEECCHHHHHHHCH		58.9822817900
862-HydroxyisobutyrylationLISRSKDKLDQVSSE
EEECCHHHHHHHCHH		58.67-
86MalonylationLISRSKDKLDQVSSE
EEECCHHHHHHHCHH		58.6726320211
86UbiquitinationLISRSKDKLDQVSSE
EEECCHHHHHHHCHH		58.6722817900
87UbiquitinationISRSKDKLDQVSSEI
EECCHHHHHHHCHHH		8.8022817900
91PhosphorylationKDKLDQVSSEIKEKF
HHHHHHHCHHHHHHH		19.3421406692
92PhosphorylationDKLDQVSSEIKEKFK
HHHHHHCHHHHHHHC		44.4721406692
95UbiquitinationDQVSSEIKEKFKVET
HHHCHHHHHHHCCEE		51.2921906983
97UbiquitinationVSSEIKEKFKVETRT
HCHHHHHHHCCEEEE		45.5422817900
99UbiquitinationSEIKEKFKVETRTIA
HHHHHHHCCEEEEEE		50.6722817900
104PhosphorylationKFKVETRTIAVDFAS
HHCCEEEEEEEECCC		22.2521406692
107UbiquitinationVETRTIAVDFASEDI
CEEEEEEEECCCHHH		5.7122817900
111PhosphorylationTIAVDFASEDIYDKI
EEEEECCCHHHHHHH		35.4821406692
115PhosphorylationDFASEDIYDKIKTGL
ECCCHHHHHHHHHCC		24.4121406692
117AcetylationASEDIYDKIKTGLAG
CCHHHHHHHHHCCCC		29.1820167786
117UbiquitinationASEDIYDKIKTGLAG
CCHHHHHHHHHCCCC		29.1821906983
119UbiquitinationEDIYDKIKTGLAGLE
HHHHHHHHHCCCCCC		42.1322817900
149UbiquitinationEYFLDVPDLDNVIKK
HHHCCCCCHHHHHHH		67.5121890473
164UbiquitinationMININILSVCKMTQL
HHCCCHHHHHHHHHC		22.9821890473
164PhosphorylationMININILSVCKMTQL
HHCCCHHHHHHHHHC		22.9820068231
167UbiquitinationINILSVCKMTQLVLP
CCHHHHHHHHHCCCC		42.7122817900
169PhosphorylationILSVCKMTQLVLPGM
HHHHHHHHHCCCCCC		12.30-
170UbiquitinationLSVCKMTQLVLPGMV
HHHHHHHHCCCCCCH		26.5221890473
175UbiquitinationMTQLVLPGMVERSKG
HHHCCCCCCHHCCCC		28.7122817900
181UbiquitinationPGMVERSKGAILNIS
CCCHHCCCCEEEEEC		59.5921906983
183UbiquitinationMVERSKGAILNISSG
CHHCCCCEEEEECCC		13.5621890473
187UbiquitinationSKGAILNISSGSGML
CCCEEEEECCCCCCC		2.8821890473
191UbiquitinationILNISSGSGMLPVPL
EEEECCCCCCCCHHH		23.9921890473
206UbiquitinationLTIYSATKTFVDFFS
HHHHHHCHHHHHHHH		39.4221890473
209UbiquitinationYSATKTFVDFFSQCL
HHHCHHHHHHHHHHH		8.3122817900
212UbiquitinationTKTFVDFFSQCLHEE
CHHHHHHHHHHHCHH		4.2221890473
217UbiquitinationDFFSQCLHEEYRSKG
HHHHHHHCHHHHHCC		33.2122817900
223UbiquitinationLHEEYRSKGVFVQSV
HCHHHHHCCCCHHHH		50.5221890473
225UbiquitinationEEYRSKGVFVQSVLP
HHHHHCCCCHHHHHH		4.9621890473
229UbiquitinationSKGVFVQSVLPYFVA
HCCCCHHHHHHHHHH		21.9621890473
233PhosphorylationFVQSVLPYFVATKLA
CHHHHHHHHHHHHHH		13.41-
237UbiquitinationVLPYFVATKLAKIRK
HHHHHHHHHHHHCCC		22.6824816145
238UbiquitinationLPYFVATKLAKIRKP
HHHHHHHHHHHCCCC		36.3921906983
241UbiquitinationFVATKLAKIRKPTLD
HHHHHHHHCCCCCCC		54.1822817900
244UbiquitinationTKLAKIRKPTLDKPS
HHHHHCCCCCCCCCC		45.9122817900
244MalonylationTKLAKIRKPTLDKPS
HHHHHCCCCCCCCCC		45.9126320211
246PhosphorylationLAKIRKPTLDKPSPE
HHHCCCCCCCCCCHH		51.1025002506
2492-HydroxyisobutyrylationIRKPTLDKPSPETFV
CCCCCCCCCCHHHHH		50.97-
249UbiquitinationIRKPTLDKPSPETFV
CCCCCCCCCCHHHHH		50.9722817900
251PhosphorylationKPTLDKPSPETFVKS
CCCCCCCCHHHHHHH		40.9023312004
254PhosphorylationLDKPSPETFVKSAIK
CCCCCHHHHHHHHHH		36.7925002506
257UbiquitinationPSPETFVKSAIKTVG
CCHHHHHHHHHHHHC		29.9427667366
258PhosphorylationSPETFVKSAIKTVGL
CHHHHHHHHHHHHCC		29.8925002506
261UbiquitinationTFVKSAIKTVGLQSR
HHHHHHHHHHCCCCC		36.5527667366
279UbiquitinationYLIHALMGSIISNLP
HHHHHHHHHHHHCCC		19.2824816145
299UbiquitinationKIVMNMNKSTRAHYL
HHHHCCCHHHHHHHH		42.3029967540
311UbiquitinationHYLKKTKKN------
HHHHHHCCC------		73.4624816145
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DHB12_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DHB12_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DHB12_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AFG32_HUMANAFG3L2physical
26344197
AT1A1_HUMANATP1A1physical
26344197
ATPG_HUMANATP5C1physical
26344197
COPB_HUMANCOPB1physical
26344197
ETFA_HUMANETFAphysical
26344197
FAS_HUMANFASNphysical
26344197
ENPL_HUMANHSP90B1physical
26344197
PHB_HUMANPHBphysical
26344197
RAB1B_HUMANRAB1Bphysical
26344197
RPN1_HUMANRPN1physical
26344197
QCR2_HUMANUQCRC2physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DHB12_HUMAN

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Related Literatures of Post-Translational Modification

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