AT1A1_HUMAN - dbPTM
AT1A1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AT1A1_HUMAN
UniProt AC P05023
Protein Name Sodium/potassium-transporting ATPase subunit alpha-1
Gene Name ATP1A1
Organism Homo sapiens (Human).
Sequence Length 1023
Subcellular Localization Cell membrane, sarcolemma
Multi-pass membrane protein . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein Description This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients..
Protein Sequence MGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Ubiquitination-----MGKGVGRDKY
-----CCCCCCCCCC		63.3823503661
4Ubiquitination----MGKGVGRDKYE
----CCCCCCCCCCC		37.6723000965
5Ubiquitination---MGKGVGRDKYEP
---CCCCCCCCCCCC		6.9122817900
6Ubiquitination--MGKGVGRDKYEPA
--CCCCCCCCCCCCC		40.5122817900
9AcetylationGKGVGRDKYEPAAVS
CCCCCCCCCCCCCCC		50.5923236377
9UbiquitinationGKGVGRDKYEPAAVS
CCCCCCCCCCCCCCC		50.5923000965
9 (in isoform 1)Ubiquitination-50.5921890473
9 (in isoform 2)Ubiquitination-50.5921890473
10PhosphorylationKGVGRDKYEPAAVSE
CCCCCCCCCCCCCCC		31.2827273156
14UbiquitinationRDKYEPAAVSEQGDK
CCCCCCCCCCCCCCC		18.9822817900
16PhosphorylationKYEPAAVSEQGDKKG
CCCCCCCCCCCCCCC		21.3423401153
16 (in isoform 4)Phosphorylation-21.3425849741
212-HydroxyisobutyrylationAVSEQGDKKGKKGKK
CCCCCCCCCCCCCCC		70.96-
21AcetylationAVSEQGDKKGKKGKK
CCCCCCCCCCCCCCC		70.96-
21UbiquitinationAVSEQGDKKGKKGKK
CCCCCCCCCCCCCCC		70.9621906983
21 (in isoform 1)Ubiquitination-70.9621890473
21 (in isoform 2)Ubiquitination-70.9621890473
22UbiquitinationVSEQGDKKGKKGKKD
CCCCCCCCCCCCCCC		79.3522817900
23UbiquitinationSEQGDKKGKKGKKDR
CCCCCCCCCCCCCCC		42.5221890473
24UbiquitinationEQGDKKGKKGKKDRD
CCCCCCCCCCCCCCC		68.2022817900
25UbiquitinationQGDKKGKKGKKDRDM
CCCCCCCCCCCCCCH		82.0022817900
27UbiquitinationDKKGKKGKKDRDMDE
CCCCCCCCCCCCHHH		61.4523503661
362-HydroxyisobutyrylationDRDMDELKKEVSMDD
CCCHHHHHHHHCCCC		44.85-
36UbiquitinationDRDMDELKKEVSMDD
CCCHHHHHHHHCCCC		44.8521906983
36 (in isoform 1)Ubiquitination-44.8521890473
36 (in isoform 2)Ubiquitination-44.8521890473
37UbiquitinationRDMDELKKEVSMDDH
CCHHHHHHHHCCCCC		75.7921906983
37 (in isoform 1)Ubiquitination-75.7921890473
37 (in isoform 2)Ubiquitination-75.7921890473
40PhosphorylationDELKKEVSMDDHKLS
HHHHHHHCCCCCCCC		20.0025307156
45UbiquitinationEVSMDDHKLSLDELH
HHCCCCCCCCHHHHH		46.9221890473
45UbiquitinationEVSMDDHKLSLDELH
HHCCCCCCCCHHHHH		46.9221890473
452-HydroxyisobutyrylationEVSMDDHKLSLDELH
HHCCCCCCCCHHHHH		46.92-
45AcetylationEVSMDDHKLSLDELH
HHCCCCCCCCHHHHH		46.9226822725
45UbiquitinationEVSMDDHKLSLDELH
HHCCCCCCCCHHHHH		46.9222817900
45 (in isoform 1)Ubiquitination-46.9221890473
45 (in isoform 2)Ubiquitination-46.9221890473
47PhosphorylationSMDDHKLSLDELHRK
CCCCCCCCHHHHHHH		38.2821082442
47 (in isoform 4)Phosphorylation-38.2824719451
54UbiquitinationSLDELHRKYGTDLSR
CHHHHHHHHCCCHHH		36.9721890473
54UbiquitinationSLDELHRKYGTDLSR
CHHHHHHHHCCCHHH		36.9721890473
542-HydroxyisobutyrylationSLDELHRKYGTDLSR
CHHHHHHHHCCCHHH		36.97-
54AcetylationSLDELHRKYGTDLSR
CHHHHHHHHCCCHHH		36.9727452117
54UbiquitinationSLDELHRKYGTDLSR
CHHHHHHHHCCCHHH		36.9727667366
54 (in isoform 1)Ubiquitination-36.9721890473
54 (in isoform 2)Ubiquitination-36.9721890473
55PhosphorylationLDELHRKYGTDLSRG
HHHHHHHHCCCHHHC		25.8027273156
55 (in isoform 4)Phosphorylation-25.8024719451
57PhosphorylationELHRKYGTDLSRGLT
HHHHHHCCCHHHCHH		30.5826356563
60PhosphorylationRKYGTDLSRGLTSAR
HHHCCCHHHCHHHHH		27.4126356563
60UbiquitinationRKYGTDLSRGLTSAR
HHHCCCHHHCHHHHH		27.4121963094
61MethylationKYGTDLSRGLTSARA
HHCCCHHHCHHHHHH		51.98-
65O-linked_GlycosylationDLSRGLTSARAAEIL
CHHHCHHHHHHHHHH		22.3229351928
81PhosphorylationRDGPNALTPPPTTPE
CCCCCCCCCCCCCHH		31.19-
85PhosphorylationNALTPPPTTPEWIKF
CCCCCCCCCHHHHHH		61.84-
86PhosphorylationALTPPPTTPEWIKFC
CCCCCCCCHHHHHHH		25.61-
91UbiquitinationPTTPEWIKFCRQLFG
CCCHHHHHHHHHHHC		39.2121963094
122UbiquitinationYSIQAATEEEPQNDN
HHHHHHCCCCCCCCC		56.4922817900
125UbiquitinationQAATEEEPQNDNLYL
HHHCCCCCCCCCHHH		41.3723000965
131UbiquitinationEPQNDNLYLGVVLSA
CCCCCCHHHHHHHHH		13.9923000965
146UbiquitinationVVIITGCFSYYQEAK
HHHHHCCCHHHHHHH		5.7932015554
149PhosphorylationITGCFSYYQEAKSSK
HHCCCHHHHHHHHHH		9.93-
153UbiquitinationFSYYQEAKSSKIMES
CHHHHHHHHHHHHHH		55.2822817900
154PhosphorylationSYYQEAKSSKIMESF
HHHHHHHHHHHHHHH		43.8628152594
155PhosphorylationYYQEAKSSKIMESFK
HHHHHHHHHHHHHHH		26.0428152594
1562-HydroxyisobutyrylationYQEAKSSKIMESFKN
HHHHHHHHHHHHHHH		53.84-
156UbiquitinationYQEAKSSKIMESFKN
HHHHHHHHHHHHHHH		53.8423000965
156 (in isoform 1)Ubiquitination-53.8421890473
156 (in isoform 2)Ubiquitination-53.8421890473
160PhosphorylationKSSKIMESFKNMVPQ
HHHHHHHHHHHCCCC		24.9228152594
162UbiquitinationSKIMESFKNMVPQQA
HHHHHHHHHCCCCCE		54.1121890473
162UbiquitinationSKIMESFKNMVPQQA
HHHHHHHHHCCCCCE		54.1121890473
162UbiquitinationSKIMESFKNMVPQQA
HHHHHHHHHCCCCCE		54.1123000965
162 (in isoform 1)Ubiquitination-54.1121890473
162 (in isoform 2)Ubiquitination-54.1121890473
163UbiquitinationKIMESFKNMVPQQAL
HHHHHHHHCCCCCEE		34.3732015554
164SulfoxidationIMESFKNMVPQQALV
HHHHHHHCCCCCEEE		4.8521406390
177UbiquitinationLVIRNGEKMSINAEE
EEEECCCCCEECCEE		39.0732015554
178SulfoxidationVIRNGEKMSINAEEV
EEECCCCCEECCEEE		4.1821406390
181UbiquitinationNGEKMSINAEEVVVG
CCCCCEECCEEEEEE		33.7123000965
1942-HydroxyisobutyrylationVGDLVEVKGGDRIPA
EECEEEEECCCCCCC		43.61-
194UbiquitinationVGDLVEVKGGDRIPA
EECEEEEECCCCCCC		43.6132015554
198MethylationVEVKGGDRIPADLRI
EEEECCCCCCCCEEE		39.81-
204MethylationDRIPADLRIISANGC
CCCCCCEEEEECCCC		25.41-
207PhosphorylationPADLRIISANGCKVD
CCCEEEEECCCCEEC		17.2029978859
212UbiquitinationIISANGCKVDNSSLT
EEECCCCEECCCCCC		54.7621890473
212UbiquitinationIISANGCKVDNSSLT
EEECCCCEECCCCCC		54.7621890473
212UbiquitinationIISANGCKVDNSSLT
EEECCCCEECCCCCC		54.7623000965
212 (in isoform 1)Ubiquitination-54.7621890473
212 (in isoform 2)Ubiquitination-54.7621890473
216PhosphorylationNGCKVDNSSLTGESE
CCCEECCCCCCCCCC		23.4323401153
217PhosphorylationGCKVDNSSLTGESEP
CCEECCCCCCCCCCC		35.8823927012
217 (in isoform 4)Phosphorylation-35.8824719451
219PhosphorylationKVDNSSLTGESEPQT
EECCCCCCCCCCCCC		40.6323927012
222PhosphorylationNSSLTGESEPQTRSP
CCCCCCCCCCCCCCC		56.7923927012
226PhosphorylationTGESEPQTRSPDFTN
CCCCCCCCCCCCCCC		43.7823927012
228PhosphorylationESEPQTRSPDFTNEN
CCCCCCCCCCCCCCC		32.0121082442
232PhosphorylationQTRSPDFTNENPLET
CCCCCCCCCCCCCCC		49.3429978859
239PhosphorylationTNENPLETRNIAFFS
CCCCCCCCCCEEEEE		36.3829978859
246PhosphorylationTRNIAFFSTNCVEGT
CCCEEEEECCCCCCC		16.5627050516
253PhosphorylationSTNCVEGTARGIVVY
ECCCCCCCCCEEEEE		10.3228857561
260PhosphorylationTARGIVVYTGDRTVM
CCCEEEEECCCCCHH		8.2923927012
260 (in isoform 4)Phosphorylation-8.2924719451
261PhosphorylationARGIVVYTGDRTVMG
CCEEEEECCCCCHHH		22.4630266825
264MethylationIVVYTGDRTVMGRIA
EEEECCCCCHHHHHH		30.48-
265PhosphorylationVVYTGDRTVMGRIAT
EEECCCCCHHHHHHH		21.4222199227
323UbiquitinationTWLEAVIFLIGIIVA
HHHHHHHHHHHHHHH		3.0622817900
328UbiquitinationVIFLIGIIVANVPEG
HHHHHHHHHHCCCCC		1.7021890473
346UbiquitinationTVTVCLTLTAKRMAR
HHHHHHHHHHHHHHH		2.5727667366
354UbiquitinationTAKRMARKNCLVKNL
HHHHHHHCCCEECCH		42.3422817900
356S-palmitoylationKRMARKNCLVKNLEA
HHHHHCCCEECCHHH		5.3221044946
359UbiquitinationARKNCLVKNLEAVET
HHCCCEECCHHHHHH		42.7521890473
359UbiquitinationARKNCLVKNLEAVET
HHCCCEECCHHHHHH		42.7521890473
359AcetylationARKNCLVKNLEAVET
HHCCCEECCHHHHHH		42.7527452117
359UbiquitinationARKNCLVKNLEAVET
HHCCCEECCHHHHHH		42.7522817900
359 (in isoform 1)Ubiquitination-42.7521890473
359 (in isoform 2)Ubiquitination-42.7521890473
369PhosphorylationEAVETLGSTSTICSD
HHHHHHCCCCCCCCC		23.4628857561
369 (in isoform 4)Phosphorylation-23.4624719451
370PhosphorylationAVETLGSTSTICSDK
HHHHHCCCCCCCCCC		28.2628857561
371PhosphorylationVETLGSTSTICSDKT
HHHHCCCCCCCCCCC		19.9228857561
372PhosphorylationETLGSTSTICSDKTG
HHHCCCCCCCCCCCC		26.5428857561
375PhosphorylationGSTSTICSDKTGTLT
CCCCCCCCCCCCCCC		37.9928857561
377AcetylationTSTICSDKTGTLTQN
CCCCCCCCCCCCCCC		32.3426051181
377UbiquitinationTSTICSDKTGTLTQN
CCCCCCCCCCCCCCC		32.3427667366
377 (in isoform 1)Ubiquitination-32.3421890473
377 (in isoform 2)Ubiquitination-32.3421890473
378PhosphorylationSTICSDKTGTLTQNR
CCCCCCCCCCCCCCC		40.1528857561
378 (in isoform 4)Phosphorylation-40.1524719451
380PhosphorylationICSDKTGTLTQNRMT
CCCCCCCCCCCCCEE		31.6828857561
382PhosphorylationSDKTGTLTQNRMTVA
CCCCCCCCCCCEEEE		24.5228857561
402PhosphorylationNQIHEADTTENQSGV
CCCCCCCCCCCCCCC		42.9528348404
403PhosphorylationQIHEADTTENQSGVS
CCCCCCCCCCCCCCC		33.2228348404
407PhosphorylationADTTENQSGVSFDKT
CCCCCCCCCCCCCHH		53.3926471730
410PhosphorylationTENQSGVSFDKTSAT
CCCCCCCCCCHHHHH		31.1126471730
413UbiquitinationQSGVSFDKTSATWLA
CCCCCCCHHHHHHHH		42.2323000965
422PhosphorylationSATWLALSRIAGLCN
HHHHHHHHHHHHHHH		18.9424719451
427UbiquitinationALSRIAGLCNRAVFQ
HHHHHHHHHHHHHHH		1.4021963094
437UbiquitinationRAVFQANQENLPILK
HHHHHHCHHCCHHHH		43.9323000965
444UbiquitinationQENLPILKRAVAGDA
HHCCHHHHHHHCCCC		38.7421890473
444UbiquitinationQENLPILKRAVAGDA
HHCCHHHHHHHCCCC		38.7421890473
4442-HydroxyisobutyrylationQENLPILKRAVAGDA
HHCCHHHHHHHCCCC		38.74-
444AcetylationQENLPILKRAVAGDA
HHCCHHHHHHHCCCC		38.7425038526
444UbiquitinationQENLPILKRAVAGDA
HHCCHHHHHHHCCCC		38.7423000965
444 (in isoform 1)Ubiquitination-38.7421890473
444 (in isoform 2)Ubiquitination-38.7421890473
445UbiquitinationENLPILKRAVAGDAS
HCCHHHHHHHCCCCC		30.7427667366
452PhosphorylationRAVAGDASESALLKC
HHHCCCCCHHHHHHH		36.5028857561
454PhosphorylationVAGDASESALLKCIE
HCCCCCHHHHHHHHH		23.0128857561
456UbiquitinationGDASESALLKCIELC
CCCCHHHHHHHHHHH		6.9923000965
458AcetylationASESALLKCIELCCG
CCHHHHHHHHHHHHC		33.7326051181
458UbiquitinationASESALLKCIELCCG
CCHHHHHHHHHHHHC		33.7321963094
463UbiquitinationLLKCIELCCGSVKEM
HHHHHHHHHCCHHHH		1.2823000965
466PhosphorylationCIELCCGSVKEMRER
HHHHHHCCHHHHHHH		18.9925159151
468AcetylationELCCGSVKEMRERYA
HHHHCCHHHHHHHHH		47.7125953088
468UbiquitinationELCCGSVKEMRERYA
HHHHCCHHHHHHHHH		47.7123000965
476UbiquitinationEMRERYAKIVEIPFN
HHHHHHHEEEECCCC		38.0521890473
476UbiquitinationEMRERYAKIVEIPFN
HHHHHHHEEEECCCC		38.0521890473
476UbiquitinationEMRERYAKIVEIPFN
HHHHHHHEEEECCCC		38.0527667366
476 (in isoform 1)Ubiquitination-38.0521890473
476 (in isoform 2)Ubiquitination-38.0521890473
477UbiquitinationMRERYAKIVEIPFNS
HHHHHHEEEECCCCC		2.2727667366
484PhosphorylationIVEIPFNSTNKYQLS
EEECCCCCCCCEEEE		33.4628857561
485PhosphorylationVEIPFNSTNKYQLSI
EECCCCCCCCEEEEE		36.5128857561
487UbiquitinationIPFNSTNKYQLSIHK
CCCCCCCCEEEEEEC		34.1721890473
487UbiquitinationIPFNSTNKYQLSIHK
CCCCCCCCEEEEEEC		34.1721890473
487AcetylationIPFNSTNKYQLSIHK
CCCCCCCCEEEEEEC		34.1723236377
487MalonylationIPFNSTNKYQLSIHK
CCCCCCCCEEEEEEC		34.1726320211
487UbiquitinationIPFNSTNKYQLSIHK
CCCCCCCCEEEEEEC		34.1723000965
487 (in isoform 1)Ubiquitination-34.1721890473
487 (in isoform 2)Ubiquitination-34.1721890473
488PhosphorylationPFNSTNKYQLSIHKN
CCCCCCCEEEEEECC		19.4328442448
494UbiquitinationKYQLSIHKNPNTSEP
CEEEEEECCCCCCCC		72.8721890473
494UbiquitinationKYQLSIHKNPNTSEP
CEEEEEECCCCCCCC		72.8721890473
494AcetylationKYQLSIHKNPNTSEP
CEEEEEECCCCCCCC		72.8726051181
494MethylationKYQLSIHKNPNTSEP
CEEEEEECCCCCCCC		72.87-
494UbiquitinationKYQLSIHKNPNTSEP
CEEEEEECCCCCCCC		72.8723000965
494 (in isoform 1)Ubiquitination-72.8721890473
494 (in isoform 2)Ubiquitination-72.8721890473
495UbiquitinationYQLSIHKNPNTSEPQ
EEEEEECCCCCCCCC		22.3823000965
498PhosphorylationSIHKNPNTSEPQHLL
EEECCCCCCCCCEEE		35.4120873877
499PhosphorylationIHKNPNTSEPQHLLV
EECCCCCCCCCEEEE		54.6520873877
499 (in isoform 4)Phosphorylation-54.6527251275
504UbiquitinationNTSEPQHLLVMKGAP
CCCCCCEEEEECCCH		3.0422817900
508UbiquitinationPQHLLVMKGAPERIL
CCEEEEECCCHHHHH		44.4321890473
508UbiquitinationPQHLLVMKGAPERIL
CCEEEEECCCHHHHH		44.4321890473
508AcetylationPQHLLVMKGAPERIL
CCEEEEECCCHHHHH		44.4327452117
508UbiquitinationPQHLLVMKGAPERIL
CCEEEEECCCHHHHH		44.4327667366
508 (in isoform 1)Ubiquitination-44.4321890473
508 (in isoform 2)Ubiquitination-44.4321890473
517MethylationAPERILDRCSSILLH
CHHHHHHHHHHHHHC		20.83-
518GlutathionylationPERILDRCSSILLHG
HHHHHHHHHHHHHCC		3.6022555962
518S-palmitoylationPERILDRCSSILLHG
HHHHHHHHHHHHHCC		3.6021044946
519PhosphorylationERILDRCSSILLHGK
HHHHHHHHHHHHCCC		22.7028348404
520PhosphorylationRILDRCSSILLHGKE
HHHHHHHHHHHCCCC		22.3828348404
5262-HydroxyisobutyrylationSSILLHGKEQPLDEE
HHHHHCCCCCCCCHH		42.29-
526SumoylationSSILLHGKEQPLDEE
HHHHHCCCCCCCCHH		42.29-
526UbiquitinationSSILLHGKEQPLDEE
HHHHHCCCCCCCCHH		42.2923000965
526 (in isoform 1)Ubiquitination-42.2921890473
535UbiquitinationQPLDEELKDAFQNAY
CCCCHHHHHHHHHHH		50.7421906983
535 (in isoform 1)Ubiquitination-50.7421890473
535 (in isoform 2)Ubiquitination-50.7421890473
542PhosphorylationKDAFQNAYLELGGLG
HHHHHHHHHHHCCHH		14.3027273156
574UbiquitinationEGFQFDTDDVNFPID
CCCCCCCCCCCCCCC		60.7623000965
581UbiquitinationDDVNFPIDNLCFVGL
CCCCCCCCCEEEEHH		42.1422817900
594UbiquitinationGLISMIDPPRAAVPD
HHHHCCCCCCCCCCC		14.8923000965
598UbiquitinationMIDPPRAAVPDAVGK
CCCCCCCCCCCHHHH		18.0423000965
6052-HydroxyisobutyrylationAVPDAVGKCRSAGIK
CCCCHHHHHHHCCCE		21.63-
605UbiquitinationAVPDAVGKCRSAGIK
CCCCHHHHHHHCCCE		21.6323000965
605 (in isoform 1)Ubiquitination-21.6321890473
605 (in isoform 2)Ubiquitination-21.6321890473
608PhosphorylationDAVGKCRSAGIKVIM
CHHHHHHHCCCEEEE		40.0720068231
6122-HydroxyisobutyrylationKCRSAGIKVIMVTGD
HHHHCCCEEEEEECC		25.45-
612AcetylationKCRSAGIKVIMVTGD
HHHHCCCEEEEEECC		25.4526051181
612UbiquitinationKCRSAGIKVIMVTGD
HHHHCCCEEEEEECC		25.4522817900
612 (in isoform 1)Ubiquitination-25.4521890473
612 (in isoform 2)Ubiquitination-25.4521890473
617PhosphorylationGIKVIMVTGDHPITA
CCEEEEEECCCCCCH		21.3620068231
623PhosphorylationVTGDHPITAKAIAKG
EECCCCCCHHHHHHC		26.9320068231
625UbiquitinationGDHPITAKAIAKGVG
CCCCCCHHHHHHCCE		31.5121890473
625UbiquitinationGDHPITAKAIAKGVG
CCCCCCHHHHHHCCE		31.5121890473
6252-HydroxyisobutyrylationGDHPITAKAIAKGVG
CCCCCCHHHHHHCCE		31.51-
625AcetylationGDHPITAKAIAKGVG
CCCCCCHHHHHHCCE		31.5127452117
625UbiquitinationGDHPITAKAIAKGVG
CCCCCCHHHHHHCCE		31.5123000965
625 (in isoform 1)Ubiquitination-31.5121890473
625 (in isoform 2)Ubiquitination-31.5121890473
629UbiquitinationITAKAIAKGVGIISE
CCHHHHHHCCEEEEC		48.2721890473
629UbiquitinationITAKAIAKGVGIISE
CCHHHHHHCCEEEEC		48.2721890473
6292-HydroxyisobutyrylationITAKAIAKGVGIISE
CCHHHHHHCCEEEEC		48.27-
629UbiquitinationITAKAIAKGVGIISE
CCHHHHHHCCEEEEC		48.2723000965
629 (in isoform 1)Ubiquitination-48.2721890473
629 (in isoform 2)Ubiquitination-48.2721890473
630UbiquitinationTAKAIAKGVGIISEG
CHHHHHHCCEEEECC		17.5427667366
635PhosphorylationAKGVGIISEGNETVE
HHCCEEEECCCCCHH		37.2125072903
635 (in isoform 2)Phosphorylation-37.2120860994
638 (in isoform 2)Phosphorylation-37.4020860994
640PhosphorylationIISEGNETVEDIAAR
EEECCCCCHHHHHHH		32.9424076635
640UbiquitinationIISEGNETVEDIAAR
EEECCCCCHHHHHHH		32.9421963094
642 (in isoform 2)Phosphorylation-51.6320860994
652NeddylationAARLNIPVSQVNPRD
HHHCCCCHHHCCHHH		5.7532015554
652UbiquitinationAARLNIPVSQVNPRD
HHHCCCCHHHCCHHH		5.7521963094
653PhosphorylationARLNIPVSQVNPRDA
HHCCCCHHHCCHHHC		24.0530266825
653 (in isoform 4)Phosphorylation-24.0524719451
6612-HydroxyisobutyrylationQVNPRDAKACVVHGS
HCCHHHCCEEEEECH		46.75-
661AcetylationQVNPRDAKACVVHGS
HCCHHHCCEEEEECH		46.7525953088
661SuccinylationQVNPRDAKACVVHGS
HCCHHHCCEEEEECH		46.75-
661SuccinylationQVNPRDAKACVVHGS
HCCHHHCCEEEEECH		46.75-
661UbiquitinationQVNPRDAKACVVHGS
HCCHHHCCEEEEECH		46.7527667366
663GlutathionylationNPRDAKACVVHGSDL
CHHHCCEEEEECHHH		3.0222555962
663S-palmitoylationNPRDAKACVVHGSDL
CHHHCCEEEEECHHH		3.0221044946
667UbiquitinationAKACVVHGSDLKDMT
CCEEEEECHHHHCCC		15.9623000965
668PhosphorylationKACVVHGSDLKDMTS
CEEEEECHHHHCCCH		25.5428985074
671AcetylationVVHGSDLKDMTSEQL
EEECHHHHCCCHHHH		50.9025953088
671UbiquitinationVVHGSDLKDMTSEQL
EEECHHHHCCCHHHH		50.9021963094
674PhosphorylationGSDLKDMTSEQLDDI
CHHHHCCCHHHHHHH		38.9727732954
675PhosphorylationSDLKDMTSEQLDDIL
HHHHCCCHHHHHHHH		19.3924076635
683UbiquitinationEQLDDILKYHTEIVF
HHHHHHHHHHHEEEE		35.0121890473
6832-HydroxyisobutyrylationEQLDDILKYHTEIVF
HHHHHHHHHHHEEEE		35.01-
683NeddylationEQLDDILKYHTEIVF
HHHHHHHHHHHEEEE		35.0132015554
683UbiquitinationEQLDDILKYHTEIVF
HHHHHHHHHHHEEEE		35.0121963094
683 (in isoform 1)Ubiquitination-35.0121890473
684PhosphorylationQLDDILKYHTEIVFA
HHHHHHHHHHEEEEE		15.5524927040
686PhosphorylationDDILKYHTEIVFART
HHHHHHHHEEEEEEC		25.0726356563
695UbiquitinationIVFARTSPQQKLIIV
EEEEECCCCCEEEEE		39.7527667366
696UbiquitinationVFARTSPQQKLIIVE
EEEECCCCCEEEEEE		53.4622817900
6982-HydroxyisobutyrylationARTSPQQKLIIVEGC
EECCCCCEEEEEECC		36.08-
698AcetylationARTSPQQKLIIVEGC
EECCCCCEEEEEECC		36.0827452117
698UbiquitinationARTSPQQKLIIVEGC
EECCCCCEEEEEECC		36.0823000965
698 (in isoform 1)Ubiquitination-36.0821890473
705GlutathionylationKLIIVEGCQRQGAIV
EEEEEECCCCCCCEE		1.5822555962
705S-palmitoylationKLIIVEGCQRQGAIV
EEEEEECCCCCCCEE		1.5829575903
715PhosphorylationQGAIVAVTGDGVNDS
CCCEEEEECCCCCCC		21.5924076635
722PhosphorylationTGDGVNDSPALKKAD
ECCCCCCCHHHHHCC		13.5829255136
722 (in isoform 4)Phosphorylation-13.5824719451
726UbiquitinationVNDSPALKKADIGVA
CCCCHHHHHCCCEEE		48.2821906983
726 (in isoform 1)Ubiquitination-48.2821890473
727UbiquitinationNDSPALKKADIGVAM
CCCHHHHHCCCEEEC		52.7421906983
727 (in isoform 1)Ubiquitination-52.7421890473
734SulfoxidationKADIGVAMGIAGSDV
HCCCEEECCCCCCHH		3.5628183972
739PhosphorylationVAMGIAGSDVSKQAA
EECCCCCCHHHHHHH		26.3022210691
742PhosphorylationGIAGSDVSKQAADMI
CCCCCHHHHHHHCEE		24.8420068231
742UbiquitinationGIAGSDVSKQAADMI
CCCCCHHHHHHHCEE		24.8421963094
743UbiquitinationIAGSDVSKQAADMIL
CCCCHHHHHHHCEEE		43.7522817900
748SulfoxidationVSKQAADMILLDDNF
HHHHHHCEEEECCCC		1.6728183972
773AcetylationRLIFDNLKKSIAYTL
EEEECCHHHHHHHHH		51.2127178108
773SuccinylationRLIFDNLKKSIAYTL
EEEECCHHHHHHHHH		51.2123954790
773UbiquitinationRLIFDNLKKSIAYTL
EEEECCHHHHHHHHH		51.2121963094
773 (in isoform 1)Ubiquitination-51.2121890473
774UbiquitinationLIFDNLKKSIAYTLT
EEECCHHHHHHHHHH		50.7022817900
809UbiquitinationLGTVTILCIDLGTDM
CCCEEEEEEECCCCH		1.6923000965
812UbiquitinationVTILCIDLGTDMVPA
EEEEEEECCCCHHHH		3.9523000965
833UbiquitinationQAESDIMKRQPRNPK
HHHHHHHHCCCCCCC		48.49-
840UbiquitinationKRQPRNPKTDKLVNE
HCCCCCCCHHHHHHH		73.2723000965
840 (in isoform 1)Ubiquitination-73.2721890473
8432-HydroxyisobutyrylationPRNPKTDKLVNERLI
CCCCCHHHHHHHHHH		60.61-
843AcetylationPRNPKTDKLVNERLI
CCCCCHHHHHHHHHH		60.6126210075
843UbiquitinationPRNPKTDKLVNERLI
CCCCCHHHHHHHHHH		60.6123000965
843 (in isoform 1)Ubiquitination-60.6121890473
901PhosphorylationWINDVEDSYGQQWTY
CHHCCHHHHCCCCCC		20.0522468782
902PhosphorylationINDVEDSYGQQWTYE
HHCCHHHHCCCCCCH		31.1322468782
907PhosphorylationDSYGQQWTYEQRKIV
HHHCCCCCCHHHHEE		16.9122468782
919UbiquitinationKIVEFTCHTAFFVSI
HEEEHHHCHHHHHHH		19.7127667366
921UbiquitinationVEFTCHTAFFVSIVV
EEHHHCHHHHHHHHH		3.3922817900
943PhosphorylationICKTRRNSVFQQGMK
EECCCCCHHHHHHCC		23.6115621037
949SulfoxidationNSVFQQGMKNKILIF
CHHHHHHCCCCEEEE		3.6228183972
9502-HydroxyisobutyrylationSVFQQGMKNKILIFG
HHHHHHCCCCEEEEE		63.01-
950UbiquitinationSVFQQGMKNKILIFG
HHHHHHCCCCEEEEE		63.0127667366
950 (in isoform 1)Ubiquitination-63.0121890473
952UbiquitinationFQQGMKNKILIFGLF
HHHHCCCCEEEEECC		33.1122817900
988UbiquitinationYPLKPTWWFCAFPYS
CCCCCCHHHCCCCHH		4.8621890473
1019UbiquitinationRPGGWVEKETYY---
CCCCCCCCCCCC---		45.8221890473
10192-HydroxyisobutyrylationRPGGWVEKETYY---
CCCCCCCCCCCC---		45.82-
1019UbiquitinationRPGGWVEKETYY---
CCCCCCCCCCCC---		45.8227667366
1019 (in isoform 1)Ubiquitination-45.8221890473
1021PhosphorylationGGWVEKETYY-----
CCCCCCCCCC-----		38.91-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
149YPhosphorylationKinaseSRCP12931
PSP
260YPhosphorylationKinaseSRCP12931
PSP
943SPhosphorylationKinasePRKACAP17612
GPS
943SPhosphorylationKinasePKA-Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
943SPhosphorylation

-
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AT1A1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PLM_HUMANFXYD1physical
14597563
ATPG_HUMANATP5C1physical
26344197
ATP5L_HUMANATP5Lphysical
26344197
VATA_HUMANATP6V1Aphysical
26344197
PYR1_HUMANCADphysical
26344197
TCPH_HUMANCCT7physical
26344197
CYB5B_HUMANCYB5Bphysical
26344197
CY1_HUMANCYC1physical
26344197
OST48_HUMANDDOSTphysical
26344197
EIF3B_HUMANEIF3Bphysical
26344197
IPO5_HUMANIPO5physical
26344197
ITA5_HUMANITGA5physical
26344197
RM40_HUMANMRPL40physical
26344197
NDUB8_HUMANNDUFB8physical
26344197
NDUS4_HUMANNDUFS4physical
26344197
NDUV1_HUMANNDUFV1physical
26344197
PYC_HUMANPCphysical
26344197
PHB_HUMANPHBphysical
26344197
RPN1_HUMANRPN1physical
26344197
MPCP_HUMANSLC25A3physical
26344197
SSRB_HUMANSSR2physical
26344197
TECR_HUMANTECRphysical
26344197
TMCO1_HUMANTMCO1physical
26344197
TMED2_HUMANTMED2physical
26344197
TPM4_HUMANTPM4physical
26344197
QCR2_HUMANUQCRC2physical
26344197
QCR8_HUMANUQCRQphysical
26344197
VDAC1_HUMANVDAC1physical
26344197
VDAC2_HUMANVDAC2physical
26344197
VDAC3_HUMANVDAC3physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00112 G-Strophanthin (JAN); Ouabain; Ouabain octahydrate
D00297 Digitoxin (JP16/USP/INN); Crystodigin (TN)
D00298 Digoxin (JP16/USP); Lanoxicaps (TN); Lanoxin (TN)
D01240 Deslanoside (JP16/USP/INN); Cedilanid-d (TN)
D01379 Proscillaridin (JAN/USAN/INN); Talusin (TN)
D01972 Lanatoside C (JP16/INN); Digilanogen C (TN)
D02587 Metildigoxin (JP16); Lanirapid (TN)
D06881 Acetyldigitoxin (INN); Acylanid (TN)
D07147 Gitoformate (INN)
D07555 Acetyldigoxin; Cedigossima (TN)
D07556 beta-Acetyldigoxin; Acetyldigoxin beta isomer; Corotal (TN)
D09847 Metildigoxin (INN); Medigoxin (BAN)
DrugBank
DB00511Acetyldigitoxin
DB01430Almitrine
DB01370Aluminium
DB01244Bepridil
DB01158Bretylium
DB01188Ciclopirox
DB01078Deslanoside
DB01119Diazoxide
DB01396Digitoxin
DB00390Digoxin
DB00903Ethacrynic acid
DB00774Hydroflumethiazide
DB01092Ouabain
DB01021Trichlormethiazide
Regulatory Network of AT1A1_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND TYR-260, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-260, AND MASSSPECTROMETRY.
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells.";
Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.;
J. Proteome Res. 8:3852-3861(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-10; TYR-55 AND TYR-260,AND MASS SPECTROMETRY.
"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks.";
Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.;
Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-260, AND MASSSPECTROMETRY.
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-260, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory