SSRB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SSRB_HUMAN
• UniProt AC: P43308
• Protein Name: Translocon-associated protein subunit beta
• Gene Name: SSR2
• Organism: Homo sapiens (Human).
• Sequence Length: 183
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
• Protein Description: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins..
• Protein Sequence: MRLLSFVVLALFAVTQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELSDDSFPPEDFGIVSGMLNVKWDRIAPASNVSHTVVLRPLKAGYFNFTSATITYLAQEDGPVVIGSTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIGIPLLLWYSSKRKYDTPKTKKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Ubiquitination	GARLLASKSLLNRYA HHHHHHCHHHHHHHH	39.24	21963094
27	2-Hydroxyisobutyrylation	GARLLASKSLLNRYA HHHHHHCHHHHHHHH	39.24	-
32	Methylation	ASKSLLNRYAVEGRD HCHHHHHHHHHCCCC	22.28	115917889
46	Ubiquitination	DLTLQYNIYNVGSSA CEEEEEEEEECCCCE	1.94	21906983
87	O-linked_Glycosylation	WDRIAPASNVSHTVV CEEECCCCCCCEEEE	36.38	30059200
88	N-linked_Glycosylation	DRIAPASNVSHTVVL EEECCCCCCCEEEEE	41.22	12754519
90	O-linked_Glycosylation	IAPASNVSHTVVLRP ECCCCCCCEEEEECE	20.07	30059200
104	N-linked_Glycosylation	PLKAGYFNFTSATIT EECCCCCEECEEEEE	30.70	12754519
125	O-linked_Glycosylation	GPVVIGSTSAPGQGG CCEEEECCCCCCCCC	24.56	OGP
157	Phosphorylation	WAAFGVMTLPSIGIP HHHHCCCCCHHCCCC	32.86	27251275
160	Phosphorylation	FGVMTLPSIGIPLLL HCCCCCHHCCCCHHH	36.24	27251275
169	Phosphorylation	GIPLLLWYSSKRKYD CCCHHHHHHCCCCCC	11.75	27251275
171	Phosphorylation	PLLLWYSSKRKYDTP CHHHHHHCCCCCCCC	22.30	27251275
177	Phosphorylation	SSKRKYDTPKTKKN- HCCCCCCCCCCCCC-	24.48	21857030
182	Ubiquitination	YDTPKTKKN------ CCCCCCCCC------	73.46	24816145
201	Ubiquitination	------------------------- -------------------------		24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SSRB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SSRB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SSRB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRPRA_HUMAN	SRPR	physical	3021779
RPN1_HUMAN	RPN1	physical	26344197
QCR2_HUMAN	UQCRC2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-88 AND ASN-104, AND MASSSPECTROMETRY.
PubMed: 19159218

"Identification and quantification of N-linked glycoproteins usinghydrazide chemistry, stable isotope labeling and mass spectrometry.";
Zhang H., Li X.-J., Martin D.B., Aebersold R.;
Nat. Biotechnol. 21:660-666(2003).
Cited for: GLYCOSYLATION AT ASN-88 AND ASN-104.
PubMed: 12754519