| UniProt ID | SRPRA_HUMAN | |
|---|---|---|
| UniProt AC | P08240 | |
| Protein Name | Signal recognition particle receptor subunit alpha | |
| Gene Name | SRPRA {ECO:0000312|HGNC:HGNC:11307} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 638 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Peripheral membrane protein. Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain. |
|
| Protein Description | Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system.. | |
| Protein Sequence | MLDFFTIFSKGGLVLWCFQGVSDSCTGPVNALIRSVLLQERGGNNSFTHEALTLKYKLDNQFELVFVVGFQKILTLTYVDKLIDDVHRLFRDKYRTEIQQQSALSLLNGTFDFQNDFLRLLREAEESSKIRAPTTMKKFEDSEKAKKPVRSMIETRGEKPKEKAKNSKKKGAKKEGSDGPLATSKPVPAEKSGLPVGPENGVELSKEELIRRKREEFIQKHGRGMEKSNKSTKSDAPKEKGKKAPRVWELGGCANKEVLDYSTPTTNGTPEAALSEDINLIRGTGSGGQLQDLDCSSSDDEGAAQNSTKPSATKGTLGGMFGMLKGLVGSKSLSREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKVMGTFSTVTSTVKQALQESLVQILQPQRRVDMLRDIMDAQRRQRPYVVTFCGVNGVGKSTNLAKISFWLLENGFSVLIAACDTFRAGAVEQLRTHTRRLSALHPPEKHGGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGFDVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQTPRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAVVAALMKA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MLDFFTIFSKGGL --CCCCEEEEECCCE | 20068231 | ||
| 9 | Phosphorylation | LDFFTIFSKGGLVLW CCCEEEEECCCEEEE | 24719451 | ||
| 41 | Methylation | RSVLLQERGGNNSFT HHHHHHHCCCCCCCC | 115917821 | ||
| 46 | Phosphorylation | QERGGNNSFTHEALT HHCCCCCCCCEEEEE | 23312004 | ||
| 48 | Phosphorylation | RGGNNSFTHEALTLK CCCCCCCCEEEEEEE | 23312004 | ||
| 110 | Ubiquitination | ALSLLNGTFDFQNDF HHHHHHCCCHHHHHH | 24816145 | ||
| 138 | Ubiquitination | RAPTTMKKFEDSEKA CCCCCHHHCCCHHHH | 24816145 | ||
| 142 | Phosphorylation | TMKKFEDSEKAKKPV CHHHCCCHHHHHHHH | 29214152 | ||
| 151 | Phosphorylation | KAKKPVRSMIETRGE HHHHHHHHHHHHCCC | 21406692 | ||
| 155 | Phosphorylation | PVRSMIETRGEKPKE HHHHHHHHCCCCHHH | 21406692 | ||
| 163 | Acetylation | RGEKPKEKAKNSKKK CCCCHHHHHHHHHCC | 133893 | ||
| 169 | Acetylation | EKAKNSKKKGAKKEG HHHHHHHCCCCCCCC | 133889 | ||
| 170 | Acetylation | KAKNSKKKGAKKEGS HHHHHHCCCCCCCCC | 133885 | ||
| 174 | Acetylation | SKKKGAKKEGSDGPL HHCCCCCCCCCCCCC | 26051181 | ||
| 177 | Phosphorylation | KGAKKEGSDGPLATS CCCCCCCCCCCCCCC | 25159151 | ||
| 183 | Phosphorylation | GSDGPLATSKPVPAE CCCCCCCCCCCCCCH | 23312004 | ||
| 184 | Phosphorylation | SDGPLATSKPVPAEK CCCCCCCCCCCCCHH | 25850435 | ||
| 185 | Acetylation | DGPLATSKPVPAEKS CCCCCCCCCCCCHHH | 26051181 | ||
| 185 | Malonylation | DGPLATSKPVPAEKS CCCCCCCCCCCCHHH | 26320211 | ||
| 192 | Phosphorylation | KPVPAEKSGLPVGPE CCCCCHHHCCCCCCC | 28555341 | ||
| 192 | Ubiquitination | KPVPAEKSGLPVGPE CCCCCHHHCCCCCCC | 29967540 | ||
| 206 | Acetylation | ENGVELSKEELIRRK CCCCCCCHHHHHHHH | 26051181 | ||
| 220 | Ubiquitination | KREEFIQKHGRGMEK HHHHHHHHHCCCHHH | 29967540 | ||
| 228 | Phosphorylation | HGRGMEKSNKSTKSD HCCCHHHCCCCCCCC | 30631047 | ||
| 231 | Phosphorylation | GMEKSNKSTKSDAPK CHHHCCCCCCCCCCH | 30631047 | ||
| 232 | Phosphorylation | MEKSNKSTKSDAPKE HHHCCCCCCCCCCHH | 30631047 | ||
| 242 | Methylation | DAPKEKGKKAPRVWE CCCHHHCCCCCCCCE | 116252045 | ||
| 261 | Phosphorylation | ANKEVLDYSTPTTNG CCCHHHCCCCCCCCC | 28796482 | ||
| 262 | Phosphorylation | NKEVLDYSTPTTNGT CCHHHCCCCCCCCCC | 28796482 | ||
| 263 | Phosphorylation | KEVLDYSTPTTNGTP CHHHCCCCCCCCCCH | 22199227 | ||
| 265 | Phosphorylation | VLDYSTPTTNGTPEA HHCCCCCCCCCCHHH | 22199227 | ||
| 266 | Phosphorylation | LDYSTPTTNGTPEAA HCCCCCCCCCCHHHH | 22199227 | ||
| 268 | Phosphorylation | YSTPTTNGTPEAALS CCCCCCCCCHHHHHH | 33259812 | ||
| 269 | Phosphorylation | STPTTNGTPEAALSE CCCCCCCCHHHHHHC | 22199227 | ||
| 275 | Phosphorylation | GTPEAALSEDINLIR CCHHHHHHCCCEEEE | 26552605 | ||
| 284 | Phosphorylation | DINLIRGTGSGGQLQ CCEEEECCCCCCCCC | 23927012 | ||
| 286 | Phosphorylation | NLIRGTGSGGQLQDL EEEECCCCCCCCCCC | 30278072 | ||
| 296 | Phosphorylation | QLQDLDCSSSDDEGA CCCCCCCCCCCCCCH | 26846344 | ||
| 297 | Phosphorylation | LQDLDCSSSDDEGAA CCCCCCCCCCCCCHH | 26846344 | ||
| 298 | Phosphorylation | QDLDCSSSDDEGAAQ CCCCCCCCCCCCHHC | 26846344 | ||
| 303 | Ubiquitination | SSSDDEGAAQNSTKP CCCCCCCHHCCCCCC | 29967540 | ||
| 307 | Phosphorylation | DEGAAQNSTKPSATK CCCHHCCCCCCCCCC | 23927012 | ||
| 308 | Phosphorylation | EGAAQNSTKPSATKG CCHHCCCCCCCCCCC | 23927012 | ||
| 311 | Phosphorylation | AQNSTKPSATKGTLG HCCCCCCCCCCCCHH | 26503892 | ||
| 313 | Phosphorylation | NSTKPSATKGTLGGM CCCCCCCCCCCHHHH | 23927012 | ||
| 316 | Ubiquitination | KPSATKGTLGGMFGM CCCCCCCCHHHHHHH | 29967540 | ||
| 316 | Phosphorylation | KPSATKGTLGGMFGM CCCCCCCCHHHHHHH | 29083192 | ||
| 331 | 2-Hydroxyisobutyrylation | LKGLVGSKSLSREDM HHHHHCCCCCCHHHH | - | ||
| 331 | Acetylation | LKGLVGSKSLSREDM HHHHHCCCCCCHHHH | 27452117 | ||
| 331 | Ubiquitination | LKGLVGSKSLSREDM HHHHHCCCCCCHHHH | 29967540 | ||
| 332 | Phosphorylation | KGLVGSKSLSREDME HHHHCCCCCCHHHHH | 28450419 | ||
| 334 | Phosphorylation | LVGSKSLSREDMESV HHCCCCCCHHHHHHH | 28450419 | ||
| 344 | Ubiquitination | DMESVLDKMRDHLIA HHHHHHHHHHHHHHH | 29967540 | ||
| 344 | 2-Hydroxyisobutyrylation | DMESVLDKMRDHLIA HHHHHHHHHHHHHHH | - | ||
| 352 | 2-Hydroxyisobutyrylation | MRDHLIAKNVAADIA HHHHHHHHHHHHHHH | - | ||
| 369 | Ubiquitination | LCESVANKLEGKVMG HHHHHHHHCCCCCCC | - | ||
| 369 | 2-Hydroxyisobutyrylation | LCESVANKLEGKVMG HHHHHHHHCCCCCCC | - | ||
| 373 | Ubiquitination | VANKLEGKVMGTFST HHHHCCCCCCCCHHH | - | ||
| 377 | O-linked_Glycosylation | LEGKVMGTFSTVTST CCCCCCCCHHHHHHH | 28411811 | ||
| 379 | Phosphorylation | GKVMGTFSTVTSTVK CCCCCCHHHHHHHHH | 24275569 | ||
| 382 | Phosphorylation | MGTFSTVTSTVKQAL CCCHHHHHHHHHHHH | - | ||
| 383 | Phosphorylation | GTFSTVTSTVKQALQ CCHHHHHHHHHHHHH | - | ||
| 384 | Phosphorylation | TFSTVTSTVKQALQE CHHHHHHHHHHHHHH | - | ||
| 464 | Ubiquitination | FRAGAVEQLRTHTRR HCCCHHHHHHHHHHH | 29967540 | ||
| 469 | Phosphorylation | VEQLRTHTRRLSALH HHHHHHHHHHHHHCC | - | ||
| 473 | Phosphorylation | RTHTRRLSALHPPEK HHHHHHHHHCCCCHH | 27067055 | ||
| 492 | Acetylation | TMVQLFEKGYGKDAA CHHHHHHCCCCCCHH | 25953088 | ||
| 492 | Malonylation | TMVQLFEKGYGKDAA CHHHHHHCCCCCCHH | 26320211 | ||
| 492 | 2-Hydroxyisobutyrylation | TMVQLFEKGYGKDAA CHHHHHHCCCCCCHH | - | ||
| 492 | Ubiquitination | TMVQLFEKGYGKDAA CHHHHHHCCCCCCHH | 29967540 | ||
| 496 | Ubiquitination | LFEKGYGKDAAGIAM HHHCCCCCCHHHHHH | - | ||
| 503 | Sulfoxidation | KDAAGIAMEAIAFAR CCHHHHHHHHHHHHH | 30846556 | ||
| 561 | Ubiquitination | LVGNEAVDQLVKFNR HHCHHHHHHHHHHHH | 29967540 | ||
| 574 | Phosphorylation | NRALADHSMAQTPRL HHHHCCCCCCCCCCC | 21406692 | ||
| 575 | Sulfoxidation | RALADHSMAQTPRLI HHHCCCCCCCCCCCC | 30846556 | ||
| 578 | Phosphorylation | ADHSMAQTPRLIDGI CCCCCCCCCCCCCEE | 25159151 | ||
| 589 | 2-Hydroxyisobutyrylation | IDGIVLTKFDTIDDK CCEEEEECCCCCCCC | - | ||
| 589 | Ubiquitination | IDGIVLTKFDTIDDK CCEEEEECCCCCCCC | 29967540 | ||
| 605 | Phosphorylation | GAAISMTYITSKPIV CCCCEEEEECCCCEE | - | ||
| 607 | Phosphorylation | AISMTYITSKPIVFV CCEEEEECCCCEEEE | - | ||
| 608 | Phosphorylation | ISMTYITSKPIVFVG CEEEEECCCCEEEEC | - | ||
| 629 | Malonylation | DLRSLNAKAVVAALM CHHHCCHHHHHHHHH | 26320211 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SRPRA_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SRPRA_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SRPRA_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SRPRB_HUMAN | SRPRB | physical | 26344197 | |
| XIAP_HUMAN | XIAP | physical | 26496610 | |
| AT2B1_HUMAN | ATP2B1 | physical | 26496610 | |
| M3K4_HUMAN | MAP3K4 | physical | 26496610 | |
| PKD2_HUMAN | PKD2 | physical | 26496610 | |
| IQEC1_HUMAN | IQSEC1 | physical | 26496610 | |
| PRS23_HUMAN | PRSS23 | physical | 26496610 | |
| TP4AP_HUMAN | TRPC4AP | physical | 26496610 | |
| SRPRB_HUMAN | SRPRB | physical | 26496610 | |
| DEFM_HUMAN | physical | 26496610 | ||
| NAA15_HUMAN | NAA15 | physical | 26496610 | |
| INT14_HUMAN | VWA9 | physical | 26496610 | |
| K2013_HUMAN | KIAA2013 | physical | 26496610 | |
| SPICE_HUMAN | SPICE1 | physical | 26496610 | |
| CCD61_HUMAN | CCDC61 | physical | 26496610 | |
| ANX13_HUMAN | ANXA13 | physical | 28514442 | |
| I27RA_HUMAN | IL27RA | physical | 28514442 | |
| ZDH17_HUMAN | ZDHHC17 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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