I27RA_HUMAN - dbPTM
I27RA_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID I27RA_HUMAN
UniProt AC Q6UWB1
Protein Name Interleukin-27 receptor subunit alpha
Gene Name IL27RA
Organism Homo sapiens (Human).
Sequence Length 636
Subcellular Localization Membrane
Single-pass type I membrane protein.
Protein Description Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms..
Protein Sequence MRGGRGAPFWLWPLPKLALLPLLWVLFQRTRPQGSAGPLQCYGVGPLGDLNCSWEPLGDLGAPSELHLQSQKYRSNKTQTVAVAAGRSWVAIPREQLTMSDKLLVWGTKAGQPLWPPVFVNLETQMKPNAPRLGPDVDFSEDDPLEATVHWAPPTWPSHKVLICQFHYRRCQEAAWTLLEPELKTIPLTPVEIQDLELATGYKVYGRCRMEKEEDLWGEWSPILSFQTPPSAPKDVWVSGNLCGTPGGEEPLLLWKAPGPCVQVSYKVWFWVGGRELSPEGITCCCSLIPSGAEWARVSAVNATSWEPLTNLSLVCLDSASAPRSVAVSSIAGSTELLVTWQPGPGEPLEHVVDWARDGDPLEKLNWVRLPPGNLSALLPGNFTVGVPYRITVTAVSASGLASASSVWGFREELAPLVGPTLWRLQDAPPGTPAIAWGEVPRHQLRGHLTHYTLCAQSGTSPSVCMNVSGNTQSVTLPDLPWGPCELWVTASTIAGQGPPGPILRLHLPDNTLRWKVLPGILFLWGLFLLGCGLSLATSGRCYHLRHKVLPRWVWEKVPDPANSSSGQPHMEQVPEAQPLGDLPILEVEEMEPPPVMESSQPAQATAPLDSGYEKHFLPTPEELGLLGPPRPQVLA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
51N-linked_GlycosylationVGPLGDLNCSWEPLG
EECCCCCCCEEECCC		23.63UniProtKB CARBOHYD
76N-linked_GlycosylationQSQKYRSNKTQTVAV
CCHHHCCCCCCEEEE		42.25UniProtKB CARBOHYD
189O-linked_GlycosylationELKTIPLTPVEIQDL
HHCCCCCCCCEEEEE		21.67OGP
189PhosphorylationELKTIPLTPVEIQDL
HHCCCCCCCCEEEEE		21.67-
265PhosphorylationPGPCVQVSYKVWFWV
CCCEEEEEEEEEEEE		11.3519413330
266PhosphorylationGPCVQVSYKVWFWVG
CCEEEEEEEEEEEEC		15.6519413330
302N-linked_GlycosylationWARVSAVNATSWEPL
EEEEECEECCCCCCC		36.90UniProtKB CARBOHYD
311N-linked_GlycosylationTSWEPLTNLSLVCLD
CCCCCCCCEEEEEEC		35.00UniProtKB CARBOHYD
374N-linked_GlycosylationWVRLPPGNLSALLPG
CEECCCCCCEEECCC		36.27UniProtKB CARBOHYD
382N-linked_GlycosylationLSALLPGNFTVGVPY
CEEECCCCEECCCCE		27.72UniProtKB CARBOHYD
432O-linked_GlycosylationLQDAPPGTPAIAWGE
ECCCCCCCCCEEEEC		18.47OGP
467N-linked_GlycosylationTSPSVCMNVSGNTQS
CCCEEEEECCCCCEE		21.48UniProtKB CARBOHYD
490O-linked_GlycosylationGPCELWVTASTIAGQ
CCEEEEEEHHHHCCC		11.87OGP
493O-linked_GlycosylationELWVTASTIAGQGPP
EEEEEHHHHCCCCCC		16.63OGP
548UbiquitinationRCYHLRHKVLPRWVW
CCCCCCCCCCCCCHH		38.75-
613PhosphorylationTAPLDSGYEKHFLPT
CCCCCCCCCCCCCCC		26.2522817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of I27RA_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of I27RA_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of I27RA_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
STAT1_HUMANSTAT1physical
12734330
JAK1_HUMANJAK1physical
12734330
IL27A_HUMANIL27physical
12121660
IL27B_HUMANEBI3physical
12121660
POTEE_HUMANPOTEEphysical
28514442
TMX4_HUMANTMX4physical
28514442
DJC18_HUMANDNAJC18physical
28514442
FND3A_HUMANFNDC3Aphysical
28514442
DEP1A_HUMANDEPDC1physical
28514442
ULBP3_HUMANULBP3physical
28514442
B4GT5_HUMANB4GALT5physical
28514442
RHBD3_HUMANRHBDD3physical
28514442
PLD6_HUMANPLD6physical
28514442
AP1G2_HUMANAP1G2physical
28514442
LENG8_HUMANLENG8physical
28514442
TMX1_HUMANTMX1physical
28514442
TNFL9_HUMANTNFSF9physical
28514442
GLMN_HUMANGLMNphysical
28514442
CALX_HUMANCANXphysical
28514442
B4GT1_HUMANB4GALT1physical
28514442
FGFR1_HUMANFGFR1physical
28514442
GBB2_HUMANGNB2physical
28514442
COX1_HUMANCOX1physical
28514442
NDC1_HUMANNDC1physical
28514442
CELR2_HUMANCELSR2physical
28514442
PLXB2_HUMANPLXNB2physical
28514442
NRP1_HUMANNRP1physical
28514442
LRP11_HUMANLRP11physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of I27RA_HUMAN

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Related Literatures of Post-Translational Modification

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