PLXB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLXB2_HUMAN
• UniProt AC: O15031
• Protein Name: Plexin-B2
• Gene Name: PLXNB2
• Organism: Homo sapiens (Human).
• Sequence Length: 1838
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity)..
• Protein Sequence: MALQLWALTLLGLLGAGASLRPRKLDFFRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQCHEAEMTDNVNQLLLLDPPRKRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVSSTGPGGDRVLFVGKGNGPHDNGIIVSTRLLDRTDSREAFEAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPARNRTLLARMCREDPNYYSYLEMDLQCRDPDIHAAAFGTCLAASVAAPGSGRVLYAVFSRDSRSSGGPGAGLCLFPLDKVHAKMEANRNACYTGTREARDIFYKPFHGDIQCGGHAPGSSKSFPCGSEHLPYPLGSRDGLRGTAVLQRGGLNLTAVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAEEASHWLWSRSKSCVAVTSAQPQNMSRRAQGEVQLTVSPLPALSEEDELLCLFGESPPHPARVEGEAVICNSPSSIPVTPPGQDHVAVTIQLLLRRGNIFLTSYQYPFYDCRQAMSLEENLPCISCVSNRWTCQWDLRYHECREASPNPEDGIVRAHMEDSCPQFLGPSPLVIPMNHETDVNFQGKNLDTVKGSSLHVGSDLLKFMEPVTMQESGTFAFRTPKLSHDANETLPLHLYVKSYGKNIDSKLHVTLYNCSFGRSDCSLCRAANPDYRCAWCGGQSRCVYEALCNTTSECPPPVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISVAGRNCSFQPERYSVSTRIVCVIEAAETPFTGGVEVDVFGKLGRSPPNVQFTFQQPKPLSVEPQQGPQAGGTTLTIHGTHLDTGSQEDVRVTLNGVPCKVTKFGAQLQCVTGPQATRGQMLLEVSYGGSPVPNPGIFFTYRENPVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVVIAEPLQSWQPPREAESLQPMTVVGTDYVFHNDTKVVFLSPAVPEEPEAYNLTVLIEMDGHRALLRTEAGAFEYVPDPTFENFTGGVKKQVNKLIHARGTNLNKAMTLQEAEAFVGAERCTMKTLTETDLYCEPPEVQPPPKRRQKRDTTHNLPEFIVKFGSREWVLGRVEYDTRVSDVPLSLILPLVIVPMVVVIAVSVYCYWRKSQQAEREYEKIKSQLEGLEESVRDRCKKEFTDLMIEMEDQTNDVHEAGIPVLDYKTYTDRVFFLPSKDGDKDVMITGKLDIPEPRRPVVEQALYQFSNLLNSKSFLINFIHTLENQREFSARAKVYFASLLTVALHGKLEYYTDIMHTLFLELLEQYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGVDAIPVKVLNCDTISQVKEKIIDQVYRGQPCSCWPRPDSVVLEWRPGSTAQILSDLDLTSQREGRWKRVNTLMHYNVRDGATLILSKVGVSQQPEDSQQDLPGERHALLEEENRVWHLVRPTDEVDEGKSKRGSVKEKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHNIQDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQIAAALENKVTDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	GLLGAGASLRPRKLD HHHCCCCCCCHHHCH	24.80	26437602
76	Ubiquitination	TGPALDNKKCTPPIE HCCCCCCCCCCCCCC	49.22	21906983
77	Ubiquitination	GPALDNKKCTPPIEA CCCCCCCCCCCCCCH	49.98	22817900
114	Phosphorylation	KRLVECGSLFKGICA HHHHHHHCHHHHHHH	42.14	24719451
126	Phosphorylation	ICALRALSNISLRLF HHHHHHHHCCEEEEE	31.00	21955146
127	N-linked_Glycosylation	CALRALSNISLRLFY HHHHHHHCCEEEEEE	28.81	17660510
129	Phosphorylation	LRALSNISLRLFYED HHHHHCCEEEEEEEC	16.22	21955146
139	Ubiquitination	LFYEDGSGEKSFVAS EEEECCCCCEEEEEE	52.46	22817900
140	Ubiquitination	FYEDGSGEKSFVASN EEECCCCCEEEEEEC	47.42	22817900
191	Phosphorylation	STRLLDRTDSREAFE EEEEECCCCCHHHHH	37.68	28857561
193	Phosphorylation	RLLDRTDSREAFEAY EEECCCCCHHHHHHH	31.26	28857561
200	Phosphorylation	SREAFEAYTDHATYK CHHHHHHHHCCCEEE	12.90	-
242	N-linked_Glycosylation	QDKHPARNRTLLARM CCCCCCCCHHHHHHH	43.31	UniProtKB CARBOHYD
343	Ubiquitination	EARDIFYKPFHGDIQ HHHHHCCCCCCCCCC	30.38	29967540
391	N-linked_Glycosylation	VLQRGGLNLTAVTVA EEECCCEEEEEEEEE	38.32	UniProtKB CARBOHYD
402	N-linked_Glycosylation	VTVAAENNHTVAFLG EEEEECCCCEEEEEE	24.58	UniProtKB CARBOHYD
419	Phosphorylation	DGRILKVYLTPDGTS CCCEEEEEECCCCCC	11.85	-
447	Phosphorylation	VKRDLVLSGDLGSLY HCCCEEEECCHHHHH	23.84	20068231
452	Phosphorylation	VLSGDLGSLYAMTQD EEECCHHHHHHCCCC	26.04	20068231
454	Phosphorylation	SGDLGSLYAMTQDKV ECCHHHHHHCCCCCE	8.95	20068231
528	N-linked_Glycosylation	VTSAQPQNMSRRAQG EECCCCCCCCCCCCC	36.76	17660510
650	Phosphorylation	YHECREASPNPEDGI HHHHHCCCCCCCCCC	22.06	-
696	Ubiquitination	GKNLDTVKGSSLHVG CCCCCCCCCCCEECC	55.99	21906983
733	N-linked_Glycosylation	PKLSHDANETLPLHL CCCCCCCCCCCCEEE	49.17	19159218
747	Ubiquitination	LYVKSYGKNIDSKLH EEEEECCCCCCCCEE	42.36	27667366
759	N-linked_Glycosylation	KLHVTLYNCSFGRSD CEEEEEEECCCCCCC	20.33	UniProtKB CARBOHYD
759	Ubiquitination	KLHVTLYNCSFGRSD CEEEEEEECCCCCCC	20.33	22817900
795	N-linked_Glycosylation	CVYEALCNTTSECPP HHHHHHHCCCCCCCC	47.44	UniProtKB CARBOHYD
810	Ubiquitination	PVITRIQPETGPLGG CEEEEECCCCCCCCC	38.45	27667366
844	N-linked_Glycosylation	RISVAGRNCSFQPER EEEECCCCCCCCCCC	25.52	17660510
1002	N-linked_Glycosylation	ASGGRSINVTGQGFS HCCCCCEECCCCCHH	26.92	UniProtKB CARBOHYD
1049	N-linked_Glycosylation	GTDYVFHNDTKVVFL EEEEEEECCCEEEEE	47.37	UniProtKB CARBOHYD
1068	N-linked_Glycosylation	PEEPEAYNLTVLIEM CCCCCHHCEEEEEEE	35.96	UniProtKB CARBOHYD
1099	N-linked_Glycosylation	VPDPTFENFTGGVKK CCCCCCCCCCCCHHH	35.27	UniProtKB CARBOHYD
1105	Ubiquitination	ENFTGGVKKQVNKLI CCCCCCHHHHHHHHH	40.54	21906983
1106	Ubiquitination	NFTGGVKKQVNKLIH CCCCCHHHHHHHHHH	58.01	22817900
1110	Ubiquitination	GVKKQVNKLIHARGT CHHHHHHHHHHHCCC	50.38	22817900
1121	Ubiquitination	ARGTNLNKAMTLQEA HCCCCHHHCCCHHHH	42.58	21906983
1124	Phosphorylation	TNLNKAMTLQEAEAF CCHHHCCCHHHHHHH	30.10	20068231
1141	Phosphorylation	AERCTMKTLTETDLY CCCCCCCCCCCCCCC	28.26	29052541
1143	Phosphorylation	RCTMKTLTETDLYCE CCCCCCCCCCCCCCC	41.91	29052541
1145	Phosphorylation	TMKTLTETDLYCEPP CCCCCCCCCCCCCCC	26.52	29052541
1168	Ubiquitination	RQKRDTTHNLPEFIV CCCCCCCCCCCHHHH	35.60	22817900
1169	Ubiquitination	QKRDTTHNLPEFIVK CCCCCCCCCCHHHHH	56.02	22817900
1173	Ubiquitination	TTHNLPEFIVKFGSR CCCCCCHHHHHHCCC	8.00	22817900
1184	Ubiquitination	FGSREWVLGRVEYDT HCCCEEEEEEEEECC	3.67	22817900
1202	Ubiquitination	DVPLSLILPLVIVPM CCCHHHHHHHHHHHH	3.04	29901268
1204	Ubiquitination	PLSLILPLVIVPMVV CHHHHHHHHHHHHHH	3.53	32015554
1224	Phosphorylation	VYCYWRKSQQAEREY HHHHHHHHHHHHHHH	20.96	-
1225	Ubiquitination	YCYWRKSQQAEREYE HHHHHHHHHHHHHHH	49.92	29901268
1227	Ubiquitination	YWRKSQQAEREYEKI HHHHHHHHHHHHHHH	15.35	32015554
1231	Phosphorylation	SQQAEREYEKIKSQL HHHHHHHHHHHHHHH	28.83	-
1233	Ubiquitination	QAEREYEKIKSQLEG HHHHHHHHHHHHHHH	55.31	22817900
1235	Ubiquitination	EREYEKIKSQLEGLE HHHHHHHHHHHHHHH	43.12	21906983
1236	Phosphorylation	REYEKIKSQLEGLEE HHHHHHHHHHHHHHH	43.39	-
1244	Phosphorylation	QLEGLEESVRDRCKK HHHHHHHHHHHHHHH	17.05	28355574
1250	Ubiquitination	ESVRDRCKKEFTDLM HHHHHHHHHHHHHHE	57.12	29967540
1256	Ubiquitination	CKKEFTDLMIEMEDQ HHHHHHHHEEEEECC	3.19	29901268
1258	Ubiquitination	KEFTDLMIEMEDQTN HHHHHHEEEEECCCC	6.23	32015554
1259	Ubiquitination	EFTDLMIEMEDQTND HHHHHEEEEECCCCC	23.66	33845483
1270	Ubiquitination	QTNDVHEAGIPVLDY CCCCCHHCCCCEECC	13.31	33845483
1279	Phosphorylation	IPVLDYKTYTDRVFF CCEECCCCCCCEEEE	25.98	28152594
1280	Phosphorylation	PVLDYKTYTDRVFFL CEECCCCCCCEEEEE	11.51	28152594
1281	Phosphorylation	VLDYKTYTDRVFFLP EECCCCCCCEEEEEE	23.66	28152594
1282	Ubiquitination	LDYKTYTDRVFFLPS ECCCCCCCEEEEEEC	34.04	33845483
1283	Methylation	DYKTYTDRVFFLPSK CCCCCCCEEEEEECC	21.24	115487937
1289	Phosphorylation	DRVFFLPSKDGDKDV CEEEEEECCCCCCCE	45.59	24719451
1290	Ubiquitination	RVFFLPSKDGDKDVM EEEEEECCCCCCCEE	64.88	33845483
1293	Ubiquitination	FLPSKDGDKDVMITG EEECCCCCCCEEEEE	54.86	33845483
1296	Ubiquitination	SKDGDKDVMITGKLD CCCCCCCEEEEEECC	3.53	22817900
1298	Ubiquitination	DGDKDVMITGKLDIP CCCCCEEEEEECCCC	4.64	22817900
1301	Ubiquitination	KDVMITGKLDIPEPR CCEEEEEECCCCCCC	34.04	33845483
1312	Ubiquitination	PEPRRPVVEQALYQF CCCCCHHHHHHHHHH	5.10	29901268
1313	Ubiquitination	EPRRPVVEQALYQFS CCCCHHHHHHHHHHH	30.30	33845483
1314	Ubiquitination	PRRPVVEQALYQFSN CCCHHHHHHHHHHHH	25.67	32015554
1317	Phosphorylation	PVVEQALYQFSNLLN HHHHHHHHHHHHHHC	15.55	27642862
1320	Phosphorylation	EQALYQFSNLLNSKS HHHHHHHHHHHCCHH	15.84	-
1324	Ubiquitination	YQFSNLLNSKSFLIN HHHHHHHCCHHHHHH	51.03	33845483
1325	Phosphorylation	QFSNLLNSKSFLINF HHHHHHCCHHHHHHH	29.64	-
1327	Phosphorylation	SNLLNSKSFLINFIH HHHHCCHHHHHHHHH	25.71	-
1349	Phosphorylation	FSARAKVYFASLLTV HHHHHHHHHHHHHHH	7.85	-
1353	Ubiquitination	AKVYFASLLTVALHG HHHHHHHHHHHHHHH	4.10	27667366
1369	Ubiquitination	LEYYTDIMHTLFLEL HHHHHHHHHHHHHHH	1.89	33845483
1380	Ubiquitination	FLELLEQYVVAKNPK HHHHHHHHHHHCCCC	6.37	33845483
1387	2-Hydroxyisobutyrylation	YVVAKNPKLMLRRSE HHHHCCCCCCCCCCH	56.79	-
1392	Ubiquitination	NPKLMLRRSETVVER CCCCCCCCCHHHHHH	34.58	32015554
1410	Phosphorylation	NWMSICLYQYLKDSA HHHHHHHHHHHHHCC	7.24	-
1412	Phosphorylation	MSICLYQYLKDSAGE HHHHHHHHHHHCCCC	11.36	-
1415	Ubiquitination	CLYQYLKDSAGEPLY HHHHHHHHCCCCHHH	40.92	32015554
1422	Phosphorylation	DSAGEPLYKLFKAIK HCCCCHHHHHHHHHH	19.16	28102081
1423	Ubiquitination	SAGEPLYKLFKAIKH CCCCHHHHHHHHHHH	55.95	22817900
1426	Ubiquitination	EPLYKLFKAIKHQVE CHHHHHHHHHHHHHH	60.69	22817900
1442	Ubiquitination	GPVDAVQKKAKYTLN CCCCHHHHHCCEECC	48.37	29967540
1446	Ubiquitination	AVQKKAKYTLNDTGL HHHHHCCEECCCCCC	22.71	32015554
1460	Ubiquitination	LLGDDVEYAPLTVSV CCCCCCCCCCEEEEE	17.23	33845483
1483	Ubiquitination	AIPVKVLNCDTISQV EEEEEEECCCCHHHH	25.30	33845483
1486	Ubiquitination	VKVLNCDTISQVKEK EEEECCCCHHHHHHH	25.40	21890473
1489	Ubiquitination	LNCDTISQVKEKIID ECCCCHHHHHHHHHH	46.59	22817900
1491	Ubiquitination	CDTISQVKEKIIDQV CCCHHHHHHHHHHHH	45.73	32015554
1493	Ubiquitination	TISQVKEKIIDQVYR CHHHHHHHHHHHHHC	38.96	29967540
1499	Phosphorylation	EKIIDQVYRGQPCSC HHHHHHHHCCCCCCC	11.91	-
1502	Ubiquitination	IDQVYRGQPCSCWPR HHHHHCCCCCCCCCC	27.16	32015554
1512	Phosphorylation	SCWPRPDSVVLEWRP CCCCCCCCEEEEECC	19.46	22468782
1514	Ubiquitination	WPRPDSVVLEWRPGS CCCCCCEEEEECCCC	4.67	33845483
1529	Ubiquitination	TAQILSDLDLTSQRE HHHHHHHCCCCCCCC	5.37	29901268
1534	Ubiquitination	SDLDLTSQREGRWKR HHCCCCCCCCCCCEE	42.06	29901268
1539	Phosphorylation	TSQREGRWKRVNTLM CCCCCCCCEEEEEEE	12.03	33259812
1544	Phosphorylation	GRWKRVNTLMHYNVR CCCEEEEEEEEEECC	23.70	28857561
1548	Phosphorylation	RVNTLMHYNVRDGAT EEEEEEEEECCCCCE	11.03	26270265
1552	Ubiquitination	LMHYNVRDGATLILS EEEEECCCCCEEEEE	46.96	29901268
1555	Phosphorylation	YNVRDGATLILSKVG EECCCCCEEEEEECC	21.62	28857561
1560	Ubiquitination	GATLILSKVGVSQQP CCEEEEEECCCCCCC	39.29	21906983
1562	Phosphorylation	TLILSKVGVSQQPED EEEEEECCCCCCCCC	19.66	33259812
1564	Phosphorylation	ILSKVGVSQQPEDSQ EEEECCCCCCCCCCC	19.71	29396449
1570	Phosphorylation	VSQQPEDSQQDLPGE CCCCCCCCCCCCCCC	28.25	28355574
1570	Ubiquitination	VSQQPEDSQQDLPGE CCCCCCCCCCCCCCC	28.25	33845483
1578	Methylation	QQDLPGERHALLEEE CCCCCCCHHHHHHHH	26.71	115487945
1583	Ubiquitination	GERHALLEEENRVWH CCHHHHHHHHCCEEE	65.20	29901268
1593	Phosphorylation	NRVWHLVRPTDEVDE CCEEEEECCCCCCCC	34.46	33259812
1602	Ubiquitination	TDEVDEGKSKRGSVK CCCCCCCCCCCCCCC	51.24	29967540
1614	Phosphorylation	SVKEKERTKAITEIY CCCHHHHHHHHHHHH	26.39	-
1621	Phosphorylation	TKAITEIYLTRLLSV HHHHHHHHHHHHHHC	8.86	28152594
1623	Phosphorylation	AITEIYLTRLLSVKG HHHHHHHHHHHHCHH	11.42	28152594
1623	Ubiquitination	AITEIYLTRLLSVKG HHHHHHHHHHHHCHH	11.42	22817900
1627	Phosphorylation	IYLTRLLSVKGTLQQ HHHHHHHHCHHHHHH	26.78	24719451
1639	Ubiquitination	LQQFVDNFFQSVLAP HHHHHHHHHHHHCCC	5.22	29901268
1649	Phosphorylation	SVLAPGHAVPPAVKY HHCCCCCCCCHHHHH	22.79	33259812
1667	Ubiquitination	FLDEQAEKHNIQDED HHHHHHHHCCCCCCC	44.99	29967540
1683	Phosphorylation	IHIWKTNSLPLRFWV EEEEECCCCCEEEHH	36.27	24719451
1726	Ubiquitination	FMDACTRTEHKLSRD HHHHHHHCCCCCCCC	25.04	29901268
1731	Ubiquitination	TRTEHKLSRDSPSNK HHCCCCCCCCCCCCC	38.55	29901268
1736	Phosphorylation	KLSRDSPSNKLLYAK CCCCCCCCCCEEEHH	51.02	28857561
1738	Ubiquitination	SRDSPSNKLLYAKEI CCCCCCCCEEEHHHH	44.18	23000965
1741	Phosphorylation	SPSNKLLYAKEISTY CCCCCEEEHHHHHHH	26.51	22817900
1743	Ubiquitination	SNKLLYAKEISTYKK CCCEEEHHHHHHHHH	41.86	23000965
1748	Phosphorylation	YAKEISTYKKMVEDY EHHHHHHHHHHHHHH	11.21	22817900
1749	Ubiquitination	AKEISTYKKMVEDYY HHHHHHHHHHHHHHH	34.19	23000965
1750	Ubiquitination	KEISTYKKMVEDYYK HHHHHHHHHHHHHHH	37.45	29967540
1756	Phosphorylation	KKMVEDYYKGIRQMV HHHHHHHHHHHHHHH	18.30	-
1757	Ubiquitination	KMVEDYYKGIRQMVQ HHHHHHHHHHHHHHH	41.45	29901268
1780	Ubiquitination	HLAEISRAHTDSLNT HHHHHHHHHHHCHHH	11.80	29901268
1782	Phosphorylation	AEISRAHTDSLNTLV HHHHHHHHHCHHHHH	26.71	20873877
1784	Phosphorylation	ISRAHTDSLNTLVAL HHHHHHHCHHHHHHH	25.36	20873877
1786	Ubiquitination	RAHTDSLNTLVALHQ HHHHHCHHHHHHHHH	35.01	29901268
1787	Phosphorylation	AHTDSLNTLVALHQL HHHHCHHHHHHHHHH	28.09	20873877
1791	Ubiquitination	SLNTLVALHQLYQYT CHHHHHHHHHHHHHH	1.74	29901268
1795	Phosphorylation	LVALHQLYQYTQKYY HHHHHHHHHHHHHHH	7.91	20873877
1797	Phosphorylation	ALHQLYQYTQKYYDE HHHHHHHHHHHHHHH	9.51	20873877
1798	Phosphorylation	LHQLYQYTQKYYDEI HHHHHHHHHHHHHHH	11.76	20873877
1801	Ubiquitination	LYQYTQKYYDEIINA HHHHHHHHHHHHHHH	13.31	23000965
1806	Ubiquitination	QKYYDEIINALEEDP HHHHHHHHHHHHHCH	2.02	23000965
1809	Ubiquitination	YDEIINALEEDPAAQ HHHHHHHHHHCHHHH	6.82	29901268
1812	Ubiquitination	IINALEEDPAAQKMQ HHHHHHHCHHHHHHH	28.85	23000965
1817	Ubiquitination	EEDPAAQKMQLAFRL HHCHHHHHHHHHHHH	24.72	21906983
1834	Ubiquitination	IAAALENKVTDL--- HHHHHHHHCCCC---	36.82	21906983
1836	Ubiquitination	AALENKVTDL----- HHHHHHCCCC-----	32.94	29901268
1840	Ubiquitination	NKVTDL--------- HHCCCC---------		29901268
1880	Ubiquitination	------------------------------------------------- -------------------------------------------------		21963094
1896	Ubiquitination	----------------------------------------------------------------- -----------------------------------------------------------------		29901268
1897	Ubiquitination	------------------------------------------------------------------ ------------------------------------------------------------------		21987572

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLXB2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLXB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLXB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTN_HUMAN	PTN	physical	16169070
TACC1_HUMAN	TACC1	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-127, AND MASSSPECTROMETRY.
PubMed: 19349973

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-127 AND ASN-733, AND MASSSPECTROMETRY.
PubMed: 19159218