dbPTM

TACC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TACC1_HUMAN
UniProt AC	O75410
Protein Name	Transforming acidic coiled-coil-containing protein 1
Gene Name	TACC1
Organism	Homo sapiens (Human).
Sequence Length	805
Subcellular Localization	Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody . Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. Isoform 5
Protein Description	Likely involved in the processes that promote cell division prior to the formation of differentiated tissues..
Protein Sequence	MAFSPWQILSPVQWAKWTWSAVRGGAAGEDEAGGPEGDPEEEDSQAETKSLSFSSDSEGNFETPEAETPIRSPFKESCDPSLGLAGPGAKSQESQEADEQLVAEVVEKCSSKTCSKPSENEVPQQAIDSHSVKNFREEPEHDFSKISIVRPFSIETKDSTDISAVLGTKAAHGCVTAVSGKALPSSPPDALQDEAMTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVEGTPLPKASYHFSPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDSGVELGEESRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKLGKTD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAFSPWQIL ------CCCCCCCEE	17.39	20068231
2 (in isoform 5)	Myristoylation	-	17.39	25807930
4	Phosphorylation	----MAFSPWQILSP ----CCCCCCCEECH	18.72	22199227
4 (in isoform 4)	Phosphorylation	-	18.72	24043423
4 (in isoform 5)	Phosphorylation	-	18.72	24043423
6 (in isoform 4)	Phosphorylation	-	9.17	24043423
6 (in isoform 5)	Phosphorylation	-	9.17	24043423
8 (in isoform 4)	Phosphorylation	-	3.48	22468782
8 (in isoform 5)	Phosphorylation	-	3.48	22468782
10	Phosphorylation	FSPWQILSPVQWAKW CCCCCEECHHHHHHH	25.34	25159151
20	Phosphorylation	QWAKWTWSAVRGGAA HHHHHHHHHHCCCCC	14.98	28555341
44	Phosphorylation	GDPEEEDSQAETKSL CCCHHHCCCCCHHCC	34.27	23401153
48	Phosphorylation	EEDSQAETKSLSFSS HHCCCCCHHCCCCCC	29.02	22167270
50	Phosphorylation	DSQAETKSLSFSSDS CCCCCHHCCCCCCCC	36.34	30278072
52	Phosphorylation	QAETKSLSFSSDSEG CCCHHCCCCCCCCCC	30.12	30278072
54	Phosphorylation	ETKSLSFSSDSEGNF CHHCCCCCCCCCCCC	29.84	25159151
55	Phosphorylation	TKSLSFSSDSEGNFE HHCCCCCCCCCCCCC	43.05	30278072
57	Phosphorylation	SLSFSSDSEGNFETP CCCCCCCCCCCCCCC	49.72	25159151
63	Phosphorylation	DSEGNFETPEAETPI CCCCCCCCCCCCCCC	23.45	28464451
68	Phosphorylation	FETPEAETPIRSPFK CCCCCCCCCCCCCCH	30.94	24173317
75	Methylation	TPIRSPFKESCDPSL CCCCCCCHHHCCCCC	52.69	115980249
75	Ubiquitination	TPIRSPFKESCDPSL CCCCCCCHHHCCCCC	52.69	-
81	Phosphorylation	FKESCDPSLGLAGPG CHHHCCCCCCCCCCC	23.09	17081983
91	Phosphorylation	LAGPGAKSQESQEAD CCCCCCCCHHCHHHH	38.35	23663014
94	Phosphorylation	PGAKSQESQEADEQL CCCCCHHCHHHHHHH	26.19	30266825
118	Phosphorylation	SKTCSKPSENEVPQQ CCCCCCCCCCCCCHH	57.71	25137130
129	Phosphorylation	VPQQAIDSHSVKNFR CCHHHHHHHCCCCHH	16.14	23403867
131	Phosphorylation	QQAIDSHSVKNFREE HHHHHHHCCCCHHHC	38.44	26657352
132 (in isoform 8)	Ubiquitination	-	5.00	21906983
144	Phosphorylation	EEPEHDFSKISIVRP HCCCCCCCCEEEEEC	34.83	25137130
147	Phosphorylation	EHDFSKISIVRPFSI CCCCCCEEEEECEEE	20.83	25159151
153	Phosphorylation	ISIVRPFSIETKDST EEEEECEEEECCCCC	23.38	28102081
156	Phosphorylation	VRPFSIETKDSTDIS EECEEEECCCCCCCH	38.18	23403867
168	Phosphorylation	DISAVLGTKAAHGCV CCHHHHCCHHHCCCE	17.22	20058876
169	Ubiquitination	ISAVLGTKAAHGCVT CHHHHCCHHHCCCEE	41.60	-
179	Phosphorylation	HGCVTAVSGKALPSS CCCEEEECCCCCCCC	31.92	20058876
218	Phosphorylation	ADLKAGNSCPELVPS HHHHCCCCCCCCCCC	30.08	26657352
225	Phosphorylation	SCPELVPSRRSKLRK CCCCCCCCHHHHCCC	32.61	30108239
228	Phosphorylation	ELVPSRRSKLRKPKP CCCCCHHHHCCCCCC	34.63	21531210
234	Acetylation	RSKLRKPKPVPLRKK HHHCCCCCCCCCCCC	62.78	12429785
240	Acetylation	PKPVPLRKKAIGGEF CCCCCCCCCCCCCCC	54.99	12429797
248	Phosphorylation	KAIGGEFSDTNAAVE CCCCCCCCCCCCCCC	38.94	30266825
250	Phosphorylation	IGGEFSDTNAAVEGT CCCCCCCCCCCCCCC	26.09	30266825
257	Phosphorylation	TNAAVEGTPLPKASY CCCCCCCCCCCCCCC	14.24	29255136
263	Phosphorylation	GTPLPKASYHFSPEE CCCCCCCCCCCCHHH	25.85	19690332
264	Phosphorylation	TPLPKASYHFSPEEL CCCCCCCCCCCHHHH	16.25	30266825
267	Phosphorylation	PKASYHFSPEELDEN CCCCCCCCHHHHCCC	20.35	30266825
275	Phosphorylation	PEELDENTSPLLGDA HHHHCCCCCCCCCCH	29.67	23401153
276	Phosphorylation	EELDENTSPLLGDAR HHHCCCCCCCCCCHH	25.73	25159151
286	Ubiquitination	LGDARFQKSPPDLKE CCCHHHCCCCCCHHC	63.32	-
287	Phosphorylation	GDARFQKSPPDLKET CCHHHCCCCCCHHCC	30.77	30108239
294	Phosphorylation	SPPDLKETPGTLSSD CCCCHHCCCCCCCCC	25.98	30624053
297	Phosphorylation	DLKETPGTLSSDTND CHHCCCCCCCCCCCC	25.35	23403867
299	Phosphorylation	KETPGTLSSDTNDSG HCCCCCCCCCCCCCC	26.46	23403867
300	Phosphorylation	ETPGTLSSDTNDSGV CCCCCCCCCCCCCCC	52.12	23403867
302	Phosphorylation	PGTLSSDTNDSGVEL CCCCCCCCCCCCCCC	42.76	23403867
305	Phosphorylation	LSSDTNDSGVELGEE CCCCCCCCCCCCCCC	46.97	25159151
313	Phosphorylation	GVELGEESRSSPLKL CCCCCCCCCCCCEEE	32.91	22199227
315	Phosphorylation	ELGEESRSSPLKLEF CCCCCCCCCCEEEEE	45.66	30266825
316	Phosphorylation	LGEESRSSPLKLEFD CCCCCCCCCEEEEEE	32.89	30266825
345 (in isoform 5)	Ubiquitination	-	6.71	21906983
347	Phosphorylation	KLGRKLGSTLTPKIQ HHHHCCCCCCCHHHC	30.58	23401153
348	Phosphorylation	LGRKLGSTLTPKIQK HHHCCCCCCCHHHCC	32.62	22199227
350	Phosphorylation	RKLGSTLTPKIQKDG HCCCCCCCHHHCCCC	23.71	21815630
357 (in isoform 4)	Ubiquitination	-	32.86	21906983
359	Phosphorylation	KIQKDGISKSAGLEQ HHCCCCCCCCCCCCC	26.53	23312004
360	Ubiquitination	IQKDGISKSAGLEQP HCCCCCCCCCCCCCC	42.26	-
361	Phosphorylation	QKDGISKSAGLEQPT CCCCCCCCCCCCCCC	22.30	30108239
373 (in isoform 6)	Ubiquitination	-	50.05	21906983
381	Phosphorylation	DGPLSQTSSKPDPSQ CCCCCCCCCCCCHHH	28.82	-
406	Phosphorylation	SHSVLQNSPPLSSEG CCHHHCCCCCCCCCC	18.22	22468782
454	Phosphorylation	HVNEILESPKKAKSR CHHHHHHCHHHHHHH	38.28	25159151
464	Phosphorylation	KAKSRLITSGCKVKK HHHHHHHCCCCCCCC	24.53	28102081
465	Phosphorylation	AKSRLITSGCKVKKH HHHHHHCCCCCCCCC	34.89	28102081
468	Ubiquitination	RLITSGCKVKKHETQ HHHCCCCCCCCCCCC	61.69	-
471	Ubiquitination	TSGCKVKKHETQSLA CCCCCCCCCCCCCHH	50.05	-
474	Phosphorylation	CKVKKHETQSLALDA CCCCCCCCCCHHHHH	24.15	23312004
476	Phosphorylation	VKKHETQSLALDACS CCCCCCCCHHHHHCC	24.03	23312004
477 (in isoform 2)	Phosphorylation	-	3.84	28270605
483	Phosphorylation	SLALDACSRDEGAVI CHHHHHCCCCCCCEE	44.48	-
491	Phosphorylation	RDEGAVISQISDISN CCCCCEEEEEHHCCC	18.18	28450419
494	Phosphorylation	GAVISQISDISNRDG CCEEEEEHHCCCCCC	22.66	28450419
497	Phosphorylation	ISQISDISNRDGHAT EEEEHHCCCCCCCCC	30.70	30576142
504	Phosphorylation	SNRDGHATDEEKLAS CCCCCCCCCHHHHHC	37.96	23401153
511	Phosphorylation	TDEEKLASTSCGQKS CCHHHHHCCCCCCCC	31.15	23927012
512	Phosphorylation	DEEKLASTSCGQKSA CHHHHHCCCCCCCCC	23.56	23927012
513	Phosphorylation	EEKLASTSCGQKSAG HHHHHCCCCCCCCCC	17.47	23927012
517	Ubiquitination	ASTSCGQKSAGAEVK HCCCCCCCCCCCCCC	27.79	-
518	Phosphorylation	STSCGQKSAGAEVKG CCCCCCCCCCCCCCC	24.85	26074081
533	Phosphorylation	EPEEDLEYFECSNVP CCHHHHCCEECCCCC	16.39	28796482
537	Phosphorylation	DLEYFECSNVPVSTI HHCCEECCCCCHHHH	33.39	28796482
542	Phosphorylation	ECSNVPVSTINHAFS ECCCCCHHHHHHHCC	19.94	27251275
543	Phosphorylation	CSNVPVSTINHAFSS CCCCCHHHHHHHCCC	26.49	27251275
549	Phosphorylation	STINHAFSSSEAGIE HHHHHHCCCCCCCCC	33.46	27251275
550	Phosphorylation	TINHAFSSSEAGIEK HHHHHCCCCCCCCCH	26.24	27251275
551	Phosphorylation	INHAFSSSEAGIEKE HHHHCCCCCCCCCHH	30.21	27251275
568	Phosphorylation	QKMEEDGSTVLGLLE HHHHCCCCHHHHHHH	27.88	22199227
569	Phosphorylation	KMEEDGSTVLGLLES HHHCCCCHHHHHHHH	25.86	22199227
576	Phosphorylation	TVLGLLESSAEKAPV HHHHHHHHCCCCCCE	34.51	22199227
577	Phosphorylation	VLGLLESSAEKAPVS HHHHHHHCCCCCCEE	30.95	22199227
588 (in isoform 3)	Ubiquitination	-	35.08	21906983
591	Phosphorylation	SVSCGGESPLDGICL EEECCCCCCCCCEEC	33.75	10470851
616	Phosphorylation	LIREEIITKEIEANE HHHHHHHHHHHHHHH	28.43	24670416
617	Ubiquitination	IREEIITKEIEANEW HHHHHHHHHHHHHHH	46.41	-
640	Acetylation	QEVLEMRKIVAEYEK HHHHHHHHHHHHHHH	39.98	7965395
640	Ubiquitination	QEVLEMRKIVAEYEK HHHHHHHHHHHHHHH	39.98	-
647	Acetylation	KIVAEYEKTIAQMIE HHHHHHHHHHHHHHH	44.31	7965407
647	Ubiquitination	KIVAEYEKTIAQMIE HHHHHHHHHHHHHHH	44.31	-
660	Phosphorylation	IEDEQRTSMTSQKSF HHHHHHHHHHCHHHH	23.42	22468782
665	Ubiquitination	RTSMTSQKSFQQLTM HHHHHCHHHHHHHHH	53.67	-
666	Phosphorylation	TSMTSQKSFQQLTME HHHHCHHHHHHHHHH	22.20	22468782
687	Phosphorylation	DLNSVERSLSDLFRR HHHHHHHHHHHHHHH	20.79	22468782
689	Phosphorylation	NSVERSLSDLFRRYE HHHHHHHHHHHHHHH	33.25	22468782
714	Ubiquitination	KNEEALKKCAQDYLA HCHHHHHHHHHHHHH	35.34	-
730	Phosphorylation	VKQEEQRYQALKIHA HHHHHHHHHHHHHHH	9.61	20068231
734	Ubiquitination	EQRYQALKIHAEEKL HHHHHHHHHHHHHHH	35.15	-
740	Acetylation	LKIHAEEKLDKANEE HHHHHHHHHHHHHHH	54.19	25953088
754	Acetylation	EIAQVRTKAKAESAA HHHHHHHHHHHHHHH	37.01	19824175
756	Ubiquitination	AQVRTKAKAESAALH HHHHHHHHHHHHHHH	55.00	-
759	Phosphorylation	RTKAKAESAALHAGL HHHHHHHHHHHHHHH	24.57	-
783	Ubiquitination	LERALQQKNQEIEEL HHHHHHHHHHHHHHH	47.87	2190698
783 (in isoform 1)	Ubiquitination	-	47.87	21906983
792	Ubiquitination	QEIEELTKICDELIA HHHHHHHHHHHHHHH	54.70	-
795 (in isoform 2)	Ubiquitination	-	58.15	21906983
800	Ubiquitination	ICDELIAKLGKTD-- HHHHHHHHHCCCC--	51.26	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
228	S	Phosphorylation	Kinase	AURC	Q9UQB9	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TACC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TACC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YETS4_HUMAN	YEATS4	physical	11903063
AURKB_HUMAN	AURKB	physical	15064709
AURKA_HUMAN	AURKA	physical	15064709
LSM7_HUMAN	LSM7	physical	14603251
TDRD7_HUMAN	TDRD7	physical	14603251
CKAP5_HUMAN	CKAP5	physical	14603251
AURKA_HUMAN	AURKA	physical	14603251
CKAP5_HUMAN	CKAP5	physical	11903063
LSM7_HUMAN	LSM7	physical	12165861
RUXG_HUMAN	SNRPG	physical	12165861
BARD1_HUMAN	BARD1	physical	19176389
KAT2A_HUMAN	KAT2A	physical	14767476
KDM1A_HUMAN	KDM1A	physical	23455924
FBW1A_HUMAN	BTRC	physical	25416956
MEMO1_HUMAN	MEMO1	physical	25416956
SH24A_HUMAN	SH2D4A	physical	25416956
LYST_HUMAN	LYST	physical	26496610
BRD3_HUMAN	BRD3	physical	26496610
RBCC1_HUMAN	RB1CC1	physical	26496610
TACC2_HUMAN	TACC2	physical	26496610
BI2L1_HUMAN	BAIAP2L1	physical	26496610
TACC2_HUMAN	TACC2	physical	28514442
RNF41_HUMAN	RNF41	physical	28514442
SKAP_HUMAN	KNSTRN	physical	28514442
FBW1A_HUMAN	BTRC	physical	28514442
FBW1B_HUMAN	FBXW11	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TACC1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Aurora-C interacts with and phosphorylates the transforming acidiccoiled-coil 1 protein."; Gabillard J.C., Ulisse S., Baldini E., Sorrenti S., Cremet J.Y.,Coccaro C., Prigent C., D'Armiento M., Arlot-Bonnemains Y.; Biochem. Biophys. Res. Commun. 408:647-653(2011). Cited for: SUBCELLULAR LOCATION, INTERACTION WITH AURKC, PHOSPHORYLATION ATSER-228 BY AURKC, AND MUTAGENESIS OF SER-228.	21531210 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50; SER-52; SER-54;SER-55 AND SER-57, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-533, AND MASSSPECTROMETRY.	15592455 [Abstract]