dbPTM

TACC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TACC2_HUMAN
UniProt AC	O95359
Protein Name	Transforming acidic coiled-coil-containing protein 2
Gene Name	TACC2
Organism	Homo sapiens (Human).
Sequence Length	2948
Subcellular Localization	Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
Protein Description	Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker..
Protein Sequence	MGNENSTSDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASLDPCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTLSDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGDPGKQQAPEKPGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPARELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLAHPVSLCGALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALKLARQIALASRSHQDAKREAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MGNENSTSDNQRTLS CCCCCCCCHHCCCCC	34.09	22817900
13	Phosphorylation	STSDNQRTLSAQTPR CCCHHCCCCCCCCCC	18.46	-
15	Phosphorylation	SDNQRTLSAQTPRSA CHHCCCCCCCCCCCC	20.09	29396449
18	Phosphorylation	QRTLSAQTPRSAQPP CCCCCCCCCCCCCCC	22.01	29396449
24 (in isoform 1)	Phosphorylation	-	38.18	20068231
24 (in isoform 6)	Phosphorylation	-	38.18	20068231
27 (in isoform 1)	Phosphorylation	-	46.31	18669648
27 (in isoform 6)	Phosphorylation	-	46.31	18669648
38	Phosphorylation	IKRKQQDTPGSPDHR HHHHHCCCCCCCCCC	25.80	20068231
41	Phosphorylation	KQQDTPGSPDHRDAS HHCCCCCCCCCCCHH	28.49	26055452
92 (in isoform 5)	Phosphorylation	-	27.08	29116813
93 (in isoform 5)	Phosphorylation	-	25.68	29116813
95 (in isoform 5)	Phosphorylation	-	4.17	29116813
97	Phosphorylation	PEGSLLPSPPPSQER CCCCCCCCCCCCCCC	50.43	21815630
124	Phosphorylation	PPEGCLASPAAAPED CCCCCCCCCCCCCCC	11.34	23312004
135	Phosphorylation	APEDGPQTQSPRREP CCCCCCCCCCCCCCC	33.86	22210691
137	Phosphorylation	EDGPQTQSPRREPAP CCCCCCCCCCCCCCC	24.62	22210691
150	Phosphorylation	APNAPGDIAAAFPAE CCCCCCCHHHCCCCC	3.30	20068231
151	Phosphorylation	PNAPGDIAAAFPAER CCCCCCHHHCCCCCC	9.47	20068231
153	Phosphorylation	APGDIAAAFPAERDS CCCCHHHCCCCCCCC	11.26	18669648
160	Phosphorylation	AFPAERDSSTPYQEI CCCCCCCCCCCHHHH	42.19	24732914
161	Phosphorylation	FPAERDSSTPYQEIA CCCCCCCCCCHHHHC	37.38	24732914
162	Phosphorylation	PAERDSSTPYQEIAA CCCCCCCCCHHHHCC	29.93	24732914
164	Phosphorylation	ERDSSTPYQEIAAVP CCCCCCCHHHHCCCC	20.90	24732914
166	Phosphorylation	DSSTPYQEIAAVPSA CCCCCHHHHCCCCCC	28.84	18669648
170	Phosphorylation	PYQEIAAVPSAGRER CHHHHCCCCCCCCCC	2.58	18669648
172	Phosphorylation	QEIAAVPSAGRERQP HHHCCCCCCCCCCCC	36.44	29083192
186	Phosphorylation	PKEEGQKSSFSFSSG CCCCCCCCCCCCCCC	28.82	20068231
187	Phosphorylation	KEEGQKSSFSFSSGI CCCCCCCCCCCCCCC	31.76	20068231
189	Phosphorylation	EGQKSSFSFSSGIDQ CCCCCCCCCCCCCCC	26.60	22210691
191	Phosphorylation	QKSSFSFSSGIDQSP CCCCCCCCCCCCCCC	26.85	20068231
192	Phosphorylation	KSSFSFSSGIDQSPG CCCCCCCCCCCCCCC	37.44	20068231
197	Phosphorylation	FSSGIDQSPGMSPVP CCCCCCCCCCCCCCC	21.48	25159151
200	Phosphorylation	GIDQSPGMSPVPLRE CCCCCCCCCCCCCCC	4.67	18669648
201	Phosphorylation	IDQSPGMSPVPLREP CCCCCCCCCCCCCCC	28.76	25159151
243 (in isoform 2)	Ubiquitination	-	2.44	21906983
245	Phosphorylation	ESRQGVASVQVTPEA HHCCCEEEEEECCCC	15.63	20068231
249	Phosphorylation	GVASVQVTPEAPAAA CEEEEEECCCCCHHH	9.79	20068231
260	Phosphorylation	PAAAQQGTESSAVLE CHHHHCCCCCCCCCC	28.49	22210691
269	Phosphorylation	SSAVLEKSPLKPMAP CCCCCCCCCCCCCCC	26.53	25159151
286	Phosphorylation	QDPAPRASDRERGQG CCCCCCHHHCCCCCC	38.18	20068231
299	Phosphorylation	QGEAPPQYLTDDLEF CCCCCCHHHCCCHHH	19.83	27642862
304	Phosphorylation	PQYLTDDLEFLRACH CHHHCCCHHHHHHHC	5.81	19664995
315	Phosphorylation	RACHLPRSNSGAAPE HHHCCCCCCCCCCCH	33.15	22210691
317	Phosphorylation	CHLPRSNSGAAPEAE HCCCCCCCCCCCHHH	30.93	22210691
324	Phosphorylation	SGAAPEAEVNAASQE CCCCCHHHHCHHHHH	34.34	20068231
325 (in isoform 2)	Phosphorylation	-	8.34	21815630
327 (in isoform 2)	Phosphorylation	-	17.42	27732954
328	Phosphorylation	PEAEVNAASQESCQQ CHHHHCHHHHHHHCC	13.42	18669648
329	Phosphorylation	EAEVNAASQESCQQP HHHHCHHHHHHHCCC	31.88	22210691
334	Phosphorylation	AASQESCQQPVGAYL HHHHHHHCCCCCCCC	60.95	16964243
339 (in isoform 2)	Phosphorylation	-	11.70	25627689
342 (in isoform 2)	Phosphorylation	-	16.38	25627689
385	Phosphorylation	TGMRGTKPNQVVCVA CCCCCCCCCEEEEEE	36.00	18669648
392	Phosphorylation	PNQVVCVAAGGQPEG CCEEEEEECCCCCCC	8.68	20068231
395	Phosphorylation	VVCVAAGGQPEGGLP EEEEECCCCCCCCCC	34.83	19664994
399	Phosphorylation	AAGGQPEGGLPVSPE ECCCCCCCCCCCCCC	50.01	19664994
411	Phosphorylation	SPEPSLLTPTEEAHP CCCCCCCCCCCCCCC	33.20	24275569
424	Phosphorylation	HPASSLASFPAAQIP CCCCHHHHCCHHHCC	36.74	27966365
437	Phosphorylation	IPIAVEEPGSSSRES CCEEEECCCCCCHHH	34.17	20068231
444	Phosphorylation	PGSSSRESVSKAGMP CCCCCHHHHHHCCCC	30.49	23403867
446	Phosphorylation	SSSRESVSKAGMPVS CCCHHHHHHCCCCCC	26.52	23403867
451	Phosphorylation	SVSKAGMPVSADAAK HHHHCCCCCCHHHHH	18.92	18669648
453	Phosphorylation	SKAGMPVSADAAKEV HHCCCCCCHHHHHHH	17.98	23403867
455	Phosphorylation	AGMPVSADAAKEVVD CCCCCCHHHHHHHHH	39.28	18669648
467	Phosphorylation	VVDAGLVGLERQVSD HHHHHHHCCCHHHHH	27.19	18669648
468	Phosphorylation	VDAGLVGLERQVSDL HHHHHHCCCHHHHHC	3.70	18669648
470	Phosphorylation	AGLVGLERQVSDLGS HHHHCCCHHHHHCCC	47.44	18669648
472	Phosphorylation	LVGLERQVSDLGSKG HHCCCHHHHHCCCCC	6.35	18669648
473	Phosphorylation	VGLERQVSDLGSKGE HCCCHHHHHCCCCCC	20.84	26657352
477	Phosphorylation	RQVSDLGSKGEHPEG HHHHHCCCCCCCCCC	44.80	26657352
481	Phosphorylation	DLGSKGEHPEGDPGE HCCCCCCCCCCCCCC	34.09	18669648
493	Phosphorylation	PGEVPAPSPQERGEH CCCCCCCCHHHCCCC	41.12	25159151
506	Phosphorylation	EHLNTEQSHEVQPGV CCCCCCCCCCCCCCC	18.51	18669648
521	Phosphorylation	PPPPLPKEQSHEVQP CCCCCCHHHCCCCCC	56.21	18669648
523	Phosphorylation	PPLPKEQSHEVQPGA CCCCHHHCCCCCCCC	23.78	18669648
525	Phosphorylation	LPKEQSHEVQPGAPP CCHHHCCCCCCCCCC	48.36	17081983
529	Phosphorylation	QSHEVQPGAPPPPLP HCCCCCCCCCCCCCC	33.36	20068231
533	Phosphorylation	VQPGAPPPPLPKAPS CCCCCCCCCCCCCCC	41.84	20068231
536	Phosphorylation	GAPPPPLPKAPSESA CCCCCCCCCCCCCCC	36.21	20068231
540	Phosphorylation	PPLPKAPSESARGPP CCCCCCCCCCCCCCC	49.39	18669648
550	Phosphorylation	ARGPPGPTDGAKVHE CCCCCCCCCCCCCCC	53.64	30576142
559	Phosphorylation	GAKVHEDSTSPAVAK CCCCCCCCCCHHHHC	28.00	25159151
560	Phosphorylation	AKVHEDSTSPAVAKE CCCCCCCCCHHHHCC	51.56	29496963
561	Phosphorylation	KVHEDSTSPAVAKEG CCCCCCCCHHHHCCC	18.14	30576142
569	Phosphorylation	PAVAKEGSRSPGDSP HHHHCCCCCCCCCCC	30.58	26657352
571	Phosphorylation	VAKEGSRSPGDSPGG HHCCCCCCCCCCCCC	34.63	26055452
575	Phosphorylation	GSRSPGDSPGGKEEA CCCCCCCCCCCCCCC	31.21	26055452
589	Phosphorylation	APEPPDGGDPGNLQG CCCCCCCCCCCCCCC	45.37	20068231
590	Phosphorylation	PEPPDGGDPGNLQGE CCCCCCCCCCCCCCC	54.16	19664994
621 (in isoform 1)	Ubiquitination	-	59.71	21906983
621 (in isoform 6)	Ubiquitination	-	59.71	21906983
632	Phosphorylation	RDHPSSHSAQPPRKG CCCCCCCCCCCCCCC	30.46	20068231
635	Phosphorylation	PSSHSAQPPRKGGAG CCCCCCCCCCCCCCC	30.31	17322306
639	Phosphorylation	SAQPPRKGGAGHTDG CCCCCCCCCCCCCCC	32.25	20068231
640	Phosphorylation	AQPPRKGGAGHTDGP CCCCCCCCCCCCCCC	31.27	20068231
644	Phosphorylation	RKGGAGHTDGPHSQT CCCCCCCCCCCCCCC	41.56	24626860
645	Phosphorylation	KGGAGHTDGPHSQTA CCCCCCCCCCCCCCC	64.05	20068231
647	Phosphorylation	GAGHTDGPHSQTAEA CCCCCCCCCCCCCHH	27.11	20068231
649	Phosphorylation	GHTDGPHSQTAEADA CCCCCCCCCCCHHHH	32.15	24626860
652	Phosphorylation	DGPHSQTAEADASGL CCCCCCCCHHHHCCC	11.44	20068231
654	Phosphorylation	PHSQTAEADASGLPH CCCCCCHHHHCCCCC	18.40	18669648
655	Phosphorylation	HSQTAEADASGLPHK CCCCCHHHHCCCCCC	32.54	18669648
657	Phosphorylation	QTAEADASGLPHKLG CCCHHHHCCCCCCCC	41.22	20068231
689 (in isoform 5)	Ubiquitination	-	37.05	21906983
703	Phosphorylation	KCPDTLQSREGLGRM CCCCHHHCCCCCCCC	35.10	20068231
712	Phosphorylation	EGLGRMESFLTLESE CCCCCCHHEEECCCC	19.06	23663014
715	Phosphorylation	GRMESFLTLESEKSD CCCHHEEECCCCCCC	26.86	23663014
718	Phosphorylation	ESFLTLESEKSDFPP HHEEECCCCCCCCCC	54.13	23663014
726	Phosphorylation	EKSDFPPTPVAEVAP CCCCCCCCCHHHCCC	30.54	24719451
728 (in isoform 3)	Ubiquitination	-	8.58	21906983
740	Phosphorylation	PKAQEGESTLEIRKM CCCCCCCCCEEEEEC	49.50	23403867
741	Phosphorylation	KAQEGESTLEIRKMG CCCCCCCCEEEEECC	24.90	23403867
749	Phosphorylation	LEIRKMGSCDGEGLL EEEEECCCCCCCCCC	12.92	20068231
757	Phosphorylation	CDGEGLLTSPDQPRG CCCCCCCCCCCCCCC	43.16	30576142
758	Phosphorylation	DGEGLLTSPDQPRGP CCCCCCCCCCCCCCC	26.84	25159151
780	Phosphorylation	EFHAGVPHPPQGENL HHCCCCCCCCCCCCH	44.24	20068231
782	Phosphorylation	HAGVPHPPQGENLAA CCCCCCCCCCCCHHH	52.34	20068231
797	Phosphorylation	DLGLTALILDQDQQG HHCCEEEEECCCCCC	3.55	20068231
799	Phosphorylation	GLTALILDQDQQGIP CCEEEEECCCCCCCC	42.91	20068231
858	Phosphorylation	PPENGKETSPSHPGF CCCCCCCCCCCCCCC	49.80	29396449
859	Phosphorylation	PENGKETSPSHPGFK CCCCCCCCCCCCCCC	26.04	25159151
861	Phosphorylation	NGKETSPSHPGFKDQ CCCCCCCCCCCCCCC	41.92	29396449
872	Phosphorylation	FKDQGADSSQIHVPV CCCCCCCCCCEECCC	24.49	22468782
889	Phosphorylation	QEDNNLPTHGGQEQA CCCCCCCCCCCHHHH	36.00	22468782
909	Phosphorylation	QSQLPKGTLSDTPTS HHHCCCCCCCCCCCC	29.25	28102081
911	Phosphorylation	QLPKGTLSDTPTSSP HCCCCCCCCCCCCCC	39.00	28102081
913	Phosphorylation	PKGTLSDTPTSSPTD CCCCCCCCCCCCCCC	25.70	28102081
915	Phosphorylation	GTLSDTPTSSPTDMV CCCCCCCCCCCCCCC	43.88	28102081
916	Phosphorylation	TLSDTPTSSPTDMVW CCCCCCCCCCCCCCC	35.21	28102081
917	Phosphorylation	LSDTPTSSPTDMVWE CCCCCCCCCCCCCCC	34.01	28102081
919	Phosphorylation	DTPTSSPTDMVWESS CCCCCCCCCCCCCCC	38.38	28102081
932	Acetylation	SSLTEESELSAPTRQ CCCCCCHHCCCCHHH	50.45	19608861
934	Phosphorylation	LTEESELSAPTRQKL CCCCHHCCCCHHHCC	28.31	23532336
937	Phosphorylation	ESELSAPTRQKLPAL CHHCCCCHHHCCCCC	45.51	23532336
958	Phosphorylation	GACGDGQSSRVSPPA CCCCCCCCCCCCCCH	26.16	26657352
959	Phosphorylation	ACGDGQSSRVSPPAA CCCCCCCCCCCCCHH	28.90	28102081
962	Acetylation	DGQSSRVSPPAADVL CCCCCCCCCCHHHHH	24.85	19608861
962	Phosphorylation	DGQSSRVSPPAADVL CCCCCCCCCCHHHHH	24.85	25159151
973	Phosphorylation	ADVLKDFSLAGNFSR HHHHHHCCCCCCCCC	27.69	28555341
983	Phosphorylation	GNFSRKETCCTGQGP CCCCCCCCCCCCCCC	18.86	-
986	Phosphorylation	SRKETCCTGQGPNKS CCCCCCCCCCCCCHH	34.39	-
993	Phosphorylation	TGQGPNKSQQALADA CCCCCCHHHHHHHHH	33.88	-
1005	Phosphorylation	ADALEEGSQHEEACQ HHHHHHHHHHHHHHH	31.48	24505115
1018	Phosphorylation	CQRHPGASEAADGCS HHHCCCHHHHCCCCC	33.41	27251275
1025	Phosphorylation	SEAADGCSPLWGLSK HHHCCCCCCCCCCCH	28.67	25159151
1030	Acetylation	GCSPLWGLSKREMAS CCCCCCCCCHHHCCC	3.54	19608861
1031	Phosphorylation	CSPLWGLSKREMASG CCCCCCCCHHHCCCC	26.23	27251275
1116	Phosphorylation	ESPKLLASFPSAGEQ CCCHHHHCCCCCCCC	37.35	22210691
1119	Phosphorylation	KLLASFPSAGEQGGE HHHHCCCCCCCCCCC	47.06	22210691
1132	Phosphorylation	GEAGAAETGGSAGAG CCCCCCCCCCCCCCC	41.96	22210691
1156	Phosphorylation	KPGEATLSCGLLQTE CCCCCEEECCCEECC	11.20	23663014
1235	Phosphorylation	PEVAAPDTPYLHVDS CCCCCCCCCCCCCCH	16.87	27642862
1237	Phosphorylation	VAAPDTPYLHVDSAA CCCCCCCCCCCCHHH	16.13	25394399
1242	Phosphorylation	TPYLHVDSAAQRGAE CCCCCCCHHHHCCCH	25.15	-
1267	Phosphorylation	DPRAPGESPCPVGEP CCCCCCCCCCCCCCC	37.40	25159151
1283	Phosphorylation	LALENAASLKLFAGS CCCCCHHHHHHHHHH	24.51	30242111
1290	Phosphorylation	SLKLFAGSLAPLLQP HHHHHHHHHHHHCCC	20.23	28176443
1310	Phosphorylation	EIPAVQASSGSPKAR CCCCEECCCCCCCCC	20.38	23663014
1311	Phosphorylation	IPAVQASSGSPKART CCCEECCCCCCCCCC	46.43	25159151
1313	Phosphorylation	AVQASSGSPKARTTE CEECCCCCCCCCCCC	25.77	30278072
1339	Trimethylation	MPLLAKGKQATGEEK CHHHHCCCCCCCCCH	35.73	-
1339	Methylation	MPLLAKGKQATGEEK CHHHHCCCCCCCCCH	35.73	23644510
1346	Trimethylation	KQATGEEKAATAPGA CCCCCCCHHCCCCCC	38.73	-
1346	Methylation	KQATGEEKAATAPGA CCCCCCCHHCCCCCC	38.73	23644510
1358	Phosphorylation	PGAGAKASGEGMAGD CCCCCCCCCCCCCCC	36.35	22210691
1388	Phosphorylation	SQDPKQGTSGGVDTS CCCCCCCCCCCCCCC	23.00	30631047
1389	Phosphorylation	QDPKQGTSGGVDTSS CCCCCCCCCCCCCCH	40.13	30631047
1401	Phosphorylation	TSSEQIATLTGFPDF CCHHHHHHHHCCCCH	26.87	30631047
1426	Phosphorylation	PVLGALATPGEKAGA CCCEEECCCCCCCCC	32.45	30576142
1546	Phosphorylation	PGLEGQAYSQLERSR CCCCHHHHHHHHHHH	6.78	27642862
1552	Phosphorylation	AYSQLERSRQELASG HHHHHHHHHHHHHCC	29.01	29396449
1558	Phosphorylation	RSRQELASGLPSPAA HHHHHHHCCCCCCHH	54.19	30576142
1562	Phosphorylation	ELASGLPSPAATQEL HHHCCCCCCHHHCCC	32.01	25159151
1566	Phosphorylation	GLPSPAATQELPVER CCCCCHHHCCCCHHH	25.36	29396449
1583	Phosphorylation	AFQVAPHSHGEEAVA HHEECCCCCCHHHHH	31.93	23312004
1596	Phosphorylation	VAQDRIPSGKQHQET HHHCCCCCCCCCCCC	57.14	24719451
1603	Phosphorylation	SGKQHQETSACDSPH CCCCCCCCCCCCCCC	18.30	30576142
1604	Phosphorylation	GKQHQETSACDSPHG CCCCCCCCCCCCCCC	26.58	26657352
1608	Phosphorylation	QETSACDSPHGEDGP CCCCCCCCCCCCCCC	20.76	26657352
1621	Phosphorylation	GPGDFAHTGVPGHVP CCCCCCCCCCCCCCC	36.12	30576142
1630	Phosphorylation	VPGHVPRSTCAPSPQ CCCCCCCCCCCCCCC	23.05	30576142
1631	Phosphorylation	PGHVPRSTCAPSPQR CCCCCCCCCCCCCCC	17.61	30576142
1635	Phosphorylation	PRSTCAPSPQREVLT CCCCCCCCCCCEEEE	18.36	28731282
1642	Phosphorylation	SPQREVLTVPEANSE CCCCEEEECCCCCCC	38.91	30576142
1648	Phosphorylation	LTVPEANSEPWTLDT EECCCCCCCCCEEEC	52.67	28102081
1652	Phosphorylation	EANSEPWTLDTLGGE CCCCCCCEEECCCCC	26.02	28102081
1732	Phosphorylation	PEAGTTRTFSVVAGD CCCCCCCEEEEEECC	20.40	28348404
1734	Phosphorylation	AGTTRTFSVVAGDLV CCCCCEEEEEECCEE	18.31	28348404
1761	Phosphorylation	KAPGMEGTAALHGDS CCCCCCCCHHHCCCC	8.75	20068231
1768	Phosphorylation	TAALHGDSPARPQQA CHHHCCCCCCCHHHH	25.67	25159151
1795	Phosphorylation	GDGKVCVSSPPEPDE CCCCEECCCCCCCCC	31.81	26270265
1796	Phosphorylation	DGKVCVSSPPEPDET CCCEECCCCCCCCCC	24.87	30576142
1818	Phosphorylation	LAPEELHTDRESPRP CCHHHHCCCCCCCCC	49.75	26437602
1822	Phosphorylation	ELHTDRESPRPGPSM HHCCCCCCCCCCCCC	27.40	30576142
1944	Phosphorylation	PDPAKDLSRSSDSEE CCHHHHCCCCCCCHH	40.00	30576142
1946	Phosphorylation	PAKDLSRSSDSEEAF HHHHCCCCCCCHHHH	34.81	30278072
1947	Phosphorylation	AKDLSRSSDSEEAFE HHHCCCCCCCHHHHC	44.01	30278072
1949	Phosphorylation	DLSRSSDSEEAFETP HCCCCCCCHHHHCCC	39.01	30278072
1955	Phosphorylation	DSEEAFETPESTTPV CCHHHHCCCCCCCCC	26.38	23927012
1958	Phosphorylation	EAFETPESTTPVKAP HHHCCCCCCCCCCCC	38.49	30576142
1959	Phosphorylation	AFETPESTTPVKAPP HHCCCCCCCCCCCCC	33.19	25159151
1960	Phosphorylation	FETPESTTPVKAPPA HCCCCCCCCCCCCCC	35.05	30576142
2068	Phosphorylation	NQEGKVNTRRKSTDS CCCCCCCCCCCCCCC	34.53	27251275
2072	Phosphorylation	KVNTRRKSTDSVPIS CCCCCCCCCCCCCCC	35.32	29255136
2073	Phosphorylation	VNTRRKSTDSVPISK CCCCCCCCCCCCCCH	35.02	29255136
2075	Phosphorylation	TRRKSTDSVPISKST CCCCCCCCCCCCHHH	29.86	23927012
2079	Phosphorylation	STDSVPISKSTLSRS CCCCCCCCHHHHCCC	17.93	23403867
2086	Phosphorylation	SKSTLSRSLSLQASD CHHHHCCCCCCCHHH	20.95	30576142
2088	Phosphorylation	STLSRSLSLQASDFD HHHCCCCCCCHHHCC	21.49	30278072
2092	Phosphorylation	RSLSLQASDFDGASS CCCCCCHHHCCCCCC	26.33	18669648
2098	Phosphorylation	ASDFDGASSSGNPEA HHHCCCCCCCCCHHH	30.48	20873877
2099	Phosphorylation	SDFDGASSSGNPEAV HHCCCCCCCCCHHHE	41.55	27251275
2100	Phosphorylation	DFDGASSSGNPEAVA HCCCCCCCCCHHHEE	39.84	30576142
2113	Phosphorylation	VALAPDAYSTGSSSA EEECCCCHHCCCCCH	17.72	30177828
2114	Phosphorylation	ALAPDAYSTGSSSAS EECCCCHHCCCCCHH	28.19	20873877
2115	Phosphorylation	LAPDAYSTGSSSASS ECCCCHHCCCCCHHH	28.54	20873877
2117	Phosphorylation	PDAYSTGSSSASSTL CCCHHCCCCCHHHHC	22.62	30177828
2118	Phosphorylation	DAYSTGSSSASSTLK CCHHCCCCCHHHHCC	31.13	30177828
2119	Phosphorylation	AYSTGSSSASSTLKR CHHCCCCCHHHHCCC	33.59	20873877
2121	Phosphorylation	STGSSSASSTLKRTK HCCCCCHHHHCCCCC	26.29	30177828
2122	Phosphorylation	TGSSSASSTLKRTKK CCCCCHHHHCCCCCC	37.16	18669648
2123	Phosphorylation	GSSSASSTLKRTKKP CCCCHHHHCCCCCCC	33.53	20873877
2127	Phosphorylation	ASSTLKRTKKPRPPS HHHHCCCCCCCCCCC	41.66	20873877
2134	Phosphorylation	TKKPRPPSLKKKQTT CCCCCCCCCCCCCCC	56.34	21406692
2145	Phosphorylation	KQTTKKPTETPPVKE CCCCCCCCCCCCCCC	62.46	26270265
2147	Phosphorylation	TTKKPTETPPVKETQ CCCCCCCCCCCCCCC	35.06	25159151
2161	Phosphorylation	QQEPDEESLVPSGEN CCCCCHHHCCCCCCC	32.40	-
2180	Phosphorylation	TKTESAKTEGPSPAL CCCCCCCCCCCCCHH	45.98	26657352
2184	Phosphorylation	SAKTEGPSPALLEET CCCCCCCCCHHHCCC	33.39	28348404
2218	Phosphorylation	EGVVPPASGGGRVQN CCCCCCCCCCCCCCC	43.68	25159151
2226	Phosphorylation	GGGRVQNSPPVGRKT CCCCCCCCCCCCCCC	17.31	29255136
2233	Phosphorylation	SPPVGRKTLPLTTAP CCCCCCCCCCCCCCC	32.04	20068231
2237	Phosphorylation	GRKTLPLTTAPEAGE CCCCCCCCCCCCCCC	20.97	20068231
2238	Phosphorylation	RKTLPLTTAPEAGEV CCCCCCCCCCCCCCC	48.15	20068231
2246	Phosphorylation	APEAGEVTPSDSGGQ CCCCCCCCCCCCCCC	16.87	25159151
2248	Phosphorylation	EAGEVTPSDSGGQED CCCCCCCCCCCCCCC	34.73	30278072
2250	Phosphorylation	GEVTPSDSGGQEDSP CCCCCCCCCCCCCCC	49.51	30278072
2256	Phosphorylation	DSGGQEDSPAKGLSV CCCCCCCCCCCCEEE	26.46	28355574
2262	Phosphorylation	DSPAKGLSVRLEFDY CCCCCCEEEEEEEEC	17.54	22210691
2269	Phosphorylation	SVRLEFDYSEDKSSW EEEEEEECCCCCCCC	21.20	27642862
2270	Phosphorylation	VRLEFDYSEDKSSWD EEEEEECCCCCCCCC	40.96	29802988
2307	Phosphorylation	RRPKMKKTPEKLDNT CCCCCCCCHHHHCCC	31.03	23927012
2314	Phosphorylation	TPEKLDNTPASPPRS CHHHHCCCCCCCCCC	21.65	23927012
2317	Phosphorylation	KLDNTPASPPRSPAE HHCCCCCCCCCCCCC	36.32	19664994
2321	Phosphorylation	TPASPPRSPAEPNDI CCCCCCCCCCCCCCC	33.95	19664994
2352	Phosphorylation	PNFNPFSSTSKMQES CCCCCCCCCHHCCCC	36.76	28555341
2359	Phosphorylation	STSKMQESPKLPQQS CCHHCCCCCCCCCCC	15.50	23927012
2366	Phosphorylation	SPKLPQQSYNFDPDT CCCCCCCCCCCCCCC	19.45	23663014
2367	Phosphorylation	PKLPQQSYNFDPDTC CCCCCCCCCCCCCCC	18.60	23403867
2373	Phosphorylation	SYNFDPDTCDESVDP CCCCCCCCCCCCCCC	27.52	30576142
2377	Phosphorylation	DPDTCDESVDPFKTS CCCCCCCCCCCCCCC	20.69	30576142
2383	Phosphorylation	ESVDPFKTSSKTPSS CCCCCCCCCCCCCCC	38.31	23312004
2384	Phosphorylation	SVDPFKTSSKTPSSP CCCCCCCCCCCCCCC	30.35	23312004
2385	Phosphorylation	VDPFKTSSKTPSSPS CCCCCCCCCCCCCCC	45.86	23312004
2387	Phosphorylation	PFKTSSKTPSSPSKS CCCCCCCCCCCCCCC	30.28	23663014
2389	Phosphorylation	KTSSKTPSSPSKSPA CCCCCCCCCCCCCCC	61.18	23927012
2390	Phosphorylation	TSSKTPSSPSKSPAS CCCCCCCCCCCCCCC	34.10	23927012
2392	Phosphorylation	SKTPSSPSKSPASFE CCCCCCCCCCCCCEE	47.95	23927012
2394	Phosphorylation	TPSSPSKSPASFEIP CCCCCCCCCCCEECC	30.00	23927012
2397	Phosphorylation	SPSKSPASFEIPASA CCCCCCCCEECCHHH	27.14	25159151
2403	Phosphorylation	ASFEIPASAMEANGV CCEECCHHHHHHCCC	23.85	23927012
2424	Phosphorylation	KPAKKKKTPLKTDTF CCCCCCCCCCCCCCE	42.61	29214152
2428	Phosphorylation	KKKTPLKTDTFRVKK CCCCCCCCCCEECCC	48.21	18669648
2430	Phosphorylation	KTPLKTDTFRVKKSP CCCCCCCCEECCCCC	20.69	23403867
2436	Phosphorylation	DTFRVKKSPKRSPLS CCEECCCCCCCCCCC	29.90	30576142
2440	Phosphorylation	VKKSPKRSPLSDPPS CCCCCCCCCCCCCCC	36.00	29255136
2443	Phosphorylation	SPKRSPLSDPPSQDP CCCCCCCCCCCCCCC	52.00	29255136
2447	Phosphorylation	SPLSDPPSQDPTPAA CCCCCCCCCCCCCCC	53.24	29255136
2451	Phosphorylation	DPPSQDPTPAATPET CCCCCCCCCCCCCCC	33.57	29255136
2455	Phosphorylation	QDPTPAATPETPPVI CCCCCCCCCCCCCEE	24.62	29255136
2458	Phosphorylation	TPAATPETPPVISAV CCCCCCCCCCEEEEE	33.81	28348404
2463	Phosphorylation	PETPPVISAVVHATD CCCCCEEEEEEECCC	18.42	23663014
2469	Phosphorylation	ISAVVHATDEEKLAV EEEEEECCCHHHHEE	29.12	23663014
2511	Phosphorylation	FVNETKFSSPTEELD HCCCCCCCCCCHHCC	36.64	29255136
2512	Phosphorylation	VNETKFSSPTEELDY CCCCCCCCCCHHCCC	38.69	19664994
2514	Phosphorylation	ETKFSSPTEELDYRN CCCCCCCCHHCCCCC	44.00	29255136
2519	Phosphorylation	SPTEELDYRNSYEIE CCCHHCCCCCHHHHH	25.07	20068231
2522	Phosphorylation	EELDYRNSYEIEYME HHCCCCCHHHHHHHH	18.36	21815630
2523	Phosphorylation	ELDYRNSYEIEYMEK HCCCCCHHHHHHHHH	25.19	27642862
2527	Phosphorylation	RNSYEIEYMEKIGSS CCHHHHHHHHHHCCC	19.08	27642862
2533	Phosphorylation	EYMEKIGSSLPQDDD HHHHHHCCCCCCCCC	31.98	25159151
2534	Phosphorylation	YMEKIGSSLPQDDDA HHHHHCCCCCCCCCC	38.56	21815630
2543	Ubiquitination	PQDDDAPKKQALYLM CCCCCCCHHHHEEEE	60.27	2190698
2543 (in isoform 4)	Ubiquitination	-	60.27	21906983
2548	Phosphorylation	APKKQALYLMFDTSQ CCHHHHEEEEEECCC	10.11	22817900
2553	Phosphorylation	ALYLMFDTSQESPVK HEEEEEECCCCCCCC	22.50	22199227
2554	Phosphorylation	LYLMFDTSQESPVKS EEEEEECCCCCCCCC	33.52	25159151
2557	Phosphorylation	MFDTSQESPVKSSPV EEECCCCCCCCCCCC	27.62	25159151
2561	Phosphorylation	SQESPVKSSPVRMSE CCCCCCCCCCCCCCC	39.86	30576142
2562	Phosphorylation	QESPVKSSPVRMSES CCCCCCCCCCCCCCC	23.00	26055452
2567	Phosphorylation	KSSPVRMSESPTPCS CCCCCCCCCCCCCCC	25.10	30278072
2569	Phosphorylation	SPVRMSESPTPCSGS CCCCCCCCCCCCCCC	27.11	10749935
2571	Phosphorylation	VRMSESPTPCSGSSF CCCCCCCCCCCCCCH	46.32	30278072
2574	Phosphorylation	SESPTPCSGSSFEET CCCCCCCCCCCHHHH	42.80	30278072
2576	Phosphorylation	SPTPCSGSSFEETEA CCCCCCCCCHHHHHH	18.63	30278072
2577	Phosphorylation	PTPCSGSSFEETEAL CCCCCCCCHHHHHHH	39.96	30278072
2581	Phosphorylation	SGSSFEETEALVNTA CCCCHHHHHHHHHHH	21.25	23927012
2587	Phosphorylation	ETEALVNTAAKNQHP HHHHHHHHHHHCCCC	22.10	23403867
2605	Phosphorylation	GLAPNQESHLQVPEK CCCCCCCCCCCCCCC	21.52	23312004
2612	Acetylation	SHLQVPEKSSQKELE CCCCCCCCCCHHHHH	49.70	26051181
2613	Phosphorylation	HLQVPEKSSQKELEA CCCCCCCCCHHHHHH	36.02	23312004
2614	Phosphorylation	LQVPEKSSQKELEAM CCCCCCCCHHHHHHC	57.23	23312004
2625	Phosphorylation	LEAMGLGTPSEAIEI HHHCCCCCCHHHEEE	28.78	18669648
2625 (in isoform 3)	Phosphorylation	-	28.78	21815630
2627 (in isoform 3)	Phosphorylation	-	39.23	27732954
2639 (in isoform 3)	Phosphorylation	-	10.28	25627689
2642 (in isoform 3)	Phosphorylation	-	11.58	25627689
2702	Phosphorylation	ARQIALASRSHQDAK HHHHHHHCCCHHHHH	34.86	20068231
2704	Phosphorylation	QIALASRSHQDAKRE HHHHHCCCHHHHHHH	24.01	20068231
2716	Phosphorylation	KREAAHPTDVSISKT HHHHCCCCCCCCCHH	38.88	21406692
2719	Phosphorylation	AAHPTDVSISKTALY HCCCCCCCCCHHHHH	24.77	20068231
2721	Phosphorylation	HPTDVSISKTALYSR CCCCCCCCHHHHHHC	19.22	20068231
2726	Phosphorylation	SISKTALYSRIGTAE CCCHHHHHHCCCCCE	8.08	-
2727	Phosphorylation	ISKTALYSRIGTAEV CCHHHHHHCCCCCEE	20.48	24719451
2736	Acetylation	IGTAEVEKPAGLLFQ CCCCEECCCCEEECC	45.39	24884061
2791	Ubiquitination	KIVAEYEKTIAQMIE HHHHHHHHHHHHHHH	44.31	-
2839	Phosphorylation	LADLFRRYEKMKEVL HHHHHHHHHHHHHHH	18.69	-
2884	Acetylation	LKVHAEEKLDRANAE HHHHHHHHHHHHHHH	47.39	19608861
2927	Acetylation	LERTLEQKNKEIEEL HHHHHHHHHHHHHHH	61.69	19814759
2929	Acetylation	RTLEQKNKEIEELTK HHHHHHHHHHHHHHH	68.08	19814771

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TACC2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TACC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TACC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YETS4_HUMAN	YEATS4	physical	12620397
SNF5_HUMAN	SMARCB1	physical	12620397
KAT2A_HUMAN	KAT2A	physical	14767476
KAT2B_HUMAN	KAT2B	physical	14767476

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TACC2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-2884, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2226, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197; SER-201; SER-493;SER-571; SER-575; SER-758; SER-962; SER-1025; SER-1267; SER-1313;THR-1426; SER-1562; SER-2072; THR-2073; SER-2226; THR-2246; SER-2256;SER-2317; SER-2321; SER-2359; SER-2389; SER-2390; SER-2392; SER-2394;SER-2403 AND SER-2512, AND MASS SPECTROMETRY.	18669648 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2256 AND SER-2512, ANDMASS SPECTROMETRY.	16964243 [Abstract]