dbPTM

YETS4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	YETS4_HUMAN
UniProt AC	O95619
Protein Name	YEATS domain-containing protein 4
Gene Name	YEATS4
Organism	Homo sapiens (Human).
Sequence Length	227
Subcellular Localization	Nucleus .
Protein Description	Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage..
Protein Sequence	MFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKKKTSFEIAELKERLKASRETINCLKNEIRKLEEDDQAKDI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Sulfoxidation	---MFKRMAEFGPDS ---CCCCCCCCCCCC	4.28	21406390
12	Phosphorylation	MAEFGPDSGGRVKGV CCCCCCCCCCCEEEE	46.40	-
17	Ubiquitination	PDSGGRVKGVTIVKP CCCCCCEEEEEEEEC	46.43	-
23	Ubiquitination	VKGVTIVKPIVYGNV EEEEEEEECEEECHH	25.77	-
23	Acetylation	VKGVTIVKPIVYGNV EEEEEEEECEEECHH	25.77	26051181
27	Phosphorylation	TIVKPIVYGNVARYF EEEECEEECHHHHHC	12.05	29496907
37	Sumoylation	VARYFGKKREEDGHT HHHHCCEECCCCCCE	66.48	28112733
64	Ubiquitination	EDMSAYVKKIQFKLH CCHHHHHHHHHEEHH	31.33	-
74	Phosphorylation	QFKLHESYGNPLRVV HEEHHHHHCCCEEEE	20.24	29496907
123	Phosphorylation	HLLKLFQSDTNAMLG HHHHHHHCCHHHHCC	38.78	20068231
125	Phosphorylation	LKLFQSDTNAMLGKK HHHHHCCHHHHCCCC	30.08	23186163
128	Sulfoxidation	FQSDTNAMLGKKTVV HHCCHHHHCCCCCHH	5.71	21406390
131	Ubiquitination	DTNAMLGKKTVVSEF CHHHHCCCCCHHHHH	41.11	21890473
131	Acetylation	DTNAMLGKKTVVSEF CHHHHCCCCCHHHHH	41.11	23954790
167	Ubiquitination	QLTLGAYKHETEFAE CHHHCCCCCCCCEEE	34.14	-
178	Ubiquitination	EFAELEVKTREKLEA CEEEEEEHHHHHHHH	32.27	-
187	2-Hydroxyisobutyrylation	REKLEAAKKKTSFEI HHHHHHHHHCCCHHH	62.95	-
187	Acetylation	REKLEAAKKKTSFEI HHHHHHHHHCCCHHH	62.95	25953088
188	Ubiquitination	EKLEAAKKKTSFEIA HHHHHHHHCCCHHHH	57.46	-
189	Ubiquitination	KLEAAKKKTSFEIAE HHHHHHHCCCHHHHH	49.01	-
190	Phosphorylation	LEAAKKKTSFEIAEL HHHHHHCCCHHHHHH	47.75	23403867
191	Phosphorylation	EAAKKKTSFEIAELK HHHHHCCCHHHHHHH	29.75	23403867
198	Ubiquitination	SFEIAELKERLKASR CHHHHHHHHHHHHHH	32.09	2190698
212	Ubiquitination	RETINCLKNEIRKLE HHHHHHHHHHHHHHH	55.52	-
212	Acetylation	RETINCLKNEIRKLE HHHHHHHHHHHHHHH	55.52	25953088
217	Ubiquitination	CLKNEIRKLEEDDQA HHHHHHHHHHHHHHH	66.95	-
225	Ubiquitination	LEEDDQAKDI----- HHHHHHHCCC-----	50.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of YETS4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of YETS4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of YETS4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TACC2_HUMAN	TACC2	physical	12620397
NUMA1_HUMAN	NUMA1	physical	11521196
CE162_HUMAN	CEP162	physical	11521196
PFD1_HUMAN	PFDN1	physical	11521196
TACC1_HUMAN	TACC1	physical	11903063
AF10_HUMAN	MLLT10	physical	11756182
SNF5_HUMAN	SMARCB1	physical	11756182
MYCN_HUMAN	MYCN	physical	22068108
KDM1A_HUMAN	KDM1A	physical	22068108
FRM4A_HUMAN	FRMD4A	physical	22068108
RNF8_HUMAN	RNF8	physical	22068108
MYC_HUMAN	MYC	physical	22068108
AP2B_HUMAN	TFAP2B	physical	16698963
EP400_HUMAN	EP400	physical	26186194
FUS_HUMAN	FUS	physical	26186194
EAF6_HUMAN	MEAF6	physical	26186194
EPC1_HUMAN	EPC1	physical	26186194
EPC2_HUMAN	EPC2	physical	26186194
SRCAP_HUMAN	SRCAP	physical	26186194
DMAP1_HUMAN	DMAP1	physical	26186194
TRRAP_HUMAN	TRRAP	physical	26186194
BRD8_HUMAN	BRD8	physical	26186194
VPS72_HUMAN	VPS72	physical	26186194
SUGP1_HUMAN	SUGP1	physical	26186194
ING3_HUMAN	ING3	physical	26186194
MYC_HUMAN	MYC	physical	26186194
HDGR2_HUMAN	HDGFRP2	physical	26186194
MY18A_HUMAN	MYO18A	physical	26186194
SNX16_HUMAN	SNX16	physical	26186194
MRGBP_HUMAN	MRGBP	physical	26186194
ACL6B_HUMAN	ACTL6B	physical	26186194
MBTD1_HUMAN	MBTD1	physical	26186194
REN3B_HUMAN	UPF3B	physical	26186194
ARP6_HUMAN	ACTR6	physical	26186194
GABPA_HUMAN	GABPA	physical	26186194
WEE1_HUMAN	WEE1	physical	26186194
MO4L2_HUMAN	MORF4L2	physical	26186194
JAZF1_HUMAN	JAZF1	physical	26186194
ZNHI1_HUMAN	ZNHIT1	physical	26186194
CL043_HUMAN	C12orf43	physical	26186194
FBX34_HUMAN	FBXO34	physical	26186194
AGGF1_HUMAN	AGGF1	physical	26186194
LENG1_HUMAN	LENG1	physical	26186194
PDIP3_HUMAN	POLDIP3	physical	26186194
AN32A_HUMAN	ANP32A	physical	26344197
EP400_HUMAN	EP400	physical	26344197
ACL6A_HUMAN	ACTL6A	physical	26496610
CX6B1_HUMAN	COX6B1	physical	26496610
ECHM_HUMAN	ECHS1	physical	26496610
FACD2_HUMAN	FANCD2	physical	26496610
MTOR_HUMAN	MTOR	physical	26496610
PLAK_HUMAN	JUP	physical	26496610
K22E_HUMAN	KRT2	physical	26496610
K2C5_HUMAN	KRT5	physical	26496610
AF17_HUMAN	MLLT6	physical	26496610
IKBE_HUMAN	NFKBIE	physical	26496610
PPM1G_HUMAN	PPM1G	physical	26496610
S10A6_HUMAN	S100A6	physical	26496610
ATX2_HUMAN	ATXN2	physical	26496610
STIL_HUMAN	STIL	physical	26496610
VPS72_HUMAN	VPS72	physical	26496610
TRRAP_HUMAN	TRRAP	physical	26496610
RUVB1_HUMAN	RUVBL1	physical	26496610
PTTG1_HUMAN	PTTG1	physical	26496610
SPN1_HUMAN	SNUPN	physical	26496610
ZNHI1_HUMAN	ZNHIT1	physical	26496610
KAT5_HUMAN	KAT5	physical	26496610
SRCAP_HUMAN	SRCAP	physical	26496610
RUVB2_HUMAN	RUVBL2	physical	26496610
BRD8_HUMAN	BRD8	physical	26496610
MO4L1_HUMAN	MORF4L1	physical	26496610
ZN292_HUMAN	ZNF292	physical	26496610
EPC2_HUMAN	EPC2	physical	26496610
DPOE3_HUMAN	POLE3	physical	26496610
ING3_HUMAN	ING3	physical	26496610
MBTD1_HUMAN	MBTD1	physical	26496610
NSD3_HUMAN	WHSC1L1	physical	26496610
MRGBP_HUMAN	MRGBP	physical	26496610
PR40A_HUMAN	PRPF40A	physical	26496610
DMAP1_HUMAN	DMAP1	physical	26496610
ZN687_HUMAN	ZNF687	physical	26496610
EP400_HUMAN	EP400	physical	26496610
TSYL2_HUMAN	TSPYL2	physical	26496610
ARP6_HUMAN	ACTR6	physical	26496610
EPC1_HUMAN	EPC1	physical	26496610
KLF16_HUMAN	KLF16	physical	26496610
DOT1L_HUMAN	DOT1L	physical	26496610
MILK1_HUMAN	MICALL1	physical	26496610
GRIN1_HUMAN	GPRIN1	physical	26496610
CDYL2_HUMAN	CDYL2	physical	26496610
PTGR2_HUMAN	PTGR2	physical	26496610
EME1_HUMAN	EME1	physical	26496610
ESCO2_HUMAN	ESCO2	physical	26496610
REEP3_HUMAN	REEP3	physical	26496610
JAZF1_HUMAN	JAZF1	physical	26496610
KPRP_HUMAN	KPRP	physical	26496610
SNX16_HUMAN	SNX16	physical	28514442
WEE1_HUMAN	WEE1	physical	28514442
ARP6_HUMAN	ACTR6	physical	28514442
VPS72_HUMAN	VPS72	physical	28514442
ZNHI1_HUMAN	ZNHIT1	physical	28514442
SRCAP_HUMAN	SRCAP	physical	28514442
EPC1_HUMAN	EPC1	physical	28514442
EPC2_HUMAN	EPC2	physical	28514442
MBTD1_HUMAN	MBTD1	physical	28514442
ING3_HUMAN	ING3	physical	28514442
DMAP1_HUMAN	DMAP1	physical	28514442
EP400_HUMAN	EP400	physical	28514442
MYC_HUMAN	MYC	physical	28514442
BRD8_HUMAN	BRD8	physical	28514442
JAZF1_HUMAN	JAZF1	physical	28514442
CL043_HUMAN	C12orf43	physical	28514442
TRRAP_HUMAN	TRRAP	physical	28514442
FBX34_HUMAN	FBXO34	physical	28514442
ACL6B_HUMAN	ACTL6B	physical	28514442
LENG1_HUMAN	LENG1	physical	28514442
MY18A_HUMAN	MYO18A	physical	28514442
AGGF1_HUMAN	AGGF1	physical	28514442
SUGP1_HUMAN	SUGP1	physical	28514442
GABPA_HUMAN	GABPA	physical	28514442
FUS_HUMAN	FUS	physical	28514442
PKN3_HUMAN	PKN3	physical	27173435
CLOCK_HUMAN	CLOCK	physical	27173435
VPS50_HUMAN	CCDC132	physical	27173435
CAVN1_HUMAN	PTRF	physical	27173435
RPR1A_HUMAN	RPRD1A	physical	27173435
RABX5_HUMAN	RABGEF1	physical	27173435
STRN_HUMAN	STRN	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of YETS4_HUMAN

Related Literatures of Post-Translational Modification