JAZF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JAZF1_HUMAN
• UniProt AC: Q86VZ6
• Protein Name: Juxtaposed with another zinc finger protein 1
• Gene Name: JAZF1
• Organism: Homo sapiens (Human).
• Sequence Length: 243
• Subcellular Localization: Nucleus .
• Protein Description: Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. [PubMed: 15302918 Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By similarity]
• Protein Sequence: MTGIAAASFFSNTCRFGGCGLHFPTLADLIEHIEDNHIDTDPRVLEKQELQQPTYVALSYINRFMTDAARREQESLKKKIQPKLSLTLSSSVSRGNVSTPPRHSSGSLTPPVTPPITPSSSFRSSTPTGSEYDEEEVDYEESDSDESWTTESAISSEAILSSMCMNGGEEKPFACPVPGCKKRYKNVNGIKYHAKNGHRTQIRVRKPFKCRCGKSYKTAQGLRHHTINFHPPVSAEIIRKMQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34 (in isoform 2)	Ubiquitination	-	55.45	21890473
47	Ubiquitination	TDPRVLEKQELQQPT CCHHHHHHHHHCCCC	44.93	21890473
47 (in isoform 1)	Ubiquitination	-	44.93	21890473
47	Ubiquitination	TDPRVLEKQELQQPT CCHHHHHHHHHCCCC	44.93	22817900
55	Phosphorylation	QELQQPTYVALSYIN HHHCCCCHHHHHHHH	7.15	-
85	Phosphorylation	KKIQPKLSLTLSSSV HHHCCCEEEEECCCC	25.98	24719451
98	Phosphorylation	SVSRGNVSTPPRHSS CCCCCCCCCCCCCCC	38.91	23312004
99	Phosphorylation	VSRGNVSTPPRHSSG CCCCCCCCCCCCCCC	32.79	23312004
104	Phosphorylation	VSTPPRHSSGSLTPP CCCCCCCCCCCCCCC	37.36	23663014
105	Phosphorylation	STPPRHSSGSLTPPV CCCCCCCCCCCCCCC	26.69	23663014
107	Phosphorylation	PPRHSSGSLTPPVTP CCCCCCCCCCCCCCC	30.90	23663014
109	Phosphorylation	RHSSGSLTPPVTPPI CCCCCCCCCCCCCCC	27.52	23927012
113	Phosphorylation	GSLTPPVTPPITPSS CCCCCCCCCCCCCCH	29.17	23927012
117	Phosphorylation	PPVTPPITPSSSFRS CCCCCCCCCCHHCCC	23.92	23663014
119	Phosphorylation	VTPPITPSSSFRSST CCCCCCCCHHCCCCC	29.93	23663014
120	Phosphorylation	TPPITPSSSFRSSTP CCCCCCCHHCCCCCC	34.40	23663014
121	Phosphorylation	PPITPSSSFRSSTPT CCCCCCHHCCCCCCC	29.08	23663014
191	Ubiquitination	YKNVNGIKYHAKNGH EECCCCEEEEEECCC	32.17	29967540
216	Phosphorylation	KCRCGKSYKTAQGLR ECCCCCCCCCCCCCC	18.82	21403953

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JAZF1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JAZF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JAZF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPARG_HUMAN	PPARG	physical	15302918
RXRA_HUMAN	RXRA	physical	15302918

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-109 AND THR-113, ANDMASS SPECTROMETRY.
PubMed: 19690332