dbPTM

PFD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PFD1_HUMAN
UniProt AC	O60925
Protein Name	Prefoldin subunit 1
Gene Name	PFDN1
Organism	Homo sapiens (Human).
Sequence Length	122
Subcellular Localization
Protein Description	Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins..
Protein Sequence	MAAPVDLELKKAFTELQAKVIDTQQKVKLADIQIEQLNRTKKHAHLTDTEIMTLVDETNMYEGVGRMFILQSKEAIHSQLLEKQKIAEEKIKELEQKKSYLERSVKEAEDNIREMLMARRAQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAPVDLEL ------CCCCCCHHH	22.07	19413330
10	Acetylation	APVDLELKKAFTELQ CCCCHHHHHHHHHHH	32.45	25953088
10	Ubiquitination	APVDLELKKAFTELQ CCCCHHHHHHHHHHH	32.45	29901268
11	Ubiquitination	PVDLELKKAFTELQA CCCHHHHHHHHHHHH	62.45	27667366
19	Ubiquitination	AFTELQAKVIDTQQK HHHHHHHHHCCCHHH	27.11	23000965
26	Acetylation	KVIDTQQKVKLADIQ HHCCCHHHHHHHHHH	31.36	25953088
28	Methylation	IDTQQKVKLADIQIE CCCHHHHHHHHHHHH	45.02	23644510
28	Ubiquitination	IDTQQKVKLADIQIE CCCHHHHHHHHHHHH	45.02	33845483
28	Malonylation	IDTQQKVKLADIQIE CCCHHHHHHHHHHHH	45.02	26320211
28	Acetylation	IDTQQKVKLADIQIE CCCHHHHHHHHHHHH	45.02	25953088
61	Phosphorylation	LVDETNMYEGVGRMF HHCCCCCCCCCCHHH	16.17	27642862
72	Phosphorylation	GRMFILQSKEAIHSQ CHHHHHHCHHHHHHH	29.08	21712546
83	Ubiquitination	IHSQLLEKQKIAEEK HHHHHHHHHHHHHHH	57.78	29967540
97	Acetylation	KIKELEQKKSYLERS HHHHHHHHHHHHHHH	34.02	25953088
99	Phosphorylation	KELEQKKSYLERSVK HHHHHHHHHHHHHHH	41.82	-
106	Ubiquitination	SYLERSVKEAEDNIR HHHHHHHHHHHHHHH	53.07	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PFD1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PFD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PFD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTS_HUMAN	ACTA1	physical	14634002
TBA1A_HUMAN	TUBA1A	physical	14634002
GASP1_HUMAN	GPRASP1	physical	16169070
HIP1_HUMAN	HIP1	physical	16169070
MIC60_HUMAN	IMMT	physical	16169070
PSME1_HUMAN	PSME1	physical	16169070
MED31_HUMAN	MED31	physical	16169070
GIT1_HUMAN	GIT1	physical	16169070
HAP1_HUMAN	HAP1	physical	16169070
CE126_HUMAN	KIAA1377	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
RLA1_HUMAN	RPLP1	physical	16169070
MIC60_HUMAN	IMMT	physical	21900206
EIF3C_HUMAN	EIF3C	physical	21900206
HMGX3_HUMAN	HMGXB3	physical	21900206
NDC80_HUMAN	NDC80	physical	21900206
GIT1_HUMAN	GIT1	physical	21900206
EDRF1_HUMAN	EDRF1	physical	21900206
EXT2_HUMAN	EXT2	physical	21900206
RMI1_HUMAN	RMI1	physical	21900206
CMGA_HUMAN	CHGA	physical	21900206
EZH2_HUMAN	EZH2	physical	21900206
INP5K_HUMAN	INPP5K	physical	21900206
RS28_HUMAN	RPS28	physical	21900206
BRK1_HUMAN	BRK1	physical	21900206
EOMES_HUMAN	EOMES	physical	21900206
FA20C_HUMAN	FAM20C	physical	21900206
K0408_HUMAN	KIAA0408	physical	21900206
DCTN1_HUMAN	DCTN1	physical	21900206
MYOME_HUMAN	PDE4DIP	physical	21900206
IF4A2_HUMAN	EIF4A2	physical	21900206
SUMO3_HUMAN	SUMO3	physical	21900206
CC85A_HUMAN	CCDC85A	physical	21900206
DGC14_HUMAN	DGCR14	physical	21900206
PLXB2_HUMAN	PLXNB2	physical	21900206
SPTN4_HUMAN	SPTBN4	physical	21900206
ODPB_HUMAN	PDHB	physical	21900206
COT1_HUMAN	NR2F1	physical	21900206
SC31A_HUMAN	SEC31A	physical	21900206
JADE1_HUMAN	JADE1	physical	21900206
TTC38_HUMAN	TTC38	physical	21900206
ALBU_HUMAN	ALB	physical	21900206
IF140_HUMAN	IFT140	physical	21900206
KPCD2_HUMAN	PRKD2	physical	21900206
ASNA_HUMAN	ASNA1	physical	21900206
HXD8_HUMAN	HOXD8	physical	21900206
PTN_HUMAN	PTN	physical	21900206
SNX5_HUMAN	SNX5	physical	21900206
ZN235_HUMAN	ZNF235	physical	21900206
PFD2_HUMAN	PFDN2	physical	22939629
PFD6_HUMAN	PFDN6	physical	22939629
PFD5_HUMAN	PFDN5	physical	22939629
PFD4_HUMAN	PFDN4	physical	22939629
AASD1_HUMAN	AARSD1	physical	22863883
DPP8_HUMAN	DPP8	physical	22863883
FEN1_HUMAN	FEN1	physical	22863883
PFD5_HUMAN	PFDN5	physical	22863883
PP2AA_HUMAN	PPP2CA	physical	22863883
KAPCB_HUMAN	PRKACB	physical	22863883
PRPS1_HUMAN	PRPS1	physical	22863883
SH3G1_HUMAN	SH3GL1	physical	22863883
TSN_HUMAN	TSN	physical	22863883
UGGG1_HUMAN	UGGT1	physical	22863883
PFD2_HUMAN	PFDN2	physical	26344197
PFD5_HUMAN	PFDN5	physical	26344197
PFD6_HUMAN	PFDN6	physical	26344197
PFD3_HUMAN	VBP1	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PFD1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]