FA20C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FA20C_HUMAN
• UniProt AC: Q8IXL6
• Protein Name: Extracellular serine/threonine protein kinase FAM20C {ECO:0000305}
• Gene Name: FAM20C {ECO:0000312|HGNC:HGNC:22140}
• Organism: Homo sapiens (Human).
• Sequence Length: 584
• Subcellular Localization: Secreted . Golgi apparatus .
• Protein Description: Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. [PubMed: 22582013]
• Protein Sequence: MKMMLVRRFRVLILMVFLVACALHIALDLLPRLERRGARPSGEPGCSCAQPAAEVAAPGWAQVRGRPGEPPAASSAAGDAGWPNKHTLRILQDFSSDPSSNLSSHSLEKLPPAAEPAERALRGRDPGALRPHDPAHRPLLRDPGPRRSESPPGPGGDASLLARLFEHPLYRVAVPPLTEEDVLFNVNSDTRLSPKAAENPDWPHAGAEGAEFLSPGEAAVDSYPNWLKFHIGINRYELYSRHNPAIEALLHDLSSQRITSVAMKSGGTQLKLIMTFQNYGQALFKPMKQTREQETPPDFFYFSDYERHNAEIAAFHLDRILDFRRVPPVAGRMVNMTKEIRDVTRDKKLWRTFFISPANNICFYGECSYYCSTEHALCGKPDQIEGSLAAFLPDLSLAKRKTWRNPWRRSYHKRKKAEWEVDPDYCEEVKQTPPYDSSHRILDVMDMTIFDFLMGNMDRHHYETFEKFGNETFIIHLDNGRGFGKYSHDELSILVPLQQCCRIRKSTYLRLQLLAKEEYKLSLLMAESLRGDQVAPVLYQPHLEALDRRLRVVLKAVRDCVERNGLHSVVDDDLDTEHRAASAR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	O-linked_Glycosylation	ERRGARPSGEPGCSC HHCCCCCCCCCCCCC		55835221
47	O-linked_Glycosylation	PSGEPGCSCAQPAAE CCCCCCCCCCCCHHH		55835227
74	Phosphorylation	PGEPPAASSAAGDAG CCCCCCHHCCCCCCC		25850435
74	O-linked_Glycosylation	PGEPPAASSAAGDAG CCCCCCHHCCCCCCC		55825815
75	Phosphorylation	GEPPAASSAAGDAGW CCCCCHHCCCCCCCC		22199227
75	O-linked_Glycosylation	GEPPAASSAAGDAGW CCCCCHHCCCCCCCC		55825819
87	O-linked_Glycosylation	AGWPNKHTLRILQDF CCCCCHHHHHHHHHH		55825825
100	Phosphorylation	DFSSDPSSNLSSHSL HHCCCCCCCCCCCCC		-
101	N-linked_Glycosylation	FSSDPSSNLSSHSLE HCCCCCCCCCCCCCC		26091039
148	O-linked_Glycosylation	RDPGPRRSESPPGPG CCCCCCCCCCCCCCC		55834053
150	O-linked_Glycosylation	PGPRRSESPPGPGGD CCCCCCCCCCCCCCC		55834057
159	Phosphorylation	PGPGGDASLLARLFE CCCCCCHHHHHHHHC		24719451
188	Phosphorylation	DVLFNVNSDTRLSPK CEEEECCCCCCCCCC		25072903
190	Phosphorylation	LFNVNSDTRLSPKAA EEECCCCCCCCCCHH		25072903
193	Phosphorylation	VNSDTRLSPKAAENP CCCCCCCCCCHHCCC		26091039
214	O-linked_Glycosylation	AEGAEFLSPGEAAVD CCCCCCCCCCCHHHH		OGP
240	Phosphorylation	INRYELYSRHNPAIE ECHHHHHHHCCHHHH		24719451
254	Phosphorylation	EALLHDLSSQRITSV HHHHHHHHCCCCCEE		-
255	Phosphorylation	ALLHDLSSQRITSVA HHHHHHHCCCCCEEE		-
260	Phosphorylation	LSSQRITSVAMKSGG HHCCCCCEEEECCCC		-
275	Phosphorylation	TQLKLIMTFQNYGQA CEEEEEEEECHHHHH		24260401
279	Phosphorylation	LIMTFQNYGQALFKP EEEEECHHHHHHHHC		24260401
335	N-linked_Glycosylation	PVAGRMVNMTKEIRD CCCCHHHHCCHHHHH		26091039
470	N-linked_Glycosylation	ETFEKFGNETFIIHL HHHHHHCCEEEEEEE		26091039
519	Phosphorylation	QLLAKEEYKLSLLMA HHHHCCHHHHHHHHH		20049867
522	Phosphorylation	AKEEYKLSLLMAESL HCCHHHHHHHHHHHH		20049867
528	Phosphorylation	LSLLMAESLRGDQVA HHHHHHHHHCCCCCC		20049867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FA20C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FA20C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FA20C_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FA20C_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 259775: Raine syndrome (RNS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.