dbPTM

PRPS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PRPS1_HUMAN
UniProt AC	P60891
Protein Name	Ribose-phosphate pyrophosphokinase 1
Gene Name	PRPS1
Organism	Homo sapiens (Human).
Sequence Length	318
Subcellular Localization
Protein Description	Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis..
Protein Sequence	MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MPNIKIFSGSSH ---CCCEEEECCCCC	44.32	21890473
5	Ubiquitination	---MPNIKIFSGSSH ---CCCEEEECCCCC	44.32	21890473
16	Phosphorylation	GSSHQDLSQKIADRL CCCCHHHHHHHHHHH	37.40	27282143
18	Ubiquitination	SHQDLSQKIADRLGL CCHHHHHHHHHHHCH	36.16	21890473
18	Ubiquitination	SHQDLSQKIADRLGL CCHHHHHHHHHHHCH	36.16	21890473
22	Methylation	LSQKIADRLGLELGK HHHHHHHHHCHHHHC	22.95	-
29	Ubiquitination	RLGLELGKVVTKKFS HHCHHHHCHHHEECC	46.27	21890473
29	Ubiquitination	RLGLELGKVVTKKFS HHCHHHHCHHHEECC	46.27	21890473
36	Phosphorylation	KVVTKKFSNQETCVE CHHHEECCCCCEEEE	46.62	24275569
40	Phosphorylation	KKFSNQETCVEIGES EECCCCCEEEECCCC	16.46	20068231
47	Phosphorylation	TCVEIGESVRGEDVY EEEECCCCCCCCCEE	16.35	20068231
91	Glutathionylation	RVTAVIPCFPYARQD CCEEEEECCCHHCCC	3.54	22555962
94	Phosphorylation	AVIPCFPYARQDKKD EEEECCCHHCCCCCC	8.31	28152594
103	Phosphorylation	RQDKKDKSRAPISAK CCCCCCCCCCCCCHH	43.75	28348404
127	Ubiquitination	GADHIITMDLHASQI CCCEEEEEECCHHHC	3.48	21890473
145	Ubiquitination	FDIPVDNLYAEPAVL CCCCCCCCCCCHHHH	3.57	21890473
146	Phosphorylation	DIPVDNLYAEPAVLK CCCCCCCCCCHHHHH	18.38	-
156	Methylation	PAVLKWIRENISEWR HHHHHHHHHHHHHHH	29.78	115489095
165	S-palmitoylation	NISEWRNCTIVSPDA HHHHHHCCEEECCCC	1.74	26865113
169	Phosphorylation	WRNCTIVSPDAGGAK HHCCEEECCCCCCCH	17.14	22210691
176	Acetylation	SPDAGGAKRVTSIAD CCCCCCCHHHHHHHH	51.15	25953088
176	Ubiquitination	SPDAGGAKRVTSIAD CCCCCCCHHHHHHHH	51.15	-
176	Malonylation	SPDAGGAKRVTSIAD CCCCCCCHHHHHHHH	51.15	26320211
179	Phosphorylation	AGGAKRVTSIADRLN CCCCHHHHHHHHHCC	20.60	23312004
180	Phosphorylation	GGAKRVTSIADRLNV CCCHHHHHHHHHCCC	16.96	20068231
184	Methylation	RVTSIADRLNVDFAL HHHHHHHHCCCCEEH	21.09	115489087
194	Ubiquitination	VDFALIHKERKKANE CCEEHHCHHHHHCCC	52.82	21890473
194	Acetylation	VDFALIHKERKKANE CCEEHHCHHHHHCCC	52.82	19608861
194	Ubiquitination	VDFALIHKERKKANE CCEEHHCHHHHHCCC	52.82	21890473
204	Methylation	KKANEVDRMVLVGDV HHCCCCCEEEEECCH	23.45	-
212	Acetylation	MVLVGDVKDRVAILV EEEECCHHHCEEEEE	44.55	19820149
212	Ubiquitination	MVLVGDVKDRVAILV EEEECCHHHCEEEEE	44.55	21890473
212	Ubiquitination	MVLVGDVKDRVAILV EEEECCHHHCEEEEE	44.55	21890473
213	Ubiquitination	VLVGDVKDRVAILVD EEECCHHHCEEEEEH	50.57	21890473
225	Phosphorylation	LVDDMADTCGTICHA EEHHHHCHHHHHHHH	11.87	28857561
228	Phosphorylation	DMADTCGTICHAADK HHHCHHHHHHHHHHH	23.68	28857561
235	Ubiquitination	TICHAADKLLSAGAT HHHHHHHHHHHCCCC	46.75	-
238	Phosphorylation	HAADKLLSAGATRVY HHHHHHHHCCCCEEE	34.78	28857561
242	Phosphorylation	KLLSAGATRVYAILT HHHHCCCCEEEHHHH	21.54	-
245	Phosphorylation	SAGATRVYAILTHGI HCCCCEEEHHHHCCC	5.66	28152594
249	Phosphorylation	TRVYAILTHGIFSGP CEEEHHHHCCCCCCH	16.37	28152594
254	Phosphorylation	ILTHGIFSGPAISRI HHHCCCCCCHHHHHH	41.78	28348404
259	Phosphorylation	IFSGPAISRINNACF CCCCHHHHHHHHHEE	29.25	28348404
265	Glutathionylation	ISRINNACFEAVVVT HHHHHHHEEEEEEEE	3.26	22555962
280	Ubiquitination	NTIPQEDKMKHCSKI CCCCHHHHCCCCCCC	49.44	-
280	Acetylation	NTIPQEDKMKHCSKI CCCCHHHHCCCCCCC	49.44	26051181
282	Ubiquitination	IPQEDKMKHCSKIQV CCHHHHCCCCCCCEE	47.39	-
303	Phosphorylation	LAEAIRRTHNGESVS HHHHHHHHCCCCEEE	15.16	20068231
308	Phosphorylation	RRTHNGESVSYLFSH HHHCCCCEEEEEEEC	20.12	20068231
310	Phosphorylation	THNGESVSYLFSHVP HCCCCEEEEEEECCC	25.95	20068231
311	Phosphorylation	HNGESVSYLFSHVPL CCCCEEEEEEECCCC	15.03	20068231
314	Phosphorylation	ESVSYLFSHVPL--- CEEEEEEECCCC---	22.45	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
103	S	Phosphorylation	Kinase	CDK1	P06493	PSP
180	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PRPS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PRPS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPG21_HUMAN	SPG21	physical	16189514
PRPS1_HUMAN	PRPS1	physical	16189514
GORS2_HUMAN	GORASP2	physical	16189514
KPRA_HUMAN	PRPSAP1	physical	16189514
PRKN_HUMAN	PARK2	physical	22792159
PRPS2_HUMAN	PRPS2	physical	22939629
TWF1_HUMAN	TWF1	physical	22939629
SYNC_HUMAN	NARS	physical	22939629
PRPS1_HUMAN	PRPS1	physical	25416956
PRPS2_HUMAN	PRPS2	physical	25416956
KPRA_HUMAN	PRPSAP1	physical	25416956
SPG21_HUMAN	SPG21	physical	25416956
EMAL4_HUMAN	EML4	physical	26186194
KPRA_HUMAN	PRPSAP1	physical	26186194
KPRB_HUMAN	PRPSAP2	physical	26186194
NMT2_HUMAN	NMT2	physical	26186194
NDUB9_HUMAN	NDUFB9	physical	26186194
PRPS3_HUMAN	PRPS1L1	physical	26186194
CK5P2_HUMAN	CDK5RAP2	physical	26186194
NFRKB_HUMAN	NFRKB	physical	26186194
ELP3_HUMAN	ELP3	physical	26186194
PLSI_HUMAN	PLS1	physical	26186194
BD1L1_HUMAN	BOD1L1	physical	26186194
UBB_HUMAN	UBB	physical	26186194
SET1A_HUMAN	SETD1A	physical	26186194
RS4Y1_HUMAN	RPS4Y1	physical	26186194
ELF2_HUMAN	ELF2	physical	26186194
BRMS1_HUMAN	BRMS1	physical	26186194
T2FA_HUMAN	GTF2F1	physical	26186194
CXXC1_HUMAN	CXXC1	physical	26186194
SYFA_HUMAN	FARSA	physical	26344197
NMD3_HUMAN	NMD3	physical	26344197
KPRA_HUMAN	PRPSAP1	physical	26344197
KPRB_HUMAN	PRPSAP2	physical	26344197
SBDS_HUMAN	SBDS	physical	26344197
PRPS2_HUMAN	PRPS2	physical	26496610
KPRA_HUMAN	PRPSAP1	physical	26496610
KPRB_HUMAN	PRPSAP2	physical	26496610
PRP19_HUMAN	PRPF19	physical	26496610
FBX31_HUMAN	FBXO31	physical	26496610
KLH13_HUMAN	KLHL13	physical	26496610
TOP1M_HUMAN	TOP1MT	physical	26496610
KPRB_HUMAN	PRPSAP2	physical	28514442
KPRA_HUMAN	PRPSAP1	physical	28514442
PRPS3_HUMAN	PRPS1L1	physical	28514442
NFRKB_HUMAN	NFRKB	physical	28514442
NDUB9_HUMAN	NDUFB9	physical	28514442
BRMS1_HUMAN	BRMS1	physical	28514442
NMT2_HUMAN	NMT2	physical	28514442
CXXC1_HUMAN	CXXC1	physical	28514442
ELF2_HUMAN	ELF2	physical	28514442
RS4Y1_HUMAN	RPS4Y1	physical	28514442
UBB_HUMAN	UBB	physical	28514442
PLSI_HUMAN	PLS1	physical	28514442
T2FA_HUMAN	GTF2F1	physical	28514442
CK5P2_HUMAN	CDK5RAP2	physical	28514442
ELP3_HUMAN	ELP3	physical	28514442
EMAL4_HUMAN	EML4	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
0000269\|PubMed	Note=Phosphoribosyl pyrophosphate synthetase I deficiency is a rare condition caused by mutations in PRPS1 that lead to variable disease phenotypes including optic atrophy, retinitis pigmentosa, ataxia, peripheral neuropathy and hearing loss. {ECO
300661
311070	Charcot-Marie-Tooth disease, X-linked recessive, 5 (CMTX5)
301835	ARTS syndrome (ARTS)
304500	Deafness, X-linked, 1 (DFNX1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PRPS1_HUMAN

Related Literatures of Post-Translational Modification