CK5P2_HUMAN - dbPTM
CK5P2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CK5P2_HUMAN
UniProt AC Q96SN8
Protein Name CDK5 regulatory subunit-associated protein 2
Gene Name CDK5RAP2
Organism Homo sapiens (Human).
Sequence Length 1893
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Golgi apparatus . Cytoplasm . Cytoplasm, cytoskeleton . Found in the pericentriolar region adhering to the surface of the centrosome and in the region of the centrosomal appendages.
Protein Description Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes. [PubMed: 26485573 In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery]
Protein Sequence MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
48PhosphorylationNGLLPNVSEETVSPT
CCCCCCCCCCCCCCC		36.0326074081
51PhosphorylationLPNVSEETVSPTRAR
CCCCCCCCCCCCCCC		23.4126074081
53PhosphorylationNVSEETVSPTRARNM
CCCCCCCCCCCCCCH		28.1526074081
55PhosphorylationSEETVSPTRARNMKD
CCCCCCCCCCCCHHH		29.4726074081
61UbiquitinationPTRARNMKDFENQIT
CCCCCCHHHHHHHHH		63.9221906983
61 (in isoform 1)Ubiquitination-63.9221890473
61 (in isoform 2)Ubiquitination-63.9221890473
61 (in isoform 3)Ubiquitination-63.9221890473
61 (in isoform 4)Ubiquitination-63.9221890473
71UbiquitinationENQITELKKENFNLK
HHHHHHHHHHCCCCE		52.38-
78 (in isoform 2)Ubiquitination-36.50-
102PhosphorylationPTEHIYKTNIELKVE
CCHHHEECCEEEEEE		25.18-
114UbiquitinationKVEVESLKRELQERE
EEEHHHHHHHHHHHH		53.78-
126UbiquitinationEREQLLIKASKAVES
HHHHHHHHHHHHHHH		46.72-
128PhosphorylationEQLLIKASKAVESLA
HHHHHHHHHHHHHHH		19.02-
129UbiquitinationQLLIKASKAVESLAE
HHHHHHHHHHHHHHH		62.40-
129 (in isoform 2)Ubiquitination-62.40-
140PhosphorylationSLAEAGGSEIQRVKE
HHHHCCCHHHHHHHH		30.52-
152UbiquitinationVKEDARKKVQQVEDL
HHHHHHHHHHHHHHH		39.46-
161PhosphorylationQQVEDLLTKRILLLE
HHHHHHHHHHHHHHH		26.10-
162UbiquitinationQVEDLLTKRILLLEK
HHHHHHHHHHHHHHH		37.09-
169UbiquitinationKRILLLEKDVTAAQA
HHHHHHHHCCHHHHH		58.42-
180UbiquitinationAAQAELEKAFAGTET
HHHHHHHHHHCCCHH		62.52-
189UbiquitinationFAGTETEKALRLRLE
HCCCHHHHHHHHHHH		61.20-
197PhosphorylationALRLRLESKLSEMKK
HHHHHHHHHHHHHHH		43.4125463755
198UbiquitinationLRLRLESKLSEMKKM
HHHHHHHHHHHHHHH		46.81-
200PhosphorylationLRLESKLSEMKKMHE
HHHHHHHHHHHHHCC		39.1125463755
241UbiquitinationEALIQCLKEEKSQMA
HHHHHHHHHHHHHCC		72.03-
247SulfoxidationLKEEKSQMACPDENV
HHHHHHHCCCCCCCC		5.5321406390
255PhosphorylationACPDENVSSGELRGL
CCCCCCCCHHHHCHH		44.1821815630
256PhosphorylationCPDENVSSGELRGLC
CCCCCCCHHHHCHHH		31.8129396449
274PhosphorylationREEKERETEAAQMEH
HHHHHHHHHHHHHHH		36.8324719451
287PhosphorylationEHQKERNSFEERIQA
HHHHHHCCHHHHHHH		40.0124719451
324PhosphorylationDKAIQGLTMALKSKE
HHHHHHHHHHHHHHH		13.7620068231
339PhosphorylationKKVEELNSEIEKLSA
HHHHHHHHHHHHHHH		53.2129083192
345PhosphorylationNSEIEKLSAAFAKAR
HHHHHHHHHHHHHHH		28.7226437602
357UbiquitinationKAREALQKAQTQEFQ
HHHHHHHHHHHHHCC		43.22-
360PhosphorylationEALQKAQTQEFQGSE
HHHHHHHHHHCCCCC		34.6229978859
366PhosphorylationQTQEFQGSEDYETAL
HHHHCCCCCCHHHHH		19.2628796482
369PhosphorylationEFQGSEDYETALSGK
HCCCCCCHHHHHCHH		15.8928796482
371PhosphorylationQGSEDYETALSGKEA
CCCCCHHHHHCHHHH		27.0328796482
374PhosphorylationEDYETALSGKEALSA
CCHHHHHCHHHHHHH		45.4129978859
376UbiquitinationYETALSGKEALSAAL
HHHHHCHHHHHHHHH		36.12-
385PhosphorylationALSAALRSQNLTKST
HHHHHHHHCCCCCHH		25.0328555341
391PhosphorylationRSQNLTKSTENHRLR
HHCCCCCHHHHHHHH		35.40-
392PhosphorylationSQNLTKSTENHRLRR
HCCCCCHHHHHHHHH		42.22-
400PhosphorylationENHRLRRSIKKITQE
HHHHHHHHHHHHHHH		32.12-
403UbiquitinationRLRRSIKKITQELSD
HHHHHHHHHHHHHHH		49.68-
409PhosphorylationKKITQELSDLQQERE
HHHHHHHHHHHHHHH		35.2130387612
431SumoylationEAHREKSKGDCTIRD
HHHHHHCCCCCCHHH		70.59-
435PhosphorylationEKSKGDCTIRDLRNE
HHCCCCCCHHHHHHH		24.6426552605
461PhosphorylationEKAMENRYKSLLSES
HHHHHHHHHHHHHHH		19.2617924679
462UbiquitinationKAMENRYKSLLSESN
HHHHHHHHHHHHHHH		31.24-
463PhosphorylationAMENRYKSLLSESNK
HHHHHHHHHHHHHHH		26.13-
466PhosphorylationNRYKSLLSESNKKLH
HHHHHHHHHHHHHHC		44.2517924679
468PhosphorylationYKSLLSESNKKLHNQ
HHHHHHHHHHHHCCH		51.0417924679
471UbiquitinationLLSESNKKLHNQEQV
HHHHHHHHHCCHHHH		60.26-
480UbiquitinationHNQEQVIKHLTESTN
CCHHHHHHHHHHHCC		33.43-
480 (in isoform 2)Ubiquitination-33.43-
486PhosphorylationIKHLTESTNQKDVLL
HHHHHHHCCHHHHHH		35.12-
489UbiquitinationLTESTNQKDVLLQKF
HHHHCCHHHHHHHHH		52.4521906983
489 (in isoform 1)Ubiquitination-52.4521890473
489 (in isoform 2)Ubiquitination-52.4521890473
489 (in isoform 3)Ubiquitination-52.4521890473
489 (in isoform 4)Ubiquitination-52.4521890473
495UbiquitinationQKDVLLQKFNEKDLE
HHHHHHHHHCHHHHH		50.5621890473
495UbiquitinationQKDVLLQKFNEKDLE
HHHHHHHHHCHHHHH		50.5621890473
495 (in isoform 1)Ubiquitination-50.5621890473
495 (in isoform 2)Ubiquitination-50.5621890473
495 (in isoform 3)Ubiquitination-50.5621890473
495 (in isoform 4)Ubiquitination-50.5621890473
527UbiquitinationSEGLITEKCSSQQPP
HCCCCCCCCCCCCCC		30.66-
527 (in isoform 2)Ubiquitination-30.66-
537UbiquitinationSQQPPGSKTIFSKEK
CCCCCCCCCCCCCCH		52.10-
537 (in isoform 2)Ubiquitination-52.10-
541PhosphorylationPGSKTIFSKEKKQSS
CCCCCCCCCCHHCCC		35.7324719451
542UbiquitinationGSKTIFSKEKKQSSD
CCCCCCCCCHHCCCC		63.90-
542 (in isoform 2)Ubiquitination-63.90-
544 (in isoform 2)Ubiquitination-60.90-
545UbiquitinationTIFSKEKKQSSDYEE
CCCCCCHHCCCCHHH		57.41-
547PhosphorylationFSKEKKQSSDYEELI
CCCCHHCCCCHHHHH		33.7730266825
548PhosphorylationSKEKKQSSDYEELIQ
CCCHHCCCCHHHHHH		41.5430266825
550PhosphorylationEKKQSSDYEELIQVL
CHHCCCCHHHHHHHH		17.1630266825
558UbiquitinationEELIQVLKKEQDIYT
HHHHHHHHHHHHHHH		56.24-
558 (in isoform 2)Ubiquitination-56.24-
559UbiquitinationELIQVLKKEQDIYTH
HHHHHHHHHHHHHHH		57.35-
559 (in isoform 2)Ubiquitination-57.35-
564PhosphorylationLKKEQDIYTHLVKSL
HHHHHHHHHHHHHHH		9.0827642862
569UbiquitinationDIYTHLVKSLQESDS
HHHHHHHHHHHCCCC		52.38-
569 (in isoform 2)Ubiquitination-52.38-
570PhosphorylationIYTHLVKSLQESDSI
HHHHHHHHHHCCCCH		28.0125690035
574PhosphorylationLVKSLQESDSINNLQ
HHHHHHCCCCHHHHH		24.5627251275
576PhosphorylationKSLQESDSINNLQAE
HHHHCCCCHHHHHHH		36.1726471730
586UbiquitinationNLQAELNKIFALRKQ
HHHHHHHHHHHHHHH		52.40-
586 (in isoform 2)Ubiquitination-52.40-
592UbiquitinationNKIFALRKQLEQDVL
HHHHHHHHHHHHHHH		61.1521890473
592UbiquitinationNKIFALRKQLEQDVL
HHHHHHHHHHHHHHH		61.1521890473
592 (in isoform 1)Ubiquitination-61.1521890473
592 (in isoform 2)Ubiquitination-61.1521890473
592 (in isoform 3)Ubiquitination-61.1521890473
592 (in isoform 4)Ubiquitination-61.1521890473
600PhosphorylationQLEQDVLSYQNLRKT
HHHHHHHHHHHHHHH		25.2328188228
606UbiquitinationLSYQNLRKTLEEQIS
HHHHHHHHHHHHHHH		61.70-
606 (in isoform 2)Ubiquitination-61.70-
613PhosphorylationKTLEEQISEIRRREE
HHHHHHHHHHHHHHH		27.0221815630
654UbiquitinationHFSQEELKKKVSDLI
CCCHHHHHHHHHHHH		54.55-
655 (in isoform 2)Ubiquitination-71.66-
656AcetylationSQEELKKKVSDLIQL
CHHHHHHHHHHHHHH		45.4412655013
656UbiquitinationSQEELKKKVSDLIQL
CHHHHHHHHHHHHHH		45.44-
656 (in isoform 2)Ubiquitination-45.44-
665AcetylationSDLIQLVKELYTDNQ
HHHHHHHHHHHCCCH		51.0612655025
665UbiquitinationSDLIQLVKELYTDNQ
HHHHHHHHHHHCCCH		51.06-
665 (in isoform 2)Ubiquitination-51.06-
675UbiquitinationYTDNQHLKKTIFDLS
HCCCHHHHHHHHCHH		45.83-
675 (in isoform 2)Ubiquitination-45.83-
676UbiquitinationTDNQHLKKTIFDLSC
CCCHHHHHHHHCHHH		53.89-
676 (in isoform 2)Ubiquitination-53.89-
677 (in isoform 2)Phosphorylation-25.8621955146
682PhosphorylationKKTIFDLSCMGFQGN
HHHHHCHHHCCCCCC		12.1421712546
682 (in isoform 2)Phosphorylation-12.1421955146
697PhosphorylationGFPDRLASTEQTELL
CCCHHCCCHHHHHHH		36.7521815630
697 (in isoform 2)Phosphorylation-36.7521955146
698PhosphorylationFPDRLASTEQTELLA
CCHHCCCHHHHHHHH		26.8921815630
698 (in isoform 2)Phosphorylation-26.8921955146
701PhosphorylationRLASTEQTELLASKE
HCCCHHHHHHHHCCC		23.5128122231
701 (in isoform 2)Phosphorylation-23.5121955146
705 (in isoform 2)Ubiquitination-31.05-
706PhosphorylationEQTELLASKEDEDTI
HHHHHHHCCCCCCCE		36.2321815630
707UbiquitinationQTELLASKEDEDTIK
HHHHHHCCCCCCCEE		64.67-
713 (in isoform 2)Ubiquitination-4.78-
723 (in isoform 2)Ubiquitination-9.44-
725PhosphorylationDDEINFLSDQHLQQS
CCHHHHCCHHHHHHH		30.9626471730
732PhosphorylationSDQHLQQSNEIMKDL
CHHHHHHHHHHHHHH		24.38-
737UbiquitinationQQSNEIMKDLSKGGC
HHHHHHHHHHHCCCC		62.27-
745UbiquitinationDLSKGGCKNGYLRHT
HHHCCCCCCCCCCCC		57.60-
755UbiquitinationYLRHTESKISDCDGA
CCCCCCCCCCCCCCC		39.74-
765 (in isoform 2)Ubiquitination-24.94-
791PhosphorylationKATLLLESRPDLLKV
HHHHHHHCCHHHHHH		49.4327251275
796 (in isoform 2)Ubiquitination-5.29-
797UbiquitinationESRPDLLKVVRELLL
HCCHHHHHHHHHHHH		46.08-
798 (in isoform 2)Ubiquitination-5.04-
815PhosphorylationFLTEQEVSGEHLDGK
HCCCCCCCCCCCCCC		37.4022817900
822UbiquitinationSGEHLDGKTEKTPKQ
CCCCCCCCCCCCCCC		53.85-
827 (in isoform 2)Ubiquitination-48.42-
830UbiquitinationTEKTPKQKGELVHFV
CCCCCCCCCCEEEEE		61.55-
837 (in isoform 2)Ubiquitination-4.07-
839PhosphorylationELVHFVQTNSFSKPH
CEEEEEEECCCCCCC		27.7720873877
841PhosphorylationVHFVQTNSFSKPHDE
EEEEEECCCCCCCHH		33.9920873877
843PhosphorylationFVQTNSFSKPHDELK
EEEECCCCCCCHHCC		45.1320873877
844UbiquitinationVQTNSFSKPHDELKL
EEECCCCCCCHHCCC		44.34-
859UbiquitinationSCEAQLVKAGEVPKV
EEEEEEECCCCCCCC		60.30-
865UbiquitinationVKAGEVPKVGLKDAS
ECCCCCCCCCCCCCC		54.86-
869UbiquitinationEVPKVGLKDASVQTV
CCCCCCCCCCCEEEE		45.37-
886UbiquitinationEGDLLRFKHEATREA
CCCHHHHCHHHHHHH		33.82-
897UbiquitinationTREAWEEKPINTALS
HHHHHHHCCCCCCCC		39.42-
901PhosphorylationWEEKPINTALSAEHR
HHHCCCCCCCCCCCC		29.6920068231
904PhosphorylationKPINTALSAEHRPEN
CCCCCCCCCCCCCHH		29.1920068231
911 (in isoform 2)Ubiquitination-39.77-
943UbiquitinationSRLPILIKPSRSLGN
CCCCEEECCCCCCCC		33.23-
945PhosphorylationLPILIKPSRSLGNMY
CCEEECCCCCCCCCC		29.5124719451
947PhosphorylationILIKPSRSLGNMYRL
EEECCCCCCCCCCCC		44.9920860994
952PhosphorylationSRSLGNMYRLPATQE
CCCCCCCCCCCCHHH		17.01-
972 (in isoform 2)Ubiquitination-33.66-
983UbiquitinationKEFKTCNKQLHQKLI
HHHHHCCHHHHHHHH		57.28-
988UbiquitinationCNKQLHQKLILAEAV
CCHHHHHHHHHHHHH		27.09-
996 (in isoform 2)Ubiquitination-6.11-
1001PhosphorylationAVMEGRPTPDKTLLN
HHHCCCCCCCCCCCC		42.6425159151
1004UbiquitinationEGRPTPDKTLLNAQP
CCCCCCCCCCCCCCC		42.13-
1005PhosphorylationGRPTPDKTLLNAQPP
CCCCCCCCCCCCCCC		43.8130387612
1017PhosphorylationQPPVGAAYQDSPGEQ
CCCCCCCCCCCCCCC		16.6029396449
1020PhosphorylationVGAAYQDSPGEQKGI
CCCCCCCCCCCCCCC		21.1925159151
1025UbiquitinationQDSPGEQKGIKTTSS
CCCCCCCCCCCCCCC		59.30-
1028UbiquitinationPGEQKGIKTTSSVWR
CCCCCCCCCCCCHHC		55.19-
1037UbiquitinationTSSVWRDKEMDSDQQ
CCCHHCCCCCCCCCH		46.49-
1053 (in isoform 2)Ubiquitination-5.04-
1059 (in isoform 2)Ubiquitination-4.55-
1061PhosphorylationCPPDDLASLPSCKEN
CCHHHHHCCCCCCCC		48.3826657352
1064PhosphorylationDDLASLPSCKENPED
HHHHCCCCCCCCHHH		43.0127251275
1074PhosphorylationENPEDVLSPTSVATY
CCHHHCCCHHHHHHH		26.4430278072
1076PhosphorylationPEDVLSPTSVATYLS
HHHCCCHHHHHHHHH		32.2430278072
1077PhosphorylationEDVLSPTSVATYLSS
HHCCCHHHHHHHHHC		17.0930278072
1080PhosphorylationLSPTSVATYLSSKSQ
CCHHHHHHHHHCCCC		23.8823663014
1081PhosphorylationSPTSVATYLSSKSQP
CHHHHHHHHHCCCCC		8.5424732914
1081 (in isoform 2)Ubiquitination-8.5421890473
1083PhosphorylationTSVATYLSSKSQPSA
HHHHHHHHCCCCCCC		25.8823663014
1083 (in isoform 2)Ubiquitination-25.88-
1084PhosphorylationSVATYLSSKSQPSAK
HHHHHHHCCCCCCCE		33.4623663014
1085UbiquitinationVATYLSSKSQPSAKV
HHHHHHCCCCCCCEE		50.13-
1089PhosphorylationLSSKSQPSAKVSVMG
HHCCCCCCCEEEEEC		32.8424850871
1091UbiquitinationSKSQPSAKVSVMGTD
CCCCCCCEEEEECCC		39.10-
1100PhosphorylationSVMGTDQSESINTSN
EEECCCCHHHCCCCC		35.8020860994
1102PhosphorylationMGTDQSESINTSNET
ECCCCHHHCCCCCHH		26.7819007248
1105PhosphorylationDQSESINTSNETEYL
CCHHHCCCCCHHHHH		31.1226471730
1111PhosphorylationNTSNETEYLKQKIHD
CCCCHHHHHHHHHHH		26.98-
1113UbiquitinationSNETEYLKQKIHDLE
CCHHHHHHHHHHHHH		48.9521906983
1113 (in isoform 1)Ubiquitination-48.9521890473
1113 (in isoform 3)Ubiquitination-48.9521890473
1113 (in isoform 4)Ubiquitination-48.9521890473
1127 (in isoform 2)Ubiquitination-49.57-
1129 (in isoform 2)Ubiquitination-3.32-
1143 (in isoform 3)Ubiquitination-2.0821890473
1152 (in isoform 2)Ubiquitination-28.5121890473
1158PhosphorylationEGAQDGLSKPKNGSD
CCCCCCCCCCCCCCC		53.0624719451
1159UbiquitinationGAQDGLSKPKNGSDG
CCCCCCCCCCCCCCC		66.12-
1161UbiquitinationQDGLSKPKNGSDGEE
CCCCCCCCCCCCCCC		77.12-
1162 (in isoform 3)Ubiquitination-64.82-
1164PhosphorylationLSKPKNGSDGEEMTF
CCCCCCCCCCCCCCH		52.4128348404
1170PhosphorylationGSDGEEMTFSSLHQV
CCCCCCCCHHHHHHH		24.5227251275
1171 (in isoform 2)Ubiquitination-4.5121890473
1172PhosphorylationDGEEMTFSSLHQVRY
CCCCCCHHHHHHHEE		23.8727251275
1173PhosphorylationGEEMTFSSLHQVRYV
CCCCCHHHHHHHEEE		26.1927251275
1174 (in isoform 3)Ubiquitination-2.9521890473
1180 (in isoform 2)Ubiquitination-2.12-
1183 (in isoform 2)Ubiquitination-3.2321890473
1184UbiquitinationVRYVKHVKILGPLAP
HEEEEEEEEECCCCH		31.7521890473
1184UbiquitinationVRYVKHVKILGPLAP
HEEEEEEEEECCCCH		31.7521890473
1184 (in isoform 1)Ubiquitination-31.7521890473
1184 (in isoform 3)Ubiquitination-31.7521890473
1184 (in isoform 4)Ubiquitination-31.7521890473
1201 (in isoform 2)Ubiquitination-48.67-
1203UbiquitinationSRVLENLKQQLEEQE
HHHHHHHHHHHHHHH		47.8021906983
1203 (in isoform 1)Ubiquitination-47.8021890473
1203 (in isoform 3)Ubiquitination-47.8021890473
1203 (in isoform 4)Ubiquitination-47.8021890473
1212UbiquitinationQLEEQEYKLQKEQNL
HHHHHHHHHHHHHHH		43.63-
1215UbiquitinationEQEYKLQKEQNLNMQ
HHHHHHHHHHHHHHH		72.2421890473
1215UbiquitinationEQEYKLQKEQNLNMQ
HHHHHHHHHHHHHHH		72.242189047
1215 (in isoform 1)Ubiquitination-72.2421890473
1215 (in isoform 3)Ubiquitination-72.2421890473
1215 (in isoform 4)Ubiquitination-72.2421890473
1229 (in isoform 2)Ubiquitination-49.32-
1233UbiquitinationEIHNLQNKFRDLSPP
HHHHHHHHHHCCCCC		28.90-
1238PhosphorylationQNKFRDLSPPRYDSL
HHHHHCCCCCCHHHH		36.8322167270
1242PhosphorylationRDLSPPRYDSLVQSQ
HCCCCCCHHHHHHHH		18.6923403867
1244PhosphorylationLSPPRYDSLVQSQAR
CCCCCHHHHHHHHHH		22.8523927012
1248PhosphorylationRYDSLVQSQARELSL
CHHHHHHHHHHHHHH		20.5123403867
1254PhosphorylationQSQARELSLQRQQIK
HHHHHHHHHHHHHHH		20.0824719451
1261UbiquitinationSLQRQQIKDGHGICV
HHHHHHHHCCCCEEE		54.01-
1288 (in isoform 2)Ubiquitination-25.80-
1320UbiquitinationEKLFLNGKSVGVEMN
HHHHHCCCCCCCCCC		40.68-
1328PhosphorylationSVGVEMNTQNELMER
CCCCCCCCHHHHHHH		31.3124114839
1342PhosphorylationRIEEDNLTYQHLLPE
HHHHCCCCHHHCCCC		27.6528796482
1343PhosphorylationIEEDNLTYQHLLPES
HHHCCCCHHHCCCCC		9.3328796482
1350PhosphorylationYQHLLPESPEPSASH
HHHCCCCCCCCCHHH		32.4023401153
1354PhosphorylationLPESPEPSASHALSD
CCCCCCCCHHHCCCC		40.5227794612
1356PhosphorylationESPEPSASHALSDYE
CCCCCCHHHCCCCCC		17.4021082442
1360PhosphorylationPSASHALSDYETSEK
CCHHHCCCCCCCCCC		38.6428796482
1362PhosphorylationASHALSDYETSEKSF
HHHCCCCCCCCCCCC		20.1028796482
1364PhosphorylationHALSDYETSEKSFFS
HCCCCCCCCCCCCCC		35.6428796482
1365PhosphorylationALSDYETSEKSFFSR
CCCCCCCCCCCCCCC		30.9628796482
1367UbiquitinationSDYETSEKSFFSRDQ
CCCCCCCCCCCCCCC		52.94-
1368PhosphorylationDYETSEKSFFSRDQK
CCCCCCCCCCCCCCC		27.7225159151
1380PhosphorylationDQKQDNETEKTSVMV
CCCCCCCCHHHHHHH		49.3829978859
1383PhosphorylationQDNETEKTSVMVNSF
CCCCCHHHHHHHCCC		21.9629978859
1384PhosphorylationDNETEKTSVMVNSFS
CCCCHHHHHHHCCCC		21.2029978859
1389PhosphorylationKTSVMVNSFSQDLLM
HHHHHHCCCCHHHHH		18.1829978859
1391PhosphorylationSVMVNSFSQDLLMEH
HHHHCCCCHHHHHHH		23.7027251275
1404PhosphorylationEHIQEIRTLRKRLEE
HHHHHHHHHHHHHHH		36.2529978859
1412PhosphorylationLRKRLEESIKTNEKL
HHHHHHHHHHHHHHH		21.7329978859
1415PhosphorylationRLEESIKTNEKLRKQ
HHHHHHHHHHHHHHH		47.1129978859
1425 (in isoform 2)Ubiquitination-55.54-
1428PhosphorylationKQLERQGSEFVQGST
HHHHHCCCHHHCCCC		21.37-
1455 (in isoform 2)Ubiquitination-4.07-
1457UbiquitinationSEIHFLRKQNQALNA
HHHHHHHHHHHHHHH		56.60-
1468UbiquitinationALNAMLIKGSRDKQK
HHHHHHHHCCHHHHH		47.04-
1483PhosphorylationENDKLRESLSRKTVS
HHHHHHHHHHHHHCC		25.8020860994
1485PhosphorylationDKLRESLSRKTVSLE
HHHHHHHHHHHCCHH		40.8024260401
1487UbiquitinationLRESLSRKTVSLEHL
HHHHHHHHHCCHHHH		50.32-
1488PhosphorylationRESLSRKTVSLEHLQ
HHHHHHHHCCHHHHH		17.7629214152
1490PhosphorylationSLSRKTVSLEHLQRE
HHHHHHCCHHHHHHH		33.0223898821
1509 (in isoform 2)Ubiquitination-48.23-
1529PhosphorylationLIQEVRCSGQELSRV
HHHHHHCCHHHHHHH		32.7128674151
1530 (in isoform 2)Ubiquitination-28.71-
1534PhosphorylationRCSGQELSRVQEEVK
HCCHHHHHHHHHHHH		29.6524114839
1534 (in isoform 2)Ubiquitination-29.65-
1541UbiquitinationSRVQEEVKLRQQLLS
HHHHHHHHHHHHHHH		41.03-
1548PhosphorylationKLRQQLLSQNDKLLQ
HHHHHHHHCCHHHHH		35.2122817900
1556PhosphorylationQNDKLLQSLRVELKA
CCHHHHHHHHHHHHH		20.3622817900
1562UbiquitinationQSLRVELKAYEKLDE
HHHHHHHHHHHHCCH		35.10-
1566UbiquitinationVELKAYEKLDEEHRR
HHHHHHHHCCHHHHH		48.87-
1587 (in isoform 4)Phosphorylation-20.4829507054
1588 (in isoform 2)Ubiquitination-14.80-
1617PhosphorylationETSSTLQSRLKEQLA
CCCHHHHHHHHHHHH		42.5720860994
1620UbiquitinationSTLQSRLKEQLARGA
HHHHHHHHHHHHHHH		42.16-
1663PhosphorylationGDKYPMESDNSFDLF
CCCCCCCCCCCCCCC		35.5225159151
1666PhosphorylationYPMESDNSFDLFDSS
CCCCCCCCCCCCCCC		25.7326471730
1672PhosphorylationNSFDLFDSSQAVTPK
CCCCCCCCCCCCCCC		19.6025159151
1673PhosphorylationSFDLFDSSQAVTPKS
CCCCCCCCCCCCCCC		24.8128348404
1682PhosphorylationAVTPKSVSETPPLSG
CCCCCCCCCCCCCCC		42.7330576142
1684PhosphorylationTPKSVSETPPLSGND
CCCCCCCCCCCCCCC		23.7728348404
1688PhosphorylationVSETPPLSGNDTDSL
CCCCCCCCCCCCCCC		41.1328348404
1690 (in isoform 2)Ubiquitination-45.71-
1692PhosphorylationPPLSGNDTDSLSCDS
CCCCCCCCCCCCCCC		31.3328348404
1694PhosphorylationLSGNDTDSLSCDSGS
CCCCCCCCCCCCCCC		25.0330576142
1696PhosphorylationGNDTDSLSCDSGSSA
CCCCCCCCCCCCCCC		21.6028348404
1699PhosphorylationTDSLSCDSGSSATST
CCCCCCCCCCCCCCC		44.9228348404
1701PhosphorylationSLSCDSGSSATSTPC
CCCCCCCCCCCCCCC		22.2828348404
1706PhosphorylationSGSSATSTPCVSRLV
CCCCCCCCCCCHHHC		19.1630576142
1722UbiquitinationGHHLWASKNGRHVLG
CCEEEECCCCHHHHH		56.53-
1737 (in isoform 2)Ubiquitination-4.03-
1766 (in isoform 2)Ubiquitination-9.05-
1769UbiquitinationTSQELGTKGPHPAPL
CCHHCCCCCCCCCCH		69.51-
1778UbiquitinationPHPAPLSKFVSSVST
CCCCCHHHHHHCHHH		58.42-
1798UbiquitinationEEAYRRLKLLWRVSL
HHHHHHHHHHEEECC		39.46-
1822UbiquitinationCEQIGEMKAEVTKLH
HHHHHHHHHHHHHHH		36.77-
1827UbiquitinationEMKAEVTKLHKKLFE
HHHHHHHHHHHHHHH		54.49-
1833 (in isoform 2)Ubiquitination-14.47-
1844UbiquitinationKKLQNTMKLLQLSKR
HHHHHHHHHHHHHHH		43.96-
1865UbiquitinationDQLVVTHKILRKARG
HHHHHHHHHHHHHCC		33.79-
1885PhosphorylationPGGAHPGTCSPSRPG
CCCCCCCCCCCCCCC		17.7923401153
1887PhosphorylationGAHPGTCSPSRPGS-
CCCCCCCCCCCCCC-		26.2522167270
1889PhosphorylationHPGTCSPSRPGS---
CCCCCCCCCCCC---		34.5122167270
1893PhosphorylationCSPSRPGS-------
CCCCCCCC-------		39.4710997877
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
102TPhosphorylationKinaseLRRK1Q38SD2
PSP
140SPhosphorylationKinaseLRRK1Q38SD2
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CK5P2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CK5P2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
STAR9_HUMANSTARD9physical
16169070
MAGH1_HUMANMAGEH1physical
16169070
PTN_HUMANPTNphysical
16169070
SENP2_HUMANSENP2physical
16169070
ZPR1_HUMANZPR1physical
16169070
ERG28_HUMANC14orf1physical
16169070
HAP1_HUMANHAP1physical
16169070
KAT5_HUMANKAT5physical
16169070
LC7L2_HUMANLUC7L2physical
16169070
DPYL1_HUMANCRMP1physical
16169070
RBM48_HUMANRBM48physical
16169070
EF1G_HUMANEEF1Gphysical
16169070
CD5R1_HUMANCDK5R1physical
10915792
CDK5_HUMANCDK5physical
10915792
GCP6_HUMANTUBGCP6physical
21135143
GCP5_HUMANTUBGCP5physical
21135143
GCP2_HUMANTUBGCP2physical
21135143
GCP3_HUMANTUBGCP3physical
21135143
NDK7_HUMANNME7physical
21135143
MZT2A_HUMANMZT2Aphysical
21135143
MZT2B_HUMANMZT2Bphysical
21135143
TBG1_HUMANTUBG1physical
21135143
PCNT_HUMANPCNTphysical
20466722
AKAP9_HUMANAKAP9physical
20466722
TSNAX_HUMANTSNAXphysical
21988832
TRI37_HUMANTRIM37physical
21988832
PHS_HUMANPCBD1physical
21988832
MARE1_HUMANMAPRE1physical
21988832
FBX25_HUMANFBXO25physical
21988832
CE152_HUMANCEP152physical
24613305
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
604804Microcephaly 3, primary, autosomal recessive (MCPH3)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CK5P2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1238, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1238; SER-1887 ANDSER-1893, AND MASS SPECTROMETRY.
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1102 AND SER-1483, ANDMASS SPECTROMETRY.
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-461; SER-466 ANDSER-468, AND MASS SPECTROMETRY.
"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-815; SER-1074 ANDSER-1238, AND MASS SPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1238; SER-1548 ANDSER-1556, AND MASS SPECTROMETRY.

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