dbPTM

FBX25_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FBX25_HUMAN
UniProt AC	Q8TCJ0
Protein Name	F-box only protein 25
Gene Name	FBXO25
Organism	Homo sapiens (Human).
Sequence Length	367
Subcellular Localization	Nucleus . In the nucleus, associates with a subnuclear dot-like structure. Colocalized with SKP1.
Protein Description	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity)..
Protein Sequence	MPFLGQDWRSPGWSWIKTEDGWKRCESCSQKLERENNRCNISHSIILNSEDGEIFNNEEHEYASKKRKKDHFRNDTNTQSFYREKWIYVHKESTKERHGYCTLGEAFNRLDFSSAIQDIRRFNYVVKLLQLIAKSQLTSLSGVAQKNYFNILDKIVQKVLDDHHNPRLIKDLLQDLSSTLCILIRGVGKSVLVGNINIWICRLETILAWQQQLQDLQMTKQVNNGLTLSDLPLHMLNNILYRFSDGWDIITLGQVTPTLYMLSEDRQLWKKLCQYHFAEKQFCRHLILSEKGHIEWKLMYFALQKHYPAKEQYGDTLHFCRHCSILFWKDYHLALLFKDSGHPCTAADPDSCFTPVSPQHFIDLFKF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Ubiquitination	SPGWSWIKTEDGWKR CCCCCEEECCCCHHH	39.33	-
20 (in isoform 3)	Phosphorylation	-	73.76	-
31	Ubiquitination	RCESCSQKLERENNR HCHHHHHHHHHHCCC	35.70	-
65	Ubiquitination	EEHEYASKKRKKDHF HHHHHHHHHHCCCCC	48.72	-
66	Ubiquitination	EHEYASKKRKKDHFR HHHHHHHHHCCCCCC	67.94	-
69	Ubiquitination	YASKKRKKDHFRNDT HHHHHHCCCCCCCCC	61.54	-
79 (in isoform 3)	Ubiquitination	-	33.34	21890473
85	Ubiquitination	TQSFYREKWIYVHKE CHHHHHHEEEEEEEC	29.87	-
124	Phosphorylation	QDIRRFNYVVKLLQL HHHHHHHHHHHHHHH	12.15	-
134	Ubiquitination	KLLQLIAKSQLTSLS HHHHHHHHHHCCCCC	31.57	-
135	Phosphorylation	LLQLIAKSQLTSLSG HHHHHHHHHCCCCCH	22.77	29052541
138	Phosphorylation	LIAKSQLTSLSGVAQ HHHHHHCCCCCHHHH	21.71	29052541
139	Phosphorylation	IAKSQLTSLSGVAQK HHHHHCCCCCHHHHH	29.18	29052541
141	Phosphorylation	KSQLTSLSGVAQKNY HHHCCCCCHHHHHHH	30.87	29052541
146 (in isoform 1)	Ubiquitination	-	43.83	21890473
146 (in isoform 2)	Ubiquitination	-	43.83	21890473
146	Ubiquitination	SLSGVAQKNYFNILD CCCHHHHHHHHHHHH	43.83	21890473
148	Phosphorylation	SGVAQKNYFNILDKI CHHHHHHHHHHHHHH	12.68	-
154	Ubiquitination	NYFNILDKIVQKVLD HHHHHHHHHHHHHHC	41.13	-
158	Ubiquitination	ILDKIVQKVLDDHHN HHHHHHHHHHCCCCC	33.59	-
178	Phosphorylation	DLLQDLSSTLCILIR HHHHHHHHHHHHHHH	32.47	-
227	Phosphorylation	KQVNNGLTLSDLPLH HHCCCCCCHHHCCHH	26.14	27174698
229	Phosphorylation	VNNGLTLSDLPLHML CCCCCCHHHCCHHHH	31.69	27174698
241	Phosphorylation	HMLNNILYRFSDGWD HHHHHHHHHCCCCCE	13.05	27174698
263	Phosphorylation	TPTLYMLSEDRQLWK CCCEEEHHHCHHHHH	22.41	26074081
271	Ubiquitination	EDRQLWKKLCQYHFA HCHHHHHHHHHHHHH	42.80	-
275	Phosphorylation	LWKKLCQYHFAEKQF HHHHHHHHHHHHHHH	9.63	26074081
280	Ubiquitination	CQYHFAEKQFCRHLI HHHHHHHHHHHHHHH	45.29	-
289	Phosphorylation	FCRHLILSEKGHIEW HHHHHHHCCCCCHHH	30.21	24719451
300	Phosphorylation	HIEWKLMYFALQKHY CHHHHHHHHHHHHHC	8.99	22817900
310	Ubiquitination	LQKHYPAKEQYGDTL HHHHCCHHHHHCCHH	40.63	-
351	Phosphorylation	CTAADPDSCFTPVSP CCCCCCCCCCCCCCH	19.27	-
354	Phosphorylation	ADPDSCFTPVSPQHF CCCCCCCCCCCHHHH	27.40	-
366	Ubiquitination	QHFIDLFKF------ HHHHHHCCC------	58.42	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
178	S	Phosphorylation	Kinase	PKCD	Q05655	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FBX25_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FBX25_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTB_HUMAN	ACTB	physical	20473970
GTD2A_HUMAN	GTF2IRD2	physical	20473970
CUL1_HUMAN	CUL1	physical	20473970
SKP1_HUMAN	SKP1	physical	20473970
CAND1_HUMAN	CAND1	physical	20473970
MYO1C_HUMAN	MYO1C	physical	20473970
PSD11_HUMAN	PSMD11	physical	20473970
ANM5_HUMAN	PRMT5	physical	20473970
MYH11_HUMAN	MYH11	physical	20473970
ML12B_HUMAN	MYL12B	physical	20473970
MYPT1_HUMAN	PPP1R12A	physical	20473970
XPO1_HUMAN	XPO1	physical	20473970
PSMD3_HUMAN	PSMD3	physical	20473970
MYO1B_HUMAN	MYO1B	physical	20473970
MYO1D_HUMAN	MYO1D	physical	20473970
TBB4A_HUMAN	TUBB4A	physical	20473970
RPN1_HUMAN	RPN1	physical	20473970
RPN2_HUMAN	RPN2	physical	20473970
AT1A1_HUMAN	ATP1A1	physical	20473970
GELS_HUMAN	GSN	physical	20473970
ATPB_HUMAN	ATP5B	physical	20473970
ENOA_HUMAN	ENO1	physical	20473970
NPM_HUMAN	NPM1	physical	20473970
GRP78_HUMAN	HSPA5	physical	20473970
HSP7C_HUMAN	HSPA8	physical	20473970
IMDH2_HUMAN	IMPDH2	physical	20473970
GFAP_HUMAN	GFAP	physical	20473970
SYDC_HUMAN	DARS	physical	20473970
AT2A2_HUMAN	ATP2A2	physical	20473970
PRS6A_HUMAN	PSMC3	physical	20473970
TCPA_HUMAN	TCP1	physical	20473970
MYL9_HUMAN	MYL9	physical	20473970
MCM3_HUMAN	MCM3	physical	20473970
ATPA_HUMAN	ATP5A1	physical	20473970
PYR1_HUMAN	CAD	physical	20473970
RL12_HUMAN	RPL12	physical	20473970
DNJA1_HUMAN	DNAJA1	physical	20473970
MCM7_HUMAN	MCM7	physical	20473970
GRP75_HUMAN	HSPA9	physical	20473970
IQGA1_HUMAN	IQGAP1	physical	20473970
TCPE_HUMAN	CCT5	physical	20473970
AT1A2_HUMAN	ATP1A2	physical	20473970
HNRPF_HUMAN	HNRNPF	physical	20473970
MSH6_HUMAN	MSH6	physical	20473970
HSP72_HUMAN	HSPA2	physical	20473970
PSMD4_HUMAN	PSMD4	physical	20473970
XPO2_HUMAN	CSE1L	physical	20473970
NP1L1_HUMAN	NAP1L1	physical	20473970
PSA_HUMAN	NPEPPS	physical	20473970
SYMC_HUMAN	MARS	physical	20473970
PRS4_HUMAN	PSMC1	physical	20473970
PRS8_HUMAN	PSMC5	physical	20473970
RS27A_HUMAN	RPS27A	physical	20473970
TBA4A_HUMAN	TUBA4A	physical	20473970
TBB4B_HUMAN	TUBB4B	physical	20473970
IGBP1_HUMAN	IGBP1	physical	20473970
PFKAP_HUMAN	PFKP	physical	20473970
EF1A2_HUMAN	EEF1A2	physical	20473970
FLII_HUMAN	FLII	physical	20473970
PSMD2_HUMAN	PSMD2	physical	20473970
TBB3_HUMAN	TUBB3	physical	20473970
MYO1A_HUMAN	MYO1A	physical	20473970
TBB2A_HUMAN	TUBB2A	physical	20473970
PSMD6_HUMAN	PSMD6	physical	20473970
PCH2_HUMAN	TRIP13	physical	20473970
FBX32_HUMAN	FBXO32	physical	20473970
TCPH_HUMAN	CCT7	physical	20473970
ACTBL_HUMAN	ACTBL2	physical	20473970
DNJC7_HUMAN	DNAJC7	physical	20473970
TMOD3_HUMAN	TMOD3	physical	20473970
SH3K1_HUMAN	SH3KBP1	physical	20473970
MPRIP_HUMAN	MPRIP	physical	20473970
CYTSA_HUMAN	SPECC1L	physical	20473970
SMC3_HUMAN	SMC3	physical	20473970
TTC9C_HUMAN	TTC9C	physical	20473970
ACTG_HUMAN	ACTG1	physical	20473970
PAWR_HUMAN	PAWR	physical	20473970
ATD3B_HUMAN	ATAD3B	physical	20473970
UACA_HUMAN	UACA	physical	20473970
TBB1_HUMAN	TUBB1	physical	20473970
ATD3A_HUMAN	ATAD3A	physical	20473970
RAI14_HUMAN	RAI14	physical	20473970
MYO5A_HUMAN	MYO5A	physical	20473970
BAG5_HUMAN	BAG5	physical	20473970
MYO6_HUMAN	MYO6	physical	20473970
MYH9_HUMAN	MYH9	physical	20473970
MYH10_HUMAN	MYH10	physical	20473970
MYH14_HUMAN	MYH14	physical	20473970
UN45A_HUMAN	UNC45A	physical	20473970
XPOT_HUMAN	XPOT	physical	20473970
IPO7_HUMAN	IPO7	physical	20473970
LPPRC_HUMAN	LRPPRC	physical	20473970
SERA_HUMAN	PHGDH	physical	20473970
ALBU_HUMAN	ALB	physical	20473970
VIME_HUMAN	VIM	physical	20473970
C1TC_HUMAN	MTHFD1	physical	20473970
EF2_HUMAN	EEF2	physical	20473970
COF1_HUMAN	CFL1	physical	20473970
TCPZ_HUMAN	CCT6A	physical	20473970
TCPQ_HUMAN	CCT8	physical	20473970
TCPD_HUMAN	CCT4	physical	20473970
COPA_HUMAN	COPA	physical	20473970
RS8_HUMAN	RPS8	physical	20473970
DREB_HUMAN	DBN1	physical	20473970
H2B2E_HUMAN	HIST2H2BE	physical	20473970
NUCL_HUMAN	NCL	physical	20473970
TBA1C_HUMAN	TUBA1C	physical	20473970
BORC5_HUMAN	LOH12CR1	physical	20473970
RUVB2_HUMAN	RUVBL2	physical	20473970
RUVB1_HUMAN	RUVBL1	physical	20473970
SKP1_HUMAN	SKP1	physical	16278047
CUL1_HUMAN	CUL1	physical	16278047
CUL1_HUMAN	CUL1	physical	16714087
SKP1_HUMAN	SKP1	physical	16714087
RBX1_HUMAN	RBX1	physical	16714087
ELK1_HUMAN	ELK1	physical	23940030
PADI4_HUMAN	PADI4	physical	23940030
HIP1_HUMAN	HIP1	physical	23940030
TMA7_HUMAN	TMA7	physical	23940030
KPCA_HUMAN	PRKCA	physical	23940030
TF2B_HUMAN	GTF2B	physical	23940030
DDX42_HUMAN	DDX42	physical	23940030
EID3_HUMAN	EID3	physical	23940030
ODFP2_HUMAN	ODF2	physical	23940030
SAMH1_HUMAN	SAMHD1	physical	23940030
RS10_HUMAN	RPS10	physical	23940030
TEANC_HUMAN	TCEANC	physical	23940030
TNIP2_HUMAN	TNIP2	physical	23940030
ARBK1_HUMAN	ADRBK1	physical	23940030
STAC_HUMAN	STAC	physical	23940030
PGFRA_HUMAN	PDGFRA	physical	23940030
EPN1_HUMAN	EPN1	physical	23940030
NUAK1_HUMAN	NUAK1	physical	23940030
PI42C_HUMAN	PIP4K2C	physical	23940030
RIOK3_HUMAN	RIOK3	physical	23940030
LUC7L_HUMAN	LUC7L	physical	23940030
CG050_HUMAN	C7orf50	physical	23940030
RPAP3_HUMAN	RPAP3	physical	23940030
RHBL4_HUMAN	RHBDD1	physical	23940030
VGFR2_HUMAN	KDR	physical	23940030
AN13A_HUMAN	ANKRD13A	physical	23940030
HP1B3_HUMAN	HP1BP3	physical	23940030
TCAL2_HUMAN	TCEAL2	physical	23940030
WSDU1_HUMAN	WDSUB1	physical	23940030
TCP1L_HUMAN	TCP10L	physical	23940030
CU077_HUMAN	TCP10L	physical	23940030
PAK4_HUMAN	PAK4	physical	23940030
CF106_HUMAN	C6orf106	physical	23940030
PSMD4_HUMAN	PSMD4	physical	23940030
SYTL2_HUMAN	SYTL2	physical	23940030
DCX_HUMAN	DCX	physical	23940030
TWF1_HUMAN	TWF1	physical	23940030
BMX_HUMAN	BMX	physical	23940030
IRS1_HUMAN	IRS1	physical	23940030
FKBP3_HUMAN	FKBP3	physical	23940030
DNJB2_HUMAN	DNAJB2	physical	23940030
PP1R8_HUMAN	PPP1R8	physical	23940030
KS6B2_HUMAN	RPS6KB2	physical	23940030
IL21_HUMAN	IL21	physical	23940030
CK063_HUMAN	C11orf63	physical	23940030
PAIRB_HUMAN	SERBP1	physical	23940030
G3BP1_HUMAN	G3BP1	physical	23940030
CDK9_HUMAN	CDK9	physical	23940030
TMG1_HUMAN	PRRG1	physical	23940030
LMCD1_HUMAN	LMCD1	physical	23940030
ING3_HUMAN	ING3	physical	23940030
K2C8_HUMAN	KRT8	physical	23940030
DYRK4_HUMAN	DYRK4	physical	23940030
CS057_HUMAN	C19orf57	physical	23940030
PRR15_HUMAN	PRR15	physical	23940030
RBM8A_HUMAN	RBM8A	physical	23940030
CENPB_HUMAN	CENPB	physical	23940030
KGP2_HUMAN	PRKG2	physical	23940030
MAT2B_HUMAN	MAT2B	physical	23940030
UBQL1_HUMAN	UBQLN1	physical	23940030
NSRP1_HUMAN	NSRP1	physical	23940030
HMCES_HUMAN	HMCES	physical	23940030
DYRK3_HUMAN	DYRK3	physical	23940030
TRUB1_HUMAN	TRUB1	physical	23940030
PPID_HUMAN	PPID	physical	23940030
IF4E2_HUMAN	EIF4E2	physical	23940030
APLF_HUMAN	APLF	physical	23940030
UBQL2_HUMAN	UBQLN2	physical	23940030
DNJC8_HUMAN	DNAJC8	physical	23940030
EGFR_HUMAN	EGFR	physical	23940030
PCKGC_HUMAN	PCK1	physical	23940030
DPTOR_HUMAN	DEPTOR	physical	23940030
UFO_HUMAN	AXL	physical	23940030
RABE2_HUMAN	RABEP2	physical	23940030
ORC4_HUMAN	ORC4	physical	21988832
NKX25_HUMAN	NKX2-5	physical	25725482
TBX5_HUMAN	TBX5	physical	25725482
UB2E3_HUMAN	UBE2E3	physical	26186194
RHG01_HUMAN	ARHGAP1	physical	26186194
PNPO_HUMAN	PNPO	physical	26186194
PNPO_HUMAN	PNPO	physical	28514442
RHG01_HUMAN	ARHGAP1	physical	28514442
UB2E3_HUMAN	UBE2E3	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FBX25_HUMAN

Related Literatures of Post-Translational Modification