IL21_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IL21_HUMAN
• UniProt AC: Q9HBE4
• Protein Name: Interleukin-21
• Gene Name: IL21
• Organism: Homo sapiens (Human).
• Sequence Length: 155
• Subcellular Localization: Secreted .
• Protein Description: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation..
• Protein Sequence: MERIVICLMVIFLGTLVHKSSSQGQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	N-linked_Glycosylation	GNNERIINVSIKKLK CCCCEEEEEEHHHHH	21.07	UniProtKB CARBOHYD
97	N-linked_Glycosylation	NVSIKKLKRKPPSTN EEEHHHHHCCCCCCC	68.22	-
102	Phosphorylation	KLKRKPPSTNAGRRQ HHHCCCCCCCCCCCH	42.70	-
103	Phosphorylation	LKRKPPSTNAGRRQK HHCCCCCCCCCCCHH	34.56	-
117	Phosphorylation	KHRLTCPSCDSYEKK HCCCCCCCCCCCCCC	32.47	30631047

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IL21_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IL21_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IL21_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DGKA_HUMAN	DGKA	physical	25241761
AL1A1_HUMAN	ALDH1A1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.