MYO1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYO1A_HUMAN
• UniProt AC: Q9UBC5
• Protein Name: Unconventional myosin-Ia
• Gene Name: MYO1A
• Organism: Homo sapiens (Human).
• Sequence Length: 1043
• Protein Description: Involved in directing the movement of organelles along actin filaments..
• Protein Sequence: MPLLEGSVGVEDLVLLEPLVEESLLKNLQLRYENKEIYTYIGNVVISVNPYQQLPIYGPEFIAKYQDYTFYELKPHIYALANVAYQSLRDRDRDQCILITGESGSGKTEASKLVMSYVAAVCGKGEQVNSVKEQLLQSNPVLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRLVKQLKGERNFHIFYQLLAGADEQLLKALKLERDTTGYAYLNHEVSRVDGMDDASSFRAVQSAMAVIGFSEEEIRQVLEVTSMVLKLGNVLVADEFQASGIPASGIRDGRGVREIGEMVGLNSEEVERALCSRTMETAKEKVVTALNVMQAQYARDALAKNIYSRLFDWIVNRINESIKVGIGEKKKVMGVLDIYGFEILEDNSFEQFVINYCNEKLQQVFIEMTLKEEQEEYKREGIPWTKVDYFDNGIICKLIEHNQRGILAMLDEECLRPGVVSDSTFLAKLNQLFSKHGHYESKVTQNAQRQYDHTMGLSCFRICHYAGKVTYNVTSFIDKNNDLLFRDLLQAMWKAQHPLLRSLFPEGNPKQASLKRPPTAGAQFKSSVAILMKNLYSKSPNYIRCIKPNEHQQRGQFSSDLVATQARYLGLLENVRVRRAGYAHRQGYGPFLERYRLLSRSTWPHWNGGDREGVEKVLGELSMSSGELAFGKTKIFIRSPKTLFYLEEQRRLRLQQLATLIQKIYRGWRCRTHYQLMRKSQILISSWFRGNMQKKCYGKIKASVLLIQAFVRGWKARKNYRKYFRSEAALTLADFIYKSMVQKFLLGLKNNLPSTNVLDKTWPAAPYKCLSTANQELQQLFYQWKCKRFRDQLSPKQVEILREKLCASELFKGKKASYPQSVPIPFCGDYIGLQGNPKLQKLKGGEEGPVLMAEAVKKVNRGNGKTSSRILLLTKGHVILTDTKKSQAKIVIGLDNVAGVSVTSLKDGLFSLHLSEMSSVGSKGDFLLVSEHVIELLTKMYRAVLDATQRQLTVTVTEKFSVRFKENSVAVKVVQGPAGGDNSKLRYKKKGSHCLEVTVQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	LEPLVEESLLKNLQL HHHHHHHHHHHHCCC	26.04	24719451
65	Phosphorylation	GPEFIAKYQDYTFYE CHHHHHHCCCCEEEE	9.52	21406692
68	Phosphorylation	FIAKYQDYTFYELKP HHHHCCCCEEEECCC	5.34	21406692
69	Phosphorylation	IAKYQDYTFYELKPH HHHCCCCEEEECCCH	28.20	21406692
71	Phosphorylation	KYQDYTFYELKPHIY HCCCCEEEECCCHHH	16.74	21406692
78	Phosphorylation	YELKPHIYALANVAY EECCCHHHHHHHHHH	7.79	22817900
85	Phosphorylation	YALANVAYQSLRDRD HHHHHHHHHHHHHCC	8.37	22817900
87	Phosphorylation	LANVAYQSLRDRDRD HHHHHHHHHHHCCCC	16.82	24719451
100	Phosphorylation	RDQCILITGESGSGK CCCEEEEECCCCCCH	31.30	-
105	Phosphorylation	LITGESGSGKTEASK EEECCCCCCHHHHHH	46.53	-
108	Phosphorylation	GESGSGKTEASKLVM CCCCCCHHHHHHHHH	40.07	-
116	Phosphorylation	EASKLVMSYVAAVCG HHHHHHHHHHHHHHC	14.69	25072903
117	Phosphorylation	ASKLVMSYVAAVCGK HHHHHHHHHHHHHCC	3.97	25072903
138	Phosphorylation	VKEQLLQSNPVLEAF HHHHHHHCCHHHHHH	42.97	-
179	Phosphorylation	SPLGGVITNYLLEKS CCCHHHHHHHHHHHH	18.53	25348772
181	Phosphorylation	LGGVITNYLLEKSRL CHHHHHHHHHHHHHH	12.19	25348772
185	Ubiquitination	ITNYLLEKSRLVKQL HHHHHHHHHHHHHHH	40.62	-
249	Phosphorylation	SSFRAVQSAMAVIGF HHHHHHHHHHHHHCC	17.26	-
286	Phosphorylation	VADEFQASGIPASGI EECCHHHCCCCCCCC	26.86	26356563
291	Phosphorylation	QASGIPASGIRDGRG HHCCCCCCCCCCCCC	29.42	26356563
310	Phosphorylation	GEMVGLNSEEVERAL HHHCCCCHHHHHHHH	39.93	27135362
321	Phosphorylation	ERALCSRTMETAKEK HHHHHHCCHHHHHHH	11.76	27135362
324	Phosphorylation	LCSRTMETAKEKVVT HHHCCHHHHHHHHHH	32.01	27135362
351	Phosphorylation	ALAKNIYSRLFDWIV HHHHHHHHHHHHHHH	20.79	24719451
382	Phosphorylation	VMGVLDIYGFEILED EEEEEEEECEEECCC	18.54	-
399	Phosphorylation	FEQFVINYCNEKLQQ HHHHHHHHHCHHHHH	5.87	-
432	Phosphorylation	IPWTKVDYFDNGIIC CCCCCCEECCCCCHH	18.80	22817900
477	Phosphorylation	AKLNQLFSKHGHYES HHHHHHHHHCCCCHH	32.13	24719451
611	Phosphorylation	LVATQARYLGLLENV HHHHHHHHHHHHHHH	14.24	28152594
631	Phosphorylation	GYAHRQGYGPFLERY CCCHHCCCCHHHHHH	17.18	-
659	Ubiquitination	GDREGVEKVLGELSM CCHHHHHHHHHHHHC	40.11	-
659	Methylation	GDREGVEKVLGELSM CCHHHHHHHHHHHHC	40.11	-
659	Acetylation	GDREGVEKVLGELSM CCHHHHHHHHHHHHC	40.11	19413330
668	Phosphorylation	LGELSMSSGELAFGK HHHHHCCCCEECCCC	27.87	19413330
766	Phosphorylation	ARKNYRKYFRSEAAL HHHHHHHHHHHHHHH	8.67	25954137
774	Phosphorylation	FRSEAALTLADFIYK HHHHHHHHHHHHHHH	18.38	25954137
780	Phosphorylation	LTLADFIYKSMVQKF HHHHHHHHHHHHHHH	9.30	25954137
837	Phosphorylation	KRFRDQLSPKQVEIL HHHHHCCCHHHHHHH	25.15	22210691
996	Phosphorylation	DATQRQLTVTVTEKF HHHCCCEEEEEEEEE	13.04	-
1004	Phosphorylation	VTVTEKFSVRFKENS EEEEEEEEEEECCCE	24.37	-
1011	Phosphorylation	SVRFKENSVAVKVVQ EEEECCCEEEEEEEE	16.73	23312004
1035	Phosphorylation	LRYKKKGSHCLEVTV EEEEECCCCCEEEEE	21.65	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYO1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYO1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYO1A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MYO1A_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 607841: Deafness, autosomal dominant, 48 (DFNA48)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.