LMCD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LMCD1_HUMAN
• UniProt AC: Q9NZU5
• Protein Name: LIM and cysteine-rich domains protein 1
• Gene Name: LMCD1
• Organism: Homo sapiens (Human).
• Sequence Length: 365
• Subcellular Localization: Cytoplasm. Nucleus. May shuttle between the cytoplasm and the nucleus..
• Protein Description: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway..
• Protein Sequence: MAKVAKDLNPGVKKMSLGQLQSARGVACLGCKGTCSGFEPHSWRKICKSCKCSQEDHCLTSDLEDDRKIGRLLMDSKYSTLTARVKGGDGIRIYKRNRMIMTNPIATGKDPTFDTITYEWAPPGVTQKLGLQYMELIPKEKQPVTGTEGAFYRRRQLMHQLPIYDQDPSRCRGLLENELKLMEEFVKQYKSEALGVGEVALPGQGGLPKEEGKQQEKPEGAETTAATTNGSLSDPSKEVEYVCELCKGAAPPDSPVVYSDRAGYNKQWHPTCFVCAKCSEPLVDLIYFWKDGAPWCGRHYCESLRPRCSGCDEIIFAEDYQRVEDLAWHRKHFVCEGCEQLLSGRAYIVTKGQLLCPTCSKSKRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	NPGVKKMSLGQLQSA CCCCCCCCHHHHHHC	37.92	22617229
22	Phosphorylation	MSLGQLQSARGVACL CCHHHHHHCCCEEEE	28.64	28857561
42	Phosphorylation	CSGFEPHSWRKICKS CCCCCCCCHHHHHHH	39.01	26437602
60	Phosphorylation	SQEDHCLTSDLEDDR CCCCCCCCCCCCCHH	26.11	-
76	Phosphorylation	IGRLLMDSKYSTLTA HHHHHHCCCCCEEEE	21.37	23663014
78	Phosphorylation	RLLMDSKYSTLTARV HHHHCCCCCEEEEEE	15.73	23663014
79	Phosphorylation	LLMDSKYSTLTARVK HHHCCCCCEEEEEEE	22.22	23663014
80	Phosphorylation	LMDSKYSTLTARVKG HHCCCCCEEEEEEEC	25.66	23663014
82	Phosphorylation	DSKYSTLTARVKGGD CCCCCEEEEEEECCC	16.71	23663014
112	Phosphorylation	IATGKDPTFDTITYE CCCCCCCCCCEEEEE	44.25	29759185
115	Phosphorylation	GKDPTFDTITYEWAP CCCCCCCEEEEECCC	15.84	29759185
117	Phosphorylation	DPTFDTITYEWAPPG CCCCCEEEEECCCCC	19.92	29759185
126	Phosphorylation	EWAPPGVTQKLGLQY ECCCCCHHHHHCHHH	26.38	-
133	Phosphorylation	TQKLGLQYMELIPKE HHHHCHHHHCCCCCC	9.52	27642862
134	Sulfoxidation	QKLGLQYMELIPKEK HHHCHHHHCCCCCCC	1.87	30846556
145	Phosphorylation	PKEKQPVTGTEGAFY CCCCCCCCCCCCHHH	45.10	-
147	Phosphorylation	EKQPVTGTEGAFYRR CCCCCCCCCCHHHHH	23.14	-
152	Phosphorylation	TGTEGAFYRRRQLMH CCCCCHHHHHHHHHH	11.59	-
158	Sulfoxidation	FYRRRQLMHQLPIYD HHHHHHHHHHCCCCC	1.11	30846556
180	Acetylation	GLLENELKLMEEFVK HHHHHHHHHHHHHHH	39.34	7482767
189	Phosphorylation	MEEFVKQYKSEALGV HHHHHHHHHHHHHCC	15.68	26270265
223	Phosphorylation	EKPEGAETTAATTNG CCCCCCCCCEEECCC	22.62	29759185
224	Phosphorylation	KPEGAETTAATTNGS CCCCCCCCEEECCCC	13.05	29759185
227	Phosphorylation	GAETTAATTNGSLSD CCCCCEEECCCCCCC	20.52	28348404
228	Phosphorylation	AETTAATTNGSLSDP CCCCEEECCCCCCCC	32.62	26657352
231	Phosphorylation	TAATTNGSLSDPSKE CEEECCCCCCCCCHH	27.11	29759185
233	Phosphorylation	ATTNGSLSDPSKEVE EECCCCCCCCCHHHH	49.53	29759185
236	Phosphorylation	NGSLSDPSKEVEYVC CCCCCCCCHHHHHHH	46.57	29759185
254	Phosphorylation	KGAAPPDSPVVYSDR CCCCCCCCCEEEECC	25.93	26657352
259	Phosphorylation	PDSPVVYSDRAGYNK CCCCEEEECCCCCCC	14.71	22673903
303	Phosphorylation	CGRHYCESLRPRCSG CCHHHHHHHCCCCCC	26.56	24719451
320	Phosphorylation	EIIFAEDYQRVEDLA EEEEECCHHHHHHHH	6.96	-
358	Phosphorylation	KGQLLCPTCSKSKRS CCEEECCCCCCCCCC	28.54	26437602
360	Phosphorylation	QLLCPTCSKSKRS-- EEECCCCCCCCCC--	42.30	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LMCD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LMCD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LMCD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.