GTD2A_HUMAN - dbPTM
GTD2A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GTD2A_HUMAN
UniProt AC Q86UP8
Protein Name General transcription factor II-I repeat domain-containing protein 2A
Gene Name GTF2IRD2
Organism Homo sapiens (Human).
Sequence Length 949
Subcellular Localization Nucleus.
Protein Description
Protein Sequence MAQVAVSTLPVEEESSSETRMVVTFLVSALESMCKELAKSKAEVACIAVYETDVFVVGTERGCAFVNARTDFQKDFAKYCVAEGLCEVKPPCPVNGMQVHSGETEILRKAVEDYFCFCYGKALGTTVMVPVPYEKMLRDQSAVVVQGLPEGVAFQHPENYDLATLKWILENKAGISFIINRPFLGPESQLGGPGMVTDAERSIVSPSESCGPINVKTEPMEDSGISLKAEAVSVKKESEDPNYYQYNMQGSHPSSTSNEVIEMELPMEDSTPLVPSEEPNEDPEAEVKIEGNTNSSSVTNSAAGVEDLNIVQVTVPDNEKERLSSIEKIKQLREQVNDLFSRKFGEAIGVDFPVKVPYRKITFNPGCVVIDGMPPGVVFKAPGYLEISSMRRILEAAEFIKFTVIRPLPGLELSNVGKRKIDQEGRVFQEKWERAYFFVEVQNIPTCLICKQSMSVSKEYNLRRHYQTNHSKHYDQYMERMRDEKLHELKKGLRKYLLGLSDTECPEQKQVFAHPSPTQKSPVQPVEDLAGNLWEKLREKIRSFVAYSIAIDEITDINNTTQLAIFIRGVDENFDVSEELLDTVPMTGTKSGNEIFSRVEKSLKKFCIDWSKLVSVASTGTPAMVDANNGLVTKLKSRVATFCKGAELKSICCIIHPESLCAQKLKMDHVMDVVVKSVNWICSRGLNHSEFTTLLYELDSQYGSLLYYTEIKWLSRGLVLKRFFESLEEIDSFMSSRGKPLPQLSSIDWIRDLAFLVDMTMHLNALNISLQGHSQIVTQMYDLIRAFLAKLCLWETHLTRNNLAHFPTLKLASRNESDGLNYIPKIAELKTEFQKRLSDFKLYESELTLFSSPFSTKIDSVHEELQMEVIDLQCNTVLKTKYDKVGIPEFYKYLWGSYPKYKHHCAKILSMFGSTYICEQLFSIMKLSKTKYCSQLKDSQWDSVLHIAT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
74UbiquitinationNARTDFQKDFAKYCV
CCCCHHHHHHHHHHH		55.60-
98UbiquitinationPCPVNGMQVHSGETE
CCCCCCEEECCCCHH		31.0429967540
104PhosphorylationMQVHSGETEILRKAV
EEECCCCHHHHHHHH		31.6720860994
106UbiquitinationVHSGETEILRKAVED
ECCCCHHHHHHHHHH		6.1829967540
135UbiquitinationMVPVPYEKMLRDQSA
EEECCHHHHCCCCCE		37.0722817900
141PhosphorylationEKMLRDQSAVVVQGL
HHHCCCCCEEEECCC		27.5925850435
166UbiquitinationNYDLATLKWILENKA
CCCHHHHHHHHHCCC		28.0332015554
172SumoylationLKWILENKAGISFII
HHHHHHCCCCEEEEE		38.32-
205PhosphorylationDAERSIVSPSESCGP
CCHHCCCCCCCCCCC		22.4928348404
207PhosphorylationERSIVSPSESCGPIN
HHCCCCCCCCCCCCC		34.3428348404
209PhosphorylationSIVSPSESCGPINVK
CCCCCCCCCCCCCCC		28.8127251275
217PhosphorylationCGPINVKTEPMEDSG
CCCCCCCCCCCCCCC		40.83-
324PhosphorylationDNEKERLSSIEKIKQ
CCHHHHHHHHHHHHH		35.1828152594
325PhosphorylationNEKERLSSIEKIKQL
CHHHHHHHHHHHHHH		39.0828152594
328UbiquitinationERLSSIEKIKQLREQ
HHHHHHHHHHHHHHH		54.2432015554
341PhosphorylationEQVNDLFSRKFGEAI
HHHHHHHHHHHHHHH		41.6920068231
343UbiquitinationVNDLFSRKFGEAIGV
HHHHHHHHHHHHHCC		57.4322817900
358PhosphorylationDFPVKVPYRKITFNP
CCCEECCCCEEEECC		27.76-
414PhosphorylationPLPGLELSNVGKRKI
CCCCCCCCCCCCCEE		21.79-
420UbiquitinationLSNVGKRKIDQEGRV
CCCCCCCEECCCCCC		54.8732142685
468PhosphorylationNLRRHYQTNHSKHYD
HHHHHHHCCCHHHHH		27.9427251275
471PhosphorylationRHYQTNHSKHYDQYM
HHHHCCCHHHHHHHH		24.1727251275
474PhosphorylationQTNHSKHYDQYMERM
HCCCHHHHHHHHHHH		14.4227251275
477PhosphorylationHSKHYDQYMERMRDE
CHHHHHHHHHHHHHH		9.6927251275
521PhosphorylationHPSPTQKSPVQPVED
CCCCCCCCCCCCHHH		22.0827251275
582UbiquitinationDVSEELLDTVPMTGT
CCCHHHHHCCCCCCC		59.2832142685
611PhosphorylationKKFCIDWSKLVSVAS
HHHCCCHHHHCHHHC		16.6228270605
615PhosphorylationIDWSKLVSVASTGTP
CCHHHHCHHHCCCCC		23.5428270605
618PhosphorylationSKLVSVASTGTPAMV
HHHCHHHCCCCCCEE		25.8028270605
619PhosphorylationKLVSVASTGTPAMVD
HHCHHHCCCCCCEEE		35.0228270605
621PhosphorylationVSVASTGTPAMVDAN
CHHHCCCCCCEEECC		14.1528270605
633PhosphorylationDANNGLVTKLKSRVA
ECCCCHHHHHHHHHH		35.3828270605
732PhosphorylationESLEEIDSFMSSRGK
HCHHHHHHHHHCCCC		28.6322210691
897PhosphorylationFYKYLWGSYPKYKHH
HHHHHHCCCHHHHHH		27.0424719451
910PhosphorylationHHCAKILSMFGSTYI
HHHHHHHHHHCHHHH		18.6227732954
914PhosphorylationKILSMFGSTYICEQL
HHHHHHCHHHHHHHH		13.5327732954
915PhosphorylationILSMFGSTYICEQLF
HHHHHCHHHHHHHHH		19.7927732954
916PhosphorylationLSMFGSTYICEQLFS
HHHHCHHHHHHHHHH		12.7920860994
923PhosphorylationYICEQLFSIMKLSKT
HHHHHHHHHHHHHCC		30.3027732954
928PhosphorylationLFSIMKLSKTKYCSQ
HHHHHHHHCCCCHHH		32.5320860994
930PhosphorylationSIMKLSKTKYCSQLK
HHHHHHCCCCHHHCC		24.7020860994
932PhosphorylationMKLSKTKYCSQLKDS
HHHHCCCCHHHCCCC		11.54-
934PhosphorylationLSKTKYCSQLKDSQW
HHCCCCHHHCCCCCC		35.14-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GTD2A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GTD2A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GTD2A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of GTD2A_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GTD2A_HUMAN

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Related Literatures of Post-Translational Modification

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