dbPTM

IRS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IRS1_HUMAN
UniProt AC	P35568
Protein Name	Insulin receptor substrate 1
Gene Name	IRS1
Organism	Homo sapiens (Human).
Sequence Length	1242
Subcellular Localization
Protein Description	May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity)..
Protein Sequence	MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGHHDGAAALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPNGHYILSRGGNGHRCTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTITHQKTPSQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTRSYPEEGLEMHPLERRGGHHRPDSSTLHTDDGYMPMSPGVAPVPSGRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGTSYGKLWTNGVGGHHSHVLPHPKPPVESSGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPHLPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQPLLHPPEPKSPGEYVNIEFGSDQSGYLSGPVAFHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQESTGVEMGRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIAAEEVSLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLSPNRNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAVGGGGGSSSSSEDVKRHSSASFENVWLRPGELGGAPKEPAKLCGAAGGLENGLNYIDLDLVKDFKQCPQECTPEPQPPPPPPPHQPLGSGESSSTRRSSEDLSAYASISFQKQPEDRQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASPPESDGF -----CCCCCCCCCC	53.50	29255136
7	Phosphorylation	-MASPPESDGFSDVR -CCCCCCCCCCCCCH	49.13	21722762
11	Phosphorylation	PPESDGFSDVRKVGY CCCCCCCCCCHHCCE	40.50	21722762
24	Phosphorylation	GYLRKPKSMHKRFFV CEECCCCCHHHHHHH	34.35	22817900
36	Phosphorylation	FFVLRAASEAGGPAR HHHHHHHHHHCCCCC	27.31	26437602
46	Phosphorylation	GGPARLEYYENEKKW CCCCCCEEECCCCCC	22.22	28152594
47	Phosphorylation	GPARLEYYENEKKWR CCCCCEEECCCCCCC	11.69	28152594
52	Acetylation	EYYENEKKWRHKSSA EEECCCCCCCCCCCC	43.19	20167786
61	Acetylation	RHKSSAPKRSIPLES CCCCCCCCCCCCHHH	59.50	20167786
87	Phosphorylation	NKHLVALYTRDEHFA CCEEEEEEECCCCEE	7.04	20058876
88	Phosphorylation	KHLVALYTRDEHFAI CEEEEEEECCCCEEE	32.28	8349691
99	Phosphorylation	HFAIAADSEAEQDSW CEEEECCCHHHHCHH	33.70	8349691
135	Phosphorylation	GAGGGGGSCSGSSGL CCCCCCCCCCCCCCC	14.37	27642862
137	Phosphorylation	GGGGGSCSGSSGLGE CCCCCCCCCCCCCCC	43.33	27642862
139	Phosphorylation	GGGSCSGSSGLGEAG CCCCCCCCCCCCCCC	12.63	27642862
140	Phosphorylation	GGSCSGSSGLGEAGE CCCCCCCCCCCCCCC	41.38	27642862
151	Phosphorylation	EAGEDLSYGDVPPGP CCCCCCCCCCCCCCH	25.33	27642862
169	Ubiquitination	EVWQVILKPKGLGQT HHHHHHHCCCCCCCH	33.29	-
171	Ubiquitination	WQVILKPKGLGQTKN HHHHHCCCCCCCHHH	66.24	27667366
183	Phosphorylation	TKNLIGIYRLCLTSK HHHHHHHHHHHHCCC	7.72	-
189	Phosphorylation	IYRLCLTSKTISFVK HHHHHHCCCEEEEEE	18.17	28509920
193	Phosphorylation	CLTSKTISFVKLNSE HHCCCEEEEEECCHH	29.26	28509920
268	Phosphorylation	SDEFRPRSKSQSSSN CCCCCCCCCCCCCCC	39.06	23927012
270	Phosphorylation	EFRPRSKSQSSSNCS CCCCCCCCCCCCCCC	36.22	29255136
272	Phosphorylation	RPRSKSQSSSNCSNP CCCCCCCCCCCCCCC	42.71	29255136
273	Phosphorylation	PRSKSQSSSNCSNPI CCCCCCCCCCCCCCC	20.24	29255136
274	Phosphorylation	RSKSQSSSNCSNPIS CCCCCCCCCCCCCCC	47.29	29255136
277	Phosphorylation	SQSSSNCSNPISVPL CCCCCCCCCCCCCCC	50.30	23927012
281	Phosphorylation	SNCSNPISVPLRRHH CCCCCCCCCCCHHHH	20.95	23927012
295	Phosphorylation	HLNNPPPSQVGLTRR HCCCCCHHHCCCCCC	43.18	28555341
303	Phosphorylation	QVGLTRRSRTESITA HCCCCCCCCCCCEEE	40.02	22322096
305	Phosphorylation	GLTRRSRTESITATS CCCCCCCCCCEEECC	35.02	22322096
307	Phosphorylation	TRRSRTESITATSPA CCCCCCCCEEECCCH	25.32	27273156
309	Phosphorylation	RSRTESITATSPASM CCCCCCEEECCCHHH	32.91	22322096
311	Phosphorylation	RTESITATSPASMVG CCCCEEECCCHHHHC	26.96	22322096
312	Phosphorylation	TESITATSPASMVGG CCCEEECCCHHHHCC	18.92	27273156
315	Phosphorylation	ITATSPASMVGGKPG EEECCCHHHHCCCCC	19.86	22322096
323	Phosphorylation	MVGGKPGSFRVRASS HHCCCCCEEEEEECC	20.57	22322096
329	Phosphorylation	GSFRVRASSDGEGTM CEEEEEECCCCCCCC	20.56	27273156
330	Phosphorylation	SFRVRASSDGEGTMS EEEEEECCCCCCCCC	48.96	29255136
335	Phosphorylation	ASSDGEGTMSRPASV ECCCCCCCCCCCCCC	13.99	30278072
337	Phosphorylation	SDGEGTMSRPASVDG CCCCCCCCCCCCCCC	34.64	30278072
341	Phosphorylation	GTMSRPASVDGSPVS CCCCCCCCCCCCCCC	24.35	30266825
345	Phosphorylation	RPASVDGSPVSPSTN CCCCCCCCCCCCCCC	20.05	30266825
348	Phosphorylation	SVDGSPVSPSTNRTH CCCCCCCCCCCCCCC	19.27	30266825
350	Phosphorylation	DGSPVSPSTNRTHAH CCCCCCCCCCCCCCC	30.70	27273156
351	Phosphorylation	GSPVSPSTNRTHAHR CCCCCCCCCCCCCCC	31.91	19664994
354	Phosphorylation	VSPSTNRTHAHRHRG CCCCCCCCCCCCCCC	26.03	27282143
362	Phosphorylation	HAHRHRGSARLHPPL CCCCCCCCCCCCCCC	15.35	22817900
372	Phosphorylation	LHPPLNHSRSIPMPA CCCCCCCCCCCCCCC	27.01	23898821
373	Methylation	HPPLNHSRSIPMPAS CCCCCCCCCCCCCCH	30.93	54556885
374	Phosphorylation	PPLNHSRSIPMPASR CCCCCCCCCCCCCHH	33.77	30266825
380	Phosphorylation	RSIPMPASRCSPSAT CCCCCCCHHCCCCCC	28.13	27251789
383	Phosphorylation	PMPASRCSPSATSPV CCCCHHCCCCCCCCC	22.30	22777824
385	Phosphorylation	PASRCSPSATSPVSL CCHHCCCCCCCCCCC	28.08	30278072
387	Phosphorylation	SRCSPSATSPVSLSS HHCCCCCCCCCCCCC	37.59	27080861
388	Phosphorylation	RCSPSATSPVSLSSS HCCCCCCCCCCCCCC	24.03	25849741
391	Phosphorylation	PSATSPVSLSSSSTS CCCCCCCCCCCCCCC	26.39	21712546
393	Phosphorylation	ATSPVSLSSSSTSGH CCCCCCCCCCCCCCC	22.22	27080861
394	Phosphorylation	TSPVSLSSSSTSGHG CCCCCCCCCCCCCCC	33.33	27080861
395	Phosphorylation	SPVSLSSSSTSGHGS CCCCCCCCCCCCCCC	33.97	27080861
396	Phosphorylation	PVSLSSSSTSGHGST CCCCCCCCCCCCCCC	28.65	27251789
397	Phosphorylation	VSLSSSSTSGHGSTS CCCCCCCCCCCCCCC	40.45	27080861
398	Phosphorylation	SLSSSSTSGHGSTSD CCCCCCCCCCCCCCC	30.64	27080861
402	Phosphorylation	SSTSGHGSTSDCLFP CCCCCCCCCCCCCCC	21.04	27080861
403	Phosphorylation	STSGHGSTSDCLFPR CCCCCCCCCCCCCCC	32.93	27080861
404	Phosphorylation	TSGHGSTSDCLFPRR CCCCCCCCCCCCCCC	28.20	27080861
412	Phosphorylation	DCLFPRRSSASVSGS CCCCCCCCCCCCCCC	31.38	27422710
413	Phosphorylation	CLFPRRSSASVSGSP CCCCCCCCCCCCCCC	23.81	25849741
415	Phosphorylation	FPRRSSASVSGSPSD CCCCCCCCCCCCCCC	20.82	25849741
417	Phosphorylation	RRSSASVSGSPSDGG CCCCCCCCCCCCCCC	30.93	30576142
419	Phosphorylation	SSASVSGSPSDGGFI CCCCCCCCCCCCCCC	17.45	25849741
421	Phosphorylation	ASVSGSPSDGGFISS CCCCCCCCCCCCCCC	51.05	23927012
427	Phosphorylation	PSDGGFISSDEYGSS CCCCCCCCCCCCCCC	29.49	25849741
428	Phosphorylation	SDGGFISSDEYGSSP CCCCCCCCCCCCCCC	29.64	23927012
431	Phosphorylation	GFISSDEYGSSPCDF CCCCCCCCCCCCCCC	27.57	23927012
433	Phosphorylation	ISSDEYGSSPCDFRS CCCCCCCCCCCCCHH	30.15	23927012
434	Phosphorylation	SSDEYGSSPCDFRSS CCCCCCCCCCCCHHH	25.78	23927012
440	Phosphorylation	SSPCDFRSSFRSVTP CCCCCCHHHHHCCCH	33.55	30576142
441	Phosphorylation	SPCDFRSSFRSVTPD CCCCCHHHHHCCCHH	22.03	22817900
444	Phosphorylation	DFRSSFRSVTPDSLG CCHHHHHCCCHHHCC	28.47	29255136
446	Phosphorylation	RSSFRSVTPDSLGHT HHHHHCCCHHHCCCC	23.71	29255136
449	Phosphorylation	FRSVTPDSLGHTPPA HHCCCHHHCCCCCCC	37.14	29255136
453	Phosphorylation	TPDSLGHTPPARGEE CHHHCCCCCCCCCCH	29.21	30266825
463	Phosphorylation	ARGEEELSNYICMGG CCCCHHHHCCEECCC	30.76	22617229
465	Phosphorylation	GEEELSNYICMGGKG CCHHHHCCEECCCCC	7.66	27259358
475	Phosphorylation	MGGKGPSTLTAPNGH CCCCCCCCCCCCCCC	31.12	28555341
483	Phosphorylation	LTAPNGHYILSRGGN CCCCCCCEEECCCCC	12.64	27642862
486	Phosphorylation	PNGHYILSRGGNGHR CCCCEEECCCCCCCC	21.22	-
495	Phosphorylation	GGNGHRCTPGTGLGT CCCCCCCCCCCCCCC	25.39	27251789
498	Phosphorylation	GHRCTPGTGLGTSPA CCCCCCCCCCCCCHH	30.36	25850435
502	Phosphorylation	TPGTGLGTSPALAGD CCCCCCCCCHHHCCC	36.26	25850435
503	Phosphorylation	PGTGLGTSPALAGDE CCCCCCCCHHHCCCH	13.33	25850435
513	Phosphorylation	LAGDEAASAADLDNR HCCCHHHHHHHHHHH	30.91	27251789
525	Phosphorylation	DNRFRKRTHSAGTSP HHHHHHHHHCCCCCC	24.18	30278072
527	Phosphorylation	RFRKRTHSAGTSPTI HHHHHHHCCCCCCCC	27.99	26055452
530	Phosphorylation	KRTHSAGTSPTITHQ HHHHCCCCCCCCCCC	31.11	30278072
531	Phosphorylation	RTHSAGTSPTITHQK HHHCCCCCCCCCCCC	21.09	30278072
533	Phosphorylation	HSAGTSPTITHQKTP HCCCCCCCCCCCCCC	37.97	22617229
535	Phosphorylation	AGTSPTITHQKTPSQ CCCCCCCCCCCCCCC	22.26	27794612
547	Phosphorylation	PSQSSVASIEEYTEM CCCCCCCCHHHHHHH	28.51	30576142
551	Phosphorylation	SVASIEEYTEMMPAY CCCCHHHHHHHCCCC	8.66	27642862
552	Phosphorylation	VASIEEYTEMMPAYP CCCHHHHHHHCCCCC	22.23	26330541
574	Phosphorylation	RLPGHRHSAFVPTRS CCCCCCCCCCCCCCC	24.29	14583092
579	Phosphorylation	RHSAFVPTRSYPEEG CCCCCCCCCCCCCCC	27.26	28555341
581	Phosphorylation	SAFVPTRSYPEEGLE CCCCCCCCCCCCCCC	47.74	23312004
582	Phosphorylation	AFVPTRSYPEEGLEM CCCCCCCCCCCCCCC	16.04	27251275
603	Phosphorylation	GGHHRPDSSTLHTDD CCCCCCCCCCCCCCC	28.09	22322096
604	Phosphorylation	GHHRPDSSTLHTDDG CCCCCCCCCCCCCCC	42.22	22322096
605	Phosphorylation	HHRPDSSTLHTDDGY CCCCCCCCCCCCCCC	26.89	26356563
608	Phosphorylation	PDSSTLHTDDGYMPM CCCCCCCCCCCCCCC	38.61	22322096
612	Phosphorylation	TLHTDDGYMPMSPGV CCCCCCCCCCCCCCE	12.68	27273156
616	Phosphorylation	DDGYMPMSPGVAPVP CCCCCCCCCCEECCC	16.78	22322096
624	Phosphorylation	PGVAPVPSGRKGSGD CCEECCCCCCCCCCC	52.01	24275569
627	Ubiquitination	APVPSGRKGSGDYMP ECCCCCCCCCCCCCC	62.04	27667366
629	Phosphorylation	VPSGRKGSGDYMPMS CCCCCCCCCCCCCCC	31.37	23927012
632	Phosphorylation	GRKGSGDYMPMSPKS CCCCCCCCCCCCCCC	13.47	27273156
636	Phosphorylation	SGDYMPMSPKSVSAP CCCCCCCCCCCCCCC	24.25	15576463
639	Phosphorylation	YMPMSPKSVSAPQQI CCCCCCCCCCCCHHH	25.37	15576463
641	Phosphorylation	PMSPKSVSAPQQIIN CCCCCCCCCCHHHCC	41.12	28787133
662	Phosphorylation	QRVDPNGYMMMSPSG CCCCCCCCEEECCCC	6.62	27273156
666	Phosphorylation	PNGYMMMSPSGGCSP CCCCEEECCCCCCCC	9.68	28442448
668	Phosphorylation	GYMMMSPSGGCSPDI CCEEECCCCCCCCCC	40.28	28442448
672	Phosphorylation	MSPSGGCSPDIGGGP ECCCCCCCCCCCCCC	28.96	28442448
680	Phosphorylation	PDIGGGPSSSSSSSN CCCCCCCCCCCCCCC	46.24	25348954
694	Phosphorylation	NAVPSGTSYGKLWTN CCCCCCCCCCCEECC	35.10	-
695	Phosphorylation	AVPSGTSYGKLWTNG CCCCCCCCCCEECCC	20.37	-
732	Phosphorylation	LLPCTGDYMNMSPVG EEECCCCCCCCCCCC	7.54	11162588
736	Phosphorylation	TGDYMNMSPVGDSNT CCCCCCCCCCCCCCC	16.07	22210691
741	Phosphorylation	NMSPVGDSNTSSPSD CCCCCCCCCCCCCCC	35.76	28348404
743	Phosphorylation	SPVGDSNTSSPSDCY CCCCCCCCCCCCCCC	34.24	28348404
744	Phosphorylation	PVGDSNTSSPSDCYY CCCCCCCCCCCCCCC	44.49	22210691
745	Phosphorylation	VGDSNTSSPSDCYYG CCCCCCCCCCCCCCC	26.78	22210691
747	Phosphorylation	DSNTSSPSDCYYGPE CCCCCCCCCCCCCCC	42.11	22210691
750	Phosphorylation	TSSPSDCYYGPEDPQ CCCCCCCCCCCCCCC	19.22	22210691
751	Phosphorylation	SSPSDCYYGPEDPQH CCCCCCCCCCCCCCC	32.32	22210691
763	Phosphorylation	PQHKPVLSYYSLPRS CCCCCCEEEEECCCC	23.43	25849741
764	Phosphorylation	QHKPVLSYYSLPRSF CCCCCEEEEECCCCC	7.91	28270605
765	Phosphorylation	HKPVLSYYSLPRSFK CCCCEEEEECCCCCC	10.60	28270605
766	Phosphorylation	KPVLSYYSLPRSFKH CCCEEEEECCCCCCC	24.54	19664994
772	Methylation	YSLPRSFKHTQRPGE EECCCCCCCCCCCCC	47.17	115971553
772	Ubiquitination	YSLPRSFKHTQRPGE EECCCCCCCCCCCCC	47.17	-
792	Phosphorylation	RHQHLRLSTSSGRLL CCCCEEEECCCCCEE	21.58	26699800
793	Phosphorylation	HQHLRLSTSSGRLLY CCCEEEECCCCCEEE	31.35	26699800
794	Phosphorylation	QHLRLSTSSGRLLYA CCEEEECCCCCEEEE	27.67	12624099
795	Phosphorylation	HLRLSTSSGRLLYAA CEEEECCCCCEEEEE	28.20	26699800
800	Phosphorylation	TSSGRLLYAATADDS CCCCCEEEEEECCCC	9.97	27642862
811	Phosphorylation	ADDSSSSTSSDSLGG CCCCCCCCCCCCCCC	33.91	8349691
820	Phosphorylation	SDSLGGGYCGARLEP CCCCCCCCCCCCCCC	7.32	27642862
844	Ubiquitination	LQPHLPRKVDTAAQT CCCCCCCCCCCHHHH	42.39	27667366
847	Phosphorylation	HLPRKVDTAAQTNSR CCCCCCCCHHHHCCC	27.21	30387612
851	Phosphorylation	KVDTAAQTNSRLARP CCCCHHHHCCCCCCC	30.36	30387612
853	Phosphorylation	DTAAQTNSRLARPTR CCHHHHCCCCCCCCC	31.87	30387612
859	Phosphorylation	NSRLARPTRLSLGDP CCCCCCCCCCCCCCC	38.39	30266825
862	Phosphorylation	LARPTRLSLGDPKAS CCCCCCCCCCCCCCC	27.32	30266825
867	Ubiquitination	RLSLGDPKASTLPRA CCCCCCCCCCCCHHH	60.76	23000965
869	Phosphorylation	SLGDPKASTLPRARE CCCCCCCCCCHHHHH	36.28	25849741
870	Phosphorylation	LGDPKASTLPRAREQ CCCCCCCCCHHHHHH	45.71	24719451
892	Phosphorylation	LHPPEPKSPGEYVNI CCCCCCCCCCCCEEE	49.18	22617229
896	Phosphorylation	EPKSPGEYVNIEFGS CCCCCCCCEEEEECC	12.52	8530377
917	Phosphorylation	SGPVAFHSSPSVRCP CCCEEECCCCCCCCC	37.17	21712546
918	Phosphorylation	GPVAFHSSPSVRCPS CCEEECCCCCCCCCH	16.78	21712546
936	Phosphorylation	PAPREEETGTEEYMK CCCCCCCCCCHHHHH	53.32	-
938	Phosphorylation	PREEETGTEEYMKMD CCCCCCCCHHHHHCC	32.82	26330541
941	Phosphorylation	EETGTEEYMKMDLGP CCCCCHHHHHCCCCC	8.87	27273156
974	Phosphorylation	PAPPGAASICRPTRA CCCCCCHHHCCCCCC	22.99	28555341
984	O-linked_Glycosylation	RPTRAVPSSRGDYMT CCCCCCCCCCCCCEE	26.52	19671924
984	Phosphorylation	RPTRAVPSSRGDYMT CCCCCCCCCCCCCEE	26.52	-
985	O-linked_Glycosylation	PTRAVPSSRGDYMTM CCCCCCCCCCCCEEE	33.92	19671924
985	Phosphorylation	PTRAVPSSRGDYMTM CCCCCCCCCCCCEEE	33.92	-
989	Phosphorylation	VPSSRGDYMTMQMSC CCCCCCCCEEEEEEC	9.41	27259358
995	Phosphorylation	DYMTMQMSCPRQSYV CCEEEEEECCCCCCC	12.22	28555341
1000	Phosphorylation	QMSCPRQSYVDTSPA EEECCCCCCCCCCCC	28.53	27080861
1001	Phosphorylation	MSCPRQSYVDTSPAA EECCCCCCCCCCCCC	8.26	27080861
1004	Phosphorylation	PRQSYVDTSPAAPVS CCCCCCCCCCCCCCC	26.94	22199227
1005	Phosphorylation	RQSYVDTSPAAPVSY CCCCCCCCCCCCCCH	14.21	25849741
1011	O-linked_Glycosylation	TSPAAPVSYADMRTG CCCCCCCCHHHHCCC	17.34	19671924
1011	Phosphorylation	TSPAAPVSYADMRTG CCCCCCCCHHHHCCC	17.34	-
1012	Phosphorylation	SPAAPVSYADMRTGI CCCCCCCHHHHCCCC	13.57	27642862
1025	Phosphorylation	GIAAEEVSLPRATMA CCCCCCCCCCHHHHH	35.62	24719451
1036	Phosphorylation	ATMAAASSSSAASAS HHHHHHHCCCHHHCC	24.48	28348404
1037	Phosphorylation	TMAAASSSSAASASP HHHHHHCCCHHHCCC	22.85	28348404
1038	Phosphorylation	MAAASSSSAASASPT HHHHHCCCHHHCCCC	29.78	28348404
1041	Phosphorylation	ASSSSAASASPTGPQ HHCCCHHHCCCCCHH	29.06	22817900
1043	Phosphorylation	SSSAASASPTGPQGA CCCHHHCCCCCHHHH	22.09	27050516
1045	Phosphorylation	SAASASPTGPQGAAE CHHHCCCCCHHHHHH	60.02	28348404
1078	Phosphorylation	AFTRVNLSPNRNQSA CEEEEECCCCCCCCC	18.22	30266825
1084	Phosphorylation	LSPNRNQSAKVIRAD CCCCCCCCCCEEECC	33.34	22199227
1100	Phosphorylation	QGCRRRHSSETFSST CCHHCCCCCCCCCCC	28.23	27273156
1101	O-linked_Glycosylation	GCRRRHSSETFSSTP CHHCCCCCCCCCCCC	34.23	19671924
1101	Phosphorylation	GCRRRHSSETFSSTP CHHCCCCCCCCCCCC	34.23	29255136
1103	Phosphorylation	RRRHSSETFSSTPSA HCCCCCCCCCCCCCC	30.66	27273156
1105	Phosphorylation	RHSSETFSSTPSATR CCCCCCCCCCCCCCC	40.50	23927012
1106	Phosphorylation	HSSETFSSTPSATRV CCCCCCCCCCCCCCC	39.90	23663014
1107	Phosphorylation	SSETFSSTPSATRVG CCCCCCCCCCCCCCC	21.77	25849741
1109	Phosphorylation	ETFSSTPSATRVGNT CCCCCCCCCCCCCCC	42.22	23927012
1111	Phosphorylation	FSSTPSATRVGNTVP CCCCCCCCCCCCCCC	30.17	23927012
1116	Phosphorylation	SATRVGNTVPFGAGA CCCCCCCCCCCCCCC	24.51	23090842
1131	Phosphorylation	AVGGGGGSSSSSEDV CCCCCCCCCCCHHHH	30.26	29116813
1132	Phosphorylation	VGGGGGSSSSSEDVK CCCCCCCCCCHHHHH	37.20	23090842
1133	Phosphorylation	GGGGGSSSSSEDVKR CCCCCCCCCHHHHHH	39.31	23090842
1134	Phosphorylation	GGGGSSSSSEDVKRH CCCCCCCCHHHHHHH	39.43	25849741
1135	Phosphorylation	GGGSSSSSEDVKRHS CCCCCCCHHHHHHHC	39.50	27050516
1142	Phosphorylation	SEDVKRHSSASFENV HHHHHHHCCCCCEEE	31.47	22617229
1143	Phosphorylation	EDVKRHSSASFENVW HHHHHHCCCCCEEEE	23.08	22617229
1145	Phosphorylation	VKRHSSASFENVWLR HHHHCCCCCEEEEEC	34.73	22617229
1179	Dephosphorylation	GLENGLNYIDLDLVK CHHCCCCCCCHHHHH	10.80	7935386
1179	Phosphorylation	GLENGLNYIDLDLVK CHHCCCCCCCHHHHH	10.80	22322096
1196	Phosphorylation	KQCPQECTPEPQPPP HHCCCCCCCCCCCCC	29.90	28985074
1213	Phosphorylation	PPHQPLGSGESSSTR CCCCCCCCCCCCCCC	47.25	28348404
1216	Phosphorylation	QPLGSGESSSTRRSS CCCCCCCCCCCCCCH	32.87	28348404
1217	Phosphorylation	PLGSGESSSTRRSSE CCCCCCCCCCCCCHH	31.27	28348404
1218	Phosphorylation	LGSGESSSTRRSSED CCCCCCCCCCCCHHH	34.90	28348404
1219	Phosphorylation	GSGESSSTRRSSEDL CCCCCCCCCCCHHHH	31.86	28348404
1222	Phosphorylation	ESSSTRRSSEDLSAY CCCCCCCCHHHHHHH	34.49	30266825
1223	Phosphorylation	SSSTRRSSEDLSAYA CCCCCCCHHHHHHHH	33.06	30266825
1227	Phosphorylation	RRSSEDLSAYASISF CCCHHHHHHHHHHEE	31.39	30266825
1229	Phosphorylation	SSEDLSAYASISFQK CHHHHHHHHHHEECC	9.48	9756938
1231	Phosphorylation	EDLSAYASISFQKQP HHHHHHHHHEECCCC	13.19	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
24	S	Phosphorylation	Kinase	PLK1	P53350	PSP
24	S	Phosphorylation	Kinase	PLK1	Q07832	PSP
24	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
24	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
99	S	Phosphorylation	Kinase	CK2	-	Uniprot
268	S	Phosphorylation	Kinase	IKK_GROUP	-	PhosphoELM
268	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS
270	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS
270	S	Phosphorylation	Kinase	P70S6K	P23443	PSP
270	S	Phosphorylation	Kinase	IKK_GROUP	-	PhosphoELM
270	S	Phosphorylation	Kinase	ATR	Q13535	PSP
272	S	Phosphorylation	Kinase	IKK_GROUP	-	PhosphoELM
272	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS
274	S	Phosphorylation	Kinase	IKK_GROUP	-	PhosphoELM
274	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS
307	S	Phosphorylation	Kinase	P70S6K	Q8BSK8	PSP
307	S	Phosphorylation	Kinase	IKK_GROUP	-	PhosphoELM
307	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
307	S	Phosphorylation	Kinase	P70S6K	P23443	PSP
307	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS
307	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS
312	S	Phosphorylation	Kinase	RPS6KB1	Q8BSK8	GPS
312	S	Phosphorylation	Kinase	RPS6KB1	P23443	Uniprot
312	S	Phosphorylation	Kinase	JNK1	P45983	PSP
312	S	Phosphorylation	Kinase	IKK_GROUP	-	PhosphoELM
312	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
312	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS
323	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS
323	S	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
323	S	Phosphorylation	Kinase	PRKCB	P05771	GPS
341	S	Phosphorylation	Kinase	IKK_GROUP	-	PhosphoELM
341	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS
345	S	Phosphorylation	Kinase	IKK_GROUP	-	PhosphoELM
345	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS
441	S	Phosphorylation	Kinase	PRKCB	P05771	GPS
441	S	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
441	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS
465	Y	Phosphorylation	Kinase	INSR	P06213	Uniprot
527	S	Phosphorylation	Kinase	P70S6K	P23443	PSP
527	S	Phosphorylation	Kinase	IKK_GROUP	-	PhosphoELM
527	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS
531	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS
531	S	Phosphorylation	Kinase	IKK_GROUP	-	PhosphoELM
574	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS
612	Y	Phosphorylation	Kinase	MET	P08581	PSP
612	Y	Phosphorylation	Kinase	INSR	P06213	Uniprot
616	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
616	S	Phosphorylation	Kinase	RPS6KB1	Q8BSK8	GPS
629	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
629	S	Phosphorylation	Kinase	AKT1	P31749	PSP
632	Y	Phosphorylation	Kinase	INSR	P06213	Uniprot
632	Y	Phosphorylation	Kinase	IGF1R	P08069	PSP
636	S	Phosphorylation	Kinase	P70S6K	Q8BSK8	PSP
636	S	Phosphorylation	Kinase	P70S6K	P23443	PSP
636	S	Phosphorylation	Kinase	MTOR	P42345	PSP
636	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
639	S	Phosphorylation	Kinase	MTOR	P42345	PSP
639	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
639	S	Phosphorylation	Kinase	RPS6KB1	Q8BSK8	GPS
662	Y	Phosphorylation	Kinase	IGF1R	P08069	PSP
732	Y	Phosphorylation	Kinase	IGF1R	P08069	PSP
794	S	Phosphorylation	Kinase	AMPK_GROUP	-	PhosphoELM
794	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
794	S	Phosphorylation	Kinase	AMPK-FAMILY	-	GPS
794	S	Phosphorylation	Kinase	AMPK	Q9Y478	Uniprot
794	S	Phosphorylation	Kinase	SIK1	P57059	PhosphoELM
794	S	Phosphorylation	Kinase	SIK2	Q9H0K1	Uniprot
794	S	Phosphorylation	Kinase	SIK2	Q8CFH6	GPS
896	Y	Phosphorylation	Kinase	MET	P08581	PSP
896	Y	Phosphorylation	Kinase	INSR	P06213	Uniprot
896	Y	Phosphorylation	Kinase	IGF1R	P08069	PSP
941	Y	Phosphorylation	Kinase	INSR	P06213	Uniprot
941	Y	Phosphorylation	Kinase	IGF1R	P08069	PSP
989	Y	Phosphorylation	Kinase	INSR	P06213	Uniprot
989	Y	Phosphorylation	Kinase	IGF1R	P08069	PSP
1101	S	Phosphorylation	Kinase	KPCT	Q04759	PhosphoELM
1101	S	Phosphorylation	Kinase	PRKCQ	Q02111	GPS
1101	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
1101	S	Phosphorylation	Kinase	PIM1	P11309	PSP
1101	S	Phosphorylation	Kinase	P70S6K	P23443	PSP
1101	S	Phosphorylation	Kinase	PIM3	Q86V86	PSP
1101	S	Phosphorylation	Kinase	PIM2	Q9P1W9	PSP
1179	Y	Phosphorylation	Kinase	IGF1R	P08069	PSP
1179	Y	Phosphorylation	Kinase	INSR	P06213	Uniprot
1229	Y	Phosphorylation	Kinase	INSR	P06213	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW8	Q8N3Y1	PMID:24658274
-	K	Ubiquitination	E3 ubiquitin ligase	FBXO40	Q9UH90	PMID:24658274
-	K	Ubiquitination	E3 ubiquitin ligase	SOCS1	O15524	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	SOCS3	O14543	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	MDM2	Q00987	PMID:15456867
-	K	Ubiquitination	E3 ubiquitin ligase	CBLB	Q13191	PMID:23187081

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
270	S	Phosphorylation	18952604
Phosphorylated at Ser-270, Ser-307, Ser-636 and Ser-1101 by RPS6KB1; phosphorylation induces accelerated degradation of IRS1.
307	S	Phosphorylation	18952604
Phosphorylated at Ser-270, Ser-307, Ser-636 and Ser-1101 by RPS6KB1; phosphorylation induces accelerated degradation of IRS1.
312	S	Phosphorylation	18498745
Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity).
636	S	Phosphorylation	17081983
Phosphorylated at Ser-270, Ser-307, Ser-636 and Ser-1101 by RPS6KB1; phosphorylation induces accelerated degradation of IRS1.
1101	S	Phosphorylation	15364919
Phosphorylated at Ser-270, Ser-307, Ser-636 and Ser-1101 by RPS6KB1; phosphorylation induces accelerated degradation of IRS1.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IRS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SOCS1_HUMAN	SOCS1	physical	12228220
P55G_HUMAN	PIK3R3	physical	10417350
GRB2_HUMAN	GRB2	physical	8491186
KHDR1_HUMAN	KHDRBS1	physical	11604231
P85A_HUMAN	PIK3R1	physical	12173038
GRB2_HUMAN	GRB2	physical	12173038
IGF1R_HUMAN	IGF1R	physical	8776723
1433E_HUMAN	YWHAE	physical	9111084
BCL2_HUMAN	BCL2	physical	10679027
B2CL1_HUMAN	BCL2L1	physical	10679027
MTOR_HUMAN	MTOR	physical	11287630
PK3CA_HUMAN	PIK3CA	physical	16354680
P85A_HUMAN	PIK3R1	physical	12730242
JAK3_HUMAN	JAK3	physical	7499365
JAK1_HUMAN	JAK1	physical	7499365
PTN1_HUMAN	PTPN1	physical	11579209
P85A_HUMAN	PIK3R1	physical	12107746
AKT1_HUMAN	AKT1	physical	10497255
IRS2_HUMAN	IRS2	physical	12554758
UBF1_HUMAN	UBTF	physical	12554758
FAK1_HUMAN	PTK2	physical	9822703
ALK_HUMAN	ALK	physical	14968112
CBLB_HUMAN	CBLB	physical	16734387
HDAC2_HUMAN	HDAC2	physical	15522123
ESR1_HUMAN	ESR1	physical	12821935
P85A_HUMAN	PIK3R1	physical	14511371
PK3CA_HUMAN	PIK3CA	physical	14511371
P85A_HUMAN	PIK3R1	physical	16354680
PK3CA_HUMAN	PIK3CA	physical	12933652
SOCS3_HUMAN	SOCS3	physical	15514089
P85A_HUMAN	PIK3R1	physical	15514089
P85A_HUMAN	PIK3R1	physical	19561084
RPTOR_HUMAN	RPTOR	physical	19561084
FBXW8_HUMAN	FBXW8	physical	23045529
UBC_HUMAN	UBC	physical	23045529
A4_HUMAN	APP	physical	21832049
PTN11_HUMAN	PTPN11	physical	22974441
GRB2_HUMAN	GRB2	physical	22974441
P85A_HUMAN	PIK3R1	physical	22974441
PLCG2_HUMAN	PLCG2	physical	22974441
SH2B1_HUMAN	SH2B1	physical	22974441
PTN11_HUMAN	PTPN11	physical	11781100
P85B_HUMAN	PIK3R2	physical	23604317
PK3CA_HUMAN	PIK3CA	physical	23604317
PK3CB_HUMAN	PIK3CB	physical	23604317
DVL2_HUMAN	DVL2	physical	24616100
P85A_HUMAN	PIK3R1	physical	23439647
SIR1_HUMAN	SIRT1	physical	17901049
P85A_HUMAN	PIK3R1	physical	9564850
INSR_HUMAN	INSR	physical	7499194
P55G_HUMAN	PIK3R3	physical	25814554
BCAR3_HUMAN	BCAR3	physical	25814554
NUMB_HUMAN	NUMB	physical	25814554
P85A_HUMAN	PIK3R1	physical	25814554
PELI1_HUMAN	PELI1	physical	25814554
FBXW8_HUMAN	FBXW8	physical	18498745
P85A_HUMAN	PIK3R1	physical	8628286
P85A_HUMAN	PIK3R1	physical	17640984
CAV2_RAT	Cav2	physical	25667086
INSR_HUMAN	INSR	physical	25667086

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
125853	Diabetes mellitus, non-insulin-dependent (NIDDM)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IRS1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-348, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1101, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1078, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-531 AND SER-1101, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"S6K directly phosphorylates IRS-1 on Ser-270 to promote insulinresistance in response to TNF-(alpha) signaling through IKK2."; Zhang J., Gao Z., Yin J., Quon M.J., Ye J.; J. Biol. Chem. 283:35375-35382(2008). Cited for: PHOSPHORYLATION AT SER-270; SER-307; SER-636 AND SER-1101.	18952604 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-629; SER-636 ANDSER-1101, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Protein kinase C Theta inhibits insulin signaling by phosphorylatingIRS1 at Ser(1101)."; Li Y., Soos T.J., Li X., Wu J., Degennaro M., Sun X., Littman D.R.,Birnbaum M.J., Polakiewicz R.D.; J. Biol. Chem. 279:45304-45307(2004). Cited for: PHOSPHORYLATION AT SER-1101.	15364919 [Abstract]
"Adipose-specific expression, phosphorylation of Ser794 in insulinreceptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2."; Horike N., Takemori H., Katoh Y., Doi J., Min L., Asano T., Sun X.J.,Yamamoto H., Kasayama S., Muraoka M., Nonaka Y., Okamoto M.; J. Biol. Chem. 278:18440-18447(2003). Cited for: MUTAGENESIS OF SER-794, AND PHOSPHORYLATION AT SER-794.	12624099 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-632, AND MASSSPECTROMETRY.	19534553 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-46; TYR-612 AND TYR-632,AND MASS SPECTROMETRY.	18083107 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-46 AND TYR-662, AND MASSSPECTROMETRY.	15592455 [Abstract]

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