dbPTM

ALK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ALK_HUMAN
UniProt AC	Q9UM73
Protein Name	ALK tyrosine kinase receptor
Gene Name	ALK
Organism	Homo sapiens (Human).
Sequence Length	1620
Subcellular Localization	Cell membrane Single-pass type I membrane protein . Membrane attachment was crucial for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway.
Protein Description	Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK..
Protein Sequence	MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	WLLPLLLSTAAVGSG HHHHHHHHHHHHCCC	18.90	24043423
16	Phosphorylation	LLPLLLSTAAVGSGM HHHHHHHHHHHCCCC	20.71	24043423
21	Phosphorylation	LSTAAVGSGMGTGQR HHHHHHCCCCCCCCC	21.00	24043423
25	Phosphorylation	AVGSGMGTGQRAGSP HHCCCCCCCCCCCCC	22.65	24043423
45	Phosphorylation	LQPREPLSYSRLQRK CCCCCCCCHHHHHCH	31.60	22817900
46	Phosphorylation	QPREPLSYSRLQRKS CCCCCCCHHHHHCHH	12.90	25884760
47	Phosphorylation	PREPLSYSRLQRKSL CCCCCCHHHHHCHHH	24.12	19664994
62	Phosphorylation	AVDFVVPSLFRVYAR HHHCHHHHHHHHHHH	28.64	46162365
76	Phosphorylation	RDLLLPPSSSELKAG HHCCCCCCHHHHCCC	44.55	27732954
77	Phosphorylation	DLLLPPSSSELKAGR HCCCCCCHHHHCCCC	33.34	27732954
78	Phosphorylation	LLLPPSSSELKAGRP CCCCCCHHHHCCCCC	51.81	27732954
169	N-linked_Glycosylation	AVGLLQFNLSELFSW HHHHHHCCHHHHHHH	29.69	UniProtKB CARBOHYD
211	Phosphorylation	LSAAIRASQPRLLFQ HHHHHHHCCCEEEEE	30.76	22817900
235	Phosphorylation	ESPTNMPSPSPDYFT CCCCCCCCCCCCCEE	27.52	22210691
244	N-linked_Glycosylation	SPDYFTWNLTWIMKD CCCCEEEEEEEEECC	25.24	UniProtKB CARBOHYD
285	N-linked_Glycosylation	PPLHDLRNQSWSWRR CCHHHHCCCCCEEEC	47.75	UniProtKB CARBOHYD
312	Phosphorylation	DGPGAERSKEMPRGS CCCCCHHCCCCCCCC	25.19	19664995
319	Phosphorylation	SKEMPRGSFLLLNTS CCCCCCCCEEEEECC	17.63	46162347
324	N-linked_Glycosylation	RGSFLLLNTSADSKH CCCEEEEECCCCCCC	31.77	UniProtKB CARBOHYD
326	Phosphorylation	SFLLLNTSADSKHTI CEEEEECCCCCCCEE	29.07	46162353
329	Phosphorylation	LLNTSADSKHTILSP EEECCCCCCCEECCH	26.50	46162359
332	Phosphorylation	TSADSKHTILSPWMR CCCCCCCEECCHHHC	27.61	27251275
335	Phosphorylation	DSKHTILSPWMRSSS CCCCEECCHHHCCCC	16.80	27251275
411	N-linked_Glycosylation	LEYISSGNRSLSAVD EEHHHCCCCEEEEEE	32.11	UniProtKB CARBOHYD
424	N-linked_Glycosylation	VDFFALKNCSEGTSP EEEEEECCCCCCCCC	35.08	UniProtKB CARBOHYD
426	Phosphorylation	FFALKNCSEGTSPGS EEEECCCCCCCCCCC	48.75	22210691
430	Phosphorylation	KNCSEGTSPGSKMAL CCCCCCCCCCCHHHH	37.81	22210691
445	N-linked_Glycosylation	QSSFTCWNGTVLQLG HCCEEEECCEEEECH	38.10	UniProtKB CARBOHYD
563	N-linked_Glycosylation	IRGVLRGNVSLVLVE HHHHHCCCEEEEEEE	17.48	UniProtKB CARBOHYD
571	N-linked_Glycosylation	VSLVLVENKTGKEQG EEEEEEECCCCCCCC	39.44	UniProtKB CARBOHYD
591	Phosphorylation	VAAYEGLSLWQWMVL EEEECCCCHHHHHHH	38.12	27542207
604	Phosphorylation	VLPLLDVSDRFWLQM HHHHHCCCHHHHHHH	23.80	27542207
627	N-linked_Glycosylation	RAIVAFDNISISLDC EEEEEECCEEEEEEE	24.37	UniProtKB CARBOHYD
709	N-linked_Glycosylation	NNAYQNSNLSVEVGS CCCCCCCCCEEEECC	43.83	UniProtKB CARBOHYD
733	Phosphorylation	WKVPATDTYSISGYG EEECCCCEEEECCCC	18.14	22210691
735	Phosphorylation	VPATDTYSISGYGAA ECCCCEEEECCCCCC	16.63	22210691
739	Phosphorylation	DTYSISGYGAAGGKG CEEEECCCCCCCCCC	9.22	22210691
808	N-linked_Glycosylation	IEEEIRVNRSVHEWA CCEEHHHCCCCCCCC	22.21	UniProtKB CARBOHYD
831	Ubiquitination	ATYVFKMKDGVPVPL CEEEEECCCCCEEEE	52.50	-
863	N-linked_Glycosylation	FHPERLENNSSVLGL CCHHHHCCCCCEEEE	59.27	UniProtKB CARBOHYD
864	N-linked_Glycosylation	HPERLENNSSVLGLN CHHHHCCCCCEEEEC	26.70	UniProtKB CARBOHYD
886	N-linked_Glycosylation	GGGGWNDNTSLLWAG CCCCCCCCCCEEECC	28.49	UniProtKB CARBOHYD
895	Phosphorylation	SLLWAGKSLQEGATG CEEECCCCCCCCCCC	34.07	28509920
901	Phosphorylation	KSLQEGATGGHSCPQ CCCCCCCCCCCCCHH	55.33	28509920
986	N-linked_Glycosylation	VNIKHYLNCSHCEVD EEEEEECCCCCCEEE	20.34	UniProtKB CARBOHYD
1075	Phosphorylation	AMQMELQSPEYKLSK HHHHHHHCCHHHHHH	32.12	27732954
1078	Phosphorylation	MELQSPEYKLSKLRT HHHHCCHHHHHHHCC	22.18	25884760
1081	Phosphorylation	QSPEYKLSKLRTSTI HCCHHHHHHHCCCCC	26.03	21082442
1085	Phosphorylation	YKLSKLRTSTIMTDY HHHHHHCCCCCCCCC	40.43	27732954
1086	Phosphorylation	KLSKLRTSTIMTDYN HHHHHCCCCCCCCCC	14.98	27732954
1087	Phosphorylation	LSKLRTSTIMTDYNP HHHHCCCCCCCCCCC	17.72	27732954
1090	Phosphorylation	LRTSTIMTDYNPNYC HCCCCCCCCCCCCCC	31.33	46162371
1092	Phosphorylation	TSTIMTDYNPNYCFA CCCCCCCCCCCCCCC	24.29	25884760
1096	Phosphorylation	MTDYNPNYCFAGKTS CCCCCCCCCCCCCCC	7.09	11110708
1103	Phosphorylation	YCFAGKTSSISDLKE CCCCCCCCCHHHHHH	29.21	27732954
1104	Phosphorylation	CFAGKTSSISDLKEV CCCCCCCCHHHHHHC	31.20	27732954
1106	Phosphorylation	AGKTSSISDLKEVPR CCCCCCHHHHHHCCC	38.55	27732954
1131	Phosphorylation	HGAFGEVYEGQVSGM CCCCCEEEECCCCCC	15.27	22817900
1143	Phosphorylation	SGMPNDPSPLQVAVK CCCCCCCCHHHHHEE	40.90	28787133
1206	Phosphorylation	MAGGDLKSFLRETRP HHCCCHHHHHHHCCC	36.49	24719451
1216	Phosphorylation	RETRPRPSQPSSLAM HHCCCCCCCCCHHHH	56.88	27732954
1219	Phosphorylation	RPRPSQPSSLAMLDL CCCCCCCCHHHHHHH	30.28	27732954
1220	Phosphorylation	PRPSQPSSLAMLDLL CCCCCCCHHHHHHHH	27.16	27732954
1278	Phosphorylation	FGMARDIYRASYYRK CCCHHHHHHHHHHCC	12.38	18083107
1281	Phosphorylation	ARDIYRASYYRKGGC HHHHHHHHHHCCCCE	17.44	23898821
1282	Phosphorylation	RDIYRASYYRKGGCA HHHHHHHHHCCCCEE	13.30	22817900
1283	Phosphorylation	DIYRASYYRKGGCAM HHHHHHHHCCCCEEE	11.89	22817900
1359	Phosphorylation	KNCPGPVYRIMTQCW CCCCCHHHHHHHHHH	9.50	18083107
1401	Phosphorylation	NTALPIEYGPLVEEE CCCCCCCCCCCCCCH	25.43	46162383
1437	Phosphorylation	AKREEERSPAAPPPL HHHHHHCCCCCCCCC	23.36	27732954
1446	Phosphorylation	AAPPPLPTTSSGKAA CCCCCCCCCCCCCCC	47.17	27732954
1447	Phosphorylation	APPPLPTTSSGKAAK CCCCCCCCCCCCCCC	20.96	27732954
1448	Phosphorylation	PPPLPTTSSGKAAKK CCCCCCCCCCCCCCC	39.30	27732954
1449	Phosphorylation	PPLPTTSSGKAAKKP CCCCCCCCCCCCCCC	42.07	27732954
1451	Methylation	LPTTSSGKAAKKPTA CCCCCCCCCCCCCCE	47.31	-
1455	Methylation	SSGKAAKKPTAAEIS CCCCCCCCCCEEEEE	42.76	-
1481	Phosphorylation	GHVNMAFSQSNPPSE CEEEEEECCCCCCHH	24.14	27732954
1483	Phosphorylation	VNMAFSQSNPPSELH EEEEECCCCCCHHHH	50.54	27732954
1487	Phosphorylation	FSQSNPPSELHKVHG ECCCCCCHHHHCCCC	54.79	27732954
1495	Phosphorylation	ELHKVHGSRNKPTSL HHHCCCCCCCCCCCC	20.15	68732247
1498	Ubiquitination	KVHGSRNKPTSLWNP CCCCCCCCCCCCCCC	48.87	-
1500	Phosphorylation	HGSRNKPTSLWNPTY CCCCCCCCCCCCCCC	37.75	29978859
1501	Phosphorylation	GSRNKPTSLWNPTYG CCCCCCCCCCCCCCC	39.66	29978859
1506	Phosphorylation	PTSLWNPTYGSWFTE CCCCCCCCCCCCCCC	36.98	25884760
1507	Phosphorylation	TSLWNPTYGSWFTEK CCCCCCCCCCCCCCC	15.49	17274988
1509	Phosphorylation	LWNPTYGSWFTEKPT CCCCCCCCCCCCCCC	14.49	25884760
1512	Phosphorylation	PTYGSWFTEKPTKKN CCCCCCCCCCCCCCC	36.52	27732954
1514	Ubiquitination	YGSWFTEKPTKKNNP CCCCCCCCCCCCCCC	55.73	-
1517	Ubiquitination	WFTEKPTKKNNPIAK CCCCCCCCCCCCCCC	63.13	-
1518	Ubiquitination	FTEKPTKKNNPIAKK CCCCCCCCCCCCCCC	65.52	-
1560	Phosphorylation	ASLLLEPSSLTANMK CEEEECCHHCCCCCE	28.71	27732954
1561	Phosphorylation	SLLLEPSSLTANMKE EEEECCHHCCCCCEE	40.22	27732954
1563	Phosphorylation	LLEPSSLTANMKEVP EECCHHCCCCCEECC	20.24	27732954
1584	Phosphorylation	FPCGNVNYGYQQQGL CCCCCCCCCCCCCCC	16.96	25884760
1586	Phosphorylation	CGNVNYGYQQQGLPL CCCCCCCCCCCCCCC	7.87	22817900
1597	Phosphorylation	GLPLEAATAPGAGHY CCCCHHCCCCCCCCH	40.19	25884760
1604	Phosphorylation	TAPGAGHYEDTILKS CCCCCCCHHHCCCCC	18.00	18923523
1607	Phosphorylation	GAGHYEDTILKSKNS CCCCHHHCCCCCCCC	19.10	23898821
1610	Methylation	HYEDTILKSKNSMNQ CHHHCCCCCCCCCCC	56.38	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1278	Y	Phosphorylation	Kinase	ALK	Q9UM73	PSP
1282	Y	Phosphorylation	Kinase	ALK	Q9UM73	PhosphoELM
1283	Y	Phosphorylation	Kinase	ALK	Q9UM73	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:15126367
-	K	Ubiquitination	E3 ubiquitin ligase	CBL	P22681	PMID:22479414

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ALK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ALK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTN_HUMAN	PTN	physical	11278720
SHC1_HUMAN	SHC1	physical	11888936
JAK3_HUMAN	JAK3	physical	11850821
SHC3_HUMAN	SHC3	physical	12185581
RAB35_HUMAN	RAB35	physical	14968112
CH60_HUMAN	HSPD1	physical	14968112
M3K4_HUMAN	MAP3K4	physical	14968112
GRB2_HUMAN	GRB2	physical	14968112
SOCS1_HUMAN	SOCS1	physical	14968112
PK3CB_HUMAN	PIK3CB	physical	14968112
RAD17_HUMAN	RAD17	physical	14968112
IRF7_HUMAN	IRF7	physical	14968112
EPHB2_HUMAN	EPHB2	physical	14968112
IF4B_HUMAN	EIF4B	physical	14968112
JIP3_HUMAN	MAPK8IP3	physical	14968112
CENPF_HUMAN	CENPF	physical	14968112
PLCB2_HUMAN	PLCB2	physical	14968112
PDX1_HUMAN	PDX1	physical	14968112
STAT3_HUMAN	STAT3	physical	14968112
MP2K7_HUMAN	MAP2K7	physical	14968112
JAK2_HUMAN	JAK2	physical	14968112
M3K5_HUMAN	MAP3K5	physical	14968112
MEP1B_HUMAN	MEP1B	physical	14968112
GAK_HUMAN	GAK	physical	14968112
EPHA1_HUMAN	EPHA1	physical	14968112
UBS3A_HUMAN	UBASH3A	physical	14968112
JAK3_HUMAN	JAK3	physical	14968112
IF2M_HUMAN	MTIF2	physical	14968112
MYLK_HUMAN	MYLK	physical	14968112
M3K1_HUMAN	MAP3K1	physical	14968112
MK01_HUMAN	MAPK1	physical	14968112
SOCS5_HUMAN	SOCS5	physical	14968112
CDK13_HUMAN	CDK13	physical	14968112
SMC6_HUMAN	SMC6	physical	14968112
IRS4_HUMAN	IRS4	physical	14968112
K1C18_HUMAN	KRT18	physical	14968112
K2C74_HUMAN	KRT74	physical	14968112
PLCG1_HUMAN	PLCG1	physical	14968112
NIPA_HUMAN	ZC3HC1	physical	12748172
PLCG1_HUMAN	PLCG1	physical	9819383
GRB2_HUMAN	GRB2	physical	9819383
HS90A_HUMAN	HSP90AA1	physical	22939624
BCAR1_HUMAN	BCAR1	physical	16105984
ACTB_HUMAN	ACTB	physical	16105984
PDLI3_HUMAN	PDLIM3	physical	16105984
VIME_HUMAN	VIM	physical	16105984
TBB4B_HUMAN	TUBB4B	physical	16105984
MYO6_HUMAN	MYO6	physical	16105984
MYH10_HUMAN	MYH10	physical	16105984
MYH9_HUMAN	MYH9	physical	16105984
GCP2_HUMAN	TUBGCP2	physical	16105984
ACTN4_HUMAN	ACTN4	physical	16105984
COR1C_HUMAN	CORO1C	physical	16105984
FLII_HUMAN	FLII	physical	16105984
BICD2_HUMAN	BICD2	physical	16105984
RACK1_HUMAN	GNB2L1	physical	16105984
GRB2_HUMAN	GRB2	physical	16105984
SRC_HUMAN	SRC	physical	16105984
PAXI_HUMAN	PXN	physical	16105984
KPCT_HUMAN	PRKCQ	physical	14968112
MYPC2_HUMAN	MYBPC2	physical	14968112
CDK9_HUMAN	CDK9	genetic	28319113
PPM1A_HUMAN	PPM1A	physical	28065597
DUS19_HUMAN	DUSP19	physical	28065597

Drug and Disease Associations

Kegg Disease
H00014	Non-small cell lung cancer
OMIM Disease
	Note=A chromosomal aberration involving ALK is found in a form of non-Hodgkin lymphoma. Translocation t(2
	5)(p23
	q35) with NPM1. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively activated. The constitutively active fusion proteins are responsible for 5-10% of non-Hodgkin lymphomas.
613014
Kegg Drug
D09731	Crizotinib (JAN/USAN/INN); Xalkori (TN)
D10450	Alectinib hydrochloride (JAN)
DrugBank
DB00171	Adenosine triphosphate
DB08865	Crizotinib

Regulatory Network of ALK_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211, AND MASSSPECTROMETRY.	16565220 [Abstract]
"Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplasticlymphoma kinase."; Kuo A.H., Stoica G.E., Riegel A.T., Wellstein A.; Oncogene 26:859-869(2007). Cited for: INTERACTION WITH IRS1 AND SHC, PHOSPHORYLATION AT TYR-1096, ANDFUNCTION.	16878150 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1078; TYR-1096;TYR-1278; TYR-1282; TYR-1283; TYR-1359 AND TYR-1507, AND MASSSPECTROMETRY.	18083107 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1078; TYR-1092;TYR-1096; TYR-1131; TYR-1278; TYR-1282; TYR-1507; TYR-1584 ANDTYR-1604, AND MASS SPECTROMETRY.	15592455 [Abstract]