PLCB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLCB2_HUMAN
• UniProt AC: Q00722
• Protein Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
• Gene Name: PLCB2
• Organism: Homo sapiens (Human).
• Sequence Length: 1185
• Protein Description: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes..
• Protein Sequence: MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKESVRACLRTCFPSEAKDKPERACECPPELCEQDPLIAKADAQESRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLLNPVLL ------CCCCCCCCC	53.52	-
48	Phosphorylation	DPKGYYLYWTYQSKE CCCCEEEEEEEECCC	4.60	30576142
51	Phosphorylation	GYYLYWTYQSKEMEF CEEEEEEEECCCEEE	9.17	30576142
56	Sulfoxidation	WTYQSKEMEFLDITS EEEECCCEEEEECCE	5.19	21406390
62	Phosphorylation	EMEFLDITSIRDTRF CEEEEECCEECCCCC	20.12	18452278
63	Phosphorylation	MEFLDITSIRDTRFG EEEEECCEECCCCCH	18.89	30576142
208	Phosphorylation	EDFPEPVYKSFLMSL HHCCHHHHHHHHHHH	16.19	-
210	Phosphorylation	FPEPVYKSFLMSLCP CCHHHHHHHHHHHCC	13.11	25404012
214	Phosphorylation	VYKSFLMSLCPRPEI HHHHHHHHHCCCHHH	29.03	22210691
235	Phosphorylation	YHAKAKPYMTKEHLT HHHCCCCCCCHHHHH	19.40	26657352
237	Phosphorylation	AKAKPYMTKEHLTKF HCCCCCCCHHHHHHH	27.69	29083192
274	Phosphorylation	VQGLIDKYEPSGINA HCHHHHHCCCCCCCC	29.35	-
277	Phosphorylation	LIDKYEPSGINAQRG HHHHCCCCCCCCCCC	40.12	-
332	Phosphorylation	SSHNTYLTAGQFSGL CCCCCEEECCCCCCC	20.51	-
337	Phosphorylation	YLTAGQFSGLSSAEM EEECCCCCCCCHHHH	30.82	-
351	Phosphorylation	MYRQVLLSGCRCVEL HHHHHHHHCCEEEEE	31.52	29083192
394	Phosphorylation	AIEAIAESAFKTSPY HHHHHHHHHHCCCCC	29.95	28270605
406	Phosphorylation	SPYPIILSFENHVDS CCCCEEEEEECCCCC	21.80	27251275
413	Phosphorylation	SFENHVDSPRQQAKM EEECCCCCHHHHHHH	22.39	27251275
419	Ubiquitination	DSPRQQAKMAEYCRT CCHHHHHHHHHHHHH	34.01	-
419	Ubiquitination	DSPRQQAKMAEYCRT CCHHHHHHHHHHHHH	34.01	-
450	Phosphorylation	KPGVPLPSPEDLRGK CCCCCCCCHHHHCCC	48.91	-
474	Phosphorylation	FSGPTSSSKDTGGEA CCCCCCCCCCCCCCC	34.03	-
531	Phosphorylation	EEIKKMQSDEGTAGL HHHHHHHCCCCCCCC	33.84	22210691
535	Phosphorylation	KMQSDEGTAGLEVTA HHHCCCCCCCCEEEE	18.59	22210691
547	Phosphorylation	VTAYEEMSSLVNYIQ EEEHHHHHHHHHHHC	24.65	22210691
552	Phosphorylation	EMSSLVNYIQPTKFV HHHHHHHHHCCCCEE	8.08	25884760
556	Phosphorylation	LVNYIQPTKFVSFEF HHHHHCCCCEEEEEE	22.27	22210691
560	Phosphorylation	IQPTKFVSFEFSAQK HCCCCEEEEEEECCC	23.38	22210691
570	Phosphorylation	FSAQKNRSYVISSFT EECCCCCCEEEEECC	32.90	22817900
571	Phosphorylation	SAQKNRSYVISSFTE ECCCCCCEEEEECCH	9.88	18187866
574	Phosphorylation	KNRSYVISSFTELKA CCCCEEEEECCHHHH	14.89	18187866
575	Phosphorylation	NRSYVISSFTELKAY CCCEEEEECCHHHHH	25.68	18187866
577	Phosphorylation	SYVISSFTELKAYDL CEEEEECCHHHHHHH	42.21	28111955
597	Phosphorylation	VQFVDYNKRQMSRIY EEEECCCCCHHHCCC	37.47	17081983
600	Phosphorylation	VDYNKRQMSRIYPKG ECCCCCHHHCCCCCC	3.18	17081983
601	Phosphorylation	DYNKRQMSRIYPKGT CCCCCHHHCCCCCCC	13.74	25599653
604	Phosphorylation	KRQMSRIYPKGTRMD CCHHHCCCCCCCCCC	9.59	17081983
672	Phosphorylation	DKQFNPFSVDRIDVV CCCCCCCCCCCCCEE	25.10	-
698	Phosphorylation	GQFLSERSVRTYVEV CCCCCCCCEEEEEEE	16.35	21712546
701	Phosphorylation	LSERSVRTYVEVELF CCCCCEEEEEEEEEE	29.75	21712546
718	Phosphorylation	PGDPKRRYRTKLSPS CCCHHHHHCCCCCCC	27.02	-
728	Phosphorylation	KLSPSTNSINPVWKE CCCCCCCCCCCCCCC	24.67	19413330
750	Phosphorylation	ILMPELASLRVAVME HHCHHHHHHEEEEEC	29.36	24719451
757 (in isoform 2)	Ubiquitination	-	57.04	21890473
761	Ubiquitination	AVMEEGNKFLGHRII EEECCCCEECCCCEE	53.47	21890473
761	Ubiquitination	AVMEEGNKFLGHRII EEECCCCEECCCCEE	53.47	21890473
761 (in isoform 1)	Ubiquitination	-	53.47	21890473
874	Methylation	PAARAGAREEAMKEA HHHHHCHHHHHHHHH	41.17	24384387
886	Phosphorylation	KEAAEPRTASLEELR HHHCCCCCCCHHHHH	31.17	28060719
888	Phosphorylation	AAEPRTASLEELREL HCCCCCCCHHHHHHH	35.38	23401153
893	Methylation	TASLEELRELKGVVK CCCHHHHHHHHHHHH	50.94	24384397
953	Phosphorylation	KLGPGKGSRKKRSLP CCCCCCCCCCCCCCC	44.40	14702039
958	Phosphorylation	KGSRKKRSLPREESA CCCCCCCCCCHHHHC	52.16	24670416
964	Phosphorylation	RSLPREESAGAAPGE CCCCHHHHCCCCCCC	27.52	23401153
1015	Phosphorylation	QHVAEQISKMMELAR HHHHHHHHHHHHHHH	17.75	30108239
1035	Phosphorylation	ELKALKETSENDTKE HHHHHHHCCCCHHHH	39.49	-
1036	Phosphorylation	LKALKETSENDTKEM HHHHHHCCCCHHHHH	35.18	-
1040	Phosphorylation	KETSENDTKEMKKKL HHCCCCHHHHHHHHH	40.25	-
1117	Ubiquitination	EQIREMEKQFQKEAL HHHHHHHHHHHHHHH	55.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLCB2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLCB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLCB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRPM7_HUMAN	TRPM7	physical	11941371
PLCB2_HUMAN	PLCB2	physical	11753430
MP2K3_HUMAN	MAP2K3	physical	12054652
MP2K6_HUMAN	MAP2K6	physical	12054652
MK14_HUMAN	MAPK14	physical	12054652
WDR36_HUMAN	WDR36	physical	21940795
TA2R_HUMAN	TBXA2R	physical	21940795
GNAQ_HUMAN	GNAQ	physical	21940795
NHRF2_HUMAN	SLC9A3R2	physical	10748023

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.