dbPTM

TRPM7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TRPM7_HUMAN
UniProt AC	Q96QT4
Protein Name	Transient receptor potential cation channel subfamily M member 7
Gene Name	TRPM7
Organism	Homo sapiens (Human).
Sequence Length	1865
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description	Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)..
Protein Sequence	MSQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELSISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFHCNILMKDDKDPQCNIFGQDLPAVPQRKEFNFPEAGSSSGALFPSAVSPPELRQRLHGVELLKIFNKNQKLGSSSTSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAFVGHRDSMDLQRFKETSNKIKILSNNNTSENTLKRVSSLAGFTDCHRTSIPVHSKQAEKISRRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLNGLTSPFKPAMDTNYYYSAVERNNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKHHCNSCCRKLKLPDLKRNDYTPDKIIFPQDEPSDLNLQPGNSTKESESTNSVRLML

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MSQKSWIE -------CCCHHHHH	42.00	20068231
2	Phosphorylation	------MSQKSWIES ------CCCHHHHHH	58.58	24850871
5	Phosphorylation	---MSQKSWIESTLT ---CCCHHHHHHHCC	26.16	24850871
9	Phosphorylation	SQKSWIESTLTKREC CCHHHHHHHCCCCCE	21.42	24850871
10	Phosphorylation	QKSWIESTLTKRECV CHHHHHHHCCCCCEE	26.17	24850871
12	Phosphorylation	SWIESTLTKRECVYI HHHHHHCCCCCEEEE	28.30	20068231
57	Phosphorylation	QHACFTASLAMKYSD HHHHHHHHHHHHHCC	17.38	-
66	Ubiquitination	AMKYSDVKLGDHFNQ HHHHCCCCCHHHHHH	52.31	-
84	Phosphorylation	EWSVEKHTEQSPTDA HHCCCCCCCCCCCCC	46.95	27080861
87	Phosphorylation	VEKHTEQSPTDAYGV CCCCCCCCCCCCCEE	24.43	27080861
89	Phosphorylation	KHTEQSPTDAYGVIN CCCCCCCCCCCEEEE	38.21	27080861
92	Phosphorylation	EQSPTDAYGVINFQG CCCCCCCCEEEECCC	18.09	27080861
101	Phosphorylation	VINFQGGSHSYRAKY EEECCCCCCEEEEEE	18.98	25159151
103	Phosphorylation	NFQGGSHSYRAKYVR ECCCCCCEEEEEEEE	20.29	23663014
104	Phosphorylation	FQGGSHSYRAKYVRL CCCCCCEEEEEEEEE	14.79	20873877
108	Phosphorylation	SHSYRAKYVRLSYDT CCEEEEEEEEECCCC	6.99	26270265
112	Phosphorylation	RAKYVRLSYDTKPEV EEEEEEECCCCCHHH	15.48	26270265
113	Phosphorylation	AKYVRLSYDTKPEVI EEEEEECCCCCHHHH	32.02	26270265
115	Phosphorylation	YVRLSYDTKPEVILQ EEEECCCCCHHHHHH	40.02	26270265
189	Ubiquitination	KHVGDALKEHASRSS HHHHHHHHHHHHCCC	49.53	-
233	Phosphorylation	QTLLNPLSKLNVLNN HHHHCHHHHHHCHHC	36.03	25850435
269	Phosphorylation	LRRELEKTINQQRIH HHHHHHHHHHHHHHH	18.78	28464451
351	Ubiquitination	PDIISTIKKTFNFGQ CCHHHHHHHHCCCCH	45.94	-
470	Phosphorylation	VSMHKFLTIPRLEEL CCHHHCCCCHHHHHH	31.87	27251275
478	Phosphorylation	IPRLEELYNTKQGPT CHHHHHHHCCCCCCC	24.86	27251275
480	Phosphorylation	RLEELYNTKQGPTNP HHHHHHCCCCCCCCC	15.93	27251275
523	Phosphorylation	IEYLMGGTYRCTYTR HHHHHCCCCCCEEEH	11.32	-
551	Phosphorylation	NRRSGRNTSSSTPQL CCCCCCCCCCCCHHH	28.73	26471730
552	Phosphorylation	RRSGRNTSSSTPQLR CCCCCCCCCCCHHHH	26.32	28450419
553	Phosphorylation	RSGRNTSSSTPQLRK CCCCCCCCCCHHHHH	35.87	28450419
554	Phosphorylation	SGRNTSSSTPQLRKS CCCCCCCCCHHHHHH	43.82	28450419
555	Phosphorylation	GRNTSSSTPQLRKSH CCCCCCCCHHHHHHH	19.59	28450419
561	Phosphorylation	STPQLRKSHESFGNR CCHHHHHHHHHHCCH	26.50	29449344
564	Phosphorylation	QLRKSHESFGNRADK HHHHHHHHHCCHHCH	32.79	29449344
667	Ubiquitination	RSMAYEAKQSDLVDD HHHHHHHHHCCCCCC	38.09	21906983
727	Phosphorylation	TCLKLAVSSRLRPFV HHHHHHHHCCCHHHH	12.25	28355574
764	Phosphorylation	SWYKVILSILVPPAI CHHHHHHHHHHCHHH	11.62	24719451
776	Phosphorylation	PAILLLEYKTKAEMS HHHHHHHCCCHHHHC	24.75	24719451
778	Phosphorylation	ILLLEYKTKAEMSHI HHHHHCCCHHHHCCC	34.29	24719451
827	Ubiquitination	ILDSNEGKNEMEIQM EECCCCCCCCEEEEE	43.48	-
836	Phosphorylation	EMEIQMKSKKLPITR CEEEEECCCCCCCCH	29.67	28060719
837	Ubiquitination	MEIQMKSKKLPITRK EEEEECCCCCCCCHH	53.46	-
907	Phosphorylation	KVREIFMSEAGKVNQ HHHHHHHCCCCCCCC	17.34	-
1107	Phosphorylation	YLQVKAISNIVWKYQ HHHHHHHHHHHHHHH	25.93	26270265
1159	Ubiquitination	DKTSDGPKLFLTEED CCCCCCCCEECCHHH	58.35	-
1163	Phosphorylation	DGPKLFLTEEDQKKL CCCCEECCHHHHHHH	29.96	22817900
1168	Acetylation	FLTEEDQKKLHDFEE ECCHHHHHHHHCHHH	70.40	20167786
1191	Phosphorylation	EKDDKFHSGSEERIR CCCCCCCCCCCCCEE	47.34	22817900
1193	Phosphorylation	DDKFHSGSEERIRVT CCCCCCCCCCCEEEE	39.02	22817900
1224	Phosphorylation	RVNYIKRSLQSLDSQ HHHHHHHHHHHHHHH	26.26	21082442
1230	Phosphorylation	RSLQSLDSQIGHLQD HHHHHHHHHCCHHHH	29.05	-
1239	Phosphorylation	IGHLQDLSALTVDTL CCHHHHHHHCCHHHH	29.53	-
1248	Phosphorylation	LTVDTLKTLTAQKAS CCHHHHHHHHHHHHH	32.24	23403867
1250	Phosphorylation	VDTLKTLTAQKASEA HHHHHHHHHHHHHHH	32.07	23403867
1253	Ubiquitination	LKTLTAQKASEASKV HHHHHHHHHHHHHHH	51.95	-
1255	Phosphorylation	TLTAQKASEASKVHN HHHHHHHHHHHHHHH	40.51	23401153
1258	Phosphorylation	AQKASEASKVHNEIT HHHHHHHHHHHHHHH	31.03	21955146
1265	Phosphorylation	SKVHNEITRELSISK HHHHHHHHHHHHHHH	16.35	29514088
1269	Phosphorylation	NEITRELSISKHLAQ HHHHHHHHHHHHHHH	21.77	20873877
1271	Phosphorylation	ITRELSISKHLAQNL HHHHHHHHHHHHHHC	15.62	21815630
1287	Phosphorylation	DDGPVRPSVWKKHGV CCCCCCHHHHHHCCH	30.00	25850435
1297	Phosphorylation	KKHGVVNTLSSSLPQ HHCCHHHCCCCCCCC	19.19	25850435
1299	Phosphorylation	HGVVNTLSSSLPQGD CCHHHCCCCCCCCCC	18.82	25850435
1300	Phosphorylation	GVVNTLSSSLPQGDL CHHHCCCCCCCCCCC	38.72	25850435
1301	Phosphorylation	VVNTLSSSLPQGDLE HHHCCCCCCCCCCCC	40.47	25850435
1350	Phosphorylation	FNFPEAGSSSGALFP CCCCCCCCCCCCCCC	28.51	26074081
1351	Phosphorylation	NFPEAGSSSGALFPS CCCCCCCCCCCCCCC	31.69	26657352
1352	Phosphorylation	FPEAGSSSGALFPSA CCCCCCCCCCCCCCC	29.77	26074081
1358	Phosphorylation	SSGALFPSAVSPPEL CCCCCCCCCCCCHHH	33.69	26074081
1361	Phosphorylation	ALFPSAVSPPELRQR CCCCCCCCCHHHHHH	34.16	27050516
1386	Phosphorylation	NKNQKLGSSSTSIPH CCCCCCCCCCCCCCC	31.39	23401153
1387	Phosphorylation	KNQKLGSSSTSIPHL CCCCCCCCCCCCCCC	35.52	29255136
1388	Phosphorylation	NQKLGSSSTSIPHLS CCCCCCCCCCCCCCC	28.06	29255136
1389	Phosphorylation	QKLGSSSTSIPHLSS CCCCCCCCCCCCCCC	32.40	29255136
1390	Phosphorylation	KLGSSSTSIPHLSSP CCCCCCCCCCCCCCC	35.75	29255136
1395	Phosphorylation	STSIPHLSSPPTKFF CCCCCCCCCCCCEEE	37.45	23403867
1396	Phosphorylation	TSIPHLSSPPTKFFV CCCCCCCCCCCEEEE	41.06	25159151
1399	Phosphorylation	PHLSSPPTKFFVSTP CCCCCCCCEEEECCC	43.82	23403867
1404	Phosphorylation	PPTKFFVSTPSQPSC CCCEEEECCCCCHHH	29.46	19664994
1405	Phosphorylation	PTKFFVSTPSQPSCK CCEEEECCCCCHHHH	22.97	25159151
1407	Phosphorylation	KFFVSTPSQPSCKSH EEEECCCCCHHHHHH	55.61	25159151
1410	Phosphorylation	VSTPSQPSCKSHLET ECCCCCHHHHHHCCC	26.92	26552605
1413	Phosphorylation	PSQPSCKSHLETGTK CCCHHHHHHCCCCCC	37.32	-
1417	Phosphorylation	SCKSHLETGTKDQET HHHHHCCCCCCCHHH	57.41	-
1419	Phosphorylation	KSHLETGTKDQETVC HHHCCCCCCCHHHCC	38.58	-
1430	Phosphorylation	ETVCSKATEGDNTEF HHCCCCCCCCCCCCC	44.21	23312004
1435	Phosphorylation	KATEGDNTEFGAFVG CCCCCCCCCCCCCCC	37.11	22817900
1446	Phosphorylation	AFVGHRDSMDLQRFK CCCCCCCCCCHHHHH	17.72	28857561
1455	Phosphorylation	DLQRFKETSNKIKIL CHHHHHHHCCCEEEE	37.88	22817900
1456	Phosphorylation	LQRFKETSNKIKILS HHHHHHHCCCEEEEC	36.90	22817900
1463	Phosphorylation	SNKIKILSNNNTSEN CCCEEEECCCCCCHH	40.77	29255136
1467	Phosphorylation	KILSNNNTSENTLKR EEECCCCCCHHHHHH	39.27	29255136
1468	Phosphorylation	ILSNNNTSENTLKRV EECCCCCCHHHHHHH	30.85	29255136
1471	Phosphorylation	NNNTSENTLKRVSSL CCCCCHHHHHHHHHH	29.60	29255136
1473	Methylation	NTSENTLKRVSSLAG CCCHHHHHHHHHHHC	49.03	-
1473	Ubiquitination	NTSENTLKRVSSLAG CCCHHHHHHHHHHHC	49.03	-
1476	Phosphorylation	ENTLKRVSSLAGFTD HHHHHHHHHHHCCCC	24.54	23401153
1477	Phosphorylation	NTLKRVSSLAGFTDC HHHHHHHHHHCCCCC	21.27	23401153
1482	Phosphorylation	VSSLAGFTDCHRTSI HHHHHCCCCCCCCCC	36.48	28348404
1487	Phosphorylation	GFTDCHRTSIPVHSK CCCCCCCCCCCCCHH	13.82	23401153
1488	Phosphorylation	FTDCHRTSIPVHSKQ CCCCCCCCCCCCHHH	25.50	30576142
1493	Phosphorylation	RTSIPVHSKQAEKIS CCCCCCCHHHHHHHH	27.05	23911959
1500	Phosphorylation	SKQAEKISRRPSTED HHHHHHHHCCCCCCC	33.05	23403867
1504	Phosphorylation	EKISRRPSTEDTHEV HHHHCCCCCCCCCCC	42.49	23401153
1505	Phosphorylation	KISRRPSTEDTHEVD HHHCCCCCCCCCCCC	40.33	27273156
1508	Phosphorylation	RRPSTEDTHEVDSKA CCCCCCCCCCCCHHH	17.44	29255136
1513	Phosphorylation	EDTHEVDSKAALIPD CCCCCCCHHHHHCCH	29.39	25159151
1527	Phosphorylation	DWLQDRPSNREMPSE HHHHCCCCCCCCCCC	49.79	20873877
1533	Phosphorylation	PSNREMPSEEGTLNG CCCCCCCCCCCCCCC	47.14	22817900
1537	Phosphorylation	EMPSEEGTLNGLTSP CCCCCCCCCCCCCCC	21.96	22817900
1542	Phosphorylation	EGTLNGLTSPFKPAM CCCCCCCCCCCCCCC	35.43	22817900
1543	Phosphorylation	GTLNGLTSPFKPAMD CCCCCCCCCCCCCCC	33.12	22817900
1551	Phosphorylation	PFKPAMDTNYYYSAV CCCCCCCCCCCCHHH	16.43	22817900
1567	Phosphorylation	RNNLMRLSQSIPFTP HCCCCHHHHCCCCCC	16.12	30266825
1569	Phosphorylation	NLMRLSQSIPFTPVP CCCHHHHCCCCCCCC	28.93	30266825
1573	Phosphorylation	LSQSIPFTPVPPRGE HHHCCCCCCCCCCCC	20.30	30266825
1583	Phosphorylation	PPRGEPVTVYRLEES CCCCCCEEEEEECCC	23.64	22817900
1585	Phosphorylation	RGEPVTVYRLEESSP CCCCEEEEEECCCCC	10.50	23312004
1598	Phosphorylation	SPNILNNSMSSWSQL CCCHHCCCCCHHHHH	20.97	22817900
1615	Phosphorylation	CAKIEFLSKEEMGGG HHHHEECCHHHHCCH	43.26	21815630
1660	Phosphorylation	EVVNTWSSIYKEDTV HHHHHHHHHCCHHHH	22.84	22817900
1685	Phosphorylation	QRAAQKLTFAFNQMK HHHHHHHHHHHHCCC	21.69	22817900
1695	Phosphorylation	FNQMKPKSIPYSPRF HHCCCCCCCCCCHHH	37.00	22817900
1730	Phosphorylation	MTGEFRKYNNNNGDE HCCCCHHCCCCCCCC	20.90	26552605
1741	Phosphorylation	NGDEIIPTNTLEEIM CCCCCCCCCHHHHHH	30.35	26552605
1743	Phosphorylation	DEIIPTNTLEEIMLA CCCCCCCHHHHHHHH	37.72	26552605
1752	Phosphorylation	EEIMLAFSHWTYEYT HHHHHHHHHCCEEEC	16.71	26552605
1755	Phosphorylation	MLAFSHWTYEYTRGE HHHHHHCCEEECCCC	10.89	26552605
1756	Phosphorylation	LAFSHWTYEYTRGEL HHHHHCCEEECCCCE	11.18	26552605
1758	Phosphorylation	FSHWTYEYTRGELLV HHHCCEEECCCCEEE	7.42	26552605
1759	Phosphorylation	SHWTYEYTRGELLVL HHCCEEECCCCEEEE	21.91	26552605
1779	Phosphorylation	GENLTDPSVIKAEEK CCCCCCHHHHCHHHH	39.01	22817900
1829	Phosphorylation	PDLKRNDYTPDKIIF CCCCCCCCCCCEEEC	24.58	21712546
1830	Phosphorylation	DLKRNDYTPDKIIFP CCCCCCCCCCEEECC	28.07	22817900
1833	Ubiquitination	RNDYTPDKIIFPQDE CCCCCCCEEECCCCC	38.62	-
1842	Phosphorylation	IFPQDEPSDLNLQPG ECCCCCCCCCCCCCC	53.32	26074081
1851	Phosphorylation	LNLQPGNSTKESEST CCCCCCCCCCCCCCC	46.93	25159151
1852	Phosphorylation	NLQPGNSTKESESTN CCCCCCCCCCCCCCC	42.71	21815630
1857	Phosphorylation	NSTKESESTNSVRLM CCCCCCCCCCCEECC	42.01	29514088
1858	Phosphorylation	STKESESTNSVRLML CCCCCCCCCCEECCC	27.71	26074081
1860	Phosphorylation	KESESTNSVRLML-- CCCCCCCCEECCC--	14.54	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1163	T	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1191	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1193	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1255	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1258	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1265	T	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1271	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1287	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1358	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1387	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1390	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1404	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1405	T	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1407	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1435	T	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1446	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1455	T	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1456	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1463	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1468	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1471	T	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1476	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1477	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1482	T	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1493	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1505	T	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1508	T	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1513	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1527	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1533	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1537	T	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1542	T	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1543	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1551	T	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1567	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1569	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1583	T	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1598	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1615	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1660	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1685	T	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1695	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1779	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1830	T	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1851	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS
1860	S	Phosphorylation	Kinase	TRPM7	Q96QT4	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TRPM7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TRPM7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRPM7_HUMAN	TRPM7	physical	14594813
H31T_HUMAN	HIST3H3	physical	14594813
MBP_HUMAN	MBP	physical	14594813
PLCG1_HUMAN	PLCG1	physical	11941371
PLCB1_HUMAN	PLCB1	physical	11941371
PLCB2_HUMAN	PLCB2	physical	11941371
PLCB3_HUMAN	PLCB3	physical	11941371

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
105500	Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TRPM7_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1404, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1477, AND MASSSPECTROMETRY.	18669648 [Abstract]