dbPTM

PLCB3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PLCB3_HUMAN
UniProt AC	Q01970
Protein Name	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
Gene Name	PLCB3
Organism	Homo sapiens (Human).
Sequence Length	1234
Subcellular Localization	Membrane Peripheral membrane protein.
Protein Description	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes..
Protein Sequence	MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNMEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNFMAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDSAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGDEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQLGSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELRGHKALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVEDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFKRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLGDGPLVACASNGHAPGSSGHLSGADSESQEENTQL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGAQPGVH ------CCCCCCCCE	33.08	22223895
26	Phosphorylation	VETLRRGSKFIKWDE HHHHHCCCCCEECCC	23.68	11278298
30	Ubiquitination	RRGSKFIKWDEETSS HCCCCCEECCCCCCC	52.29	-
67	Phosphorylation	EVDTLDISSIRDTRT EEEEEEHHHCCCCCC	21.27	24719451
68	Phosphorylation	VDTLDISSIRDTRTG EEEEEHHHCCCCCCC	23.21	25954137
94	Ubiquitination	REVLGFGGPDARLEE HHHHCCCCCCHHHHH	18.04	29967540
106	Ubiquitination	LEEKLMTVVSGPDPV HHHHHHHHHCCCCCC	1.69	29967540
129	Ubiquitination	AVQDDTAKVWSEELF EECCCHHHHHCHHHH	46.45	21963094
148	Phosphorylation	NILAQNASRNTFLRK HHHHHHCCCCHHHHH	33.34	22210691
161	Malonylation	RKAYTKLKLQVNQDG HHHHHHHCEEECCCC	38.13	26320211
161	Ubiquitination	RKAYTKLKLQVNQDG HHHHHHHCEEECCCC	38.13	29967540
161	Acetylation	RKAYTKLKLQVNQDG HHHHHHHCEEECCCC	38.13	25953088
173	Ubiquitination	QDGRIPVKNILKMFS CCCCCCHHHHHHHHC	32.68	29967540
196	Ubiquitination	ALESCGLKFNRSESI HHHHCCCCCCCCCCC	26.36	21963094
264	Phosphorylation	PRLNEVLYPPLRPSQ CCHHHCCCCCCCHHH	14.16	28060719
270	Phosphorylation	LYPPLRPSQARLLIE CCCCCCHHHHHHHHH	30.00	25159151
279	Phosphorylation	ARLLIEKYEPNQQFL HHHHHHHCCCCHHHH	24.67	-
399	Phosphorylation	VLEAIAETAFKTSPY HHHHHHHHHCCCCCC	28.51	29514088
407	Phosphorylation	AFKTSPYPVILSFEN HCCCCCCCEEEEEEC	15.28	32645325
424	Ubiquitination	DSAKQQAKMAEYCRS HHHHHHHHHHHHHHH	34.01	-
428	Phosphorylation	QQAKMAEYCRSIFGD HHHHHHHHHHHHHCC	5.43	22817900
474	Phosphorylation	NKKRHRPSAGGPDSA CCCCCCCCCCCCCCC	39.23	25159151
480	Phosphorylation	PSAGGPDSAGRKRPL CCCCCCCCCCCCCCH	35.44	25159151
490	Phosphorylation	RKRPLEQSNSALSES CCCCHHHHCCCCCCC	24.31	21406692
492	Phosphorylation	RPLEQSNSALSESSA CCHHHHCCCCCCCCC	35.51	21406692
495	Phosphorylation	EQSNSALSESSAATE HHHCCCCCCCCCCCC	34.84	21406692
497	Phosphorylation	SNSALSESSAATEPS HCCCCCCCCCCCCCC	23.15	21406692
498	Phosphorylation	NSALSESSAATEPSS CCCCCCCCCCCCCCC	20.19	21406692
501	Phosphorylation	LSESSAATEPSSPQL CCCCCCCCCCCCCCC	48.41	21406692
504	Phosphorylation	SSAATEPSSPQLGSP CCCCCCCCCCCCCCC	48.71	30576142
505	Phosphorylation	SAATEPSSPQLGSPS CCCCCCCCCCCCCCC	27.64	21406692
510	Phosphorylation	PSSPQLGSPSSDSCP CCCCCCCCCCCCCCC	30.15	21406692
512	Phosphorylation	SPQLGSPSSDSCPGL CCCCCCCCCCCCCCC	48.77	21406692
513	Phosphorylation	PQLGSPSSDSCPGLS CCCCCCCCCCCCCCC	36.61	21406692
515	Phosphorylation	LGSPSSDSCPGLSNG CCCCCCCCCCCCCCC	24.94	21406692
520	Phosphorylation	SDSCPGLSNGEEVGL CCCCCCCCCCCCCCC	49.02	21406692
531	Phosphorylation	EVGLEKPSLEPQKSL CCCCCCCCCCCCCCC	57.33	21406692
537	Phosphorylation	PSLEPQKSLGDEGLN CCCCCCCCCCCCCCC	32.13	29255136
548	Phosphorylation	EGLNRGPYVLGPADR CCCCCCCCCCCCCCC	15.90	29978859
568	Phosphorylation	DEEEEEQTDPKKPTT HHHHHHHCCCCCCCC	58.51	30108239
572	Acetylation	EEQTDPKKPTTDEGT HHHCCCCCCCCCCCC	53.65	19822945
596	Phosphorylation	EMSTLVNYIEPVKFK HHHHHHHHHHCCCCC	10.13	27642862
603	Malonylation	YIEPVKFKSFEAARK HHHCCCCCHHHHHHH	48.82	32601280
619	Phosphorylation	NKCFEMSSFVETKAM CCCCCHHHHHHHHHH	31.81	27050516
632	Phosphorylation	AMEQLTKSPMEFVEY HHHHHHCCCHHHHHH	25.01	25159151
639	Phosphorylation	SPMEFVEYNKQQLSR CCHHHHHHCHHHHHH	23.51	26126808
737	Ubiquitination	VKVISGQFLSDRKVG EEEEECCCCCCCEEE	8.88	21890473
746	Phosphorylation	SDRKVGIYVEVDMFG CCCEEEEEEEEECCC	5.66	-
758	Phosphorylation	MFGLPVDTRRKYRTR CCCCCCCCCHHHCCC	32.38	30257219
761	Ubiquitination	LPVDTRRKYRTRTSQ CCCCCCHHHCCCCCC	35.47	21890473
793	Phosphorylation	VVLPTLASLRIAAFE HHHHHHHHHHHEEEE	22.69	24719451
804	Ubiquitination	AAFEEGGKFVGHRIL EEEECCCEECCEEEE	47.97	23000965
814	Phosphorylation	GHRILPVSAIRSGYH CEEEEEHHHHHCCCE	18.95	21406692
847	Phosphorylation	IYTEASDYIPDDHQD HHHCHHHCCCCCCHH	16.32	22817900
855	Phosphorylation	IPDDHQDYAEALINP CCCCCHHHHHHHHCH	10.36	25884760
859	Phosphorylation	HQDYAEALINPIKHV CHHHHHHHHCHHHHH	2.68	32142685
867	Phosphorylation	INPIKHVSLMDQRAR HCHHHHHHHHHHHHH	20.07	27251275
909	Phosphorylation	SQPSSNPTPSPLDAS CCCCCCCCCCCCCCC	40.42	24275569
911	Phosphorylation	PSSNPTPSPLDASPR CCCCCCCCCCCCCCC	40.34	24275569
916	Phosphorylation	TPSPLDASPRRPPGP CCCCCCCCCCCCCCC	20.71	28188228
924	Phosphorylation	PRRPPGPTTSPASTS CCCCCCCCCCCCCCC	45.91	22167270
925	Phosphorylation	RRPPGPTTSPASTSL CCCCCCCCCCCCCCC	35.53	22167270
926	Phosphorylation	RPPGPTTSPASTSLS CCCCCCCCCCCCCCC	22.43	22167270
929	Phosphorylation	GPTTSPASTSLSSPG CCCCCCCCCCCCCCC	23.16	30266825
930	Phosphorylation	PTTSPASTSLSSPGQ CCCCCCCCCCCCCCC	35.47	30266825
931	Phosphorylation	TTSPASTSLSSPGQR CCCCCCCCCCCCCCH	24.61	30266825
933	Phosphorylation	SPASTSLSSPGQRDD CCCCCCCCCCCCHHH	33.96	30266825
934	Phosphorylation	PASTSLSSPGQRDDL CCCCCCCCCCCHHHH	38.04	30266825
944	Phosphorylation	QRDDLIASILSEVAP CHHHHHHHHHHHCCC	19.64	29496963
947	Phosphorylation	DLIASILSEVAPTPL HHHHHHHHHCCCCCH	28.49	30177828
952	Phosphorylation	ILSEVAPTPLDELRG HHHHCCCCCHHHHCC	27.09	20068231
962	Ubiquitination	DELRGHKALVKLRSR HHHCCCHHHHHHHHH	16.35	22817900
987	Phosphorylation	KHQRKAVTLTRRLLD HHHHHHHHHHHHHHH	27.54	24719451
1014	Ubiquitination	LRPGALGGAADVEDT CCCCCCCCCCCCCCC	20.59	33845483
1029	Ubiquitination	KEGEDEAKRYQEFQN CCCHHHHHHHHHHHH	49.98	22817900
1031	Phosphorylation	GEDEAKRYQEFQNRQ CHHHHHHHHHHHHHH	16.22	22817900
1038	Phosphorylation	YQEFQNRQVQSLLEL HHHHHHHHHHHHHHH	45.19	33259812
1081	Ubiquitination	DANTTQFKRLKEMNE CCCCHHHHHHHHHHH	47.18	33845483
1081	Acetylation	DANTTQFKRLKEMNE CCCCHHHHHHHHHHH	47.18	24179709
1081	2-Hydroxyisobutyrylation	DANTTQFKRLKEMNE CCCCHHHHHHHHHHH	47.18	-
1100	Ubiquitination	ELQKILDRKRHNSIS HHHHHHHHHHHCCHH	34.17	29967540
1105	Phosphorylation	LDRKRHNSISEAKMR HHHHHHCCHHHHHHH	22.74	28176443
1107	Phosphorylation	RKRHNSISEAKMRDK HHHHCCHHHHHHHHH	31.18	28176443
1122	Phosphorylation	HKKEAELTEINRRHI HHHHHHHHHHHHHHH	26.73	22817900
1130	Phosphorylation	EINRRHITESVNSIR HHHHHHHHHHHHHHH	18.97	-
1167	Ubiquitination	QLAEEEPKLLAQLAQ HHHHHCHHHHHHHHH	60.45	29967540
1209	Phosphorylation	GPLVACASNGHAPGS CCEEEECCCCCCCCC	43.14	28348404
1216	Phosphorylation	SNGHAPGSSGHLSGA CCCCCCCCCCCCCCC	31.89	26074081
1217	Phosphorylation	NGHAPGSSGHLSGAD CCCCCCCCCCCCCCC	35.83	26074081
1221	Phosphorylation	PGSSGHLSGADSESQ CCCCCCCCCCCCCCH	26.68	26074081
1225	Phosphorylation	GHLSGADSESQEENT CCCCCCCCCCHHHHC	38.32	28348404
1227	Phosphorylation	LSGADSESQEENTQL CCCCCCCCHHHHCCC	47.01	28348404
1232	Phosphorylation	SESQEENTQL----- CCCHHHHCCC-----	34.23	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
26	S	Phosphorylation	Kinase	PRKG2	Q13237	GPS
26	S	Phosphorylation	Kinase	PKG-FAMILY	-	GPS
537	S	Phosphorylation	Kinase	KCC2A	Q9UQM7	PhosphoELM
537	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
537	S	Phosphorylation	Kinase	CAM-KII_GROUP	-	PhosphoELM
1105	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
1105	S	Phosphorylation	Kinase	PRKG2	Q13237	GPS
1105	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
1105	S	Phosphorylation	Kinase	PRKCB	P05771	GPS
1105	S	Phosphorylation	Kinase	PRKCG	P05129	GPS
1105	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
1105	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
1105	S	Phosphorylation	Kinase	PKG-FAMILY	-	GPS
1105	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PLCB3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PLCB3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NHRF2_HUMAN	SLC9A3R2	physical	10748023
ANXA6_MOUSE	Anxa6	physical	12821674
GNAQ_MOUSE	Gnaq	physical	20966218
GNAQ_MOUSE	Gnaq	physical	23377541
SMYD3_HUMAN	SMYD3	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PLCB3_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-537; SER-926; SER-931AND SER-934, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-537, AND MASSSPECTROMETRY.	15302935 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1122, AND MASSSPECTROMETRY.	17081983 [Abstract]