ANXA6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANXA6_MOUSE
• UniProt AC: P14824
• Protein Name: Annexin A6
• Gene Name: Anxa6
• Organism: Mus musculus (Mouse).
• Sequence Length: 673
• Subcellular Localization: Cytoplasm. Melanosome.
• Protein Description: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores..
• Protein Sequence: MAKIAQGAMYRGSVHDFPEFDANQDAEALYTAMKGFGSDKESILELITSRSNKQRQEICQNYKSLYGKDLIEDLKYELTGKFERLIVNLMRPLAYCDAKEIKDAISGVGTDEKCLIEILASRTNEQMHQLVAAYKDAYERDLESDIIGDTSGHFQKMLVVLLQGTRENDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKALLKLCGGDDDAAGQFFPEAAQVAYQMWELSAVSRVELKGTVCAANDFNPDADAKALRKAMKGIGTDEATIIDIVTHRSNAQRQQIRQTFKSHFGRDLMADLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKTLIEILATRTNAEIRAINEAYKEDYHKSLEDALSSDTSGHFRRILISLATGNREEGGENRDQAQEDAQVAAEILEIADTPSGDKTSLETRFMTVLCTRSYPHLRRVFQEFIKKTNYDIEHVIKKEMSGDVKDAFVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRVMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDFMKALLALCGGED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAKIAQGAM ------CCCCCCCCC	16.38	-
3	Acetylation	-----MAKIAQGAMY -----CCCCCCCCCC	36.96	23806337
3	Malonylation	-----MAKIAQGAMY -----CCCCCCCCCC	36.96	26320211
3	Ubiquitination	-----MAKIAQGAMY -----CCCCCCCCCC	36.96	-
10	Phosphorylation	KIAQGAMYRGSVHDF CCCCCCCCCCCCCCC	15.99	25159016
13	Phosphorylation	QGAMYRGSVHDFPEF CCCCCCCCCCCCCCC	13.79	25159016
30	Phosphorylation	NQDAEALYTAMKGFG CCCHHHHHHHHHCCC	10.25	20438120
31	Phosphorylation	QDAEALYTAMKGFGS CCHHHHHHHHHCCCC	22.56	25367039
34	Acetylation	EALYTAMKGFGSDKE HHHHHHHHCCCCCHH	48.93	23954790
34	Ubiquitination	EALYTAMKGFGSDKE HHHHHHHHCCCCCHH	48.93	22790023
38	Phosphorylation	TAMKGFGSDKESILE HHHHCCCCCHHHHHH	43.16	23984901
40	Acetylation	MKGFGSDKESILELI HHCCCCCHHHHHHHH	55.87	23954790
40	Ubiquitination	MKGFGSDKESILELI HHCCCCCHHHHHHHH	55.87	22790023
42	Phosphorylation	GFGSDKESILELITS CCCCCHHHHHHHHHH	37.91	26824392
48	Phosphorylation	ESILELITSRSNKQR HHHHHHHHHCCHHHH	30.61	14463147
51	Phosphorylation	LELITSRSNKQRQEI HHHHHHCCHHHHHHH	48.42	22817900
59	S-palmitoylation	NKQRQEICQNYKSLY HHHHHHHHHHHHHHH	1.79	28526873
63	Acetylation	QEICQNYKSLYGKDL HHHHHHHHHHHCHHH	41.35	-
63	Ubiquitination	QEICQNYKSLYGKDL HHHHHHHHHHHCHHH	41.35	22790023
68	Acetylation	NYKSLYGKDLIEDLK HHHHHHCHHHHHHHH	35.49	23236377
68	Succinylation	NYKSLYGKDLIEDLK HHHHHHCHHHHHHHH	35.49	23954790
68	Ubiquitination	NYKSLYGKDLIEDLK HHHHHHCHHHHHHHH	35.49	-
75	Acetylation	KDLIEDLKYELTGKF HHHHHHHHHHHHCHH	49.34	22733758
81	Acetylation	LKYELTGKFERLIVN HHHHHHCHHHHHHHH	38.52	22826441
81	Malonylation	LKYELTGKFERLIVN HHHHHHCHHHHHHHH	38.52	26320211
81	Ubiquitination	LKYELTGKFERLIVN HHHHHHCHHHHHHHH	38.52	-
95	Phosphorylation	NLMRPLAYCDAKEIK HHHHHHHHCCHHHHH	9.88	75351
96	S-nitrosocysteine	LMRPLAYCDAKEIKD HHHHHHHCCHHHHHH	3.22	-
96	S-nitrosylation	LMRPLAYCDAKEIKD HHHHHHHCCHHHHHH	3.22	21278135
96	S-palmitoylation	LMRPLAYCDAKEIKD HHHHHHHCCHHHHHH	3.22	26165157
99	Ubiquitination	PLAYCDAKEIKDAIS HHHHCCHHHHHHHHC	46.88	22790023
102	Acetylation	YCDAKEIKDAISGVG HCCHHHHHHHHCCCC	42.05	23954790
102	Malonylation	YCDAKEIKDAISGVG HCCHHHHHHHHCCCC	42.05	26320211
102	Succinylation	YCDAKEIKDAISGVG HCCHHHHHHHHCCCC	42.05	23954790
106	Phosphorylation	KEIKDAISGVGTDEK HHHHHHHCCCCCCHH	29.19	36523977
110	Phosphorylation	DAISGVGTDEKCLIE HHHCCCCCCHHHHHH	38.28	36524627
114	S-palmitoylation	GVGTDEKCLIEILAS CCCCCHHHHHHHHHH	4.32	26165157
123	Phosphorylation	IEILASRTNEQMHQL HHHHHHCCHHHHHHH	40.38	24899341
135	Ubiquitination	HQLVAAYKDAYERDL HHHHHHHHHHHHHHH	31.02	22790023
144	Phosphorylation	AYERDLESDIIGDTS HHHHHHCCCCCCCCC	41.21	81018505
150	Phosphorylation	ESDIIGDTSGHFQKM CCCCCCCCCHHHHHH	31.25	20531401
151	Phosphorylation	SDIIGDTSGHFQKML CCCCCCCCHHHHHHH	34.70	69085387
201	Phosphorylation	TDEAQFIYILGNRSK CCHHHEEEEECCCCH	7.44	22817900
224	Acetylation	EYLKTTGKPIEASIR HHHHHHCCCCCHHHC	40.50	22826441
229	Phosphorylation	TGKPIEASIRGELSG HCCCCCHHHCCCCCC	10.46	36013353
235	Phosphorylation	ASIRGELSGDFEKLM HHHCCCCCCCHHHHH	31.82	27180971
247	Acetylation	KLMLAVVKCIRSTPE HHHHHHHHHHHCCHH	19.83	22826441
265	Acetylation	ERLFKAMKGLGTRDN HHHHHHHCCCCCCCC	56.71	7630827
265	Malonylation	ERLFKAMKGLGTRDN HHHHHHHCCCCCCCC	56.71	26320211
273	Phosphorylation	GLGTRDNTLIRIMVS CCCCCCCHHEEEEEE	28.05	29514104
299	Acetylation	IFRTKYEKSLYSMIK HHHHHHHHHHHHHHH	42.54	23864654
299	Malonylation	IFRTKYEKSLYSMIK HHHHHHHHHHHHHHH	42.54	26320211
299	Succinylation	IFRTKYEKSLYSMIK HHHHHHHHHHHHHHH	42.54	23954790
302	Phosphorylation	TKYEKSLYSMIKNDT HHHHHHHHHHHHCCC	11.86	138803
303	Phosphorylation	KYEKSLYSMIKNDTS HHHHHHHHHHHCCCC	21.23	46164731
306	Acetylation	KSLYSMIKNDTSGEY HHHHHHHHCCCCHHH	39.88	23864654
306	Malonylation	KSLYSMIKNDTSGEY HHHHHHHHCCCCHHH	39.88	26320211
306	Ubiquitination	KSLYSMIKNDTSGEY HHHHHHHHCCCCHHH	39.88	-
310	Phosphorylation	SMIKNDTSGEYKKAL HHHHCCCCHHHHHHH	32.27	23684622
314	Acetylation	NDTSGEYKKALLKLC CCCCHHHHHHHHHHH	27.54	22826441
358	S-nitrosocysteine	VELKGTVCAANDFNP EEEECEEEECCCCCC	2.73	-
358	S-nitrosylation	VELKGTVCAANDFNP EEEECEEEECCCCCC	2.73	21278135
358	S-palmitoylation	VELKGTVCAANDFNP EEEECEEEECCCCCC	2.73	28526873
370	Acetylation	FNPDADAKALRKAMK CCCCHHHHHHHHHHC	48.80	23864654
370	Malonylation	FNPDADAKALRKAMK CCCCHHHHHHHHHHC	48.80	26320211
370	Ubiquitination	FNPDADAKALRKAMK CCCCHHHHHHHHHHC	48.80	-
377	Malonylation	KALRKAMKGIGTDEA HHHHHHHCCCCCCCH	52.84	26073543
377	Ubiquitination	KALRKAMKGIGTDEA HHHHHHHCCCCCCCH	52.84	-
406	Malonylation	QQIRQTFKSHFGRDL HHHHHHHHHHHCHHH	46.54	26320211
406	Ubiquitination	QQIRQTFKSHFGRDL HHHHHHHHHHHCHHH	46.54	-
418	Acetylation	RDLMADLKSEISGDL HHHHHHHHHHHCHHH	46.74	22826441
418	Succinylation	RDLMADLKSEISGDL HHHHHHHHHHHCHHH	46.74	23954790
422	Phosphorylation	ADLKSEISGDLARLI HHHHHHHCHHHHHHH	23.39	27180971
442	Acetylation	PPAHYDAKQLKKAME CCCCCCHHHHHHHHC	53.95	23864654
442	Malonylation	PPAHYDAKQLKKAME CCCCCCHHHHHHHHC	53.95	26320211
442	Ubiquitination	PPAHYDAKQLKKAME CCCCCCHHHHHHHHC	53.95	-
456	Acetylation	EGAGTDEKTLIEILA CCCCCCHHHHHHHHH	51.98	23954790
456	Ubiquitination	EGAGTDEKTLIEILA CCCCCCHHHHHHHHH	51.98	22790023
466	Phosphorylation	IEILATRTNAEIRAI HHHHHHCCHHHHHHH	34.13	28464351
478	Acetylation	RAINEAYKEDYHKSL HHHHHHHHHHHHHHH	51.67	23201123
478	Succinylation	RAINEAYKEDYHKSL HHHHHHHHHHHHHHH	51.67	23954790
478	Ubiquitination	RAINEAYKEDYHKSL HHHHHHHHHHHHHHH	51.67	-
483	Acetylation	AYKEDYHKSLEDALS HHHHHHHHHHHHHHH	50.97	23236377
483	Ubiquitination	AYKEDYHKSLEDALS HHHHHHHHHHHHHHH	50.97	22790023
484	Phosphorylation	YKEDYHKSLEDALSS HHHHHHHHHHHHHHC	24.55	24899341
490	Phosphorylation	KSLEDALSSDTSGHF HHHHHHHHCCCCHHH	28.08	30635358
491	Phosphorylation	SLEDALSSDTSGHFR HHHHHHHCCCCHHHH	45.84	30635358
493	Phosphorylation	EDALSSDTSGHFRRI HHHHHCCCCHHHHHH	38.26	28464351
494	Phosphorylation	DALSSDTSGHFRRIL HHHHCCCCHHHHHHH	34.95	30635358
535	Phosphorylation	EILEIADTPSGDKTS HHHHHCCCCCCCCCC	15.44	29899451
537	Phosphorylation	LEIADTPSGDKTSLE HHHCCCCCCCCCCHH	62.81	-
552	S-nitrosocysteine	TRFMTVLCTRSYPHL HHHHHHHHCCCCHHH	2.30	-
552	S-nitrosylation	TRFMTVLCTRSYPHL HHHHHHHHCCCCHHH	2.30	21278135
552	S-palmitoylation	TRFMTVLCTRSYPHL HHHHHHHHCCCCHHH	2.30	28526873
568	Acetylation	RVFQEFIKKTNYDIE HHHHHHHHHCCCCHH	59.89	22826441
579	Acetylation	YDIEHVIKKEMSGDV CCHHHHHHHHHCCCH	41.41	23954790
579	Malonylation	YDIEHVIKKEMSGDV CCHHHHHHHHHCCCH	41.41	32601280
579	Succinylation	YDIEHVIKKEMSGDV CCHHHHHHHHHCCCH	41.41	23954790
587	Acetylation	KEMSGDVKDAFVAIV HHHCCCHHHHHHHHH	48.34	23954790
600	Succinylation	IVQSVKNKPLFFADK HHHHHCCCCCCCHHH	37.06	23954790
600	Ubiquitination	IVQSVKNKPLFFADK HHHHHCCCCCCCHHH	37.06	-
607	Ubiquitination	KPLFFADKLYKSMKG CCCCCHHHHHHHCCC	50.73	22790023
609	Phosphorylation	LFFADKLYKSMKGAG CCCHHHHHHHCCCCC	13.52	75355
613	Acetylation	DKLYKSMKGAGTDEK HHHHHHCCCCCCCHH	53.34	7630837
620	Acetylation	KGAGTDEKTLTRVMV CCCCCCHHHHHHHHH	52.20	23806337
620	Malonylation	KGAGTDEKTLTRVMV CCCCCCHHHHHHHHH	52.20	26320211
628	Phosphorylation	TLTRVMVSRSEIDLL HHHHHHHCHHHHCHH	16.40	37006819
630	Phosphorylation	TRVMVSRSEIDLLNI HHHHHCHHHHCHHHH	31.25	26370283
644	Acetylation	IRREFIEKYDKSLHQ HHHHHHHHHCHHHHH	54.67	22826441
657	Phosphorylation	HQAIEGDTSGDFMKA HHHHCCCCCHHHHHH	45.53	22210690
658	Phosphorylation	QAIEGDTSGDFMKAL HHHCCCCCHHHHHHH	40.90	22210690

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANXA6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANXA6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANXA6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ANXA6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-30, AND MASSSPECTROMETRY.
PubMed: 18034455

"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling.";
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.;
J. Immunol. 179:5864-5876(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-201, AND MASSSPECTROMETRY.
PubMed: 17947660