| UniProt ID | SMYD3_HUMAN | |
|---|---|---|
| UniProt AC | Q9H7B4 | |
| Protein Name | Histone-lysine N-methyltransferase SMYD3 | |
| Gene Name | SMYD3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 428 | |
| Subcellular Localization | Cytoplasm . Nucleus . Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M. | |
| Protein Description | Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. [PubMed: 15235609] | |
| Protein Sequence | MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MEPLKVEK -------CCCCCHHH | 12.35 | 22814378 | |
| 5 | Ubiquitination | ---MEPLKVEKFATA ---CCCCCHHHHHCC | 60.09 | - | |
| 5 | Sumoylation | ---MEPLKVEKFATA ---CCCCCHHHHHCC | 60.09 | - | |
| 22 | Phosphorylation | GNGLRAVTPLRPGEL CCCCEEECCCCCCCE | 18.67 | 29255136 | |
| 33 | Phosphorylation | PGELLFRSDPLAYTV CCCEEECCCCCCEEE | 35.92 | 27251275 | |
| 42 | Ubiquitination | PLAYTVCKGSRGVVC CCCEEECCCCCCCCC | 56.43 | - | |
| 42 | Acetylation | PLAYTVCKGSRGVVC CCCEEECCCCCCCCC | 56.43 | 25953088 | |
| 56 | Ubiquitination | CDRCLLGKEKLMRCS CCHHHCCHHHHHCHH | 52.20 | - | |
| 63 (in isoform 3) | Ubiquitination | - | 23.19 | 21890473 | |
| 69 | Acetylation | CSQCRVAKYCSAKCQ HHHHHHHHHHCHHHH | 43.89 | 25953088 | |
| 74 | Acetylation | VAKYCSAKCQKKAWP HHHHHCHHHHHHCCC | 22.39 | 25953088 | |
| 78 | Ubiquitination | CSAKCQKKAWPDHKR HCHHHHHHCCCCCCC | 29.79 | - | |
| 84 | Ubiquitination | KKAWPDHKRECKCLK HHCCCCCCCCCHHHH | 58.22 | - | |
| 92 | Phosphorylation | RECKCLKSCKPRYPP CCCHHHHHCCCCCCC | 17.90 | 26074081 | |
| 97 | Phosphorylation | LKSCKPRYPPDSVRL HHHCCCCCCCCHHHH | 27.87 | 26074081 | |
| 101 | Phosphorylation | KPRYPPDSVRLLGRV CCCCCCCHHHHHHHH | 18.21 | 26074081 | |
| 113 | Sulfoxidation | GRVVFKLMDGAPSES HHHHHHHHCCCCCHH | 4.62 | 21406390 | |
| 122 (in isoform 1) | Ubiquitination | - | 63.10 | 21890473 | |
| 122 | Ubiquitination | GAPSESEKLYSFYDL CCCCHHHHHHHHHHC | 63.10 | 21906983 | |
| 124 | Phosphorylation | PSESEKLYSFYDLES CCHHHHHHHHHHCHH | 14.06 | 20562096 | |
| 135 | Ubiquitination | DLESNINKLTEDKKE HCHHHHHHCCCCHHH | 53.65 | - | |
| 141 | Ubiquitination | NKLTEDKKEGLRQLV HHCCCCHHHHHHHHH | 70.14 | - | |
| 208 (in isoform 2) | Ubiquitination | - | 8.62 | 21890473 | |
| 221 (in isoform 2) | Ubiquitination | - | 5.62 | 21890473 | |
| 239 | Phosphorylation | GEELTICYLDMLMTS CCHHHHHHHHHHCCC | 11.24 | 16805913 | |
| 271 | Ubiquitination | FRCQTQDKDADMLTG EEECCCCCCCCCCCC | 45.02 | - | |
| 292 | Ubiquitination | EVQESLKKIEELKAH HHHHHHHHHHHHHHH | 61.72 | - | |
| 297 | Ubiquitination | LKKIEELKAHWKWEQ HHHHHHHHHHCCHHH | 41.29 | - | |
| 319 (in isoform 3) | Ubiquitination | - | 51.87 | 21890473 | |
| 326 | Phosphorylation | RLPDINIYQLKVLDC CCCCCCEEHHHHHHH | 11.87 | 27642862 | |
| 332 (in isoform 3) | Ubiquitination | - | 22.55 | 21890473 | |
| 375 | Ubiquitination | VRGVQVMKVGKLQLH CCCEEEEEECEEEEC | 49.32 | - | |
| 378 (in isoform 1) | Ubiquitination | - | 35.73 | 21890473 | |
| 378 | Ubiquitination | VQVMKVGKLQLHQGM EEEEEECEEEECCCC | 35.73 | 21890473 | |
| 391 | Acetylation | GMFPQAMKNLRLAFD CCCHHHHHHHHHHHH | 56.71 | 25953088 | |
| 391 (in isoform 1) | Ubiquitination | - | 56.71 | 21890473 | |
| 391 | Ubiquitination | GMFPQAMKNLRLAFD CCCHHHHHHHHHHHH | 56.71 | 21890473 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SMYD3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SMYD3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SMYD3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MEST_HUMAN | MEST | physical | 17353931 | |
| RPB1_HUMAN | POLR2A | physical | 15235609 | |
| HS90A_HUMAN | HSP90AA1 | physical | 15235609 | |
| H31T_HUMAN | HIST3H3 | physical | 15235609 | |
| ESR1_HUMAN | ESR1 | physical | 19509295 | |
| EZH2_HUMAN | EZH2 | physical | 22659877 | |
| A4_HUMAN | APP | physical | 21832049 | |
| VANG1_HUMAN | VANGL1 | physical | 21988832 | |
| HS90A_HUMAN | HSP90AA1 | physical | 26186194 | |
| HS90B_HUMAN | HSP90AB1 | physical | 26186194 | |
| MAGD4_HUMAN | MAGED4B | physical | 26186194 | |
| KDM3B_HUMAN | KDM3B | physical | 26186194 | |
| HS90A_HUMAN | HSP90AA1 | physical | 28514442 | |
| HS90B_HUMAN | HSP90AB1 | physical | 28514442 | |
| KDM3B_HUMAN | KDM3B | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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