| UniProt ID | MAGD4_HUMAN | |
|---|---|---|
| UniProt AC | Q96JG8 | |
| Protein Name | Melanoma-associated antigen D4 | |
| Gene Name | MAGED4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 741 | |
| Subcellular Localization | ||
| Protein Description | May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.. | |
| Protein Sequence | MAEGSFSVQSESYSVEDMDEGSDEVGEEEMVEGNDYEEFGAFGGYGTLTSFDIHILRAFGSLGPGLRILSNEPWELENPVLAQTLVEALQLDPETLANETAARAANVARAAASNRAARAAAAAARTAFSQVVASHRVATPQVSGEDTQPTTYAAEAQGPTPEPPLASPQTSQMLVTSKMAAPEAPATSAQSQTGSPAQEAATEGPSSACAFSQAPCAREVDANRPSTAFLGQNDVFDFTQPAGVSGMAFPRPKRPAPAQEAATEGPSAASGVPQTGPGREVAATRPKTTKSGKALAKTRWVEPQNVVAAAAAKAKMATSIPEPEGAAAATAQHSAEPWARMGGKRTKKSKHLDDEYESSEEERETPAVPPTWRASQPSLTVRAQLAPRPPMAPRSQIPSRHVLCLPPRNVTLLQERANKLVKYLMIKDYKKIPIKRADMLKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYILVCTRDSSARLLGKTKDTPRLSLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPFLGDLRKLITDDFVKQKYLEYKKIPNSNPPEYEFLWGLRARHETSKMRVLRFIAQNQNRDPREWKAHFLEAVDDAFKTMDVDMAEEHARAQMRAQMNIGDEALIGRWSWDDIQVELLTWDEDGDFGDAWARIPFAFWARYHQYILNSNRANRRATWRAGVSSGTNGGASTSVLDGPSTSSTIRTRNAARAGASFFSWIQHR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MAEGSFSVQSES ---CCCCCCEECCCC | 13.07 | - | |
| 7 | Phosphorylation | -MAEGSFSVQSESYS -CCCCCCEECCCCCC | 22.42 | - | |
| 14 | Phosphorylation | SVQSESYSVEDMDEG EECCCCCCCCCCCCC | 28.45 | - | |
| 167 | Phosphorylation | TPEPPLASPQTSQML CCCCCCCCCCCHHEE | 25.81 | 27251275 | |
| 191 | Phosphorylation | APATSAQSQTGSPAQ CCCCCCCCCCCCHHH | 29.44 | 28348404 | |
| 193 | Phosphorylation | ATSAQSQTGSPAQEA CCCCCCCCCCHHHHH | 44.89 | 28348404 | |
| 195 | Phosphorylation | SAQSQTGSPAQEAAT CCCCCCCCHHHHHHH | 22.05 | 28348404 | |
| 202 | Phosphorylation | SPAQEAATEGPSSAC CHHHHHHHHCCCCHH | 48.82 | 28348404 | |
| 206 | Phosphorylation | EAATEGPSSACAFSQ HHHHHCCCCHHHHCC | 41.23 | 28348404 | |
| 207 | Phosphorylation | AATEGPSSACAFSQA HHHHCCCCHHHHCCC | 30.42 | 28348404 | |
| 289 | Phosphorylation | AATRPKTTKSGKALA ECCCCCCCCCCCCCC | 29.37 | - | |
| 291 | Phosphorylation | TRPKTTKSGKALAKT CCCCCCCCCCCCCCC | 43.35 | - | |
| 313 | Ubiquitination | VVAAAAAKAKMATSI HHHHHHHHHHHCCCC | 43.76 | - | |
| 315 | Ubiquitination | AAAAAKAKMATSIPE HHHHHHHHHCCCCCC | 28.50 | - | |
| 356 | Phosphorylation | SKHLDDEYESSEEER CCCCCCCHHCCHHHH | 28.27 | 27732954 | |
| 358 | Phosphorylation | HLDDEYESSEEERET CCCCCHHCCHHHHCC | 41.99 | 20363803 | |
| 359 | Phosphorylation | LDDEYESSEEERETP CCCCHHCCHHHHCCC | 36.77 | 20363803 | |
| 365 | Phosphorylation | SSEEERETPAVPPTW CCHHHHCCCCCCCCC | 23.83 | 24719451 | |
| 422 (in isoform 1) | Ubiquitination | - | 43.00 | 21906983 | |
| 422 | Ubiquitination | ERANKLVKYLMIKDY HHHHHHHHHHHCCCC | 43.00 | 2190698 | |
| 422 (in isoform 2) | Ubiquitination | - | 43.00 | 21906983 | |
| 422 (in isoform 4) | Ubiquitination | - | 43.00 | 21906983 | |
| 427 | Ubiquitination | LVKYLMIKDYKKIPI HHHHHHCCCCCCCCC | 40.83 | - | |
| 441 | Ubiquitination | IKRADMLKDVIREYD CCHHHHHHHHHHHHH | 43.22 | - | |
| 480 | Phosphorylation | IDKEEHLYILVCTRD CCCCCCEEEEEEECC | 8.30 | 26074081 | |
| 485 | Phosphorylation | HLYILVCTRDSSARL CEEEEEEECCHHHHH | 29.99 | 26074081 | |
| 495 | Ubiquitination | SSARLLGKTKDTPRL HHHHHCCCCCCCHHH | 52.98 | - | |
| 520 | Phosphorylation | FMNGNRASEAVLWEA HHCCCHHHHHHHHHH | 23.89 | - | |
| 530 | Ubiquitination | VLWEALRKMGLRPGV HHHHHHHHCCCCCCC | 37.86 | - | |
| 546 | Methylation | HPFLGDLRKLITDDF CCCHHHHHHHHCCHH | 36.15 | 115482493 | |
| 547 | Ubiquitination | PFLGDLRKLITDDFV CCHHHHHHHHCCHHH | 52.09 | - | |
| 555 | Ubiquitination | LITDDFVKQKYLEYK HHCCHHHHHHHHHCC | 40.86 | - | |
| 557 | Ubiquitination | TDDFVKQKYLEYKKI CCHHHHHHHHHCCCC | 46.19 | - | |
| 563 | Ubiquitination | QKYLEYKKIPNSNPP HHHHHCCCCCCCCCC | 63.59 | - | |
| 572 | Phosphorylation | PNSNPPEYEFLWGLR CCCCCCHHHHHHHHH | 20.11 | - | |
| 605 | Ubiquitination | NRDPREWKAHFLEAV CCCHHHHHHHHHHHH | 27.51 | - | |
| 711 | Phosphorylation | TNGGASTSVLDGPST CCCCCCCCCCCCCCC | 20.42 | - | |
| 719 | Phosphorylation | VLDGPSTSSTIRTRN CCCCCCCCCHHHHHH | 29.80 | - | |
| 720 | Phosphorylation | LDGPSTSSTIRTRNA CCCCCCCCHHHHHHH | 28.13 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MAGD4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MAGD4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MAGD4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| EID3_HUMAN | EID3 | physical | 21364888 | |
| NSE4A_HUMAN | NSMCE4A | physical | 21364888 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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