| UniProt ID | EID3_HUMAN | |
|---|---|---|
| UniProt AC | Q8N140 | |
| Protein Name | EP300-interacting inhibitor of differentiation 3 | |
| Gene Name | EID3 {ECO:0000312|EMBL:AAH27612.1} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 333 | |
| Subcellular Localization | Nucleus . Cytoplasm . Chromosome, telomere . May shuttle between nucleus and cytoplasm. | |
| Protein Description | Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.; Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.. | |
| Protein Sequence | MKMDVSVRAAGCSDDLSSGEADVDPKLLELTADEEKCRSIRRQYRQLMYCVRQNREDIVSSANNSLTEALEEANVLFDGVSRTREAALDARFLVMASDLGKEKAKQLNSDMNFFNQLAFCDFLFLFVGLNWMEGDPDKLSDCDDSIALSFWKAIEKEATSWMVKAETFHFVFGSFKLERSAPKPRLEHQKKVRKMEENGNMPTKLQKLDLSSYPEATEKNVERILGLLQTYFRKYPDTPVSYFEFVIDPNSFSRTVENIFYVSFIVRDGFARIRLDEDRLPILEPMNVNQMGEGNDSSCHGRKQGVISLTLQEWKNIVAAFEISEAMITYSSY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MKMDVSVRAAGCS --CCCCEEECCCCCC | 11.13 | 20068231 | |
| 13 | Phosphorylation | SVRAAGCSDDLSSGE EECCCCCCCCCCCCC | 32.99 | 20068231 | |
| 17 | Phosphorylation | AGCSDDLSSGEADVD CCCCCCCCCCCCCCC | 43.20 | 20068231 | |
| 18 | Phosphorylation | GCSDDLSSGEADVDP CCCCCCCCCCCCCCH | 48.20 | 20068231 | |
| 207 | Ubiquitination | NMPTKLQKLDLSSYP CCCCHHHHCCHHHCH | 55.17 | - | |
| 230 | Phosphorylation | RILGLLQTYFRKYPD HHHHHHHHHHHHCCC | 25.29 | 20068231 | |
| 231 | Phosphorylation | ILGLLQTYFRKYPDT HHHHHHHHHHHCCCC | 6.60 | 20068231 | |
| 235 | Phosphorylation | LQTYFRKYPDTPVSY HHHHHHHCCCCCCEE | 11.33 | 20068231 | |
| 238 | Phosphorylation | YFRKYPDTPVSYFEF HHHHCCCCCCEEEEE | 22.53 | 20068231 | |
| 241 | Phosphorylation | KYPDTPVSYFEFVID HCCCCCCEEEEEEEC | 25.88 | 20068231 | |
| 242 | Phosphorylation | YPDTPVSYFEFVIDP CCCCCCEEEEEEECC | 13.83 | 20068231 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EID3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EID3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EID3_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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