| UniProt ID | MAGA1_HUMAN | |
|---|---|---|
| UniProt AC | P43355 | |
| Protein Name | Melanoma-associated antigen 1 | |
| Gene Name | MAGEA1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 309 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.. | |
| Protein Sequence | MSLEQRSLHCKPEEALEAQQEALGLVCVQAATSSSSPLVLGTLEEVPTAGSTDPPQSPQGASAFPTTINFTRQRQPSEGSSSREEEGPSTSCILESLFRAVITKKVADLVGFLLLKYRAREPVTKAEMLESVIKNYKHCFPEIFGKASESLQLVFGIDVKEADPTGHSYVLVTCLGLSYDGLLGDNQIMPKTGFLIIVLVMIAMEGGHAPEEEIWEELSVMEVYDGREHSAYGEPRKLLTQDLVQEKYLEYRQVPDSDPARYEFLWGPRALAETSYVKVLEYVIKVSARVRFFFPSLREAALREEEEGV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSLEQRSLH ------CCHHHHHHC | 40.38 | 24850871 | |
| 7 | Phosphorylation | -MSLEQRSLHCKPEE -CCHHHHHHCCCHHH | 23.35 | 24850871 | |
| 57 | Phosphorylation | GSTDPPQSPQGASAF CCCCCCCCCCCCCCC | 25.60 | 20068231 | |
| 62 | Phosphorylation | PQSPQGASAFPTTIN CCCCCCCCCCCEEEE | 36.95 | 20068231 | |
| 77 | Phosphorylation | FTRQRQPSEGSSSRE EEECCCCCCCCCCCC | 46.37 | 23663014 | |
| 80 | Phosphorylation | QRQPSEGSSSREEEG CCCCCCCCCCCCCCC | 22.53 | 26503892 | |
| 81 | Phosphorylation | RQPSEGSSSREEEGP CCCCCCCCCCCCCCC | 44.25 | 23663014 | |
| 82 | Phosphorylation | QPSEGSSSREEEGPS CCCCCCCCCCCCCCC | 45.46 | 26503892 | |
| 89 | Phosphorylation | SREEEGPSTSCILES CCCCCCCCHHHHHHH | 43.75 | 23663014 | |
| 90 | Phosphorylation | REEEGPSTSCILESL CCCCCCCHHHHHHHH | 30.65 | 23663014 | |
| 91 | Phosphorylation | EEEGPSTSCILESLF CCCCCCHHHHHHHHH | 11.96 | 23663014 | |
| 96 | Phosphorylation | STSCILESLFRAVIT CHHHHHHHHHHHHHH | 29.39 | 28102081 | |
| 104 | Ubiquitination | LFRAVITKKVADLVG HHHHHHHHHHHHHHH | 33.84 | 23000965 | |
| 105 | Ubiquitination | FRAVITKKVADLVGF HHHHHHHHHHHHHHH | 33.72 | 23000965 | |
| 116 | Ubiquitination | LVGFLLLKYRAREPV HHHHHHHHHHCCCCC | 32.43 | 21906983 | |
| 124 | Phosphorylation | YRAREPVTKAEMLES HHCCCCCCHHHHHHH | 34.94 | 20068231 | |
| 125 | Ubiquitination | RAREPVTKAEMLESV HCCCCCCHHHHHHHH | 42.45 | 23000965 | |
| 134 | Ubiquitination | EMLESVIKNYKHCFP HHHHHHHHHCHHHCH | 52.66 | 21987572 | |
| 137 | Ubiquitination | ESVIKNYKHCFPEIF HHHHHHCHHHCHHHH | 43.20 | - | |
| 160 | Acetylation | LVFGIDVKEADPTGH EEECEEEECCCCCCC | 43.36 | 30590239 | |
| 237 | Ubiquitination | SAYGEPRKLLTQDLV CCCCCCCHHHCHHHH | 59.57 | 23000965 | |
| 247 | Ubiquitination | TQDLVQEKYLEYRQV CHHHHHHHHHHHCCC | 37.74 | 23000965 | |
| 251 | Phosphorylation | VQEKYLEYRQVPDSD HHHHHHHHCCCCCCC | 12.07 | - | |
| 276 | Phosphorylation | RALAETSYVKVLEYV HHHHCCCHHHHHHHH | 16.23 | 22817900 | |
| 278 | Methylation | LAETSYVKVLEYVIK HHCCCHHHHHHHHHH | 32.63 | 24682187 | |
| 278 | Ubiquitination | LAETSYVKVLEYVIK HHCCCHHHHHHHHHH | 32.63 | 23000965 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MAGA1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MAGA1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MAGA1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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