dbPTM

GRDN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GRDN_HUMAN
UniProt AC	Q3V6T2
Protein Name	Girdin
Gene Name	CCDC88A
Organism	Homo sapiens (Human).
Sequence Length	1871
Subcellular Localization	Membrane . Cell membrane . Cytoplasm, cytosol . Cytoplasmic vesicle . Cell projection, lamellipodium . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Localizes to the cell
Protein Description	Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself (By similarity). Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. [PubMed: 16139227 Required for formation of actin stress fibers and lamellipodia]
Protein Sequence	MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLESQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVLAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYATLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRNSKSRSREQQSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	PLLEQFMTSPLVTWV HHHHHHCCCCCCHHH	28.60	23401153
16	Phosphorylation	LLEQFMTSPLVTWVK HHHHHCCCCCCHHHH	12.40	23401153
228	Phosphorylation	LHFLPHASSSAQSPC CCCCCCCCCCCCCCC	23.07	30108239
229	Phosphorylation	HFLPHASSSAQSPCG CCCCCCCCCCCCCCC	30.40	23401153
230	Phosphorylation	FLPHASSSAQSPCGS CCCCCCCCCCCCCCC	28.03	23927012
233	Phosphorylation	HASSSAQSPCGSPGM CCCCCCCCCCCCCCC	23.13	23401153
233 (in isoform 3)	Phosphorylation	-	23.13	27251275
237	Phosphorylation	SAQSPCGSPGMKRTE CCCCCCCCCCCCCCC	25.62	23401153
237 (in isoform 3)	Phosphorylation	-	25.62	27251275
243	Phosphorylation	GSPGMKRTESRQHLS CCCCCCCCCCCCHHH	32.56	24117733
243 (in isoform 3)	Phosphorylation	-	32.56	24719451
245	Phosphorylation	PGMKRTESRQHLSVE CCCCCCCCCCHHHHH	36.31	28464451
245 (in isoform 3)	Phosphorylation	-	36.31	27251275
250	Phosphorylation	TESRQHLSVELADAK CCCCCHHHHHHHHHH	16.06	30576142
414	Phosphorylation	ELMEENMTLEMAQKQ HHHHHCCHHHHHHHH	31.02	30576142
448	Acetylation	ELSEAPQKSLGHEVN CCCHHHHHHHCHHHH	46.73	25953088
449	Phosphorylation	LSEAPQKSLGHEVNE CCHHHHHHHCHHHHH	34.04	23401153
449 (in isoform 3)	Phosphorylation	-	34.04	24719451
458	Phosphorylation	GHEVNELTSSRLLKL CHHHHHHHHHHHHHH	20.62	28555341
459	Phosphorylation	HEVNELTSSRLLKLE HHHHHHHHHHHHHHH	26.53	28555341
471	Phosphorylation	KLEMENQSLTKTVEE HHHHHCCHHHHHHHH	49.98	28555341
528	Phosphorylation	LQNCQNLSKDLMKEK HHHHHHHCHHHHHHH	31.50	-
568	Phosphorylation	EHLNQTVSSLRQRSQ HHHHHHHHHHHHHHH	27.35	24719451
569	Phosphorylation	HLNQTVSSLRQRSQI HHHHHHHHHHHHHHH	24.20	24719451
595	Phosphorylation	ENKILHESIKETSSK HHHHHHHHHHHHHHH	28.36	-
600	Phosphorylation	HESIKETSSKLSKIE HHHHHHHHHHHHHHH	26.94	23403867
601	Phosphorylation	ESIKETSSKLSKIEF HHHHHHHHHHHHHHH	45.06	23403867
697	Phosphorylation	ESLEKENSQLDEENL HHHHHHHCCCCHHHH	32.96	24719451
697 (in isoform 3)	Phosphorylation	-	32.96	24719451
712	Phosphorylation	ELRRNVESLKCASMK HHHHCHHHHHHHHHH	28.92	24719451
712 (in isoform 3)	Phosphorylation	-	28.92	24719451
719	Acetylation	SLKCASMKMAQLQLE HHHHHHHHHHHHHHH	28.70	25953088
739	Acetylation	SEKEQLKKGLELLKA HHHHHHHHHHHHHHH	76.85	19413330
739 (in isoform 2)	Acetylation	-	76.85	-
747	Phosphorylation	GLELLKASFKKTERL HHHHHHHHCCCCCCE	35.69	26074081
747 (in isoform 3)	Phosphorylation	-	35.69	24719451
751	Phosphorylation	LKASFKKTERLEVSY HHHHCCCCCCEEEEE	27.25	26074081
757	Phosphorylation	KTERLEVSYQGLDIE CCCCEEEEECCCCHH	11.45	26074081
758	Phosphorylation	TERLEVSYQGLDIEN CCCEEEEECCCCHHH	16.27	26074081
771	Phosphorylation	ENQRLQKTLENSNKK HHHHHHHHHHHHHHH	26.75	21712546
775	Phosphorylation	LQKTLENSNKKIQQL HHHHHHHHHHHHHHH	40.42	21712546
819	Phosphorylation	QLEKENKSLEQETSQ HHHHHHHHHHHHHHH	49.04	22468782
824	Phosphorylation	NKSLEQETSQLEKDK HHHHHHHHHHHHHHH	22.82	22468782
825	O-linked_Glycosylation	KSLEQETSQLEKDKK HHHHHHHHHHHHHHH	31.83	30379171
876	Phosphorylation	LSKEIGIYKESCVRL HHHHHCCHHHHHHHH	11.95	-
903	Phosphorylation	RATIDIKTLVTLRED HHEECHHHHHHHHHH	27.13	22210691
913	Phosphorylation	TLREDLVSEKLKTQQ HHHHHHHHHHHHHHH	35.99	22210691
959	Phosphorylation	SRYKLLESKLESTLK HHHHHHHHHHHHHHH	42.37	-
999	Phosphorylation	QLRQELKTVKKNYEA HHHHHHHHHHHHHHH	50.62	-
1018 (in isoform 3)	Phosphorylation	-	28.93	27251275
1019	Phosphorylation	DEERMVQSSPPISGE HHHHHHHCCCCCCCC	33.14	29255136
1019 (in isoform 3)	Phosphorylation	-	33.14	24719451
1020	Phosphorylation	EERMVQSSPPISGED HHHHHHCCCCCCCCC	20.01	29255136
1024	Phosphorylation	VQSSPPISGEDNKWE HHCCCCCCCCCCCCH	41.73	28450419
1034	Phosphorylation	DNKWERESQETTREL CCCCHHHHHHHHHHH	39.27	30576142
1090	Phosphorylation	ILALQRQTVSLQEQN HHHHHHCCCCHHHHC	17.79	24043423
1092	Phosphorylation	ALQRQTVSLQEQNTT HHHHCCCCHHHHCHH	27.94	24043423
1098	Phosphorylation	VSLQEQNTTLQTQNA CCHHHHCHHHHHHHH	28.69	24043423
1099	Phosphorylation	SLQEQNTTLQTQNAK CHHHHCHHHHHHHHE	25.15	24043423
1102	Phosphorylation	EQNTTLQTQNAKLQV HHCHHHHHHHHEEEE	27.23	24043423
1151	Phosphorylation	KEREDLKSLYDSLIK HHHHHHHHHHHHHCC	39.19	23898821
1153	Phosphorylation	REDLKSLYDSLIKDH HHHHHHHHHHHCCHH	15.58	23898821
1155	Phosphorylation	DLKSLYDSLIKDHEK HHHHHHHHHCCHHHH	20.59	24719451
1174	Phosphorylation	HERQASEYESLISKH HHHHHHHHHHHHHHH	14.34	27642862
1176	Phosphorylation	RQASEYESLISKHGT HHHHHHHHHHHHHCC	30.05	24719451
1186	Phosphorylation	SKHGTLKSAHKNLEV HHHCCHHHHHHCCHH	38.42	22468782
1220	Acetylation	EDLEKMLKVEQEKML HHHHHHHHHHHHHHH	39.98	20167786
1225	Acetylation	MLKVEQEKMLLENKN HHHHHHHHHHHHCCC	34.24	20167786
1254	Phosphorylation	NDRLNHTYSQLLKET CHHHHHHHHHHHHHH	6.20	27642862
1273	Phosphorylation	TDHKNLKSLLNNSKL CCCHHHHHHHHCCHH	41.05	23312004
1278	Phosphorylation	LKSLLNNSKLEQTRL HHHHHHCCHHHHHHH	37.23	23312004
1278 (in isoform 2)	Phosphorylation	-	37.23	-
1314	Phosphorylation	NNQCELLSQLKGNLE HHHHHHHHHHCCCHH	46.20	24719451
1381	Phosphorylation	EEKIMDQYKFYDPSP HHHHHHHHCCCCCCC	9.98	27642862
1384	Phosphorylation	IMDQYKFYDPSPPRR HHHHHCCCCCCCCCC	23.85	29396449
1386 (in isoform 3)	Phosphorylation	-	37.04	24719451
1387	Phosphorylation	QYKFYDPSPPRRRGN HHCCCCCCCCCCCCC	44.64	19664994
1387 (in isoform 2)	Phosphorylation	-	44.64	-
1397	Phosphorylation	RRRGNWITLKMRKLI CCCCCCCHHHHHHHH	16.37	23186163
1416 (in isoform 3)	Phosphorylation	-	54.37	24719451
1417	Phosphorylation	INRERQKSLTLTPTR HCHHHHHCCEECCCC	20.46	23401153
1417 (in isoform 2)	Phosphorylation	-	20.46	-
1419	Phosphorylation	RERQKSLTLTPTRSD HHHHHCCEECCCCCC	35.36	30266825
1419 (in isoform 2)	Phosphorylation	-	35.36	-
1420 (in isoform 3)	Phosphorylation	-	7.00	27251275
1421	Phosphorylation	RQKSLTLTPTRSDSS HHHCCEECCCCCCCC	19.85	25159151
1423	Phosphorylation	KSLTLTPTRSDSSEG HCCEECCCCCCCCCC	37.25	22199227
1425	Phosphorylation	LTLTPTRSDSSEGFL CEECCCCCCCCCCCC	44.30	29978859
1427	Phosphorylation	LTPTRSDSSEGFLQL ECCCCCCCCCCCCCC	31.38	28192239
1428	Phosphorylation	TPTRSDSSEGFLQLP CCCCCCCCCCCCCCC	46.89	29978859
1438 (in isoform 3)	Phosphorylation	-	45.27	27251275
1439	Phosphorylation	LQLPHQDSQDSSSVG CCCCCCCCCCCCCCC	29.35	29978859
1442	Phosphorylation	PHQDSQDSSSVGSNS CCCCCCCCCCCCCCC	19.51	29978859
1443	Phosphorylation	HQDSQDSSSVGSNSL CCCCCCCCCCCCCCC	37.01	29978859
1444	Phosphorylation	QDSQDSSSVGSNSLE CCCCCCCCCCCCCCC	34.15	29978859
1447	Phosphorylation	QDSSSVGSNSLEDGQ CCCCCCCCCCCCCCC	22.53	29978859
1449	Phosphorylation	SSSVGSNSLEDGQTL CCCCCCCCCCCCCCC	34.53	23186163
1458	Phosphorylation	EDGQTLGTKKSSMVA CCCCCCCCCHHHHHH	38.11	24461736
1461	Phosphorylation	QTLGTKKSSMVALKR CCCCCCHHHHHHHHC	25.81	-
1462	Phosphorylation	TLGTKKSSMVALKRL CCCCCHHHHHHHHCC	26.59	23403867
1467	Methylation	KSSMVALKRLPFLRN HHHHHHHHCCHHHCC	42.00	-
1477 (in isoform 4)	Phosphorylation	-	74.34	25954137
1478 (in isoform 2)	Phosphorylation	-	68.05	25954137
1479 (in isoform 4)	Phosphorylation	-	66.43	25954137
1480 (in isoform 2)	Phosphorylation	-	67.43	25954137
1480 (in isoform 4)	Phosphorylation	-	67.43	28348404
1481 (in isoform 2)	Phosphorylation	-	48.30	28348404
1488 (in isoform 3)	Phosphorylation	-	15.38	27251275
1489	Phosphorylation	MKACYRRSMSMNDLV HHHHHHHHCCHHHHH	13.25	27251275
1490 (in isoform 3)	Phosphorylation	-	4.12	27251275
1491	Phosphorylation	ACYRRSMSMNDLVQS HHHHHHCCHHHHHHH	18.71	27251275
1491 (in isoform 4)	Phosphorylation	-	18.71	25954137
1492 (in isoform 2)	Phosphorylation	-	3.20	25954137
1498	Phosphorylation	SMNDLVQSMVLAGQW CHHHHHHHHHHCCCC	11.90	-
1505 (in isoform 3)	Phosphorylation	-	11.21	27251275
1506	Phosphorylation	MVLAGQWTGSTENLE HHHCCCCCCCCCCCC	17.23	27251275
1508	Phosphorylation	LAGQWTGSTENLEVP HCCCCCCCCCCCCCC	25.77	27251275
1509	Phosphorylation	AGQWTGSTENLEVPD CCCCCCCCCCCCCCC	30.18	27251275
1532 (in isoform 3)	Phosphorylation	-	4.24	27251275
1533	Phosphorylation	ELGAMAFSTTAINFS HHHCCEEEEECCCHH	18.47	28348404
1534	Phosphorylation	LGAMAFSTTAINFST HHCCEEEEECCCHHH	17.50	28348404
1535	Phosphorylation	GAMAFSTTAINFSTV HCCEEEEECCCHHHC	25.09	28348404
1558 (in isoform 3)	Phosphorylation	-	58.29	24719451
1559	Phosphorylation	QLVNNKDTTSFEDIS HHCCCCCCCCHHHCC	26.42	23401153
1560	Phosphorylation	LVNNKDTTSFEDISP HCCCCCCCCHHHCCC	41.36	23401153
1560 (in isoform 3)	Phosphorylation	-	41.36	27251275
1561	Phosphorylation	VNNKDTTSFEDISPQ CCCCCCCCHHHCCCC	28.82	30266825
1566	Phosphorylation	TTSFEDISPQGVSDD CCCHHHCCCCCCCCC	24.40	30266825
1571	Phosphorylation	DISPQGVSDDSSTGS HCCCCCCCCCCCCCC	42.39	23403867
1574	Phosphorylation	PQGVSDDSSTGSRVH CCCCCCCCCCCCCEE	34.49	23403867
1575	Phosphorylation	QGVSDDSSTGSRVHA CCCCCCCCCCCCEEE	43.72	23403867
1576	Phosphorylation	GVSDDSSTGSRVHAS CCCCCCCCCCCEEEC	43.03	23403867
1578	Phosphorylation	SDDSSTGSRVHASRP CCCCCCCCCEEECCC	31.08	23403867
1583	Phosphorylation	TGSRVHASRPASLDS CCCCEEECCCCCCCC	24.74	23927012
1586 (in isoform 3)	Phosphorylation	-	22.93	24719451
1587	Phosphorylation	VHASRPASLDSGRTS EEECCCCCCCCCCCC	35.08	29255136
1590	Phosphorylation	SRPASLDSGRTSTSN CCCCCCCCCCCCCCC	35.15	23927012
1593	Phosphorylation	ASLDSGRTSTSNSNN CCCCCCCCCCCCCCC	39.62	29978859
1594	Phosphorylation	SLDSGRTSTSNSNNN CCCCCCCCCCCCCCC	28.60	25159151
1595	Phosphorylation	LDSGRTSTSNSNNNA CCCCCCCCCCCCCCC	31.17	29978859
1596	Phosphorylation	DSGRTSTSNSNNNAS CCCCCCCCCCCCCCC	37.72	29978859
1598	Phosphorylation	GRTSTSNSNNNASLH CCCCCCCCCCCCCCE	40.48	29978859
1602 (in isoform 3)	Phosphorylation	-	18.65	27251275
1603	Phosphorylation	SNSNNNASLHEVKAG CCCCCCCCCEEEHHC	32.17	29507054
1622	Phosphorylation	QSRPQSHSSGEFSLL CCCCCCCCCCCCEEE	45.33	28348404
1623	Phosphorylation	SRPQSHSSGEFSLLH CCCCCCCCCCCEEEE	36.60	28348404
1627	Phosphorylation	SHSSGEFSLLHDHEA CCCCCCCEEEECHHH	26.22	28348404
1645 (in isoform 2)	Phosphorylation	-	18.21	-
1647 (in isoform 2)	Phosphorylation	-	37.21	-
1650	Phosphorylation	IQYLKRQTRSSPVLQ HHHHHHHCCCCHHHH	36.23	23403867
1650 (in isoform 2)	Phosphorylation	-	36.23	-
1651 (in isoform 3)	Phosphorylation	-	27.14	27251275
1652	Phosphorylation	YLKRQTRSSPVLQHK HHHHHCCCCHHHHHH	42.24	30266825
1652 (in isoform 3)	Phosphorylation	-	42.24	24719451
1653	Phosphorylation	LKRQTRSSPVLQHKI HHHHCCCCHHHHHHH	18.75	30266825
1660 (in isoform 3)	Phosphorylation	-	4.17	27251275
1661	Phosphorylation	PVLQHKISETLESRH HHHHHHHHHHHHHHC	29.36	27732954
1663	Phosphorylation	LQHKISETLESRHHK HHHHHHHHHHHHCCC	29.09	30177828
1666	Phosphorylation	KISETLESRHHKIKT HHHHHHHHHCCCCCC	39.77	30177828
1673	Phosphorylation	SRHHKIKTGSPGSEV HHCCCCCCCCCCCCE	46.49	25159151
1674 (in isoform 2)	Phosphorylation	-	27.17	-
1674 (in isoform 3)	Phosphorylation	-	27.17	24719451
1675	Phosphorylation	HHKIKTGSPGSEVVT CCCCCCCCCCCCEEE	31.18	25159151
1678	Phosphorylation	IKTGSPGSEVVTLQQ CCCCCCCCCEEEHHH	30.51	25159151
1682	Phosphorylation	SPGSEVVTLQQFLEE CCCCCEEEHHHHHHH	24.83	28176443
1689 (in isoform 2)	Phosphorylation	-	62.85	-
1690	Phosphorylation	LQQFLEESNKLTSVQ HHHHHHHCCCCCCEE	29.86	20068231
1694	Phosphorylation	LEESNKLTSVQIKSS HHHCCCCCCEEECCC	28.58	26074081
1695	Phosphorylation	EESNKLTSVQIKSSS HHCCCCCCEEECCCC	23.59	26074081
1700	Phosphorylation	LTSVQIKSSSQENLL CCCEEECCCCCHHHH	36.53	23401153
1701	Phosphorylation	TSVQIKSSSQENLLD CCEEECCCCCHHHHH	30.91	29255136
1701 (in isoform 3)	Phosphorylation	-	30.91	24719451
1702	Phosphorylation	SVQIKSSSQENLLDE CEEECCCCCHHHHHH	48.91	19664994
1713	Phosphorylation	LLDEVMKSLSVSSDF HHHHHHHHCCCCHHH	14.05	30266825
1715	Phosphorylation	DEVMKSLSVSSDFLG HHHHHHCCCCHHHCC	27.35	30266825
1716 (in isoform 3)	Phosphorylation	-	8.45	24719451
1717	Phosphorylation	VMKSLSVSSDFLGKD HHHHCCCCHHHCCCC	22.33	19664994
1718	Phosphorylation	MKSLSVSSDFLGKDK HHHCCCCHHHCCCCC	30.17	30266825
1727 (in isoform 5)	Phosphorylation	-	10.22	27732954
1728	Phosphorylation	LGKDKPVSCGLARSV CCCCCCCCCCCCCCC	15.82	26074081
1732 (in isoform 5)	Phosphorylation	-	6.23	27732954
1733 (in isoform 3)	Phosphorylation	-	42.51	27251275
1734	Phosphorylation	VSCGLARSVSGKTPG CCCCCCCCCCCCCCC	18.28	21945579
1735 (in isoform 3)	Phosphorylation	-	7.93	24719451
1736	Phosphorylation	CGLARSVSGKTPGDF CCCCCCCCCCCCCCC	35.50	21945579
1737 (in isoform 2)	Phosphorylation	-	35.38	-
1738	Acetylation	LARSVSGKTPGDFYD CCCCCCCCCCCCCCC	44.00	25953088
1739	Phosphorylation	ARSVSGKTPGDFYDR CCCCCCCCCCCCCCC	35.71	21945579
1744	Phosphorylation	GKTPGDFYDRRTTKP CCCCCCCCCCCCCCC	17.18	21945579
1745 (in isoform 5)	Phosphorylation	-	33.31	27107777
1761	Phosphorylation	LRPGPRKTEDTYFIS CCCCCCCCCCCEEEC	40.13	21945579
1764	Phosphorylation	GPRKTEDTYFISSAG CCCCCCCCEEECCCC	17.69	21945579
1765	Phosphorylation	PRKTEDTYFISSAGK CCCCCCCEEECCCCC	15.96	21945579
1768	Phosphorylation	TEDTYFISSAGKPTP CCCCEEECCCCCCCC	12.30	21945579
1769	Phosphorylation	EDTYFISSAGKPTPG CCCEEECCCCCCCCC	35.90	21945579
1773 (in isoform 2)	Phosphorylation	-	42.80	-
1774	Phosphorylation	ISSAGKPTPGTQGKI ECCCCCCCCCCCCCE	37.52	22210691
1777	Phosphorylation	AGKPTPGTQGKIKLV CCCCCCCCCCCEEEE	35.04	21945579
1786 (in isoform 3)	Phosphorylation	-	37.77	24719451
1787	Phosphorylation	KIKLVKESSLSRQSK CEEEEEHHHHCCCCC	30.75	29514088
1788	Phosphorylation	IKLVKESSLSRQSKD EEEEEHHHHCCCCCC	31.30	29514088
1790	Phosphorylation	LVKESSLSRQSKDSN EEEHHHHCCCCCCCC	30.16	23312004
1791 (in isoform 2)	Phosphorylation	-	50.51	-
1792 (in isoform 2)	Phosphorylation	-	52.00	-
1794	Methylation	SSLSRQSKDSNPYAT HHHCCCCCCCCCCCC	57.76	-
1796	Phosphorylation	LSRQSKDSNPYATLP HCCCCCCCCCCCCCC	43.36	21945579
1799	Phosphorylation	QSKDSNPYATLPRAS CCCCCCCCCCCCCCH	19.23	21945579
1800 (in isoform 3)	Phosphorylation	-	12.15	24719451
1801	Phosphorylation	KDSNPYATLPRASSV CCCCCCCCCCCCHHH	31.30	21945579
1806	Phosphorylation	YATLPRASSVISTAE CCCCCCCHHHHHCCC	26.81	20873877
1806 (in isoform 3)	Phosphorylation	-	26.81	24719451
1807	Phosphorylation	ATLPRASSVISTAEG CCCCCCHHHHHCCCC	23.61	20873877
1809 (in isoform 2)	Phosphorylation	-	3.06	-
1810	Phosphorylation	PRASSVISTAEGTTR CCCHHHHHCCCCCCC	21.29	20873877
1811	Phosphorylation	RASSVISTAEGTTRR CCHHHHHCCCCCCCC	20.01	20873877
1818 (in isoform 3)	Phosphorylation	-	30.63	24719451
1819	O-linked_Glycosylation	AEGTTRRTSIHDFLT CCCCCCCCCHHHHCC	28.83	30379171
1819	Phosphorylation	AEGTTRRTSIHDFLT CCCCCCCCCHHHHCC	28.83	23401153
1819 (in isoform 3)	Phosphorylation	-	28.83	27251275
1820	Phosphorylation	EGTTRRTSIHDFLTK CCCCCCCCHHHHCCC	19.00	29255136
1826	Phosphorylation	TSIHDFLTKDSRLPI CCHHHHCCCCCCCCC	32.57	29255136
1834	Phosphorylation	KDSRLPISVDSPPAA CCCCCCCCCCCCCCC	20.24	21815630
1837	Phosphorylation	RLPISVDSPPAAADS CCCCCCCCCCCCCCC	30.54	25159151
1844	Phosphorylation	SPPAAADSNTTAASN CCCCCCCCCCCCCCC	31.20	25332170
1847	Phosphorylation	AAADSNTTAASNVDK CCCCCCCCCCCCHHH	25.20	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
233	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
233	S	Phosphorylation	Kinase	ERK2	P63085	PSP
237	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
237	S	Phosphorylation	Kinase	ERK2	P63085	PSP
1417	S	Phosphorylation	Kinase	AKT1	P31749	Uniprot
1675	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
1690	S	Phosphorylation	Kinase	PKCT	Q04759	PSP
1765	Y	Phosphorylation	Kinase	EGFR	P00533	PSP
1765	Y	Phosphorylation	Kinase	SRC	P12931	PSP
1799	Y	Phosphorylation	Kinase	EGFR	P00533	PSP
1799	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
1417	S	Phosphorylation	16139227
Tyrosine phosphorylation is required for AKT1-dependent phosphorylation of Ser-1417.
1690	S	Phosphorylation	23509302
Phosphorylation at Ser-1690 by PRKCQ disrupts interaction with GNAI3 and inhibits guanine nucleotide exchange factor activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GRDN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRDN_HUMAN	CCDC88A	physical	16139227
AKT1_HUMAN	AKT1	physical	15753085
GNAI3_HUMAN	GNAI3	physical	21209316
ANXA1_HUMAN	ANXA1	physical	26496610
ANXA7_HUMAN	ANXA7	physical	26496610
CAPG_HUMAN	CAPG	physical	26496610
CETN2_HUMAN	CETN2	physical	26496610
TPP1_HUMAN	TPP1	physical	26496610
NSF_HUMAN	NSF	physical	26496610
PDE3A_HUMAN	PDE3A	physical	26496610
KPYM_HUMAN	PKM	physical	26496610
RPB11_HUMAN	POLR2J	physical	26496610
RAN_HUMAN	RAN	physical	26496610
RBM4_HUMAN	RBM4	physical	26496610
RCN1_HUMAN	RCN1	physical	26496610
1433E_HUMAN	YWHAE	physical	26496610
BAG6_HUMAN	BAG6	physical	26496610
HDAC3_HUMAN	HDAC3	physical	26496610
FUBP3_HUMAN	FUBP3	physical	26496610
CELF1_HUMAN	CELF1	physical	26496610
NEST_HUMAN	NES	physical	26496610
SRSF8_HUMAN	SRSF8	physical	26496610
GANAB_HUMAN	GANAB	physical	26496610
IWS1_HUMAN	IWS1	physical	26496610
RBM26_HUMAN	RBM26	physical	26496610
DLRB1_HUMAN	DYNLRB1	physical	26496610
EME1_HUMAN	EME1	physical	26496610
SNX1_HUMAN	SNX1	physical	15882442
EGFR_HUMAN	EGFR	physical	15882442
PLEC_HUMAN	PLEC	physical	27173435
AAK1_HUMAN	AAK1	physical	27173435
SC24B_HUMAN	SEC24B	physical	27173435
VIP2_HUMAN	PPIP5K2	physical	27173435
UB2D2_HUMAN	UBE2D2	physical	27173435
DVL3_HUMAN	DVL3	physical	27173435
LUZP1_HUMAN	LUZP1	physical	27173435
URGCP_HUMAN	URGCP	physical	27173435
QSER1_HUMAN	QSER1	physical	27173435
NUP88_HUMAN	NUP88	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GRDN_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1387; THR-1673 ANDSER-1837, AND MASS SPECTROMETRY.	18669648 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1387, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Akt/PKB regulates actin organization and cell motility viaGirdin/APE."; Enomoto A., Murakami H., Asai N., Morone N., Watanabe T., Kawai K.,Murakumo Y., Usukura J., Kaibuchi K., Takahashi M.; Dev. Cell 9:389-402(2005). Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, INTERACTION WITHAKT1, INTERACTION WITH PHOSPHOINOSITIDES, HOMOOLIGOMERIZATION,SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION AT SER-1417BY AKT1, AND MUTAGENESIS OF SER-1417.	16139227 [Abstract]

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