URGCP_HUMAN - dbPTM
URGCP_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID URGCP_HUMAN
UniProt AC Q8TCY9
Protein Name Up-regulator of cell proliferation
Gene Name URGCP
Organism Homo sapiens (Human).
Sequence Length 931
Subcellular Localization Cytoplasm . Nucleus . In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei.
Protein Description May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer..
Protein Sequence MASPGIEVELLGKGHSDLGEVAPEIKASERRTAVAIADLEWREMEGDDCEFRYGDGTNEAQDNDFPTVERSRLQEMLSLLGLETYQVQKLSLQDSLQISFDSMKNWAPQVPKDLPWNFLRKLQALNADARNTTMVLDVLPDARPVEKESQMEEEIIYWDPADDLAADIYSFSELPTPDTPVNPLDLLCALLLSSDSFLQQEIALKMALCQFALPLVLPDSENHYHTFLLWAMRGIVRTWWSQPPRGMGSFREDSVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSPGHRQWDCFWHRDLNLGTNAREISDGLVEISWFFPSGREDLDIFPEPVAFLNLRGDIGSHWLQFKLLTEISSAVFILTDNISKKEYKLLYSMKESTTKYYFILSPYRGKRNTNLRFLNKLIPVLKIDHSHVLVKVSSTDSDSFVKRIRAIVGNVLRAPCRRVSVEDMAHAARKLGLKVDEDCEECQKAKDRMERITRKIKDSDAYRRDELRLQGDPWRKAAQVEKEFCQLQWAVDPPEKHRAELRRRLLELRMQQNGHDPSSGVQEFISGISSPSLSEKQYFLRWMEWGLARVAQPRLRQPPETLLTLRPKHGGTTDVGEPLWPEPLGVEHFLREMGQFYEAESCLVEAGRLPAGQRRFAHFPGLASELLLTGLPLELIDGSTLSMPVRWVTGLLKELHVRLERRSRLVVLSTVGVPGTGKSTLLNTMFGLRFATGKSCGPRGAFMQLITVAEGFSQDLGCDHILVIDSGGLIGGALTSAGDRFELEASLATLLMGLSNVTVISLAETKDIPAAILHAFLRLEKTGHMPNYQFVYQNLHDVSVPGPRPRDKRQLLDPPGDLSRAAAQMEKQGDGFRALAGLAFCDPEKQHIWHIPGLWHGAPPMAAVSLAYSEAIFELKRCLLENIRNGLSNQNKNIQQLIELVRRL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MASPGIEVEL
-----CCCCCEEEEE		23.5129255136
3 (in isoform 3)Phosphorylation-23.5125159151
53PhosphorylationGDDCEFRYGDGTNEA
CCCCEEECCCCCCCC		25.5329978859
57PhosphorylationEFRYGDGTNEAQDND
EEECCCCCCCCCCCC		34.3329978859
78PhosphorylationSRLQEMLSLLGLETY
HHHHHHHHHHCCCCE		21.9025627689
121UbiquitinationLPWNFLRKLQALNAD
CCHHHHHHHHHHCCC		47.28-
200 (in isoform 3)Ubiquitination-46.3321906983
220PhosphorylationLPLVLPDSENHYHTF
HCEECCCCCCHHHHH		38.0629759185
238PhosphorylationAMRGIVRTWWSQPPR
HHHHHHHHHHCCCCC		22.0129083192
241PhosphorylationGIVRTWWSQPPRGMG
HHHHHHHCCCCCCCC		25.1129083192
266 (in isoform 2)Ubiquitination-4.4321906983
275UbiquitinationMDVSSNSKSQLLNAV
EECCCCCHHHHHHHH		46.6121906983
275 (in isoform 1)Ubiquitination-46.6121906983
302PhosphorylationHRDLNLGTNAREISD
CCCCCCCCCCEEECC		28.9522985185
354 (in isoform 3)Ubiquitination-3.1221906983
371MethylationNISKKEYKLLYSMKE
CCCHHHHHHHHCCCC		32.8623644510
377UbiquitinationYKLLYSMKESTTKYY
HHHHHCCCCCCCEEE		42.44-
383PhosphorylationMKESTTKYYFILSPY
CCCCCCEEEEEECCC		11.08-
384PhosphorylationKESTTKYYFILSPYR
CCCCCEEEEEECCCC		5.9118083107
390PhosphorylationYYFILSPYRGKRNTN
EEEEECCCCCCCCCC		28.7318083107
403UbiquitinationTNLRFLNKLIPVLKI
CCHHHHHHHHEEEEE		50.36-
420 (in isoform 2)Ubiquitination-23.0821906983
429UbiquitinationTDSDSFVKRIRAIVG
CCCHHHHHHHHHHHH		39.8521906983
429 (in isoform 1)Ubiquitination-39.8521906983
447PhosphorylationRAPCRRVSVEDMAHA
HCCCCCCCHHHHHHH		20.2728985074
457UbiquitinationDMAHAARKLGLKVDE
HHHHHHHHHCCCCCC		42.03-
461UbiquitinationAARKLGLKVDEDCEE
HHHHHCCCCCCCHHH		45.93-
484UbiquitinationERITRKIKDSDAYRR
HHHHHHHCCCCCHHH		54.97-
503UbiquitinationLQGDPWRKAAQVEKE
HCCCHHHHHHHHHHH		44.18-
509UbiquitinationRKAAQVEKEFCQLQW
HHHHHHHHHHHHCHH		58.18-
563UbiquitinationSSPSLSEKQYFLRWM
CCCCCCHHHHHHHHH		47.09-
591PhosphorylationQPPETLLTLRPKHGG
CCCCEEEECCCCCCC		24.67-
680UbiquitinationRWVTGLLKELHVRLE
HHHHHHHHHHHHHHH		64.37-
690PhosphorylationHVRLERRSRLVVLST
HHHHHHHCCEEEEEE		35.8721712546
696PhosphorylationRSRLVVLSTVGVPGT
HCCEEEEEEECCCCC		14.9421712546
711PhosphorylationGKSTLLNTMFGLRFA
CHHHHHHHHCCCHHC		17.5321712546
721UbiquitinationGLRFATGKSCGPRGA
CCHHCCCCCCCCHHH		37.91-
779 (in isoform 3)Ubiquitination-5.9621906983
788PhosphorylationLSNVTVISLAETKDI
CCCCEEEEHHHCCCC		19.7215302935
792PhosphorylationTVISLAETKDIPAAI
EEEEHHHCCCCCHHH		28.5415302935
845 (in isoform 2)Ubiquitination-4.6521906983
854 (in isoform 1)Ubiquitination-54.9921906983
854UbiquitinationRAAAQMEKQGDGFRA
HHHHHHHHCCCHHHH		54.992190698
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of URGCP_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of URGCP_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of URGCP_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VIME_HUMANVIMphysical
22939629
VIP2_HUMANPPIP5K2physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of URGCP_HUMAN

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Related Literatures of Post-Translational Modification

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