WDR26_HUMAN - dbPTM
WDR26_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WDR26_HUMAN
UniProt AC Q9H7D7
Protein Name WD repeat-containing protein 26
Gene Name WDR26
Organism Homo sapiens (Human).
Sequence Length 661
Subcellular Localization Cytoplasm . Mitochondrion .
Protein Description G-beta-like protein involved in cell signal transduction. [PubMed: 15378603]
Protein Sequence MQANGAGGGGGGGGGGGGGGGGGGGQGQTPELACLSAQNGESSPSSSSSAGDLAHANGLLPSAPSAASNNSNSLNVNNGVPGGAAAASSATVAAASATTAASSSLATPELGSSLKKKKRLSQSDEDVIRLIGQHLNGLGLNQTVDLLMQESGCRLEHPSATKFRNHVMEGDWDKAENDLNELKPLVHSPHAIVVRGALEISQTLLGIIVRMKFLLLQQKYLEYLEDGKVLEALQVLRCELTPLKYNTERIHVLSGYLMCSHAEDLRAKAEWEGKGTASRSKLLDKLQTYLPPSVMLPPRRLQTLLRQAVELQRDRCLYHNTKLDNNLDSVSLLIDHVCSRRQFPCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGPAPFIDHQNIEEECSSMDS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Ubiquitination------MQANGAGGG
------CCCCCCCCC		43.4621890473
34UbiquitinationGQTPELACLSAQNGE
CCCCCEEEEECCCCC		4.8823000965
112UbiquitinationLATPELGSSLKKKKR
CCCHHHHHHHHHCHH		45.1627667366
121PhosphorylationLKKKKRLSQSDEDVI
HHHCHHCCCCHHHHH		31.5029255136
121 (in isoform 2)Phosphorylation-31.50-
123PhosphorylationKKKRLSQSDEDVIRL
HCHHCCCCHHHHHHH		39.3229255136
123 (in isoform 2)Phosphorylation-39.32-
159UbiquitinationGCRLEHPSATKFRNH
CCCCCCCCHHHHHCH		50.9427667366
162UbiquitinationLEHPSATKFRNHVME
CCCCCHHHHHCHHHC		41.8833845483
174UbiquitinationVMEGDWDKAENDLNE
HHCCCHHHHHCCHHH		54.0329967540
183UbiquitinationENDLNELKPLVHSPH
HCCHHHHHHCCCCCC		30.0829967540
188PhosphorylationELKPLVHSPHAIVVR
HHHHCCCCCCEEEEE		15.7628555341
188 (in isoform 2)Phosphorylation-15.7625159151
196UbiquitinationPHAIVVRGALEISQT
CCEEEEECHHHHHHH		23.9321890473
201PhosphorylationVRGALEISQTLLGII
EECHHHHHHHHHHHH		14.0327251275
207 (in isoform 2)Phosphorylation-2.38-
212UbiquitinationLGIIVRMKFLLLQQK
HHHHHHHHHHHHHHH		23.4621890473
212 (in isoform 1)Ubiquitination-23.4621890473
220PhosphorylationFLLLQQKYLEYLEDG
HHHHHHHHHHHHCCC		10.6323917254
221PhosphorylationLLLQQKYLEYLEDGK
HHHHHHHHHHHCCCC		4.4932645325
223PhosphorylationLQQKYLEYLEDGKVL
HHHHHHHHHCCCCHH		16.8820068231
228UbiquitinationLEYLEDGKVLEALQV
HHHHCCCCHHHHHHH		56.8423000965
244UbiquitinationRCELTPLKYNTERIH
HCCCCCCCCCHHHEE		37.3423000965
258UbiquitinationHVLSGYLMCSHAEDL
EEHHHHEECCCHHHH		1.3332015554
262UbiquitinationGYLMCSHAEDLRAKA
HHEECCCHHHHHHHH		8.8433845483
274UbiquitinationAKAEWEGKGTASRSK
HHHHHCCCCHHHHHH		41.3932015554
279UbiquitinationEGKGTASRSKLLDKL
CCCCHHHHHHHHHHH		35.0321890473
303PhosphorylationLPPRRLQTLLRQAVE
CCHHHHHHHHHHHHH		32.14-
326UbiquitinationHNTKLDNNLDSVSLL
CCCCCCCCCHHHHHH		44.9121890473
344UbiquitinationVCSRRQFPCYTQQIL
HHHHCCCCCCHHHHH		11.2333845483
353UbiquitinationYTQQILTEHCNEVWF
CHHHHHHHCCCEEEE		42.8932015554
353 (in isoform 2)Ubiquitination-42.8921890473
368UbiquitinationCKFSNDGTKLATGSK
EEECCCCCEECCCCC		26.2527667366
369UbiquitinationKFSNDGTKLATGSKD
EECCCCCEECCCCCC		41.4721906983
369 (in isoform 1)Ubiquitination-41.4721890473
374UbiquitinationGTKLATGSKDTTVII
CCEECCCCCCCEEEE		24.0132015554
443UbiquitinationELRTKMSQSHEDSLT
CCCCCCCCCCCCCCC		45.3630230243
459UbiquitinationVAWNPDGKRFVTGGQ
EEECCCCCCCCCCCC		50.4730230243
469UbiquitinationVTGGQRGQFYQCDLD
CCCCCCCEEEEECCC		35.7432015554
498UbiquitinationLWCLSDGKTVLASDT
EEEECCCCEEEEECC		40.21-
520UbiquitinationNFEDLTDRNIVQEDH
CHHHCCCCCCCCCCC		29.5521890473
520 (in isoform 2)Ubiquitination-29.5521890473
520MethylationNFEDLTDRNIVQEDH
CHHHCCCCCCCCCCC		29.55115919929
535UbiquitinationPIMSFTISKNGRLAL
CEEEEEECCCCEEEE		19.6021890473
536UbiquitinationIMSFTISKNGRLALL
EEEEEECCCCEEEEE		60.6221890473
536 (in isoform 1)Ubiquitination-60.6221890473
559UbiquitinationLWDLQDRVLVRKYQG
EHHCCCCEEEHHCCC		8.5730230243
613PhosphorylationIAELTGHTRTVNCVS
HHHHCCCCEEEECEE		29.40-
620PhosphorylationTRTVNCVSWNPQIPS
CEEEECEECCCCCCC		24.2825307156
637PhosphorylationASASDDGTVRIWGPA
EECCCCCCEEEEEEC		17.3825307156
657PhosphorylationQNIEEECSSMDS---
CCHHHHHHCCCC---		31.7926471730
658PhosphorylationNIEEECSSMDS----
CHHHHHHCCCC----		37.9626471730
661PhosphorylationEECSSMDS-------
HHHHCCCC-------		33.2222617229
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WDR26_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WDR26_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WDR26_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
WDR5_HUMANWDR5physical
17041588
GBB1_HUMANGNB1physical
22065575
GBG2_HUMANGNG2physical
22065575
ZN131_HUMANZNF131physical
22939629
ZN687_HUMANZNF687physical
22939629
GID8_HUMANGID8physical
22863883
PNO1_HUMANPNO1physical
22863883
RANB9_HUMANRANBP9physical
22863883
RS15A_HUMANRPS15Aphysical
22863883
RS24_HUMANRPS24physical
22863883
RS26_HUMANRPS26physical
22863883
RS6_HUMANRPS6physical
22863883
RS7_HUMANRPS7physical
22863883
RS8_HUMANRPS8physical
22863883
TSR1_HUMANTSR1physical
22863883
PLCB2_HUMANPLCB2physical
23625927
GBB1_HUMANGNB1physical
23625927
PLCB2_RATPlcb2physical
23625927
AXIN1_HUMANAXIN1physical
27098453
RBP10_HUMANRANBP10physical
27173435
ARMC8_HUMANARMC8physical
27173435
GBB1_HUMANGNB1physical
26895380
PK3CB_HUMANPIK3CBphysical
26895380
AKT2_HUMANAKT2physical
26895380
P85A_HUMANPIK3R1physical
26895380
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WDR26_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121, AND MASSSPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121, AND MASSSPECTROMETRY.

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