RS26_HUMAN - dbPTM
RS26_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RS26_HUMAN
UniProt AC P62854
Protein Name 40S ribosomal protein S26
Gene Name RPS26
Organism Homo sapiens (Human).
Sequence Length 115
Subcellular Localization Cytoplasm, cytosol . Cytoplasm . Rough endoplasmic reticulum . Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein Description
Protein Sequence MTKKRRNNGRAKKGRGHVQPIRCTNCARCVPKDKAIKKFVIRNIVEAAAVRDISEASVFDAYVLPKLYVKLHYCVSCAIHSKVVRNRSREARKDRTPPPRFRPAGAAPRPPPKPM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
15MethylationNGRAKKGRGHVQPIR
CCCCCCCCCCCCCCC		40.71115492613
54PhosphorylationAAAVRDISEASVFDA
HHHCCCCHHHHCCCC		31.2520873877
57PhosphorylationVRDISEASVFDAYVL
CCCCHHHHCCCCHHH		21.1821712546
62PhosphorylationEASVFDAYVLPKLYV
HHHCCCCHHHHHHHH		12.3628152594
66AcetylationFDAYVLPKLYVKLHY
CCCHHHHHHHHHHHH		48.5723236377
66UbiquitinationFDAYVLPKLYVKLHY
CCCHHHHHHHHHHHH		48.5721890473
66MalonylationFDAYVLPKLYVKLHY
CCCHHHHHHHHHHHH		48.5726320211
662-HydroxyisobutyrylationFDAYVLPKLYVKLHY
CCCHHHHHHHHHHHH		48.57-
66SumoylationFDAYVLPKLYVKLHY
CCCHHHHHHHHHHHH		48.57-
70UbiquitinationVLPKLYVKLHYCVSC
HHHHHHHHHHHHHHH		18.91-
73PhosphorylationKLYVKLHYCVSCAIH
HHHHHHHHHHHHHHH		12.6527080861
74GlutathionylationLYVKLHYCVSCAIHS
HHHHHHHHHHHHHHH		0.9522555962
76PhosphorylationVKLHYCVSCAIHSKV
HHHHHHHHHHHHHHH		8.3527080861
81PhosphorylationCVSCAIHSKVVRNRS
HHHHHHHHHHHHCCC		22.4927080861
82UbiquitinationVSCAIHSKVVRNRSR
HHHHHHHHHHHCCCH		30.50-
82AcetylationVSCAIHSKVVRNRSR
HHHHHHHHHHHCCCH		30.5025953088
96PhosphorylationREARKDRTPPPRFRP
HHHHCCCCCCCCCCC		50.7330266825
113AcetylationAAPRPPPKPM-----
CCCCCCCCCC-----		60.5322649439
113MethylationAAPRPPPKPM-----
CCCCCCCCCC-----		60.5322649439
115SulfoxidationPRPPPKPM-------
CCCCCCCC-------		12.2328183972
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RS26_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RS26_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RS26_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TSR2_HUMANTSR2physical
16189514
A4_HUMANAPPphysical
21832049
RS3A_HUMANRPS3Aphysical
22939629
RS3_HUMANRPS3physical
22939629
RS4X_HUMANRPS4Xphysical
22939629
RS8_HUMANRPS8physical
22939629
RS6_HUMANRPS6physical
22939629
RS2_HUMANRPS2physical
22939629
RSSA_HUMANRPSAphysical
22939629
RS5_HUMANRPS5physical
22939629
RS27A_HUMANRPS27Aphysical
22939629
UBIM_HUMANFAUphysical
22939629
TM165_HUMANTMEM165physical
22939629
TXTP_HUMANSLC25A1physical
22939629
RT11_HUMANMRPS11physical
22939629
TSR2_HUMANTSR2physical
19060904
MDM2_HUMANMDM2physical
23728348
P53_HUMANTP53physical
23728348
DC1I2_HUMANDYNC1I2physical
22863883
EIF3A_HUMANEIF3Aphysical
22863883
EIFCL_HUMANEIF3CLphysical
22863883
EIF3K_HUMANEIF3Kphysical
22863883
PNO1_HUMANPNO1physical
22863883
RS10_HUMANRPS10physical
22863883
RS12_HUMANRPS12physical
22863883
RS14_HUMANRPS14physical
22863883
RS16_HUMANRPS16physical
22863883
RS19_HUMANRPS19physical
22863883
RS20_HUMANRPS20physical
22863883
RS23_HUMANRPS23physical
22863883
RS24_HUMANRPS24physical
22863883
RS25_HUMANRPS25physical
22863883
RS28_HUMANRPS28physical
22863883
RS2_HUMANRPS2physical
22863883
RS3_HUMANRPS3physical
22863883
RS5_HUMANRPS5physical
22863883
RS6_HUMANRPS6physical
22863883
SND1_HUMANSND1physical
22863883
TSR1_HUMANTSR1physical
22863883
PYM1_HUMANWIBGphysical
22863883
TSR2_HUMANTSR2physical
25416956
ARI4B_HUMANARID4Bphysical
26344197
RL10A_HUMANRPL10Aphysical
26344197
RL12_HUMANRPL12physical
26344197
RL15_HUMANRPL15physical
26344197
RL23A_HUMANRPL23Aphysical
26344197
RL37A_HUMANRPL37Aphysical
26344197
RL5_HUMANRPL5physical
26344197
RL7_HUMANRPL7physical
26344197
RL7A_HUMANRPL7Aphysical
26344197
RL9_HUMANRPL9physical
26344197
RS16_HUMANRPS16physical
26344197
RS17_HUMANRPS17physical
26344197
RS19_HUMANRPS19physical
26344197
RS25_HUMANRPS25physical
26344197
RS4X_HUMANRPS4Xphysical
26344197
RS6_HUMANRPS6physical
26344197
TMED2_HUMANTMED2physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
There are no disease associations of PTM sites.
OMIM Disease
613309Diamond-Blackfan anemia 10 (DBA10)
Kegg Drug
There are no disease associations of PTM sites.
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RS26_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-66 AND LYS-113, AND MASSSPECTROMETRY.
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-96, AND MASSSPECTROMETRY.

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