TSR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSR2_HUMAN
• UniProt AC: Q969E8
• Protein Name: Pre-rRNA-processing protein TSR2 homolog
• Gene Name: TSR2
• Organism: Homo sapiens (Human).
• Sequence Length: 191
• Protein Description: May be involved in 20S pre-rRNA processing..
• Protein Sequence: MAGAAEDARALFRAGVCAALEAWPALQIAVENGFGGVHSQEKAKWLGGAVEDYFMRNADLELDEVEDFLGELLTNEFDTVVEDGSLPQVSQQLQTMFHHFQRGDGAALREMASCITQRKCKVTATALKTARETDEDEDDVDSVEEMEVTATNDGAATDGVCPQPEPSDPDAQTIKEEDIVEDGWTIVRRKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Ubiquitination	VHSQEKAKWLGGAVE CCCHHHHHHHHHHHH	54.76	21890473
121	Ubiquitination	CITQRKCKVTATALK HHHHCCCHHHHHHHH	45.73	-
128	Ubiquitination	KVTATALKTARETDE HHHHHHHHHHHHCCC	37.36	-
128	Acetylation	KVTATALKTARETDE HHHHHHHHHHHHCCC	37.36	25953088
129	Phosphorylation	VTATALKTARETDED HHHHHHHHHHHCCCC	31.62	21406692
133	Phosphorylation	ALKTARETDEDEDDV HHHHHHHCCCCCCCC	38.85	21406692
142	Phosphorylation	EDEDDVDSVEEMEVT CCCCCCCCCEEEEEE	31.14	21406692
149	Phosphorylation	SVEEMEVTATNDGAA CCEEEEEEEECCCCC	17.92	21406692
151	Phosphorylation	EEMEVTATNDGAATD EEEEEEEECCCCCCC	25.20	21406692
157	Phosphorylation	ATNDGAATDGVCPQP EECCCCCCCCCCCCC	32.52	21406692
167	Phosphorylation	VCPQPEPSDPDAQTI CCCCCCCCCCCCCCC	61.18	21406692
173	Phosphorylation	PSDPDAQTIKEEDIV CCCCCCCCCCHHHHC	35.42	21406692
175	Sumoylation	DPDAQTIKEEDIVED CCCCCCCCHHHHCCC	59.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TSR2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TSR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZBTB9_HUMAN	ZBTB9	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 300946: Diamond-Blackfan anemia 14, with mandibulofacial dysostosis (DBA14)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.