TM165_HUMAN - dbPTM
TM165_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TM165_HUMAN
UniProt AC Q9HC07
Protein Name Transmembrane protein 165
Gene Name TMEM165
Organism Homo sapiens (Human).
Sequence Length 324
Subcellular Localization Golgi apparatus membrane
Multi-pass membrane protein . Golgi apparatus, trans-Golgi network membrane. Lysosome membrane. Early endosome membrane. Late endosome membrane.
Protein Description May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis. Therefore, it may play an indirect role in protein glycosylation..
Protein Sequence MAAAAPGNGRASAPRLLLLFLVPLLWAPAAVRAGPDEDLSHRNKEPPAPAQQLQPQPVAVQGPEPARVEKIFTPAAPVHTNKEDPATQTNLGFIHAFVAAISVIIVSELGDKTFFIAAIMAMRYNRLTVLAGAMLALGLMTCLSVLFGYATTVIPRVYTYYVSTVLFAIFGIRMLREGLKMSPDEGQEELEEVQAELKKKDEEFQRTKLLNGPGDVETGTSITVPQKKWLHFISPIFVQALTLTFLAEWGDRSQLTTIVLAAREDPYGVAVGGTVGHCLCTGLAVIGGRMIAQKISVRTVTIIGGIVFLAFAFSALFISPDSGF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
40O-linked_GlycosylationAGPDEDLSHRNKEPP
CCCCCCCCCCCCCCC		32.49OGP
73O-linked_GlycosylationARVEKIFTPAAPVHT
CCEEEEECCCCCCCC		18.5855833725
80O-linked_GlycosylationTPAAPVHTNKEDPAT
CCCCCCCCCCCCCCC		48.5055833731
117UbiquitinationGDKTFFIAAIMAMRY
CCHHHHHHHHHHHHH		5.93-
117UbiquitinationGDKTFFIAAIMAMRY
CCHHHHHHHHHHHHH		5.9321963094
128PhosphorylationAMRYNRLTVLAGAML
HHHHCHHHHHHHHHH		15.3824043423
135UbiquitinationTVLAGAMLALGLMTC
HHHHHHHHHHHHHHH		3.36-
135UbiquitinationTVLAGAMLALGLMTC
HHHHHHHHHHHHHHH		3.3622817900
136UbiquitinationVLAGAMLALGLMTCL
HHHHHHHHHHHHHHH		6.1122817900
137UbiquitinationLAGAMLALGLMTCLS
HHHHHHHHHHHHHHH		4.8222817900
141PhosphorylationMLALGLMTCLSVLFG
HHHHHHHHHHHHHHH		18.4824043423
144PhosphorylationLGLMTCLSVLFGYAT
HHHHHHHHHHHHHHH		20.9424043423
145UbiquitinationGLMTCLSVLFGYATT
HHHHHHHHHHHHHHH		3.1121890473
145UbiquitinationGLMTCLSVLFGYATT
HHHHHHHHHHHHHHH		3.11-
149PhosphorylationCLSVLFGYATTVIPR
HHHHHHHHHHHHCHH		8.0824043423
151PhosphorylationSVLFGYATTVIPRVY
HHHHHHHHHHCHHHH		17.0824043423
152PhosphorylationVLFGYATTVIPRVYT
HHHHHHHHHCHHHHH		14.3124043423
163PhosphorylationRVYTYYVSTVLFAIF
HHHHHHHHHHHHHHH		9.18-
164UbiquitinationVYTYYVSTVLFAIFG
HHHHHHHHHHHHHHH		15.9321890473
164UbiquitinationVYTYYVSTVLFAIFG
HHHHHHHHHHHHHHH		15.93-
165UbiquitinationYTYYVSTVLFAIFGI
HHHHHHHHHHHHHHH		3.0122817900
165UbiquitinationYTYYVSTVLFAIFGI
HHHHHHHHHHHHHHH		3.01-
180UbiquitinationRMLREGLKMSPDEGQ
HHHHHHCCCCCCCCH		48.4621906983
181SulfoxidationMLREGLKMSPDEGQE
HHHHHCCCCCCCCHH		9.3930846556
198UbiquitinationEEVQAELKKKDEEFQ
HHHHHHHHHCCHHHH		49.6421906983
199UbiquitinationEVQAELKKKDEEFQR
HHHHHHHHCCHHHHH		77.4322817900
200UbiquitinationVQAELKKKDEEFQRT
HHHHHHHCCHHHHHH		69.6422817900
207PhosphorylationKDEEFQRTKLLNGPG
CCHHHHHHHCCCCCC		18.43-
208UbiquitinationDEEFQRTKLLNGPGD
CHHHHHHHCCCCCCC		53.8421890473
208UbiquitinationDEEFQRTKLLNGPGD
CHHHHHHHCCCCCCC		53.8423000965
218PhosphorylationNGPGDVETGTSITVP
CCCCCCCCCCCCCCC		45.6828857561
220PhosphorylationPGDVETGTSITVPQK
CCCCCCCCCCCCCCC		25.1127251275
221PhosphorylationGDVETGTSITVPQKK
CCCCCCCCCCCCCCH		20.0125159151
223PhosphorylationVETGTSITVPQKKWL
CCCCCCCCCCCCHHH		26.3825627689
227UbiquitinationTSITVPQKKWLHFIS
CCCCCCCCHHHHHHH		39.5921890473
227UbiquitinationTSITVPQKKWLHFIS
CCCCCCCCHHHHHHH		39.5921906983
228UbiquitinationSITVPQKKWLHFISP
CCCCCCCHHHHHHHH		50.1422817900
231UbiquitinationVPQKKWLHFISPIFV
CCCCHHHHHHHHHHH		19.5121890473
231UbiquitinationVPQKKWLHFISPIFV
CCCCHHHHHHHHHHH		19.51-
253PhosphorylationLAEWGDRSQLTTIVL
HHHHCCHHHCCEEEE		33.99-
256PhosphorylationWGDRSQLTTIVLAAR
HCCHHHCCEEEEEEC		13.57-
267PhosphorylationLAAREDPYGVAVGGT
EEECCCCCCEECCCH		36.2327251275
274PhosphorylationYGVAVGGTVGHCLCT
CCEECCCHHHHHHHH		19.8627251275
281PhosphorylationTVGHCLCTGLAVIGG
HHHHHHHHCCCEECC		23.4527251275
294UbiquitinationGGRMIAQKISVRTVT
CCHHHHHCCCCEEEE		28.1122817900
294UbiquitinationGGRMIAQKISVRTVT
CCHHHHHCCCCEEEE		28.1121890473
296PhosphorylationRMIAQKISVRTVTII
HHHHHCCCCEEEEEE		16.7528787133
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TM165_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TM165_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TM165_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ARPC2_HUMANARPC2genetic
26472760
AT2C1_HUMANATP2C1genetic
26472760
UBE4B_HUMANUBE4Bgenetic
26472760
PPME1_HUMANPPME1genetic
26472760
WDR62_HUMANWDR62genetic
26472760
VPS35_HUMANVPS35genetic
26472760
PTAR1_HUMANPTAR1genetic
26472760
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614727Congenital disorder of glycosylation 2K (CDG2K)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TM165_HUMAN

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Related Literatures of Post-Translational Modification

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