dbPTM

WDR62_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WDR62_HUMAN
UniProt AC	O43379
Protein Name	WD repeat-containing protein 62
Gene Name	WDR62
Organism	Homo sapiens (Human).
Sequence Length	1518
Subcellular Localization	Nucleus . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Shows cell cycle-dependent localization. Accumulate
Protein Description	Required for cerebral cortical development. Plays a role in neuronal proliferation and migration. [PubMed: 20890278]
Protein Sequence	MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEVYPEFEDQRACLPSGSFLTCSSDNTIRFWNLDSSPDSHWQKNIFSNTLLKVVYVENDIQHLQDMSHFPDRGSENGTPMDVKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHLGPEITNCMKQHLLEIDHRQQQQHTNDKKRSGHPRQDTYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDPDPRCLLTNGKLPLWAKRLLGDDDVADGLAFHAKRSYQPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQSLASLLSESESPQEAGRGHPSFLPQQKESSEASELILYSLEAEVTVTGTDSQYCRKEVEAGPGDQQGDSYLRVSSDSPKDQSPPEDSGESEADLECSFAAIHSPAPPPDPAPRFATSLPHFPGCAGPTEDELSLPEGPSVPSSSLPQTPEQEKFLRHHFETLTESPCRALGDVEASEAEDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKSPEVKLMDRGGSQPRAGTGYASPDRTHVLAAGKAEETLEAWRPPPPCLTSLASCVPASSVLPTDRNLPTPTSAPTPGLAQGVHAPSTCSYMEATASSRARISRSISLGDSEGPIVATLAQPLRRPSSVGELASLGQELQAITTATTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQPPVDTQPGVTVPAVSFPAPSPVEESALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGGTASLLEPTSGALGLLQGSPARWSEPWVPVEALPPSPLELSRVGNILHRLQTTFQEALDLYRVLVSSGQVDTGQQQARTELVSTFLWIHSQLEAECLVGTSVAPAQALPSPGPPSPPTLYPLASPDLQALLEHYSELLVQAVRRKARGH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAVGSGGY ------CCCCCCCCC	23.35	22814378
6	Phosphorylation	--MAAVGSGGYARND --CCCCCCCCCCCCC	23.57	19691289
6 (in isoform 4)	Phosphorylation	-	23.57	-
9	Phosphorylation	AAVGSGGYARNDAGE CCCCCCCCCCCCHHC	13.10	22199227
9 (in isoform 4)	Phosphorylation	-	13.10	27642862
20	Phosphorylation	DAGEKLPSVMAGVPA CHHCCCCCCCCCCCC	34.65	28555341
32	Phosphorylation	VPARRGQSSPPPAPP CCCCCCCCCCCCCCC	47.86	22167270
33	Phosphorylation	PARRGQSSPPPAPPI CCCCCCCCCCCCCCC	33.27	19664994
33 (in isoform 4)	Phosphorylation	-	33.27	24719451
46	Phosphorylation	PICLRRRTRLSTASE CCCCCCCCCCCCCCH	33.86	28176443
46 (in isoform 4)	Phosphorylation	-	33.86	-
49	Phosphorylation	LRRRTRLSTASEETV CCCCCCCCCCCHHHH	20.73	29255136
49 (in isoform 4)	Phosphorylation	-	20.73	24719451
50	Phosphorylation	RRRTRLSTASEETVQ CCCCCCCCCCHHHHH	38.50	27273156
50 (in isoform 4)	Phosphorylation	-	38.50	-
52	Phosphorylation	RTRLSTASEETVQNR CCCCCCCCHHHHHHC	35.73	29255136
52 (in isoform 4)	Phosphorylation	-	35.73	24719451
55	Phosphorylation	LSTASEETVQNRVSL CCCCCHHHHHHCCCH	24.28	29255136
69	Phosphorylation	LEKVLGITAQNSSGL HHHHHCCEEECCCCC	22.01	28985074
87	Phosphorylation	PGTGHVAYLAGCVVV CCCCCHHEEECEEEE	8.94	28985074
102	Ubiquitination	ILDPKENKQQHIFNT EECCCCCHHHHHHHH	53.04	29967540
102 (in isoform 4)	Ubiquitination	-	53.04	-
112	Ubiquitination	HIFNTARKSLSALAF HHHHHHHHHHHHHEE	53.97	29967540
112 (in isoform 4)	Ubiquitination	-	53.97	-
113	Phosphorylation	IFNTARKSLSALAFS HHHHHHHHHHHHEEC	23.23	-
120	Phosphorylation	SLSALAFSPDGKYIV HHHHHEECCCCCEEE	19.24	-
138	Ubiquitination	NGHRPAVRIWDVEEK CCCCCCEEEEEHHHH	26.79	27667366
145	Ubiquitination	RIWDVEEKNQVAEML EEEEHHHHHHHHHHH	38.89	29967540
145 (in isoform 4)	Ubiquitination	-	38.89	-
156	Phosphorylation	AEMLGHKYGVACVAF HHHHCCCCCEEEEEE	15.91	20068231
156 (in isoform 4)	Phosphorylation	-	15.91	-
164	Phosphorylation	GVACVAFSPNMKHIV CEEEEEECCCHHHHH	12.96	20068231
164 (in isoform 4)	Phosphorylation	-	12.96	-
187	Ubiquitination	VLNVWDWKKDIVVAS EEEEEECCCCEEEEC	37.79	27667366
205	Phosphorylation	SCRVIALSFSEDSSY EEEEEEEECCCCCCE	20.08	26074081
207	Phosphorylation	RVIALSFSEDSSYFV EEEEEECCCCCCEEE	36.80	26074081
210	Phosphorylation	ALSFSEDSSYFVTVG EEECCCCCCEEEEEC	23.92	26074081
211	Phosphorylation	LSFSEDSSYFVTVGN EECCCCCCEEEEECC	34.61	26074081
212	Phosphorylation	SFSEDSSYFVTVGNR ECCCCCCEEEEECCC	13.16	26074081
215	Phosphorylation	EDSSYFVTVGNRHVR CCCCEEEEECCCEEE	16.88	26074081
229	Phosphorylation	RFWFLEVSTETKVTS EEEEEEEECCCEEEE	15.91	26074081
230	Phosphorylation	FWFLEVSTETKVTST EEEEEEECCCEEEEC	53.50	26074081
232	Phosphorylation	FLEVSTETKVTSTVP EEEEECCCEEEECCE	30.79	26074081
325	Ubiquitination	RIFQAHSLHYLANLP HHHHHHCHHHHHCCC	1.90	27667366
444	Phosphorylation	IRFWNLDSSPDSHWQ EEEEECCCCCCCHHH	47.11	25627689
445	Phosphorylation	RFWNLDSSPDSHWQK EEEECCCCCCCHHHH	32.18	25159151
452	Ubiquitination	SPDSHWQKNIFSNTL CCCCHHHHCCCCCCE	46.98	-
452 (in isoform 4)	Ubiquitination	-	46.98	-
492	Ubiquitination	NGTPMDVKAGVRVMQ CCCCCCHHCCEEEEE	34.85	29967540
492 (in isoform 4)	Ubiquitination	-	34.85	-
501	Phosphorylation	GVRVMQVSPDGQHLA CEEEEEECCCCCCCC	10.61	25159151
501 (in isoform 4)	Phosphorylation	-	10.61	24719451
509	Phosphorylation	PDGQHLASGDRSGNL CCCCCCCCCCCCCCE	47.81	23186163
513	Phosphorylation	HLASGDRSGNLRIHE CCCCCCCCCCEEEEE	36.45	22817900
544	Ubiquitination	VLCLEYSKPETGLTL EEEEECCCCCCCCEE	46.07	27667366
568	Ubiquitination	IHVLNVEKNYNLEQT EEEEEECCCCCHHHH	61.52	29967540
581	Phosphorylation	QTLDDHSSSITAIKF HHHCCCHHCEEEEEE	23.49	26437602
582	Phosphorylation	TLDDHSSSITAIKFA HHCCCHHCEEEEEEC	27.29	28555341
587	Ubiquitination	SSSITAIKFAGNRDI HHCEEEEEECCCCCE	27.05	29967540
587 (in isoform 4)	Ubiquitination	-	27.05	-
598	Phosphorylation	NRDIQMISCGADKSI CCCEEEEEECCCCEE	10.93	20860994
603	Ubiquitination	MISCGADKSIYFRSA EEEECCCCEEEEEEC	37.91	29967540
603 (in isoform 4)	Ubiquitination	-	37.91	-
614	Phosphorylation	FRSAQQGSDGLHFVR EEECCCCCCCEEEEE	24.94	19691289
614 (in isoform 4)	Phosphorylation	-	24.94	-
642 (in isoform 4)	Phosphorylation	-	5.48	27642862
656	Ubiquitination	DRNVRVYNTVNGKQK CCCEEEEEEECCEEC	34.39	27667366
661	Ubiquitination	VYNTVNGKQKKCYKG EEEEECCEECCEECC	54.46	27667366
666	Phosphorylation	NGKQKKCYKGSQGDE CCEECCEECCCCCCC	27.54	-
667	Ubiquitination	GKQKKCYKGSQGDEG CEECCEECCCCCCCC	62.65	29967540
675	Phosphorylation	GSQGDEGSLLKVHVD CCCCCCCCEEEEEEC	28.60	24719451
678	Ubiquitination	GDEGSLLKVHVDPSG CCCCCEEEEEECCCC	35.27	29967540
684	Phosphorylation	LKVHVDPSGTFLATS EEEEECCCCCEEEEE	46.10	-
781	Phosphorylation	SGHPRQDTYVSTPSE CCCCCCCCCCCCHHH	19.93	26074081
782	Phosphorylation	GHPRQDTYVSTPSEI CCCCCCCCCCCHHHH	10.74	26074081
784	Phosphorylation	PRQDTYVSTPSEIHS CCCCCCCCCHHHHHC	24.96	28450419
785	Phosphorylation	RQDTYVSTPSEIHSL CCCCCCCCHHHHHCC	22.31	28450419
787	Phosphorylation	DTYVSTPSEIHSLSP CCCCCCHHHHHCCCC	49.63	28450419
791	Phosphorylation	STPSEIHSLSPGEQT CCHHHHHCCCCCCCC	35.88	28450419
793	Phosphorylation	PSEIHSLSPGEQTED HHHHHCCCCCCCCCC	33.60	28450419
798	Phosphorylation	SLSPGEQTEDDLEEE CCCCCCCCCCHHHHH	36.76	30576142
814	Phosphorylation	EPEEMLKTPSKDSLD CHHHHHCCCCCCCCC	28.91	19691289
814 (in isoform 4)	Phosphorylation	-	28.91	-
816	Phosphorylation	EEMLKTPSKDSLDPD HHHHCCCCCCCCCCC	55.09	20860994
817	Ubiquitination	EMLKTPSKDSLDPDP HHHCCCCCCCCCCCC	53.17	29967540
819	Phosphorylation	LKTPSKDSLDPDPRC HCCCCCCCCCCCCCC	38.11	19691289
819 (in isoform 4)	Phosphorylation	-	38.11	-
829	Phosphorylation	PDPRCLLTNGKLPLW CCCCCEECCCCCCHH	29.04	29396449
832	Acetylation	RCLLTNGKLPLWAKR CCEECCCCCCHHHHH	49.34	25953088
832	Ubiquitination	RCLLTNGKLPLWAKR CCEECCCCCCHHHHH	49.34	29967540
832 (in isoform 4)	Ubiquitination	-	49.34	-
838	Ubiquitination	GKLPLWAKRLLGDDD CCCCHHHHHHHCCCC	31.81	29967540
838 (in isoform 4)	Ubiquitination	-	31.81	-
855	Ubiquitination	DGLAFHAKRSYQPHG HHHHHHHHCCCCCCC	33.05	32015554
855 (in isoform 4)	Ubiquitination	-	33.05	-
857	Phosphorylation	LAFHAKRSYQPHGRW HHHHHHCCCCCCCHH	27.67	20860994
897	Phosphorylation	KPESLENSILDSLEP CHHHHHCCHHHHCCH	18.36	-
926	Phosphorylation	EAGRGHPSFLPQQKE HCCCCCCCCCCCCCC	33.47	28674419
935	Phosphorylation	LPQQKESSEASELIL CCCCCCCCCHHHHHH	37.97	22210691
944	Phosphorylation	ASELILYSLEAEVTV HHHHHHHEEEEEEEE	19.11	-
961	Ubiquitination	TDSQYCRKEVEAGPG CCHHHEEEEEECCCC	63.65	29967540
961 (in isoform 4)	Ubiquitination	-	63.65	-
974	Phosphorylation	PGDQQGDSYLRVSSD CCCCCCCCEEEECCC	32.65	25159151
974 (in isoform 4)	Phosphorylation	-	32.65	27251275
975	Phosphorylation	GDQQGDSYLRVSSDS CCCCCCCEEEECCCC	11.85	18669648
975 (in isoform 4)	Phosphorylation	-	11.85	-
979	Phosphorylation	GDSYLRVSSDSPKDQ CCCEEEECCCCCCCC	23.22	28985074
980	Phosphorylation	DSYLRVSSDSPKDQS CCEEEECCCCCCCCC	38.97	25159151
982	Phosphorylation	YLRVSSDSPKDQSPP EEEECCCCCCCCCCC	35.48	30576142
987	Phosphorylation	SDSPKDQSPPEDSGE CCCCCCCCCCCCCCC	53.18	30576142
987 (in isoform 4)	Phosphorylation	-	53.18	-
992	Phosphorylation	DQSPPEDSGESEADL CCCCCCCCCCCHHHH	42.68	30576142
992 (in isoform 4)	Phosphorylation	-	42.68	-
995	Phosphorylation	PPEDSGESEADLECS CCCCCCCCHHHHEEE	41.43	30576142
995 (in isoform 4)	Phosphorylation	-	41.43	-
1002	Phosphorylation	SEADLECSFAAIHSP CHHHHEEEEEEECCC	14.45	26074081
1008	Phosphorylation	CSFAAIHSPAPPPDP EEEEEECCCCCCCCC	19.35	26074081
1021	Phosphorylation	DPAPRFATSLPHFPG CCCCCCCCCCCCCCC	28.25	20873877
1022	Phosphorylation	PAPRFATSLPHFPGC CCCCCCCCCCCCCCC	36.15	20873877
1033	Phosphorylation	FPGCAGPTEDELSLP CCCCCCCCCCCCCCC	55.97	23663014
1038	Phosphorylation	GPTEDELSLPEGPSV CCCCCCCCCCCCCCC	39.57	20873877
1044	Phosphorylation	LSLPEGPSVPSSSLP CCCCCCCCCCCCCCC	58.48	23663014
1047	Phosphorylation	PEGPSVPSSSLPQTP CCCCCCCCCCCCCCH	30.33	23898821
1047 (in isoform 4)	Phosphorylation	-	30.33	27251275
1048	Phosphorylation	EGPSVPSSSLPQTPE CCCCCCCCCCCCCHH	29.80	19276368
1049	Phosphorylation	GPSVPSSSLPQTPEQ CCCCCCCCCCCCHHH	48.70	25159151
1049 (in isoform 4)	Phosphorylation	-	48.70	-
1053	Phosphorylation	PSSSLPQTPEQEKFL CCCCCCCCHHHHHHH	27.18	25159151
1053 (in isoform 4)	Phosphorylation	-	27.18	27251275
1066	Phosphorylation	FLRHHFETLTESPCR HHHHHHHHHCCCCCH	37.73	29255136
1066 (in isoform 4)	Phosphorylation	-	37.73	27174698
1068	Phosphorylation	RHHFETLTESPCRAL HHHHHHHCCCCCHHH	41.66	30266825
1068 (in isoform 4)	Phosphorylation	-	41.66	27174698
1070	Phosphorylation	HFETLTESPCRALGD HHHHHCCCCCHHHCC	24.86	23401153
1070 (in isoform 4)	Phosphorylation	-	24.86	29743597
1081	Phosphorylation	ALGDVEASEAEDHFF HHCCCCHHHCCCCCC	24.67	28555341
1093	Phosphorylation	HFFNPRLSISTQFLS CCCCCCHHHHHHHHH	18.77	20068231
1095	Phosphorylation	FNPRLSISTQFLSSL CCCCHHHHHHHHHHH	16.87	28348404
1096	Phosphorylation	NPRLSISTQFLSSLQ CCCHHHHHHHHHHHH	22.98	24719451
1098 (in isoform 4)	Phosphorylation	-	7.86	-
1100	Phosphorylation	SISTQFLSSLQKASR HHHHHHHHHHHHHHC	30.23	24719451
1101	Phosphorylation	ISTQFLSSLQKASRF HHHHHHHHHHHHHCC	36.65	25159151
1101 (in isoform 4)	Phosphorylation	-	36.65	24719451
1105 (in isoform 4)	Phosphorylation	-	7.93	24719451
1106	Phosphorylation	LSSLQKASRFTHTFP HHHHHHHHCCCCCCC	34.66	20068231
1106 (in isoform 4)	Phosphorylation	-	34.66	-
1117	Phosphorylation	HTFPPRATQCLVKSP CCCCCCCCEEEECCC	22.54	30576142
1122	Ubiquitination	RATQCLVKSPEVKLM CCCEEEECCCCEEEE	47.55	29967540
1123	Phosphorylation	ATQCLVKSPEVKLMD CCEEEECCCCEEEEC	20.86	30266825
1127	Acetylation	LVKSPEVKLMDRGGS EECCCCEEEECCCCC	36.11	25953088
1127	Ubiquitination	LVKSPEVKLMDRGGS EECCCCEEEECCCCC	36.11	29967540
1127 (in isoform 4)	Ubiquitination	-	36.11	-
1128 (in isoform 4)	Phosphorylation	-	5.36	24719451
1131	Methylation	PEVKLMDRGGSQPRA CCEEEECCCCCCCCC	37.09	115920013
1132	Ubiquitination	EVKLMDRGGSQPRAG CEEEECCCCCCCCCC	35.52	29967540
1134	Phosphorylation	KLMDRGGSQPRAGTG EEECCCCCCCCCCCC	39.57	26074081
1140	Phosphorylation	GSQPRAGTGYASPDR CCCCCCCCCCCCCCC	26.49	30266825
1142	Phosphorylation	QPRAGTGYASPDRTH CCCCCCCCCCCCCCE	12.07	30278072
1144	Phosphorylation	RAGTGYASPDRTHVL CCCCCCCCCCCCEEE	20.89	29255136
1145 (in isoform 4)	Phosphorylation	-	27.25	-
1147	Phosphorylation	TGYASPDRTHVLAAG CCCCCCCCCEEEECC	30.07	32142685
1148	Phosphorylation	GYASPDRTHVLAAGK CCCCCCCCEEEECCC	24.58	30266825
1149 (in isoform 4)	Phosphorylation	-	17.31	24719451
1159	Phosphorylation	AAGKAEETLEAWRPP ECCCHHHHHHHHCCC	22.77	26074081
1175	Phosphorylation	PCLTSLASCVPASSV CCHHHHHHCCCHHHC	22.42	26074081
1180	Phosphorylation	LASCVPASSVLPTDR HHHCCCHHHCCCCCC	18.21	26074081
1181	Phosphorylation	ASCVPASSVLPTDRN HHCCCHHHCCCCCCC	29.76	26074081
1185	Phosphorylation	PASSVLPTDRNLPTP CHHHCCCCCCCCCCC	43.35	26074081
1191	Phosphorylation	PTDRNLPTPTSAPTP CCCCCCCCCCCCCCC	42.22	27422710
1193	Phosphorylation	DRNLPTPTSAPTPGL CCCCCCCCCCCCCCC	39.74	26074081
1194	Phosphorylation	RNLPTPTSAPTPGLA CCCCCCCCCCCCCCC	33.19	27174698
1196 (in isoform 4)	Phosphorylation	-	38.60	24719451
1197	Phosphorylation	PTPTSAPTPGLAQGV CCCCCCCCCCCCCCC	29.70	26074081
1208	Phosphorylation	AQGVHAPSTCSYMEA CCCCCCCCCCCHHHH	42.71	21712546
1219	Phosphorylation	YMEATASSRARISRS HHHHCHHHCCEEEEE	27.74	-
1224	Phosphorylation	ASSRARISRSISLGD HHHCCEEEEEECCCC	17.89	21712546
1226	Phosphorylation	SRARISRSISLGDSE HCCEEEEEECCCCCC	15.11	29255136
1228	Phosphorylation	ARISRSISLGDSEGP CEEEEEECCCCCCCC	27.78	29255136
1231 (in isoform 4)	Phosphorylation	-	49.13	-
1232	Phosphorylation	RSISLGDSEGPIVAT EEECCCCCCCCCEEE	42.53	30266825
1233 (in isoform 4)	Phosphorylation	-	73.97	24719451
1237	Phosphorylation	GDSEGPIVATLAQPL CCCCCCCEEEECCCC	3.61	32142685
1237 (in isoform 4)	Phosphorylation	-	3.61	-
1239	Phosphorylation	SEGPIVATLAQPLRR CCCCCEEEECCCCCC	16.25	28176443
1248	Phosphorylation	AQPLRRPSSVGELAS CCCCCCCCHHHHHHH	35.53	25159151
1249	Phosphorylation	QPLRRPSSVGELASL CCCCCCCHHHHHHHH	36.50	25159151
1253 (in isoform 4)	Phosphorylation	-	3.01	24719451
1254 (in isoform 4)	Phosphorylation	-	9.82	-
1255	Phosphorylation	SSVGELASLGQELQA CHHHHHHHHHHHHHH	45.73	28787133
1264	Phosphorylation	GQELQAITTATTPSL HHHHHHHHCCCCCCC	17.25	28102081
1265	Phosphorylation	QELQAITTATTPSLD HHHHHHHCCCCCCCC	18.85	29632367
1267	Phosphorylation	LQAITTATTPSLDSE HHHHHCCCCCCCCCC	36.83	28102081
1268	Phosphorylation	QAITTATTPSLDSEG HHHHCCCCCCCCCCC	14.39	21712546
1270	Phosphorylation	ITTATTPSLDSEGQE HHCCCCCCCCCCCCC	42.59	28450419
1273	Phosphorylation	ATTPSLDSEGQEPAL CCCCCCCCCCCCCCH	49.25	28450419
1273 (in isoform 4)	Phosphorylation	-	49.25	-
1315	Phosphorylation	VDTQPGVTVPAVSFP CCCCCCCEEEEEECC	27.04	28122231
1320	Phosphorylation	GVTVPAVSFPAPSPV CCEEEEEECCCCCCH	27.84	29978859
1325	Phosphorylation	AVSFPAPSPVEESAL EEECCCCCCHHHHHH	43.62	28464451
1330	Phosphorylation	APSPVEESALRLHGS CCCCHHHHHHHHCCC	21.06	29978859
1330 (in isoform 4)	Phosphorylation	-	21.06	27251275
1337	Phosphorylation	SALRLHGSAFRPSLP HHHHHCCCCCCCCCC	17.31	30108239
1342	Phosphorylation	HGSAFRPSLPAPESP CCCCCCCCCCCCCCC	42.61	26055452
1347 (in isoform 4)	Phosphorylation	-	72.22	-
1348	Phosphorylation	PSLPAPESPGLPAHP CCCCCCCCCCCCCCC	24.18	29255136
1353 (in isoform 4)	Phosphorylation	-	32.06	24719451
1356	Phosphorylation	PGLPAHPSNPQLPEA CCCCCCCCCCCCCCC	51.80	30576142
1371	Phosphorylation	RPGIPGGTASLLEPT CCCCCCCCHHHCCCC	20.98	28122231
1373	Phosphorylation	GIPGGTASLLEPTSG CCCCCCHHHCCCCCC	33.07	28464451
1378	Phosphorylation	TASLLEPTSGALGLL CHHHCCCCCCCHHHH	30.34	28122231
1379	Phosphorylation	ASLLEPTSGALGLLQ HHHCCCCCCCHHHHC	32.55	28122231
1388	Phosphorylation	ALGLLQGSPARWSEP CHHHHCCCCCCCCCC	11.48	29978859
1393	Phosphorylation	QGSPARWSEPWVPVE CCCCCCCCCCEECCC	28.38	28176443
1393 (in isoform 4)	Phosphorylation	-	28.38	24719451
1405	Phosphorylation	PVEALPPSPLELSRV CCCCCCCCCCHHHHH	39.93	28176443
1410	Phosphorylation	PPSPLELSRVGNILH CCCCCHHHHHHHHHH	18.62	28450419
1410 (in isoform 4)	Phosphorylation	-	18.62	24719451
1421	Phosphorylation	NILHRLQTTFQEALD HHHHHHHHHHHHHHH	33.88	30631047
1422	Phosphorylation	ILHRLQTTFQEALDL HHHHHHHHHHHHHHH	15.45	30631047
1430	Phosphorylation	FQEALDLYRVLVSSG HHHHHHHHHHHHHCC	9.80	30631047
1435	Phosphorylation	DLYRVLVSSGQVDTG HHHHHHHHCCCCCCC	25.29	19691289
1436	Phosphorylation	LYRVLVSSGQVDTGQ HHHHHHHCCCCCCCC	26.26	19691289
1440 (in isoform 4)	Phosphorylation	-	36.91	-
1441	Phosphorylation	VSSGQVDTGQQQART HHCCCCCCCCHHHHH	37.72	19691289
1441 (in isoform 4)	Phosphorylation	-	37.72	-
1446 (in isoform 4)	Phosphorylation	-	18.94	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
32	S	Phosphorylation	Kinase	AURA	O14965	PSP
33	S	Phosphorylation	Kinase	AURA	O14965	PSP
49	S	Phosphorylation	Kinase	AURKA	O14965	GPS
50	T	Phosphorylation	Kinase	AURKA	O14965	GPS
897	S	Phosphorylation	Kinase	PLK1	P53350	PSP
1053	T	Phosphorylation	Kinase	JNK1	P45983	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WDR62_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WDR62_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WDR62_HUMAN	WDR62	physical	16169070
RALY_HUMAN	RALY	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
TBP_HUMAN	TBP	physical	16169070
MK09_HUMAN	MAPK9	physical	19910486
MK08_HUMAN	MAPK8	physical	19910486
KIFC3_HUMAN	KIFC3	physical	26496610
PDE3A_HUMAN	PDE3A	physical	26496610
1433G_HUMAN	YWHAG	physical	26496610
1433F_HUMAN	YWHAH	physical	26496610
BCL7B_HUMAN	BCL7B	physical	26496610
BAG2_HUMAN	BAG2	physical	26496610
CE170_HUMAN	CEP170	physical	26496610
CEPT1_HUMAN	CEPT1	physical	26496610
1433T_HUMAN	YWHAQ	physical	26496610
MABP1_HUMAN	MAPKBP1	physical	26496610
SYIM_HUMAN	IARS2	physical	26496610
GRDN_HUMAN	CCDC88A	physical	26496610
ENKD1_HUMAN	ENKD1	physical	26496610
CE170_HUMAN	CEP170	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
604317	Microcephaly 2, primary, autosomal recessive, with or without cortical malformations (MCPH2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WDR62_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-33; SER-1049; THR-1053 AND SER-1228, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6; TYR-9; SER-33;SER-49; SER-52; SER-501; SER-819; SER-974; SER-1101; SER-1123;SER-1144; THR-1191; SER-1436 AND THR-1441, ACETYLATION [LARGE SCALEANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19007248 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; THR-50; SER-1228;SER-1248; SER-1249 AND THR-1264, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-33; SER-1049; THR-1053 AND SER-1228, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; THR-50; SER-52;SER-501; SER-1049; THR-1053; SER-1123; SER-1228; SER-1249 ANDTHR-1268, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1070; SER-1248 ANDSER-1249, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6; TYR-9; SER-33;SER-49; SER-52; SER-501; SER-819; SER-974; SER-1101; SER-1123;SER-1144; THR-1191; SER-1436 AND THR-1441, ACETYLATION [LARGE SCALEANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19007248 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1053; SER-1070;SER-1093; SER-1101; SER-1228 AND SER-1405, AND MASS SPECTROMETRY.	16565220 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-987; SER-992; SER-995AND SER-1348, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33, AND MASSSPECTROMETRY.	15302935 [Abstract]