MABP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MABP1_HUMAN
• UniProt AC: O60336
• Protein Name: Mitogen-activated protein kinase-binding protein 1
• Gene Name: MAPKBP1
• Organism: Homo sapiens (Human).
• Sequence Length: 1514
• Subcellular Localization: Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle pole . Not detected in the cilium. Localized around the poles of the mitotic spindle from prophase to anaphase in mitotic cells.
• Protein Description: Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response. [PubMed: 22700971 Involved in JNK signaling pathway (By similarity]
• Protein Sequence: MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPRSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPGPALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGFLDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKHGQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPSDNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSESTEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGAAPGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGNGANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVHSLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGRPSRPHSYQNPTTSSMAKISRSISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGRAPGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQGPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSVAGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSELLLRAVERRMERKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAVEGSTIT ------CCCCCCHHH	21.26	22814378
6	Phosphorylation	--MAVEGSTITSRIK --CCCCCCHHHHHHH	11.79	26437602
9	Phosphorylation	AVEGSTITSRIKNLL CCCCCHHHHHHHHHH	16.43	26437602
18	Phosphorylation	RIKNLLRSPSIKLRR HHHHHHCCCCCEEEC	23.98	25159151
20	Phosphorylation	KNLLRSPSIKLRRSK HHHHCCCCCEEECCC	33.33	25159151
81	Ubiquitination	LFNPRKHKQHHILNS EECCCHHHCHHHCCC	55.12	29967540
261	Phosphorylation	SGLLCEFSDRRLLDK CCEEEEECCHHHHHH	14.12	-
457	Phosphorylation	IIYVDGNTQALLDTE EEEECCCCCEEEECC	22.28	22210691
463	Phosphorylation	NTQALLDTELPGGDK CCCEEEECCCCCCCC	39.12	22210691
474	Phosphorylation	GGDKADASLLDPRVG CCCCCCHHHCCCCCC	29.97	27174698
484	Phosphorylation	DPRVGIRSVCVSPNG CCCCCCEEEEECCCC	20.25	28985074
488	Phosphorylation	GIRSVCVSPNGQHLA CCEEEEECCCCCCCC	13.92	26657352
496	Phosphorylation	PNGQHLASGDRMGTL CCCCCCCCCCCCCCC	47.81	20860994
502	Phosphorylation	ASGDRMGTLRVHELQ CCCCCCCCCCHHHHH	11.31	28634298
510	Phosphorylation	LRVHELQSLSEMLKV CCHHHHHHHHHHHCC	46.62	28634298
512	Phosphorylation	VHELQSLSEMLKVEA HHHHHHHHHHHCCEE	26.63	28634298
541	Phosphorylation	TGLKLLASASRDRLI HHHHHHHHHCCCCEE	27.09	22210691
543	Phosphorylation	LKLLASASRDRLIHV HHHHHHHCCCCEEEE	32.02	22210691
600	Ubiquitination	IYFRTAQKSGDGVQF EEEEECCCCCCCCEE	54.67	-
631	Phosphorylation	VEPSWKYTAIGCQDR CCCCCEEEEEEECCC	14.20	24425749
649	Ubiquitination	IFNISSGKQKKLFKG EEEECCCCCEEEECC	61.97	29967540
655	Ubiquitination	GKQKKLFKGSQGEDG CCCEEEECCCCCCCC	69.00	29967540
655	Methylation	GKQKKLFKGSQGEDG CCCEEEECCCCCCCC	69.00	115972735
733	Phosphorylation	CIFVWRLSSEMTISM EEEEEEECCCCCHHH	18.71	29255136
734	Phosphorylation	IFVWRLSSEMTISMR EEEEEECCCCCHHHH	35.66	29255136
755	Phosphorylation	RQRQRGGKQQGPSSP HHHHHCCCCCCCCCC	42.12	33259812
760	Phosphorylation	GGKQQGPSSPQRASG CCCCCCCCCCCCCCC	62.57	25850435
761	Phosphorylation	GKQQGPSSPQRASGP CCCCCCCCCCCCCCC	28.34	23403867
766	Phosphorylation	PSSPQRASGPNRHQA CCCCCCCCCCCCCCC	57.90	23090842
775	Phosphorylation	PNRHQAPSMLSPGPA CCCCCCCCCCCCCCC	35.06	30177828
778	Phosphorylation	HQAPSMLSPGPALSS CCCCCCCCCCCCCCC	21.11	22210691
784	Phosphorylation	LSPGPALSSDSDKEG CCCCCCCCCCCCCCC	33.92	29116813
785	Phosphorylation	SPGPALSSDSDKEGE CCCCCCCCCCCCCCC	41.82	29116813
787	Phosphorylation	GPALSSDSDKEGEDE CCCCCCCCCCCCCCC	53.16	29116813
796	Phosphorylation	KEGEDEGTEEELPAL CCCCCCCCHHHCCHH	37.87	30177828
809	Phosphorylation	ALPVLAKSTKKALAS HHHHHHHCCCHHHHC	39.59	-
816	Phosphorylation	STKKALASVPSPALP CCCHHHHCCCCCCCC	35.10	29255136
819	Phosphorylation	KALASVPSPALPRSL HHHHCCCCCCCCCCC	22.20	29255136
825	Phosphorylation	PSPALPRSLSHWEMS CCCCCCCCCCHHHHH	32.08	23312004
827	Phosphorylation	PALPRSLSHWEMSRA CCCCCCCCHHHHHHH	28.00	23090842
865	Phosphorylation	VQPGVELSVRSMLDL CCCCCCEEHHHHHCH	11.28	20860994
868	Phosphorylation	GVELSVRSMLDLRQL CCCEEHHHHHCHHHH	22.88	24719451
907	Phosphorylation	HGQEALETSLTSQNE HHHHHHHHHCCCCCC	29.86	28787133
910	Phosphorylation	EALETSLTSQNEKPP HHHHHHCCCCCCCCC	28.21	28787133
922	Phosphorylation	KPPRPQASQPCSYPH CCCCCCCCCCCCHHH	29.43	28787133
935	Phosphorylation	PHIIRLLSQEEGVFA HHHHHHHHCCCCCCC	39.89	28464451
1062	Phosphorylation	LQEGSPQTPDQEQFL CCCCCCCCCCHHHHH	32.01	21552520
1096	Phosphorylation	PERSESRSISSRFLL CCCCCCCCCCHHHHE	35.78	24719451
1098	Phosphorylation	RSESRSISSRFLLQV CCCCCCCCHHHHEEE	19.39	23403867
1099	Phosphorylation	SESRSISSRFLLQVQ CCCCCCCHHHHEEEE	25.94	24719451
1107	Phosphorylation	RFLLQVQTRPLREPS HHHEEEECCCCCCCC	35.08	23403867
1154	Phosphorylation	APPEVEPSSGNPSPQ CCCCCCCCCCCCCHH	37.05	25850435
1155	Phosphorylation	PPEVEPSSGNPSPQQ CCCCCCCCCCCCHHH	53.99	25850435
1159	Phosphorylation	EPSSGNPSPQQAASV CCCCCCCCHHHHHHH	39.06	25850435
1165	Phosphorylation	PSPQQAASVLLPRCR CCHHHHHHHHCCCCC	19.13	25850435
1186	Phosphorylation	WAPKRVATASPFSGL CCCCCEECCCCCCHH	25.47	22199227
1188	Phosphorylation	PKRVATASPFSGLQK CCCEECCCCCCHHHH	23.32	22199227
1191	Phosphorylation	VATASPFSGLQKAQS EECCCCCCHHHHHHH	41.81	22199227
1192	Phosphorylation	ATASPFSGLQKAQSV ECCCCCCHHHHHHHH	32.29	32142685
1198	Phosphorylation	SGLQKAQSVHSLVPQ CHHHHHHHHHHCCCH	27.02	29255136
1201	Phosphorylation	QKAQSVHSLVPQERH HHHHHHHHCCCHHHH	28.98	23403867
1211	Phosphorylation	PQERHEASLQAPSPG CHHHHHHHHCCCCCC	20.30	28555341
1216	Phosphorylation	EASLQAPSPGALLSR HHHHCCCCCCCCEEC	38.69	25159151
1259	Phosphorylation	TSSMAKISRSISVGE HHHHHHHHCCEECCC	21.19	29514088
1261	Phosphorylation	SMAKISRSISVGENL HHHHHHCCEECCCCC	16.66	27794612
1263	Phosphorylation	AKISRSISVGENLGL HHHHCCEECCCCCEE	25.89	23401153
1283	Phosphorylation	AHAPIRVSPLSKLAL CCCCCEECCHHHHCC	15.41	30576142
1286	Phosphorylation	PIRVSPLSKLALPSR CCEECCHHHHCCCCC	29.07	22199227
1309	Phosphorylation	KPLPDRPTLAAFSPV CCCCCCCCEEEECCC	29.89	22199227
1314	Phosphorylation	RPTLAAFSPVTKGRA CCCEEEECCCCCCCC	17.46	22199227
1317	Phosphorylation	LAAFSPVTKGRAPGE EEEECCCCCCCCCCC	31.03	22199227
1351	Phosphorylation	WACLGEGTTPKPRTE EEECCCCCCCCCCCC	35.31	26074081
1352	Phosphorylation	ACLGEGTTPKPRTEC EECCCCCCCCCCCCC	39.92	26074081
1357	Phosphorylation	GTTPKPRTECQAHPG CCCCCCCCCCCCCCC	50.03	26074081
1366	Phosphorylation	CQAHPGPSSPCAQQL CCCCCCCCCCHHHHC	53.48	26074081
1367	Phosphorylation	QAHPGPSSPCAQQLP CCCCCCCCCHHHHCC	27.42	26657352
1376	Phosphorylation	CAQQLPVSSLFQGPE HHHHCCHHHHCCCCC	21.27	26074081
1377	Phosphorylation	AQQLPVSSLFQGPEN HHHCCHHHHCCCCCC	33.18	26074081
1439	Phosphorylation	QAVRLYHSVAGCKMP HHHHHHHHHCCCCCC	10.49	29507054
1477	Phosphorylation	AVAGAVLSSPGSSPG HHHHHHHCCCCCCCC	28.08	27251275
1478	Phosphorylation	VAGAVLSSPGSSPGA HHHHHHCCCCCCCCC	29.17	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MABP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MABP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MABP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATL4_HUMAN	ADAMTSL4	physical	25416956
TEX11_HUMAN	TEX11	physical	25416956
ALG13_HUMAN	ALG13	physical	25416956
KR412_HUMAN	KRTAP4-12	physical	25416956
KRA32_HUMAN	KRTAP3-2	physical	25416956
KRA92_HUMAN	KRTAP9-2	physical	25416956
KRA94_HUMAN	KRTAP9-4	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR101_HUMAN	KRTAP10-1	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.