TEX11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TEX11_HUMAN
• UniProt AC: Q8IYF3
• Protein Name: Testis-expressed protein 11
• Gene Name: TEX11
• Organism: Homo sapiens (Human).
• Sequence Length: 940
• Subcellular Localization: Chromosome. Forms arrays of discrete foci along synaptonemal complexes in spermatocytes and fetal oocytes..
• Protein Description: Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity)..
• Protein Sequence: MISAHCNLRLLCSSDSSASASQVAGTTEVVENLVTNDNSPNIPEAIDRLFSDIANINRESMAEITDIQIEEMAVNLWNWALTIGGGWLVNEEQKIRLHYVACKLLSMCEASFASEQSIQRLIMMNMRIGKEWLDAGNFLIADECFQAAVASLEQLYVKLIQRSSPEADLTMEKITVESDHFRVLSYQAESAVAQGDFQRASMCVLQCKDMLMRLPQMTSSLHHLCYNFGVETQKNNKYEESSFWLSQSYDIGKMDKKSTGPEMLAKVLRLLATNYLDWDDTKYYDKALNAVNLANKEHLSSPGLFLKMKILLKGETSNEELLEAVMEILHLDMPLDFCLNIAKLLMDHERESVGFHFLTIIHERFKSSENIGKVLILHTDMLLQRKEELLAKEKIEEIFLAHQTGRQLTAESMNWLHNILWRQAASSFEVQNYTDALQWYYYSLRFYSTDEMDLDFTKLQRNMACCYLNLQQLDKAKEAVAEAERHDPRNVFTQFYIFKIAVIEGNSERALQAIITLENILTDEESEDNDLVAERGSPTMLLSLAAQFALENGQQIVAEKALEYLAQHSEDQEQVLTAVKCLLRFLLPKIAEMPESEDKKKEMDRLLTCLNRAFVKLSQPFGEEALSLESRANEAQWFRKTAWNLAVQCDKDPVMMREFFILSYKMSQFCPSDQVILIARKTCLLMAVAVDLEQGRKASTAFEQTMFLSRALEEIQTCNDIHNFLKQTGTFSNDSCEKLLLLYEFEVRAKLNDPLLESFLESVWELPHLETKTFETIAIIAMEKPAHYPLIALKALKKALLLYKKEEPIDISQYSKCMHNLVNLSVPDGASNVELCPLEEVWGYFEDALSHISRTKDYPEMEILWLMVKSWNTGVLMFSRSKYASAEKWCGLALRFLNHLTSFKESYETQMNMLYSQLVEALSNNKGPVFHEHGYWSKSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
175	Phosphorylation	DLTMEKITVESDHFR CCEEEEEEEECCCEE	29.32	-
284	Phosphorylation	DWDDTKYYDKALNAV CCCCCHHHHHHHHHH	16.72	22817900
368	Phosphorylation	IHERFKSSENIGKVL HHHHHHCCCCHHHHE	34.94	23532336
443	Phosphorylation	ALQWYYYSLRFYSTD HHHHHHHHCCCCCCC	9.28	24719451
507	Phosphorylation	IAVIEGNSERALQAI EEEECCCHHHHHHHH	39.04	21659604
682	Phosphorylation	VILIARKTCLLMAVA HHEEEHHHHHHHHHH	11.66	-
743	Phosphorylation	CEKLLLLYEFEVRAK HHHHHHHHEEHHHHH	20.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TEX11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TEX11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TEX11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EFHC1_HUMAN	EFHC1	physical	16189514
CJ082_HUMAN	C10orf82	physical	16189514
ZN414_HUMAN	ZNF414	physical	16189514
T22D4_HUMAN	TSC22D4	physical	16189514
COKA1_HUMAN	COL20A1	physical	16189514
CFA53_HUMAN	CFAP53	physical	16189514
HYI_HUMAN	HYI	physical	16189514
SKT_HUMAN	KIAA1217	physical	16189514
TCHP_HUMAN	TCHP	physical	16189514
C2CD6_HUMAN	ALS2CR11	physical	16189514
P66B_HUMAN	GATAD2B	physical	25416956
COKA1_HUMAN	COL20A1	physical	25416956
DUS21_HUMAN	DUSP21	physical	25416956
T22D4_HUMAN	TSC22D4	physical	25416956
HYI_HUMAN	HYI	physical	25416956
FBF1_HUMAN	FBF1	physical	25416956
RIBC1_HUMAN	RIBC1	physical	25416956
PPR18_HUMAN	PPP1R18	physical	25416956
SPERT_HUMAN	SPERT	physical	25416956
CENPP_HUMAN	CENPP	physical	25416956
CF226_HUMAN	C6orf226	physical	25416956
BORC8_HUMAN	MEF2BNB	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 309120: Spermatogenic failure, X-linked, 2 (SPGFX2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.