CENPP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CENPP_HUMAN
• UniProt AC: Q6IPU0
• Protein Name: Centromere protein P
• Gene Name: CENPP
• Organism: Homo sapiens (Human).
• Sequence Length: 288
• Subcellular Localization: Nucleus . Chromosome, centromere . Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
• Protein Description: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex..
• Protein Sequence: MDAELAEVRALQAEIAALRRACEDPPAPWEEKSRVQKSFQAIHQFNLEGWKSSKDLKNQLGHLESELSFLSTLTGINIRNHSKQTEDLTSTEMTEKSIRKVLQRHRLSGNCHMVTFQLEFQILEIQNKERLSSAVTDLNIIMEPTECSELSEFVSRAEERKDLFMFFRSLHFFVEWFEYRKRTFKHLKEKYPDAVYLSEGPSSCSMGIRSASRPGFELVIVWRIQIDEDGKVFPKLDLLTKVPQRALELDKNRAIETAPLSFRTLVGLLGIEAALESLIKSLCAEENN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Ubiquitination	PPAPWEEKSRVQKSF CCCCHHHHHHHHHHH	31.86	-
37	Ubiquitination	EEKSRVQKSFQAIHQ HHHHHHHHHHHHHHH	50.83	21890473
38	Phosphorylation	EKSRVQKSFQAIHQF HHHHHHHHHHHHHHC	12.90	22199227
68	Ubiquitination	GHLESELSFLSTLTG HHHHHHHHHHHHHHC	21.79	-
78	Ubiquitination	STLTGINIRNHSKQT HHHHCCEECCCCCCC	4.39	-
83	Ubiquitination	INIRNHSKQTEDLTS CEECCCCCCCCCCCC	54.40	-
85	Phosphorylation	IRNHSKQTEDLTSTE ECCCCCCCCCCCCCC	34.89	-
89	Phosphorylation	SKQTEDLTSTEMTEK CCCCCCCCCCCCCHH	46.02	20860994
93	Sulfoxidation	EDLTSTEMTEKSIRK CCCCCCCCCHHHHHH	6.25	21406390
94	Phosphorylation	DLTSTEMTEKSIRKV CCCCCCCCHHHHHHH	33.75	-
96	Ubiquitination	TSTEMTEKSIRKVLQ CCCCCCHHHHHHHHH	41.85	-
205	Phosphorylation	SEGPSSCSMGIRSAS CCCCCCCCCCCCCCC	23.22	20068231
241	Ubiquitination	PKLDLLTKVPQRALE CCHHHHCCCCHHHHH	52.46	-
251	Ubiquitination	QRALELDKNRAIETA HHHHHCCCCCHHHCC	62.04	-
257	Phosphorylation	DKNRAIETAPLSFRT CCCCHHHCCCCCHHH	27.71	-
261	Phosphorylation	AIETAPLSFRTLVGL HHHCCCCCHHHHHHH	16.18	-
277	Phosphorylation	GIEAALESLIKSLCA HHHHHHHHHHHHHHH	35.92	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CENPP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CENPP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CENPP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CENPU_HUMAN	CENPU	physical	21454580
CENPH_HUMAN	CENPH	physical	16622420
CENPI_HUMAN	CENPI	physical	16622420
CENPO_HUMAN	CENPO	physical	16622420
CENPQ_HUMAN	CENPQ	physical	16622420
CENPR_HUMAN	ITGB3BP	physical	16622420
CENPU_HUMAN	CENPU	physical	16622420
AINX_HUMAN	INA	physical	26186194
CENPO_HUMAN	CENPO	physical	26186194
CENPQ_HUMAN	CENPQ	physical	26186194
CENPR_HUMAN	ITGB3BP	physical	26186194
CENPU_HUMAN	CENPU	physical	26186194
CENPO_HUMAN	CENPO	physical	28514442
CENPR_HUMAN	ITGB3BP	physical	28514442
CENPU_HUMAN	CENPU	physical	28514442
CENPQ_HUMAN	CENPQ	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.