dbPTM

CENPQ_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CENPQ_HUMAN
UniProt AC	Q7L2Z9
Protein Name	Centromere protein Q
Gene Name	CENPQ
Organism	Homo sapiens (Human).
Sequence Length	268
Subcellular Localization	Nucleus . Chromosome, centromere . Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Protein Description	Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. [PubMed: 16622420 Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores]
Protein Sequence	MSGKANASKKNAQQLKRNPKRKKDNEEVVLSENKVRNTVKKNKNHLKDLSSEGQTKHTNLKHGKTAASKRKTWQPLSKSTRDHLQTMMESVIMTILSNSIKEKEEIQYHLNFLKKRLLQQCETLKVPPKKMEDLTNVSSLLNMERARDKANEEGLALLQEEIDKMVETTELMTGNIQSLKNKIQILASEVEEEEERVKQMHQINSSGVLSLPELSQKTLKAPTLQKEILALIPNQNALLKDLDILHNSSQMKSMSTFIEEAYKKLDAS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Ubiquitination	GKANASKKNAQQLKR CCCHHCHHHHHHHHH	55.83	25015289
10	Acetylation	GKANASKKNAQQLKR CCCHHCHHHHHHHHH	55.83	30587593
23	Ubiquitination	KRNPKRKKDNEEVVL HHCCCCCCCCCCCCC	70.58	24816145
31	Phosphorylation	DNEEVVLSENKVRNT CCCCCCCCCHHHHHH	27.75	25159151
34	Ubiquitination	EVVLSENKVRNTVKK CCCCCCHHHHHHHHH	38.22	29967540
47	Ubiquitination	KKNKNHLKDLSSEGQ HHCCHHHHHHCCCCC	49.42	33845483
50	Phosphorylation	KNHLKDLSSEGQTKH CHHHHHHCCCCCCCC	36.16	25159151
51	Phosphorylation	NHLKDLSSEGQTKHT HHHHHHCCCCCCCCC	53.71	24732914
55	Phosphorylation	DLSSEGQTKHTNLKH HHCCCCCCCCCCCCC	35.33	24732914
56	Ubiquitination	LSSEGQTKHTNLKHG HCCCCCCCCCCCCCC	40.31	32015554
68	Phosphorylation	KHGKTAASKRKTWQP CCCCCCCHHCCCCCC	30.45	24260401
71	Ubiquitination	KTAASKRKTWQPLSK CCCCHHCCCCCCCCH	58.83	29967540
78	Ubiquitination	KTWQPLSKSTRDHLQ CCCCCCCHHHHHHHH	64.63	22817900
81	Ubiquitination	QPLSKSTRDHLQTMM CCCCHHHHHHHHHHH	36.12	21890473
86	Phosphorylation	STRDHLQTMMESVIM HHHHHHHHHHHHHHH	25.50	25262027
101	Ubiquitination	TILSNSIKEKEEIQY HHHHCCCCCHHHHHH	63.66	32015554
108	Phosphorylation	KEKEEIQYHLNFLKK CCHHHHHHHHHHHHH	17.59	29449344
123	Phosphorylation	RLLQQCETLKVPPKK HHHHHHHCCCCCCHH	39.23	25690035
130	Ubiquitination	TLKVPPKKMEDLTNV CCCCCCHHHHHHCCH	53.98	29967540
135	Phosphorylation	PKKMEDLTNVSSLLN CHHHHHHCCHHHHHC	45.99	18691976
138	Phosphorylation	MEDLTNVSSLLNMER HHHHCCHHHHHCHHH	19.82	21712546
139	Phosphorylation	EDLTNVSSLLNMERA HHHCCHHHHHCHHHH	32.37	21815630
149	Ubiquitination	NMERARDKANEEGLA CHHHHHHHCHHHHHH	47.78	29967540
168	Phosphorylation	EIDKMVETTELMTGN HHHHHHHHHHHHHCC	17.73	26270265
169	Phosphorylation	IDKMVETTELMTGNI HHHHHHHHHHHHCCH	17.39	26270265
173	Phosphorylation	VETTELMTGNIQSLK HHHHHHHHCCHHHHH	39.44	26270265
178	Phosphorylation	LMTGNIQSLKNKIQI HHHCCHHHHHHHHHH	37.20	26270265
180	Ubiquitination	TGNIQSLKNKIQILA HCCHHHHHHHHHHHH	62.53	32015554
182	Ubiquitination	NIQSLKNKIQILASE CHHHHHHHHHHHHHH	34.11	29967540
217	Ubiquitination	SLPELSQKTLKAPTL CHHHHCHHHCCCCCH	53.07	29967540
248	Phosphorylation	DLDILHNSSQMKSMS HHHHHCCCHHHHHHH	15.94	23663014
249	Phosphorylation	LDILHNSSQMKSMST HHHHCCCHHHHHHHH	39.34	30266825
253	Phosphorylation	HNSSQMKSMSTFIEE CCCHHHHHHHHHHHH	16.78	-
255	Phosphorylation	SSQMKSMSTFIEEAY CHHHHHHHHHHHHHH	27.53	-
256	Phosphorylation	SQMKSMSTFIEEAYK HHHHHHHHHHHHHHH	21.71	20860994
268	Phosphorylation	AYKKLDAS------- HHHHHCCC-------	40.18	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
123	T	Phosphorylation	Kinase	PLK1	P53350	PSP
135	T	Phosphorylation	Kinase	PLK1	P53350	PSP
138	S	Phosphorylation	Kinase	PLK1	P53350	PSP
139	S	Phosphorylation	Kinase	PLK1	P53350	PSP
248	S	Phosphorylation	Kinase	PLK1	P53350	PSP
249	S	Phosphorylation	Kinase	PLK1	P53350	PSP
253	S	Phosphorylation	Kinase	PLK1	P53350	PSP
255	S	Phosphorylation	Kinase	PLK1	P53350	PSP
256	T	Phosphorylation	Kinase	PLK1	P53350	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
50	S	Phosphorylation		21406692
Phosphorylation at Ser-50 is essential for CENPE recruitment to kinetochores and orderly chromosome congression.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CENPQ_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CENPU_HUMAN	CENPU	physical	21454580
CENPQ_HUMAN	CENPQ	physical	21454580
A4_HUMAN	APP	physical	21832049
CS057_HUMAN	C19orf57	physical	19060904
KDM1A_HUMAN	KDM1A	physical	23455924
CENPC_HUMAN	CENPC	physical	26496610
CENPI_HUMAN	CENPI	physical	26496610
RL10A_HUMAN	RPL10A	physical	26496610
RL9_HUMAN	RPL9	physical	26496610
RL18_HUMAN	RPL18	physical	26496610
RS11_HUMAN	RPS11	physical	26496610
RS14_HUMAN	RPS14	physical	26496610
RS16_HUMAN	RPS16	physical	26496610
ZFX_HUMAN	ZFX	physical	26496610
MRCKA_HUMAN	CDC42BPA	physical	26496610
SC24C_HUMAN	SEC24C	physical	26496610
SP16H_HUMAN	SUPT16H	physical	26496610
CENPR_HUMAN	ITGB3BP	physical	26496610
VPS4A_HUMAN	VPS4A	physical	26496610
TSR1_HUMAN	TSR1	physical	26496610
CENPN_HUMAN	CENPN	physical	26496610
CENPK_HUMAN	CENPK	physical	26496610
CENPH_HUMAN	CENPH	physical	26496610
CENPM_HUMAN	CENPM	physical	26496610
CENPO_HUMAN	CENPO	physical	26496610
CENPU_HUMAN	CENPU	physical	26496610
CENPT_HUMAN	CENPT	physical	26496610
CCNL2_HUMAN	CCNL2	physical	26496610
CENPX_HUMAN	STRA13	physical	26496610
CENPP_HUMAN	CENPP	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CENPQ_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31 AND SER-50, AND MASSSPECTROMETRY.	19007248 [Abstract]

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