CENPM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CENPM_HUMAN
• UniProt AC: Q9NSP4
• Protein Name: Centromere protein M
• Gene Name: CENPM
• Organism: Homo sapiens (Human).
• Sequence Length: 180
• Subcellular Localization: Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells (By similarity). Localizes in the kinetochore domain of centromeres..
• Protein Description: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres..
• Protein Sequence: MSVLRPLDKLPGLNTATILLVGTEDALLQQLADSMLKEDCASELKVHLAKSLPLPSSVNRPRIDLIVFVVNLHSKYSLQNTEESLRHVDASFFLGKVCFLATGAGRESHCSIHRHTVVKLAHTYQSPLLYCDLEVEGFRATMAQRLVRVLQICAGHVPGVSALNLLSLLRSSEGPSLEDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSVLRPLDK ------CCCCCCHHH	29.83	23401153
45	Ubiquitination	EDCASELKVHLAKSL HHHHHHHHHHHHHCC	24.45	-
51	Phosphorylation	LKVHLAKSLPLPSSV HHHHHHHCCCCCCCC	29.61	30619164
56	Phosphorylation	AKSLPLPSSVNRPRI HHCCCCCCCCCCCCC	55.38	30619164
57	Phosphorylation	KSLPLPSSVNRPRID HCCCCCCCCCCCCCE	22.82	30619164
76	Phosphorylation	VVNLHSKYSLQNTEE EEECCHHHHCCCHHH	20.03	29496907
81	Phosphorylation	SKYSLQNTEESLRHV HHHHCCCHHHHHHHC	28.33	29978859
84	Phosphorylation	SLQNTEESLRHVDAS HCCCHHHHHHHCCHH	25.19	29978859
108	O-linked_Glycosylation	ATGAGRESHCSIHRH HCCCCCCCCCEECHH	28.56	29351928
111	O-linked_Glycosylation	AGRESHCSIHRHTVV CCCCCCCEECHHHHH	18.92	29351928
114 (in isoform 2)	Phosphorylation	-	26.04	20068231
116 (in isoform 2)	Phosphorylation	-	27.27	20068231
123	Phosphorylation	TVVKLAHTYQSPLLY HHHHHHEECCCCEEE	20.04	29496907
130	Phosphorylation	TYQSPLLYCDLEVEG ECCCCEEEEECEECH	7.50	29496907
176	Phosphorylation	LRSSEGPSLEDL--- HHCCCCCCCCCC---	56.07	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CENPM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CENPM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CENPM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CENPC_HUMAN	CENPC	physical	16622419
CENPI_HUMAN	CENPI	physical	16622419
CENPT_HUMAN	CENPT	physical	16622419
CENPN_HUMAN	CENPN	physical	16622419
CENPL_HUMAN	CENPL	physical	16622419
CENPO_HUMAN	CENPO	physical	16622419
CENPK_HUMAN	CENPK	physical	16622419
CENPP_HUMAN	CENPP	physical	16622419
CENPQ_HUMAN	CENPQ	physical	16622419
ARRB2_HUMAN	ARRB2	physical	26186194
DOK2_HUMAN	DOK2	physical	26186194
OXLD1_HUMAN	OXLD1	physical	28514442
DOK2_HUMAN	DOK2	physical	28514442
PCP2_HUMAN	PCP2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.