CENPL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CENPL_HUMAN
• UniProt AC: Q8N0S6
• Protein Name: Centromere protein L
• Gene Name: CENPL
• Organism: Homo sapiens (Human).
• Sequence Length: 344
• Subcellular Localization: Nucleus . Chromosome, centromere . Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
• Protein Description: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex..
• Protein Sequence: MDSYSAPESTPSASSRPEDYFIGATPLQKRLESVRKQSSFILTPPRRKIPQCSQLQEDVDPQKVAFLLHKQWTLYSLTPLYKFSYSNLKEYSRLLNAFIVAEKQKGLAVEVGEDFNIKVIFSTLLGMKGTQRDPEAFLVQIVSKSQLPSENREGKVLWTGWFCCVFGDSLLETVSEDFTCLPLFLANGAESNTAIIGTWFQKTFDCYFSPLAINAFNLSWMAAMWTACKMDHYVATTEFLWSVPCSPQSLDISFAIHPEDAKALWDSVHKTPGEVTQEEVDLFMDCLYSHFHRHFKIHLSATRLVRVSTSVASAHTDGKIKILCHKYLIGVLAYLTELAIFQIE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDSYSAPEST -----CCCCCCCCCC	21.49	23663014
4	Phosphorylation	----MDSYSAPESTP ----CCCCCCCCCCC	12.46	23663014
5	Phosphorylation	---MDSYSAPESTPS ---CCCCCCCCCCCC	41.10	23663014
9	Phosphorylation	DSYSAPESTPSASSR CCCCCCCCCCCCCCC	44.55	23663014
10	Phosphorylation	SYSAPESTPSASSRP CCCCCCCCCCCCCCC	21.43	23663014
12	Phosphorylation	SAPESTPSASSRPED CCCCCCCCCCCCCCC	40.65	23663014
14	Phosphorylation	PESTPSASSRPEDYF CCCCCCCCCCCCCCC	31.08	23663014
15	Phosphorylation	ESTPSASSRPEDYFI CCCCCCCCCCCCCCC	52.12	23663014
38	Phosphorylation	LESVRKQSSFILTPP HHHHHHHCCCCCCCC	30.19	30266825
39	Phosphorylation	ESVRKQSSFILTPPR HHHHHHCCCCCCCCC	17.51	30266825
43 (in isoform 2)	Phosphorylation	-	26.82	24719451
43	Phosphorylation	KQSSFILTPPRRKIP HHCCCCCCCCCCCCC	26.82	30266825
48	Ubiquitination	ILTPPRRKIPQCSQL CCCCCCCCCCCCHHC	61.08	-
53	Phosphorylation	RRKIPQCSQLQEDVD CCCCCCCHHCCCCCC	28.78	30266825
63 (in isoform 3)	Ubiquitination	-	40.70	21890473
63 (in isoform 1)	Ubiquitination	-	40.70	21890473
63 (in isoform 2)	Ubiquitination	-	40.70	21890473
63	Ubiquitination	QEDVDPQKVAFLLHK CCCCCHHHHHHHHHC	40.70	21890473
73	Phosphorylation	FLLHKQWTLYSLTPL HHHHCCCHHHHCCCC	17.21	20068231
75	Phosphorylation	LHKQWTLYSLTPLYK HHCCCHHHHCCCCHH	8.34	20068231
76	Phosphorylation	HKQWTLYSLTPLYKF HCCCHHHHCCCCHHC	28.95	20068231
78	Phosphorylation	QWTLYSLTPLYKFSY CCHHHHCCCCHHCCC	12.81	20068231
81	Phosphorylation	LYSLTPLYKFSYSNL HHHCCCCHHCCCCCH	15.93	20068231
89 (in isoform 2)	Ubiquitination	-	59.88	-
89	Ubiquitination	KFSYSNLKEYSRLLN HCCCCCHHHHHHHHH	59.88	-
122	Phosphorylation	FNIKVIFSTLLGMKG CCCHHHHHHHHCCCC	13.66	22210691
123	Phosphorylation	NIKVIFSTLLGMKGT CCHHHHHHHHCCCCC	18.43	22210691
144	Ubiquitination	FLVQIVSKSQLPSEN HHEEECCHHHCCCCC	31.18	2190698
144 (in isoform 1)	Ubiquitination	-	31.18	21890473
310	Phosphorylation	RLVRVSTSVASAHTD HEEEEECCHHCCCCC	14.26	-
321	Ubiquitination	AHTDGKIKILCHKYL CCCCCCCHHHHHHHH	32.86	-
367 (in isoform 2)	Ubiquitination	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CENPL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CENPL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CENPL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JMJD6_HUMAN	JMJD6	physical	23455924
FAM9B_HUMAN	FAM9B	physical	25416956
ICK_HUMAN	ICK	physical	26186194
ICK_HUMAN	ICK	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.