dbPTM

ARRB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ARRB2_HUMAN
UniProt AC	P32121
Protein Name	Beta-arrestin-2
Gene Name	ARRB2
Organism	Homo sapiens (Human).
Sequence Length	409
Subcellular Localization	Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit. Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs.
Protein Description	Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6 and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as signaling scaffold for the AKT1 pathway. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa-B-dependent activation by interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved in endocytosis of low-density lipoprotein receptor/LDLR. Involved in endocytosis of smoothened homolog/Smo, which also requires GRK2. Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Involved in insulin resistance by acting as insulin-induced signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in IL8-mediated granule release in neutrophils. Involved in the internalization of the atypical chemokine receptor ACKR3..
Protein Sequence	MGEKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLFIATYQAFPPVPNPPRPPTRLQDRLLRKLGQHAHPFFFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSLEEKSHKRNSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLFSTAQYKCPVAQLEQDDQVSPSSTFCKVYTITPLLSDNREKRGLALDGKLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPHDHIPLPRPQSAAPETDVPVDTNLIEFDTNYATDDDIVFEDFARLRLKGMKDDDYDDQLC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	GTRVFKKSSPNCKLT CCEEECCCCCCCEEE	52.17	-
14	Phosphorylation	TRVFKKSSPNCKLTV CEEECCCCCCCEEEE	29.07	-
18	Acetylation	KKSSPNCKLTVYLGK CCCCCCCEEEEEECC	54.56	25953088
20	Phosphorylation	SSPNCKLTVYLGKRD CCCCCEEEEEECCHH	7.81	-
25	Acetylation	KLTVYLGKRDFVDHL EEEEEECCHHHHHCC	46.31	25953088
34	Ubiquitination	DFVDHLDKVDPVDGV HHHHCCCCCCCCCCE	55.70	-
48	Phosphorylation	VVLVDPDYLKDRKVF EEEECHHHHCCCEEE	22.50	20090780
48 (in isoform 3)	Phosphorylation	-	22.50	25147952
50	Ubiquitination	LVDPDYLKDRKVFVT EECHHHHCCCEEEEE	49.62	-
75	Phosphorylation	DLDVLGLSFRKDLFI CCEEEEEEECCCEEE	22.62	24719451
78	Ubiquitination	VLGLSFRKDLFIATY EEEEEECCCEEEEEE	57.69	21890473
78	Ubiquitination	VLGLSFRKDLFIATY EEEEEECCCEEEEEE	57.69	21890473
78	Ubiquitination	VLGLSFRKDLFIATY EEEEEECCCEEEEEE	57.69	21890473
108 (in isoform 3)	Ubiquitination	-	57.87	-
108	Ubiquitination	LQDRLLRKLGQHAHP HHHHHHHHHHCCCCC	57.87	-
153 (in isoform 3)	Ubiquitination	-	57.67	-
153	Ubiquitination	EIRAFCAKSLEEKSH HHHHHHHHHHHHHCC	57.67	-
153	Acetylation	EIRAFCAKSLEEKSH HHHHHHHHHHHHHCC	57.67	23749302
159	Phosphorylation	AKSLEEKSHKRNSVR HHHHHHHCCCCCEEE	37.20	-
163 (in isoform 2)	Ubiquitination	-	50.05	21890473
164	Phosphorylation	EKSHKRNSVRLVIRK HHCCCCCEEEEEEEE	16.79	27282143
171 (in isoform 3)	Ubiquitination	-	29.30	-
171	Ubiquitination	SVRLVIRKVQFAPEK EEEEEEEEEECCCCC	29.30	-
176	Hydroxylation	IRKVQFAPEKPGPQP EEEEECCCCCCCCCC	51.97	21255264
178 (in isoform 1)	Ubiquitination	-	54.97	21890473
178 (in isoform 3)	Ubiquitination	-	54.97	21890473
178	Ubiquitination	KVQFAPEKPGPQPSA EEECCCCCCCCCCCH	54.97	2190698
181	Hydroxylation	FAPEKPGPQPSAETT CCCCCCCCCCCHHHH	51.98	21255264
197	Phosphorylation	HFLMSDRSLHLEASL HHHHCCCCEEEEEEC	25.73	28348404
230	Acetylation	NNSTKTVKKIKVSVR CCCCCCEEEEEEEHH	54.75	20167786
231	Acetylation	NSTKTVKKIKVSVRQ CCCCCEEEEEEEHHH	43.34	20167786
233	Acetylation	TKTVKKIKVSVRQYA CCCEEEEEEEHHHHH	37.02	20167786
266	Phosphorylation	QDDQVSPSSTFCKVY CCCCCCCCCCEEEEE	34.21	30576142
267	Phosphorylation	DDQVSPSSTFCKVYT CCCCCCCCCEEEEEE	28.96	30576142
273	Phosphorylation	SSTFCKVYTITPLLS CCCEEEEEEECCCCC	4.29	30576142
276	Phosphorylation	FCKVYTITPLLSDNR EEEEEEECCCCCCCH	10.49	-
293	Acetylation	RGLALDGKLKHEDTN CCEECCCCCCCCCCC	54.77	25953088
293	Sumoylation	RGLALDGKLKHEDTN CCEECCCCCCCCCCC	54.77	-
293 (in isoform 3)	Ubiquitination	-	54.77	-
293	Ubiquitination	RGLALDGKLKHEDTN CCEECCCCCCCCCCC	54.77	-
295 (in isoform 3)	Ubiquitination	-	48.73	-
295	Sumoylation	LALDGKLKHEDTNLA EECCCCCCCCCCCCC	48.73	-
295	Ubiquitination	LALDGKLKHEDTNLA EECCCCCCCCCCCCC	48.73	-
295	Sumoylation	LALDGKLKHEDTNLA EECCCCCCCCCCCCC	48.73	-
308	Ubiquitination	LASSTIVKEGANKEV CCCCEEEECCCCHHH	46.72	-
327	Acetylation	VSYRVKVKLVVSRGG EEEEEEEEEEEECCC	29.82	25953088
331	Phosphorylation	VKVKLVVSRGGDVSV EEEEEEEECCCCEEE	20.09	24719451
360	Phosphorylation	IPLPRPQSAAPETDV CCCCCCCCCCCCCCC	29.13	26074081
382	Phosphorylation	EFDTNYATDDDIVFE EEECCCCCCCCCEEH	29.60	14702039
397	Ubiquitination	DFARLRLKGMKDDDY HHHHHHHCCCCCCCC	50.99	-
397	Sumoylation	DFARLRLKGMKDDDY HHHHHHHCCCCCCCC	50.99	-
400	Sumoylation	RLRLKGMKDDDYDDQ HHHHCCCCCCCCCCC	67.67	-
404	Phosphorylation	KGMKDDDYDDQLC-- CCCCCCCCCCCCC--	28.54	28796482
409 (in isoform 3)	Ubiquitination	-	4.33	-
425	Phosphorylation	----------------------- -----------------------		27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
14	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
14	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
276	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
276	T	Phosphorylation	Kinase	MAPK3	P27361	GPS
382	T	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
382	T	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
382	T	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	MDM2	Q00987	PMID:12488444

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
382	T	Phosphorylation		11877451
Phosphorylated at Thr-382 in the cytoplasm; probably dephosphorylated at the plasma membrane.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ARRB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNDS_HUMAN	RALGDS	physical	12105416
NOLC1_HUMAN	NOLC1	physical	17353931
TCOF_HUMAN	TCOF1	physical	17353931
DDX27_HUMAN	DDX27	physical	17353931
AP3B1_HUMAN	AP3B1	physical	17353931
IMA4_HUMAN	KPNA3	physical	17353931
IMA3_HUMAN	KPNA4	physical	17353931
BOP1_HUMAN	BOP1	physical	17353931
ARRB1_HUMAN	ARRB1	physical	17353931
RM44_HUMAN	MRPL44	physical	17353931
RM43_HUMAN	MRPL43	physical	17353931
FBRL_HUMAN	FBL	physical	17353931
PESC_HUMAN	PES1	physical	17353931
RL7L_HUMAN	RPL7L1	physical	17353931
RAB5C_HUMAN	RAB5C	physical	17353931
SMRC2_HUMAN	SMARCC2	physical	16169070
MED8_HUMAN	MED8	physical	16169070
STC2_HUMAN	STC2	physical	16169070
ARF6_HUMAN	ARF6	physical	11533043
MDM2_HUMAN	MDM2	physical	12488444
MK03_HUMAN	MAPK3	physical	12473660
AP2B1_HUMAN	AP2B1	physical	10097102
M3K5_HUMAN	MAP3K5	physical	11090355
MP2K4_HUMAN	MAP2K4	physical	11090355
NEDD4_HUMAN	NEDD4	physical	18544533
MDM2_HUMAN	MDM2	physical	18544533
ITCH_HUMAN	ITCH	physical	18544533
MK01_HUMAN	MAPK1	physical	15699045
UBP33_HUMAN	USP33	physical	19424180
AGRG1_HUMAN	GPR56	physical	21708946
UBP33_HUMAN	USP33	physical	19363159
PRKN_HUMAN	PARK2	physical	21466165
MDM2_HUMAN	MDM2	physical	21466165
M3K5_HUMAN	MAP3K5	physical	19306926
CHIP_HUMAN	STUB1	physical	19306926
MP2K1_HUMAN	MAP2K1	physical	11226259
MK01_HUMAN	MAPK1	physical	11226259
AKT1_HUMAN	AKT1	physical	18191226
MDM2_HUMAN	MDM2	physical	21389118
PTPA_HUMAN	PPP2R4	physical	21502318
TEBP_HUMAN	PTGES3	physical	21502318
IGF1R_HUMAN	IGF1R	physical	15878855
MDM2_HUMAN	MDM2	physical	15878855
ARRB1_HUMAN	ARRB1	physical	17620599
ARRS_HUMAN	SAG	physical	17620599
ARRC_HUMAN	ARR3	physical	17620599
1433B_HUMAN	YWHAB	physical	17620599
1433G_HUMAN	YWHAG	physical	17620599
1433T_HUMAN	YWHAQ	physical	17620599
1433F_HUMAN	YWHAH	physical	17620599
1433E_HUMAN	YWHAE	physical	17620599
STK38_HUMAN	STK38	physical	17620599
SCYL2_HUMAN	SCYL2	physical	17620599
DGKZ_HUMAN	DGKZ	physical	17620599
DGKE_HUMAN	DGKE	physical	17620599
CSK21_HUMAN	CSNK2A1	physical	17620599
MK01_HUMAN	MAPK1	physical	17620599
KCC2D_HUMAN	CAMK2D	physical	17620599
CDK13_HUMAN	CDK13	physical	17620599
CDK3_HUMAN	CDK3	physical	17620599
CDK7_HUMAN	CDK7	physical	17620599
KC1AL_HUMAN	CSNK1A1L	physical	17620599
E2AK4_HUMAN	EIF2AK4	physical	17620599
PPM1A_HUMAN	PPM1A	physical	17620599
PPM1B_HUMAN	PPM1B	physical	17620599
2AAA_HUMAN	PPP2R1A	physical	17620599
MYPT1_HUMAN	PPP1R12A	physical	17620599
CLCA_HUMAN	CLTA	physical	17620599
CLCB_HUMAN	CLTB	physical	17620599
AP2A1_HUMAN	AP2A1	physical	17620599
AP2B1_HUMAN	AP2B1	physical	17620599
RFIP5_HUMAN	RAB11FIP5	physical	17620599
VPS35_HUMAN	VPS35	physical	17620599
CPNE1_HUMAN	CPNE1	physical	17620599
AP3D1_HUMAN	AP3D1	physical	17620599
ARHG6_HUMAN	ARHGEF6	physical	17620599
RAGP1_HUMAN	RANGAP1	physical	17620599
RHG21_HUMAN	ARHGAP21	physical	17620599
G3BP2_HUMAN	G3BP2	physical	17620599
ANXA2_HUMAN	ANXA2	physical	17620599
TAB1_HUMAN	TAB1	physical	17620599
IKKA_HUMAN	CHUK	physical	17620599
CTNA1_HUMAN	CTNNA1	physical	17620599
CTND1_HUMAN	CTNND1	physical	17620599
SDC3_HUMAN	SDC3	physical	17620599
ANM1_HUMAN	PRMT1	physical	17620599
WDR26_HUMAN	WDR26	physical	17620599
H11_HUMAN	HIST1H1A	physical	17620599
H1X_HUMAN	H1FX	physical	17620599
H2A2B_HUMAN	HIST2H2AB	physical	17620599
XRCC6_HUMAN	XRCC6	physical	17620599
HDAC2_HUMAN	HDAC2	physical	17620599
H2B1O_HUMAN	HIST1H2BO	physical	17620599
XRCC5_HUMAN	XRCC5	physical	17620599
LBR_HUMAN	LBR	physical	17620599
MCM3_HUMAN	MCM3	physical	17620599
NOLC1_HUMAN	NOLC1	physical	17620599
TCOF_HUMAN	TCOF1	physical	17620599
ANM5_HUMAN	PRMT5	physical	17620599
NPM_HUMAN	NPM1	physical	17620599
ERH_HUMAN	ERH	physical	17620599
TIF1B_HUMAN	TRIM28	physical	17620599
YBOX1_HUMAN	YBX1	physical	17620599
LEO1_HUMAN	LEO1	physical	17620599
THOC4_HUMAN	ALYREF	physical	17620599
ZRAB2_HUMAN	ZRANB2	physical	17620599
TR150_HUMAN	THRAP3	physical	17620599
HTSF1_HUMAN	HTATSF1	physical	17620599
RPA1_HUMAN	POLR1A	physical	17620599
RPA2_HUMAN	POLR1B	physical	17620599
ILF3_HUMAN	ILF3	physical	17620599
RPA43_HUMAN	TWISTNB	physical	17620599
NP1L1_HUMAN	NAP1L1	physical	17620599
YBOX3_HUMAN	YBX3	physical	17620599
NOP10_HUMAN	NOP10	physical	17620599
RBM10_HUMAN	RBM10	physical	17620599
NUCL_HUMAN	NCL	physical	17620599
NOP56_HUMAN	NOP56	physical	17620599
SF3B1_HUMAN	SF3B1	physical	17620599
SF3B2_HUMAN	SF3B2	physical	17620599
SFPQ_HUMAN	SFPQ	physical	17620599
NONO_HUMAN	NONO	physical	17620599
DDX3X_HUMAN	DDX3X	physical	17620599
DHX15_HUMAN	DHX15	physical	17620599
SRRM2_HUMAN	SRRM2	physical	17620599
SMD1_HUMAN	SNRPD1	physical	17620599
SMD2_HUMAN	SNRPD2	physical	17620599
ROA1_HUMAN	HNRNPA1	physical	17620599
ROA2_HUMAN	HNRNPA2B1	physical	17620599
HNRPD_HUMAN	HNRNPD	physical	17620599
HNRH1_HUMAN	HNRNPH1	physical	17620599
HNRPK_HUMAN	HNRNPK	physical	17620599
HNRPM_HUMAN	HNRNPM	physical	17620599
HNRPU_HUMAN	HNRNPU	physical	17620599
ROA0_HUMAN	HNRNPA0	physical	17620599
HNRPC_HUMAN	HNRNPC	physical	17620599
HNRPF_HUMAN	HNRNPF	physical	17620599
HNRH2_HUMAN	HNRNPH2	physical	17620599
PTBP1_HUMAN	PTBP1	physical	17620599
HNRPR_HUMAN	HNRNPR	physical	17620599
SF3B3_HUMAN	SF3B3	physical	17620599
DKC1_HUMAN	DKC1	physical	17620599
FBRL_HUMAN	FBL	physical	17620599
U5S1_HUMAN	EFTUD2	physical	17620599
PABP3_HUMAN	PABPC3	physical	17620599
PABP4_HUMAN	PABPC4	physical	17620599
PAIRB_HUMAN	SERBP1	physical	17620599
IF4B_HUMAN	EIF4B	physical	17620599
EF1A2_HUMAN	EEF1A2	physical	17620599
PABP1_HUMAN	PABPC1	physical	17620599
IF2B1_HUMAN	IGF2BP1	physical	17620599
RS3A_HUMAN	RPS3A	physical	17620599
RS3_HUMAN	RPS3	physical	17620599
RS17_HUMAN	RPS17	physical	17620599
RS19_HUMAN	RPS19	physical	17620599
RL7A_HUMAN	RPL7A	physical	17620599
RL7_HUMAN	RPL7	physical	17620599
RL12_HUMAN	RPL12	physical	17620599
RL18_HUMAN	RPL18	physical	17620599
RL21_HUMAN	RPL21	physical	17620599
RL22_HUMAN	RPL22	physical	17620599
RL31_HUMAN	RPL31	physical	17620599
RLA0_HUMAN	RPLP0	physical	17620599
RLA1_HUMAN	RPLP1	physical	17620599
RLA2_HUMAN	RPLP2	physical	17620599
RS6_HUMAN	RPS6	physical	17620599
RS7_HUMAN	RPS7	physical	17620599
RS8_HUMAN	RPS8	physical	17620599
RS13_HUMAN	RPS13	physical	17620599
RL3_HUMAN	RPL3	physical	17620599
RL6_HUMAN	RPL6	physical	17620599
RL14_HUMAN	RPL14	physical	17620599
RL15_HUMAN	RPL15	physical	17620599
RL28_HUMAN	RPL28	physical	17620599
EF2_HUMAN	EEF2	physical	17620599
ACTB_HUMAN	ACTB	physical	17620599
TBA4A_HUMAN	TUBA4A	physical	17620599
TBA3C_HUMAN	TUBA3C	physical	17620599
TBA1C_HUMAN	TUBA1C	physical	17620599
TBB2A_HUMAN	TUBB2A	physical	17620599
TBB4B_HUMAN	TUBB4B	physical	17620599
TBB3_HUMAN	TUBB3	physical	17620599
VIME_HUMAN	VIM	physical	17620599
ACTH_HUMAN	ACTG2	physical	17620599
TBB4A_HUMAN	TUBB4A	physical	17620599
TBA1A_HUMAN	TUBA1A	physical	17620599
COF1_HUMAN	CFL1	physical	17620599
FLNA_HUMAN	FLNA	physical	17620599
GELS_HUMAN	GSN	physical	17620599
TMOD3_HUMAN	TMOD3	physical	17620599
SPTN1_HUMAN	SPTAN1	physical	17620599
ARP5L_HUMAN	ARPC5L	physical	17620599
SPTB2_HUMAN	SPTBN1	physical	17620599
LIMA1_HUMAN	LIMA1	physical	17620599
MAP1B_HUMAN	MAP1B	physical	17620599
CAZA1_HUMAN	CAPZA1	physical	17620599
CAZA2_HUMAN	CAPZA2	physical	17620599
SRC8_HUMAN	CTTN	physical	17620599
DREB_HUMAN	DBN1	physical	17620599
MYH9_HUMAN	MYH9	physical	17620599
MYO1C_HUMAN	MYO1C	physical	17620599
MYL6_HUMAN	MYL6	physical	17620599
DYHC1_HUMAN	DYNC1H1	physical	17620599
MYH10_HUMAN	MYH10	physical	17620599
KPYM_HUMAN	PKM	physical	17620599
G3P_HUMAN	GAPDH	physical	17620599
FAS_HUMAN	FASN	physical	17620599
F263_HUMAN	PFKFB3	physical	17620599
PDIA1_HUMAN	P4HB	physical	17620599
SDHA_HUMAN	SDHA	physical	17620599
RPN2_HUMAN	RPN2	physical	17620599
NAA10_HUMAN	NAA10	physical	17620599
PYRG1_HUMAN	CTPS1	physical	17620599
DDX1_HUMAN	DDX1	physical	17620599
HSP7C_HUMAN	HSPA8	physical	17620599
HS71L_HUMAN	HSPA1L	physical	17620599
HS90B_HUMAN	HSP90AB1	physical	17620599
TCPZ_HUMAN	CCT6A	physical	17620599
ICLN_HUMAN	CLNS1A	physical	17620599
KCAB1_HUMAN	KCNAB1	physical	17620599
TRPV4_HUMAN	TRPV4	physical	17620599
CLIC1_HUMAN	CLIC1	physical	17620599
BCLF1_HUMAN	BCLAF1	physical	17620599
GRP78_HUMAN	HSPA5	physical	17620599
RS27A_HUMAN	RPS27A	physical	17620599
UBB_HUMAN	UBB	physical	17620599
UBC_HUMAN	UBC	physical	17620599
CAN1_HUMAN	CAPN1	physical	17620599
RL40_HUMAN	UBA52	physical	17620599
UBR5_HUMAN	UBR5	physical	17620599
SPIN1_HUMAN	SPIN1	physical	17620599
SPIN3_HUMAN	SPIN3	physical	17620599
NKTR_HUMAN	NKTR	physical	17620599
DCD_HUMAN	DCD	physical	17620599
C1QBP_HUMAN	C1QBP	physical	17620599
MEP50_HUMAN	WDR77	physical	17620599
HDGR2_HUMAN	HDGFRP2	physical	17620599
BOLA2_HUMAN	BOLA2	physical	17620599
MOB1A_HUMAN	MOB1A	physical	17620599
COPRS_HUMAN	COPRS	physical	17620599
PAK5_HUMAN	PAK7	physical	17620599
M3K1_HUMAN	MAP3K1	physical	17620599
M3K14_HUMAN	MAP3K14	physical	17620599
WEE1_HUMAN	WEE1	physical	17620599
CDK4_HUMAN	CDK4	physical	17620599
PRP4B_HUMAN	PRPF4B	physical	17620599
P3C2A_HUMAN	PIK3C2A	physical	17620599
SRPK2_HUMAN	SRPK2	physical	17620599
M3K7_HUMAN	MAP3K7	physical	17620599
KPB2_HUMAN	PHKA2	physical	17620599
AP2A2_HUMAN	AP2A2	physical	17620599
AP3B2_HUMAN	AP3B2	physical	17620599
LRP11_HUMAN	LRP11	physical	17620599
RHG17_HUMAN	ARHGAP17	physical	17620599
ARHGB_HUMAN	ARHGEF11	physical	17620599
ARHGC_HUMAN	ARHGEF12	physical	17620599
PDE4D_HUMAN	PDE4D	physical	17620599
AFAD_HUMAN	MLLT4	physical	17620599
S10A9_HUMAN	S100A9	physical	17620599
H12_HUMAN	HIST1H1C	physical	17620599
H2AX_HUMAN	H2AFX	physical	17620599
RFA1_HUMAN	RPA1	physical	17620599
RPAC1_HUMAN	POLR1C	physical	17620599
RPAB1_HUMAN	POLR2E	physical	17620599
STAT1_HUMAN	STAT1	physical	17620599
MYCD_HUMAN	MYOCD	physical	17620599
CENPF_HUMAN	CENPF	physical	17620599
DDX5_HUMAN	DDX5	physical	17620599
RS4X_HUMAN	RPS4X	physical	17620599
RL4_HUMAN	RPL4	physical	17620599
RL11_HUMAN	RPL11	physical	17620599
RL19_HUMAN	RPL19	physical	17620599
RL30_HUMAN	RPL30	physical	17620599
RL26_HUMAN	RPL26	physical	17620599
RL35A_HUMAN	RPL35A	physical	17620599
RL35_HUMAN	RPL35	physical	17620599
RL36_HUMAN	RPL36	physical	17620599
EF1A1_HUMAN	EEF1A1	physical	17620599
ACTC_HUMAN	ACTC1	physical	17620599
LAP2A_HUMAN	TMPO	physical	17620599
LAP2B_HUMAN	TMPO	physical	17620599
E41L3_HUMAN	EPB41L3	physical	17620599
BSN_HUMAN	BSN	physical	17620599
PPIA_HUMAN	PPIA	physical	17620599
HSP76_HUMAN	HSPA6	physical	17620599
CUL5_HUMAN	CUL5	physical	17620599
CASB_HUMAN	CSN2	physical	17620599
IMB1_HUMAN	KPNB1	physical	17620599
TERA_HUMAN	VCP	physical	17620599
NSUN2_HUMAN	NSUN2	physical	17620599
PRP4_HUMAN	PRPF4	physical	17620599
MDM2_HUMAN	MDM2	physical	21081496
TRAF6_HUMAN	TRAF6	physical	16378096
UBC_HUMAN	UBC	physical	21378163
MDM2_HUMAN	MDM2	physical	17984062
AP2M1_HUMAN	AP2M1	physical	17984062
FLNA_HUMAN	FLNA	physical	17984062
SL9A5_HUMAN	SLC9A5	physical	15699339
IKBA_HUMAN	NFKBIA	physical	15173580
IGF1R_HUMAN	IGF1R	physical	23188799
IKBA_HUMAN	NFKBIA	physical	15125834
EDNRA_HUMAN	EDNRA	physical	19202075
SRC_HUMAN	SRC	physical	19202075
GLUC_HUMAN	GCG	physical	18445652
MP2K4_HUMAN	MAP2K4	physical	19782076
AKT1_HUMAN	AKT1	physical	19262695
CSK_HUMAN	CSK	physical	19262695
LIMK1_HUMAN	LIMK1	physical	17500066
AGRB1_HUMAN	BAI1	physical	23782696
MDM2_HUMAN	MDM2	physical	21988832
PTGDS_HUMAN	PTGDS	physical	21112970
UBP33_HUMAN	USP33	physical	24377933
MK09_HUMAN	MAPK9	physical	25416956
HGS_HUMAN	HGS	physical	23208550
NEDD4_HUMAN	NEDD4	physical	23208550
ARRD3_HUMAN	ARRDC3	physical	23208550
TRAF6_HUMAN	TRAF6	physical	25425640
ALS_HUMAN	IGFALS	physical	26344197
AP2B1_HUMAN	AP2B1	physical	21118812
HGS_HUMAN	HGS	physical	20505072
OPSD_HUMAN	RHO	physical	9852134
SRC_HUMAN	SRC	physical	11877451
AP3B2_HUMAN	AP3B2	physical	11877451
AP1B1_HUMAN	AP1B1	physical	11877451
RAF1_HUMAN	RAF1	physical	11226259
SYNE2_HUMAN	SYNE2	physical	26496610
ANR11_HUMAN	ANKRD11	physical	26496610
PPM1B_HUMAN	PPM1B	physical	25241761
M3K1_HUMAN	MAP3K1	physical	25241761
SRC8_HUMAN	CTTN	physical	25241761
CTNA1_HUMAN	CTNNA1	physical	25241761
MK01_HUMAN	MAPK1	physical	25241761
IKKA_HUMAN	CHUK	physical	25241761
TAB2_HUMAN	TAB2	physical	25241761
KPCB_HUMAN	PRKCB	physical	26545496
DRD2_HUMAN	DRD2	physical	25162404
DRD4_HUMAN	DRD4	physical	27155323
KLH12_HUMAN	KLHL12	physical	27155323
CUL3_HUMAN	CUL3	physical	27155323
PE2R2_HUMAN	PTGER2	physical	11418617
PE2R4_HUMAN	PTGER4	physical	11418617
ARRB1_HUMAN	ARRB1	physical	28514442
ARRC_HUMAN	ARR3	physical	28514442
KANK1_HUMAN	KANK1	physical	28514442
BRPF1_HUMAN	BRPF1	physical	28514442
DIEXF_HUMAN	DIEXF	physical	28514442
NAA15_HUMAN	NAA15	physical	28514442
RTF1_HUMAN	RTF1	physical	28514442
RFX1_HUMAN	RFX1	physical	28514442
WDR70_HUMAN	WDR70	physical	28514442
CR025_HUMAN	C18orf25	physical	28514442
RAD18_HUMAN	RAD18	physical	28514442
NOLC1_HUMAN	NOLC1	physical	28514442
SAHH3_HUMAN	AHCYL2	physical	28514442
FLNB_HUMAN	FLNB	physical	28514442
AFF4_HUMAN	AFF4	physical	28514442
ENL_HUMAN	MLLT1	physical	28514442
AF9_HUMAN	MLLT3	physical	28514442
IKBL1_HUMAN	NFKBIL1	physical	28514442
CENPB_HUMAN	CENPB	physical	28514442
JPH1_HUMAN	JPH1	physical	28514442
E41L5_HUMAN	EPB41L5	physical	28514442
SAHH2_HUMAN	AHCYL1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ARRB2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Regulation of arrestin-3 phosphorylation by casein kinase II."; Kim Y.-M., Barak L.S., Caron M.G., Benovic J.L.; J. Biol. Chem. 277:16837-16846(2002). Cited for: FUNCTION IN INTERNALIZATION OF ADBR2, PHOSPHORYLATION AT THR-382,INTERACTION WITH AP2B1; CLATHRIN AND SRC, SUBCELLULAR LOCATION, ANDMUTAGENESIS OF THR-382.	11877451 [Abstract]

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