KCAB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCAB1_HUMAN
• UniProt AC: Q14722
• Protein Name: Voltage-gated potassium channel subunit beta-1
• Gene Name: KCNAB1
• Organism: Homo sapiens (Human).
• Sequence Length: 419
• Subcellular Localization: Cytoplasm . Membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel al
• Protein Description: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. [PubMed: 7499366]
• Protein Sequence: MLAARTGAAGSQISEENTKLRRQSGFSVAGKDKSPKKASENAKDSSLSPSGESQLRARQLALLREVEMNWYLKLCDLSSEHTTVCTTGMPHRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKERIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILRNKPYSKKDYRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4 (in isoform 2)	Phosphorylation	-	12.95	23663014
6	Phosphorylation	--MLAARTGAAGSQI --CCCCCCCCCCCCC	26.84	27762562
8 (in isoform 2)	Phosphorylation	-	14.18	23663014
11	Phosphorylation	ARTGAAGSQISEENT CCCCCCCCCCCHHHH	21.44	27762562
14	Phosphorylation	GAAGSQISEENTKLR CCCCCCCCHHHHHHH	31.08	27762562
18	Phosphorylation	SQISEENTKLRRQSG CCCCHHHHHHHHHHC	34.43	27762562
24	Phosphorylation	NTKLRRQSGFSVAGK HHHHHHHHCCCCCCC	39.74	22964224
24 (in isoform 3)	Phosphorylation	-	39.74	-
27	Phosphorylation	LRRQSGFSVAGKDKS HHHHHCCCCCCCCCC	18.00	22964224
34	Phosphorylation	SVAGKDKSPKKASEN CCCCCCCCCCCHHCC	52.68	22964224
37	Acetylation	GKDKSPKKASENAKD CCCCCCCCHHCCCCC	61.60	7851223
39	Phosphorylation	DKSPKKASENAKDSS CCCCCCHHCCCCCCC	40.02	-
45	Phosphorylation	ASENAKDSSLSPSGE HHCCCCCCCCCCCHH	32.26	26657352
48	Phosphorylation	NAKDSSLSPSGESQL CCCCCCCCCCHHHHH	20.97	26657352
50	Phosphorylation	KDSSLSPSGESQLRA CCCCCCCCHHHHHHH	52.39	26657352
65 (in isoform 2)	Phosphorylation	-	42.68	-
67 (in isoform 3)	Phosphorylation	-	23.26	-
69 (in isoform 2)	Phosphorylation	-	15.67	-
71	Phosphorylation	REVEMNWYLKLCDLS HHHHHHHHHHHHCCC	6.75	30576142
80 (in isoform 3)	Phosphorylation	-	41.71	-
83	Phosphorylation	DLSSEHTTVCTTGMP CCCCCCCEEECCCCC	18.58	30576142
96	Ubiquitination	MPHRNLGKSGLRVSC CCCCCCCCCCCEEEE	44.51	-
153	Phosphorylation	KAEVILGSIIKKKGW CCEEHHHHHHHHCCC	20.07	24719451
163	Phosphorylation	KKKGWRRSSLVITTK HHCCCCCCEEEEEEE	21.32	23401153
164	Phosphorylation	KKGWRRSSLVITTKL HCCCCCCEEEEEEEE	25.50	26657352
168	Phosphorylation	RRSSLVITTKLYWGG CCCEEEEEEEEECCC	15.48	23882029
169	Phosphorylation	RSSLVITTKLYWGGK CCEEEEEEEEECCCC	14.13	23882029
186	Ubiquitination	TERGLSRKHIIEGLK CCCCCCHHHHHHHHH	35.46	-
236	Phosphorylation	INQGMAMYWGTSRWS HHHHCHHHCCCCCHH	7.37	-
269	Phosphorylation	PVCEQAEYHLFQREK HHHHHHHHHHHHHHC	13.57	29978859
414	Acetylation	LRNKPYSKKDYRS-- HHCCCCCHHHCCC--	43.77	7373265

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCAB1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCAB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCAB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
PUR9_HUMAN	ATIC	physical	26344197
KCAB2_HUMAN	KCNAB2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.