dbPTM

RFIP5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RFIP5_HUMAN
UniProt AC	Q9BXF6
Protein Name	Rab11 family-interacting protein 5
Gene Name	RAB11FIP5
Organism	Homo sapiens (Human).
Sequence Length	653
Subcellular Localization	Cytoplasm. Recycling endosome membrane Peripheral membrane protein. Early endosome membrane Peripheral membrane protein. Golgi apparatus membrane Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane Peripheral membrane protein.
Protein Description	Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis..
Protein Sequence	MALVRGAEPAAGPSRWLPTHVQVTVLRARGLRGKSSGAGSTSDAYTVIQVGREKYSTSVVEKTHGCPEWREECSFELPPGALDGLLRAQEADAGPAPWAASSAAACELVLTTMHRSLIGVDKFLGQATVALDEVFGAGRAQHTQWYKLHSKPGKKEKERGEIEVTIQFTRNNLSASMFDLSMKDKPRSPFSKIRDKMKGKKKYDLESASAILPSSAIEDPDLGSLGKMGKAKGFFLRNKLRKSSLTQSNTSLGSDSTLSSASGSLAYQGPGAELLTRSPSRSSWLSTEGGRDSAQSPKLFTHKRTYSDEANQMRVAPPRALLDLQGHLDAASRSSLCVNGSHIYNEEPQGPVRHRSSISGSLPSSGSLQAVSSRFSEEGPRSTDDTWPRGSRSNSSSEAVLGQEELSAQAKVLAPGASHPGEEEGARLPEGKPVQVATPIVASSEAVAEKEGARKEERKPRMGLFHHHHQGLSRSELGRRSSLGEKGGPILGASPHHSSSGEEKAKSSWFGLREAKDPTQKPSPHPVKPLSAAPVEGSPDRKQSRSSLSIALSSGLEKLKTVTSGSIQPVTQAPQAGQMVDTKRLKDSAVLDQSAKYYHLTHDELISLLLQRERELSQRDEHVQELESYIDRLLVRIMETSPTLLQIPPGPPK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Methylation	---MALVRGAEPAAG ---CCCCCCCCCCCC	39.18	115489879
116	Phosphorylation	VLTTMHRSLIGVDKF HHHHHHHHHHCHHHH	15.06	30266825
150	O-linked_Glycosylation	TQWYKLHSKPGKKEK CHHHHCCCCCCCHHH	51.48	30379171
165	Phosphorylation	ERGEIEVTIQFTRNN HCCEEEEEEEEECCC	9.03	-
174	Phosphorylation	QFTRNNLSASMFDLS EEECCCCCHHHEECH	22.03	29255136
176	Phosphorylation	TRNNLSASMFDLSMK ECCCCCHHHEECHHC	19.33	29255136
181	Phosphorylation	SASMFDLSMKDKPRS CHHHEECHHCCCCCC	26.15	29255136
188	Phosphorylation	SMKDKPRSPFSKIRD HHCCCCCCCCHHHHH	38.53	23401153
191	Phosphorylation	DKPRSPFSKIRDKMK CCCCCCCHHHHHHHC	30.47	30266825
203	Phosphorylation	KMKGKKKYDLESASA HHCCCCCCCHHHHHH	34.34	30206219
207	Phosphorylation	KKKYDLESASAILPS CCCCCHHHHHHHCCH	34.52	30266825
209	Phosphorylation	KYDLESASAILPSSA CCCHHHHHHHCCHHH	25.73	30266825
214	Phosphorylation	SASAILPSSAIEDPD HHHHHCCHHHCCCCC	29.02	30266825
215	Phosphorylation	ASAILPSSAIEDPDL HHHHCCHHHCCCCCC	31.18	30266825
224	Phosphorylation	IEDPDLGSLGKMGKA CCCCCCCHHCHHHHH	41.04	30266825
232	Methylation	LGKMGKAKGFFLRNK HCHHHHHHHHHHHHH	60.79	115976029
243	Phosphorylation	LRNKLRKSSLTQSNT HHHHHHHHCCCCCCC	24.93	26657352
244	Phosphorylation	RNKLRKSSLTQSNTS HHHHHHHCCCCCCCC	38.17	28450419
246	Phosphorylation	KLRKSSLTQSNTSLG HHHHHCCCCCCCCCC	31.72	26657352
248	Phosphorylation	RKSSLTQSNTSLGSD HHHCCCCCCCCCCCC	36.52	28450419
250	Phosphorylation	SSLTQSNTSLGSDST HCCCCCCCCCCCCCC	30.49	28450419
251	Phosphorylation	SLTQSNTSLGSDSTL CCCCCCCCCCCCCCC	34.68	28450419
254	Phosphorylation	QSNTSLGSDSTLSSA CCCCCCCCCCCCCCC	33.41	28450419
256	Phosphorylation	NTSLGSDSTLSSASG CCCCCCCCCCCCCCC	32.71	28450419
257	Phosphorylation	TSLGSDSTLSSASGS CCCCCCCCCCCCCCC	35.33	28450419
259	Phosphorylation	LGSDSTLSSASGSLA CCCCCCCCCCCCCCC	24.77	28450419
260	Phosphorylation	GSDSTLSSASGSLAY CCCCCCCCCCCCCCC	29.57	28450419
262	Phosphorylation	DSTLSSASGSLAYQG CCCCCCCCCCCCCCC	30.75	28450419
264	Phosphorylation	TLSSASGSLAYQGPG CCCCCCCCCCCCCCC	13.82	28450419
267	Phosphorylation	SASGSLAYQGPGAEL CCCCCCCCCCCCCEE	21.21	27642862
276	Phosphorylation	GPGAELLTRSPSRSS CCCCEEEECCCCHHC	41.55	28450419
278	Phosphorylation	GAELLTRSPSRSSWL CCEEEECCCCHHCCC	23.22	22617229
280	Phosphorylation	ELLTRSPSRSSWLST EEEECCCCHHCCCCC	46.14	25159151
282	Phosphorylation	LTRSPSRSSWLSTEG EECCCCHHCCCCCCC	30.15	25159151
283	Phosphorylation	TRSPSRSSWLSTEGG ECCCCHHCCCCCCCC	30.81	25159151
286	Phosphorylation	PSRSSWLSTEGGRDS CCHHCCCCCCCCCCC	20.39	25159151
287	Phosphorylation	SRSSWLSTEGGRDSA CHHCCCCCCCCCCCC	36.16	22617229
293	Phosphorylation	STEGGRDSAQSPKLF CCCCCCCCCCCCCCC	27.18	23403867
296	Phosphorylation	GGRDSAQSPKLFTHK CCCCCCCCCCCCCCC	24.58	25159151
305	Phosphorylation	KLFTHKRTYSDEANQ CCCCCCCCCCHHHHH	31.98	30266825
306	Phosphorylation	LFTHKRTYSDEANQM CCCCCCCCCHHHHHC	20.39	29255136
307	Phosphorylation	FTHKRTYSDEANQMR CCCCCCCCHHHHHCC	28.50	19664994
332	Phosphorylation	QGHLDAASRSSLCVN HHCCCHHCCCCEEEC	34.12	28857561
334	Phosphorylation	HLDAASRSSLCVNGS CCCHHCCCCEEECCH	25.76	21945579
335	Phosphorylation	LDAASRSSLCVNGSH CCHHCCCCEEECCHH	25.36	21945579
341	Phosphorylation	SSLCVNGSHIYNEEP CCEEECCHHCCCCCC	11.08	21945579
344	Phosphorylation	CVNGSHIYNEEPQGP EECCHHCCCCCCCCC	15.88	21945579
356	Phosphorylation	QGPVRHRSSISGSLP CCCCCCCCCCCCCCC	26.37	25159151
357	Phosphorylation	GPVRHRSSISGSLPS CCCCCCCCCCCCCCC	22.26	23927012
359	Phosphorylation	VRHRSSISGSLPSSG CCCCCCCCCCCCCCC	25.03	23927012
361	Phosphorylation	HRSSISGSLPSSGSL CCCCCCCCCCCCCCH	30.25	25159151
364	Phosphorylation	SISGSLPSSGSLQAV CCCCCCCCCCCHHHH	53.26	23927012
365	Phosphorylation	ISGSLPSSGSLQAVS CCCCCCCCCCHHHHH	30.38	23927012
367	Phosphorylation	GSLPSSGSLQAVSSR CCCCCCCCHHHHHHC	21.18	23927012
372	Phosphorylation	SGSLQAVSSRFSEEG CCCHHHHHHCCCCCC	20.86	23927012
373	Phosphorylation	GSLQAVSSRFSEEGP CCHHHHHHCCCCCCC	30.64	23927012
376	Phosphorylation	QAVSSRFSEEGPRST HHHHHCCCCCCCCCC	33.36	28985074
382	Phosphorylation	FSEEGPRSTDDTWPR CCCCCCCCCCCCCCC	39.04	24719451
383	Phosphorylation	SEEGPRSTDDTWPRG CCCCCCCCCCCCCCC	38.89	28857561
386	Phosphorylation	GPRSTDDTWPRGSRS CCCCCCCCCCCCCCC	39.93	23403867
391	Phosphorylation	DDTWPRGSRSNSSSE CCCCCCCCCCCCCHH	33.54	23927012
393	Phosphorylation	TWPRGSRSNSSSEAV CCCCCCCCCCCHHCC	42.64	30266825
395	Phosphorylation	PRGSRSNSSSEAVLG CCCCCCCCCHHCCCC	36.17	29255136
396	Phosphorylation	RGSRSNSSSEAVLGQ CCCCCCCCHHCCCCH	36.13	30266825
397	Phosphorylation	GSRSNSSSEAVLGQE CCCCCCCHHCCCCHH	29.42	30266825
407	Phosphorylation	VLGQEELSAQAKVLA CCCHHHHHHHCEEEC	22.93	23403867
418	Phosphorylation	KVLAPGASHPGEEEG EEECCCCCCCCCCCC	35.81	28857561
438	Phosphorylation	GKPVQVATPIVASSE CCCEEEECCEEECHH	18.07	25850435
443	Phosphorylation	VATPIVASSEAVAEK EECCEEECHHHHHHH	20.16	25850435
444	Phosphorylation	ATPIVASSEAVAEKE ECCEEECHHHHHHHH	21.60	25850435
473	Phosphorylation	HHHHQGLSRSELGRR CCCCCCCCHHHHHCC	40.35	27251275
475	Phosphorylation	HHQGLSRSELGRRSS CCCCCCHHHHHCCCC	33.52	29514088
481	Phosphorylation	RSELGRRSSLGEKGG HHHHHCCCCCCCCCC	28.67	26699800
482	Phosphorylation	SELGRRSSLGEKGGP HHHHCCCCCCCCCCC	38.28	26699800
494	Phosphorylation	GGPILGASPHHSSSG CCCCCCCCCCCCCCH	23.98	25159151
498	Phosphorylation	LGASPHHSSSGEEKA CCCCCCCCCCHHHHH	24.14	25159151
499	Phosphorylation	GASPHHSSSGEEKAK CCCCCCCCCHHHHHH	37.70	25159151
500	Phosphorylation	ASPHHSSSGEEKAKS CCCCCCCCHHHHHHH	53.92	23403867
519	Phosphorylation	LREAKDPTQKPSPHP CCCCCCCCCCCCCCC	60.40	23403867
523	Phosphorylation	KDPTQKPSPHPVKPL CCCCCCCCCCCCCCC	42.76	23403867
531	Phosphorylation	PHPVKPLSAAPVEGS CCCCCCCCCCCCCCC	30.80	23663014
538	Phosphorylation	SAAPVEGSPDRKQSR CCCCCCCCCCHHHCH	15.32	28355574
544	Phosphorylation	GSPDRKQSRSSLSIA CCCCHHHCHHHHHHH	36.85	20068231
546	Phosphorylation	PDRKQSRSSLSIALS CCHHHCHHHHHHHHH	40.66	30266825
547	Phosphorylation	DRKQSRSSLSIALSS CHHHCHHHHHHHHHH	25.65	30266825
549	Phosphorylation	KQSRSSLSIALSSGL HHCHHHHHHHHHHHH	14.04	30266825
553	Phosphorylation	SSLSIALSSGLEKLK HHHHHHHHHHHHHCC	17.21	30266825
554	Phosphorylation	SLSIALSSGLEKLKT HHHHHHHHHHHHCCE	48.52	30266825
558	Ubiquitination	ALSSGLEKLKTVTSG HHHHHHHHCCEECCC	61.40	21906983
560	Ubiquitination	SSGLEKLKTVTSGSI HHHHHHCCEECCCCC	52.60	21906983
561	Phosphorylation	SGLEKLKTVTSGSIQ HHHHHCCEECCCCCC	39.18	24114839
563	Phosphorylation	LEKLKTVTSGSIQPV HHHCCEECCCCCCCC	32.38	25159151
564	Phosphorylation	EKLKTVTSGSIQPVT HHCCEECCCCCCCCC	26.63	25159151
566	Phosphorylation	LKTVTSGSIQPVTQA CCEECCCCCCCCCCC	20.16	25159151
571	Phosphorylation	SGSIQPVTQAPQAGQ CCCCCCCCCCCCCCC	26.20	25693802
583	2-Hydroxyisobutyrylation	AGQMVDTKRLKDSAV CCCCCCCCCCCCHHH	51.80	-
583	Acetylation	AGQMVDTKRLKDSAV CCCCCCCCCCCCHHH	51.80	26051181
583	Ubiquitination	AGQMVDTKRLKDSAV CCCCCCCCCCCCHHH	51.80	21906983
586	Ubiquitination	MVDTKRLKDSAVLDQ CCCCCCCCCHHHHHH	54.38	2190698
588	Phosphorylation	DTKRLKDSAVLDQSA CCCCCCCHHHHHHCC	20.77	23312004
594	Phosphorylation	DSAVLDQSAKYYHLT CHHHHHHCCCEECCC	26.79	23312004
628	Phosphorylation	EHVQELESYIDRLLV HHHHHHHHHHHHHHH	39.76	-
629	Phosphorylation	HVQELESYIDRLLVR HHHHHHHHHHHHHHH	9.47	-
640	Phosphorylation	LLVRIMETSPTLLQI HHHHHHHCCCCCCCC	23.72	28060719
641	Phosphorylation	LVRIMETSPTLLQIP HHHHHHCCCCCCCCC	11.55	28060719
643	Phosphorylation	RIMETSPTLLQIPPG HHHHCCCCCCCCCCC	39.61	28060719

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
188	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
276	T	Phosphorylation	Kinase	GSK3B	P49841	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
357	S	Phosphorylation		23186163
Phosphorylation at Ser-357 is PKA-dependent.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RFIP5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RFIP5_HUMAN	RAB11FIP5	physical	12364336
RAB25_HUMAN	RAB25	physical	11481332
RB11A_HUMAN	RAB11A	physical	11481332
SNAG_HUMAN	NAPG	physical	11278501
ECHM_HUMAN	ECHS1	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RFIP5_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307; SER-359 ANDSER-553, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307 AND SER-538, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188 AND SER-307, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry."; Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.; Anal. Chem. 76:2763-2772(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174, AND MASSSPECTROMETRY.	15144186 [Abstract]

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