RAB25_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB25_HUMAN
• UniProt AC: P57735
• Protein Name: Ras-related protein Rab-25
• Gene Name: RAB25 {ECO:0000312|HGNC:HGNC:18238}
• Organism: Homo sapiens (Human).
• Sequence Length: 213
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cell projection, pseudopodium membrane . Cytoplasmic vesicle . Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips.
• Protein Description: Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. [PubMed: 17925226 Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity]
• Protein Sequence: MGNGTEEDYNFVFKVVLIGESGVGKTNLLSRFTRNEFSHDSRTTIGVEFSTRTVMLGTAAVKAQIWDTAGLERYRAITSAYYRGAVGALLVFDLTKHQTYAVVERWLKELYDHAEATIVVMLVGNKSDLSQAREVPTEEARMFAENNGLLFLETSALDSTNVELAFETVLKEIFAKVSKQRQNSIRTNAITLGSAQAGQEPGPGEKRACCISL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	GNGTEEDYNFVFKVV CCCCHHHHCEEEEEE	17.49	25106551
25	Ubiquitination	IGESGVGKTNLLSRF ECCCCCCHHHHHHHH	31.65	23503661
33	Phosphorylation	TNLLSRFTRNEFSHD HHHHHHHHCCCCCCC	31.32	20068231
43	Phosphorylation	EFSHDSRTTIGVEFS CCCCCCCCEEEEEEE	27.07	23286773
44	Phosphorylation	FSHDSRTTIGVEFST CCCCCCCEEEEEEEC	18.02	23286773
50	Phosphorylation	TTIGVEFSTRTVMLG CEEEEEEECCEEEEC	11.95	23286773
51	Phosphorylation	TIGVEFSTRTVMLGT EEEEEEECCEEEECC	35.36	23286773
53	Phosphorylation	GVEFSTRTVMLGTAA EEEEECCEEEECCHH	15.45	23286773
74	Phosphorylation	DTAGLERYRAITSAY CCCCHHHHHHHHHHH	8.60	28152594
75	Methylation	TAGLERYRAITSAYY CCCHHHHHHHHHHHH	26.24	-
78	Phosphorylation	LERYRAITSAYYRGA HHHHHHHHHHHHHHC	13.30	30266825
79	Phosphorylation	ERYRAITSAYYRGAV HHHHHHHHHHHHHCC	14.25	30266825
81	Phosphorylation	YRAITSAYYRGAVGA HHHHHHHHHHHCCCE	8.08	23403867
82	Phosphorylation	RAITSAYYRGAVGAL HHHHHHHHHHCCCEE	11.42	28152594
95	Phosphorylation	ALLVFDLTKHQTYAV EEEEEECCCHHHHHH	28.46	-
176	Ubiquitination	VLKEIFAKVSKQRQN HHHHHHHHHHHHHHH	35.97	32015554
184	Phosphorylation	VSKQRQNSIRTNAIT HHHHHHHCCCCCEEE	12.71	20068231
187	Phosphorylation	QRQNSIRTNAITLGS HHHHCCCCCEEEECC	27.60	29262532
191	Phosphorylation	SIRTNAITLGSAQAG CCCCCEEEECCCCCC	23.74	29262532
194	Phosphorylation	TNAITLGSAQAGQEP CCEEEECCCCCCCCC	21.96	29262532
206	Ubiquitination	QEPGPGEKRACCISL CCCCCCCCCEEEEEC	51.73	27667366
209	Geranylgeranylation	GPGEKRACCISL--- CCCCCCEEEEEC---	2.16	-
210	Methylation	PGEKRACCISL---- CCCCCEEEEEC----	2.01	-
210	Geranylgeranylation	PGEKRACCISL---- CCCCCEEEEEC----	2.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAB25_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAB25_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB25_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AP2S1_HUMAN	AP2S1	physical	17353931
RFIP1_HUMAN	RAB11FIP1	physical	11495908
RFIP2_HUMAN	RAB11FIP2	physical	11495908
RFIP3_HUMAN	RAB11FIP3	physical	11495908
RFIP5_HUMAN	RAB11FIP5	physical	11495908
OPTN_HUMAN	OPTN	physical	24056041
RFIP5_HUMAN	RAB11FIP5	physical	24056041

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.