OPTN_HUMAN - dbPTM
OPTN_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID OPTN_HUMAN
UniProt AC Q96CV9
Protein Name Optineurin
Gene Name OPTN
Organism Homo sapiens (Human).
Sequence Length 577
Subcellular Localization Cytoplasm, perinuclear region. Golgi apparatus . Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome. Found in the perinuclear region and associates with the Golgi apparatus (PubMed:275344
Protein Description Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. [PubMed: 27534431 Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation]
Protein Sequence MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAEDRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MSHQPLSCLTEKED
-CCCCCCCCCCCCCC		17.4829514088
10PhosphorylationHQPLSCLTEKEDSPS
CCCCCCCCCCCCCCC		49.7129514088
15PhosphorylationCLTEKEDSPSESTGN
CCCCCCCCCCCCCCC		31.2725159151
17PhosphorylationTEKEDSPSESTGNGP
CCCCCCCCCCCCCCC		48.4028348404
19PhosphorylationKEDSPSESTGNGPPH
CCCCCCCCCCCCCCC		46.0528348404
20PhosphorylationEDSPSESTGNGPPHL
CCCCCCCCCCCCCCC		30.5228348404
34PhosphorylationLAHPNLDTFTPEELL
CCCCCCCCCCHHHHH		32.3528348404
36PhosphorylationHPNLDTFTPEELLQQ
CCCCCCCCHHHHHHH		31.7028348404
49PhosphorylationQQMKELLTENHQLKE
HHHHHHHHHCHHHHH		47.5725690035
78UbiquitinationELSAWTEKQKEERQF
HHHHHHHHHHHHHHH		60.3329967540
90PhosphorylationRQFFEIQSKEAKERL
HHHHHHCCHHHHHHH		37.8229396449
91UbiquitinationQFFEIQSKEAKERLM
HHHHHCCHHHHHHHH		45.3629967540
98SulfoxidationKEAKERLMALSHENE
HHHHHHHHHHHHHHH		4.4030846556
101PhosphorylationKERLMALSHENEKLK
HHHHHHHHHHHHHHH		21.1524275569
140UbiquitinationRAEAEQEKDQLRTQV
HHHHHHHHHHHHHHH		50.9324816145
154UbiquitinationVVRLQAEKADLLGIV
HHHHHHHHHHHHHHH		50.66-
162PhosphorylationADLLGIVSELQLKLN
HHHHHHHHHEEHHHC		30.5725693802
170PhosphorylationELQLKLNSSGSSEDS
HEEHHHCCCCCCCCC		46.6530278072
171PhosphorylationLQLKLNSSGSSEDSF
EEHHHCCCCCCCCCE		41.4430278072
173PhosphorylationLKLNSSGSSEDSFVE
HHHCCCCCCCCCEEE		32.2823927012
174PhosphorylationKLNSSGSSEDSFVEI
HHCCCCCCCCCEEEE		49.2823927012
177PhosphorylationSSGSSEDSFVEIRMA
CCCCCCCCEEEEEEC		27.4319664994
183SulfoxidationDSFVEIRMAEGEAEG
CCEEEEEECCCCCCC		4.9730846556
191PhosphorylationAEGEAEGSVKEIKHS
CCCCCCCCCEEEECC		22.8629978859
198 (in isoform 2)Phosphorylation-26.9225056879
198PhosphorylationSVKEIKHSPGPTRTV
CCEEEECCCCCCEEE		26.9230266825
202PhosphorylationIKHSPGPTRTVSTGT
EECCCCCCEEEECCC		44.9123403867
204PhosphorylationHSPGPTRTVSTGTAL
CCCCCCEEEECCCHH		22.6829978859
206PhosphorylationPGPTRTVSTGTALSK
CCCCEEEECCCHHHH		22.1023401153
206O-linked_GlycosylationPGPTRTVSTGTALSK
CCCCEEEECCCHHHH		22.1030379171
207PhosphorylationGPTRTVSTGTALSKY
CCCEEEECCCHHHHH		33.9329978859
209PhosphorylationTRTVSTGTALSKYRS
CEEEECCCHHHHHHH		25.2329978859
212O-linked_GlycosylationVSTGTALSKYRSRSA
EECCCHHHHHHHCCC		25.7730379171
212PhosphorylationVSTGTALSKYRSRSA
EECCCHHHHHHHCCC		25.7729978859
212 (in isoform 2)Phosphorylation-25.7722210691
213MalonylationSTGTALSKYRSRSAD
ECCCHHHHHHHCCCC		45.6026320211
213UbiquitinationSTGTALSKYRSRSAD
ECCCHHHHHHHCCCC		45.6023000965
214PhosphorylationTGTALSKYRSRSADG
CCCHHHHHHHCCCCC		15.5029514088
216PhosphorylationTALSKYRSRSADGAK
CHHHHHHHCCCCCCC		27.7429514088
218PhosphorylationLSKYRSRSADGAKNY
HHHHHHCCCCCCCCC		31.7727422710
234PhosphorylationEHEELTVSQLLLCLR
CCCCCHHHHHHHHHH		15.1827251275
266UbiquitinationERVSDFEKKTSNRSE
HHHHHHHHHHCCHHH		62.4424816145
268PhosphorylationVSDFEKKTSNRSEIE
HHHHHHHHCCHHHHH		42.1521130716
269PhosphorylationSDFEKKTSNRSEIET
HHHHHHHCCHHHHHC		38.8421130716
272PhosphorylationEKKTSNRSEIETQTE
HHHHCCHHHHHCCCC		47.3728985074
278PhosphorylationRSEIETQTEGSTEKE
HHHHHCCCCCCCCCC		50.1321130716
281PhosphorylationIETQTEGSTEKENDE
HHCCCCCCCCCCCCC		27.4525627689
282PhosphorylationETQTEGSTEKENDEE
HCCCCCCCCCCCCCC		63.0325627689
294PhosphorylationDEEKGPETVGSEVEA
CCCCCCCCHHHHHHH		33.0427251275
297PhosphorylationKGPETVGSEVEALNL
CCCCCHHHHHHHHHH		33.8527251275
308PhosphorylationALNLQVTSLFKELQE
HHHHHHHHHHHHHHH		32.7124719451
311UbiquitinationLQVTSLFKELQEAHT
HHHHHHHHHHHHHHH		63.9132015554
313 (in isoform 2)Ubiquitination-6.01-
316 (in isoform 2)Ubiquitination-11.59-
319UbiquitinationELQEAHTKLSEAELM
HHHHHHHHHCHHHHH		40.68-
321 (in isoform 2)Ubiquitination-31.23-
322UbiquitinationEAHTKLSEAELMKKR
HHHHHHCHHHHHHHH		57.21-
327UbiquitinationLSEAELMKKRLQEKC
HCHHHHHHHHHHHHH		47.57-
333AcetylationMKKRLQEKCQALERK
HHHHHHHHHHHHHHH		20.7720167786
333MalonylationMKKRLQEKCQALERK
HHHHHHHHHHHHHHH		20.7726320211
333UbiquitinationMKKRLQEKCQALERK
HHHHHHHHHHHHHHH		20.7730230243
340UbiquitinationKCQALERKNSAIPSE
HHHHHHHHCCCCCHH		45.9729967540
340MalonylationKCQALERKNSAIPSE
HHHHHHHHCCCCCHH		45.9726320211
342PhosphorylationQALERKNSAIPSELN
HHHHHHCCCCCHHHC		30.5223927012
346PhosphorylationRKNSAIPSELNEKQE
HHCCCCCHHHCCCCE		48.9130266825
351UbiquitinationIPSELNEKQELVYTN
CCHHHCCCCEEEECC		48.2629967540
356PhosphorylationNEKQELVYTNKKLEL
CCCCEEEECCCCHHH		19.74-
367PhosphorylationKLELQVESMLSEIKM
CHHHHHHHHHHHHHH		26.6028857561
391 (in isoform 3)Ubiquitination-3.4421890473
424UbiquitinationKVDRAVLKELSEKLE
HHHHHHHHHHHHHHH		50.4332015554
429UbiquitinationVLKELSEKLELAEKA
HHHHHHHHHHHHHHH		43.8332142685
432 (in isoform 3)Ubiquitination-12.3621890473
435UbiquitinationEKLELAEKALASKQL
HHHHHHHHHHHHHHH		42.9932015554
442 (in isoform 2)Ubiquitination-5.3821890473
444 (in isoform 3)Ubiquitination-6.8321890473
448NeddylationQLQMDEMKQTIAKQE
HHCHHHHHHHHHHHH		42.0932015554
448UbiquitinationQLQMDEMKQTIAKQE
HHCHHHHHHHHHHHH		42.0923000965
448 (in isoform 1)Ubiquitination-42.0921890473
453AcetylationEMKQTIAKQEEDLET
HHHHHHHHHHHHHHH		55.1630591039
453UbiquitinationEMKQTIAKQEEDLET
HHHHHHHHHHHHHHH		55.1623000965
461SulfoxidationQEEDLETMTILRAQM
HHHHHHHHHHHHHHH		1.2830846556
468SulfoxidationMTILRAQMEVYCSDF
HHHHHHHHHHHHHHH		3.5230846556
471PhosphorylationLRAQMEVYCSDFHAE
HHHHHHHHHHHHHHH		3.4929978859
473PhosphorylationAQMEVYCSDFHAERA
HHHHHHHHHHHHHHH		26.1419581576
483 (in isoform 2)Ubiquitination-52.1921890473
484UbiquitinationAERAAREKIHEEKEQ
HHHHHHHHHHHHHHH		43.7522817900
489 (in isoform 1)Ubiquitination-48.0221890473
489UbiquitinationREKIHEEKEQLALQL
HHHHHHHHHHHHHHH		48.0222817900
495 (in isoform 2)Ubiquitination-23.0521890473
501 (in isoform 1)Ubiquitination-50.7621890473
501UbiquitinationLQLAVLLKENDAFED
HHHHHHHHHCCCCCC		50.7621963094
513PhosphorylationFEDGGRQSLMEMQSR
CCCCCHHHHHHHHHH		28.4626657352
519PhosphorylationQSLMEMQSRHGARTS
HHHHHHHHHHCCCCC		25.5730108239
525PhosphorylationQSRHGARTSDSDQQA
HHHHCCCCCCHHHHH		36.0320201521
526PhosphorylationSRHGARTSDSDQQAY
HHHCCCCCCHHHHHH		29.5725159151
528PhosphorylationHGARTSDSDQQAYLV
HCCCCCCHHHHHHHH		36.7730266825
533PhosphorylationSDSDQQAYLVQRGAE
CCHHHHHHHHHCCCC		11.7623927012
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
177SPhosphorylationKinasePLK1P53350
PSP
177SPhosphorylationKinaseTBK1Q9UHD2
Uniprot
473SPhosphorylationKinaseTBK1Q9UHD2
PSP
513SPhosphorylationKinaseIKBKBO14920
GPS
513SPhosphorylationKinaseTBK1Q9UHD2
PSP
-KUbiquitinationE3 ubiquitin ligaseHACE1Q8IYU2
PMID:25026213
-KUbiquitinationE3 ubiquitin ligaseDCAF4Q8WV16
PMID:32014991
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of OPTN_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of OPTN_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
WASC3_HUMANCCDC53physical
16189514
TBC17_HUMANTBC1D17physical
16189514
HD_HUMANHTTphysical
11137014
RAB8A_HUMANRAB8Aphysical
11137014
CYLD_HUMANCYLDphysical
21408173
RIPK1_HUMANRIPK1physical
21408173
CDN1A_HUMANCDKN1Aphysical
19609363
TAXB1_HUMANTAX1BP1physical
19609363
IF5A2_HUMANEIF5A2physical
21903422
KCD17_HUMANKCTD17physical
21903422
EM55_HUMANMPP1physical
21903422
MPP6_HUMANMPP6physical
21903422
TBK1_HUMANTBK1physical
21903422
1433B_HUMANYWHABphysical
21903422
1433G_HUMANYWHAGphysical
21903422
1433F_HUMANYWHAHphysical
21903422
1433T_HUMANYWHAQphysical
21903422
1433Z_HUMANYWHAZphysical
21903422
ZN384_HUMANZNF384physical
21903422
TFR1_HUMANTFRCphysical
20085643
MLP3A_HUMANMAP1LC3Aphysical
21617041
UBC_HUMANUBCphysical
21617041
TBK1_HUMANTBK1physical
20174559
TRAF3_HUMANTRAF3physical
20174559
RAB8A_HUMANRAB8Aphysical
20634958
TFR1_HUMANTFRCphysical
20634958
TBK1_HUMANTBK1physical
18307994
OPTN_HUMANOPTNphysical
20161783
RAB8A_HUMANRAB8Aphysical
20161783
MYO6_HUMANMYO6physical
20161783
TFR1_HUMANTFRCphysical
20161783
MYO6_HUMANMYO6physical
15837803
UBC_HUMANUBCphysical
17702576
RIPK1_HUMANRIPK1physical
17702576
TRADD_HUMANTRADDphysical
17702576
TNR1A_HUMANTNFRSF1Aphysical
22675546
RIPK1_HUMANRIPK1physical
22675546
MLP3B_HUMANMAP1LC3Bphysical
23805866
EPS15_HUMANEPS15physical
17626244
RB11A_HUMANRAB11Aphysical
17626244
TNIP1_HUMANTNIP1physical
21988832
PIAS4_HUMANPIAS4physical
21988832
TFR1_HUMANTFRCphysical
23357852
QCR8_HUMANUQCRQphysical
20195357
SLF2_HUMANFAM178Aphysical
20195357
GNAS3_HUMANGNASphysical
20195357
GNAS2_HUMANGNASphysical
20195357
ALEX_HUMANGNASphysical
20195357
GNAS1_HUMANGNASphysical
20195357
RAB8A_RATRab8aphysical
24683533
TBC17_HUMANTBC1D17physical
22854040
OPTN_HUMANOPTNphysical
24983867
HACE1_HUMANHACE1physical
25026213
SQSTM_HUMANSQSTM1physical
25026213
PRKN_HUMANPARK2physical
25294927
OPTN_HUMANOPTNphysical
25416956
TNIP1_HUMANTNIP1physical
25416956
RAB10_HUMANRAB10physical
25416956
WASC3_HUMANCCDC53physical
25416956
ZN398_HUMANZNF398physical
25416956
TBC15_HUMANTBC1D15physical
25416956
ZN329_HUMANZNF329physical
25416956
ZN670_HUMANZNF670physical
25416956
UBC_HUMANUBCphysical
21862579
SODC_HUMANSOD1physical
23178947
GBRAP_HUMANGABARAPphysical
21617041
GBRL1_HUMANGABARAPL1physical
21617041
GBRL2_HUMANGABARAPL2physical
21617041
MLP3B_HUMANMAP1LC3Bphysical
21617041
ATG8_YEASTATG8physical
21617041
TNIP1_HUMANTNIP1physical
21516116
LNX2_HUMANLNX2physical
21516116
WASC3_HUMANCCDC53physical
21516116
CDC23_HUMANCDC23physical
21516116
F1892_HUMANFAM189A2physical
21516116
TBK1_HUMANTBK1physical
25803835
NRL_HUMANNRLphysical
23956131
UBC_HUMANUBCphysical
26451915
MLP3C_HUMANMAP1LC3Cphysical
26451915
UBC_HUMANUBCphysical
26365381
TBK1_HUMANTBK1physical
26365381
UBC_HUMANUBCphysical
25969509
CYLD_HUMANCYLDphysical
25923723
MYO6_HUMANMYO6physical
26971995
MYH6_HUMANMYH6physical
25859013
UBC_HUMANUBCphysical
27035970
TBK1_HUMANTBK1physical
27035970
UBC_HUMANUBCphysical
27552911
NEMO_HUMANIKBKGphysical
27552911
RIPK1_HUMANRIPK1physical
27552911
CASP8_HUMANCASP8physical
27552911
TBK1_HUMANTBK1physical
27538435
ZMYM6_HUMANZMYM6physical
28514442
UBC_HUMANUBCphysical
28319114
ATG5_MOUSEAtg5physical
29133525
WIPI2_MOUSEWipi2physical
29133525
A16L1_HUMANATG16L1physical
29133525
ATG5_HUMANATG5physical
29133525
WIPI2_HUMANWIPI2physical
29133525
MYO6_HUMANMYO6physical
19805065
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
137760Glaucoma 1, open angle, E (GLC1E)
606657Glaucoma, normal pressure (NPG)
613435Amyotrophic lateral sclerosis 12 (ALS12)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of OPTN_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphorylation of the autophagy receptor optineurin restrictsSalmonella growth.";
Wild P., Farhan H., McEwan D.G., Wagner S., Rogov V.V., Brady N.R.,Richter B., Korac J., Waidmann O., Choudhary C., Dotsch V., Bumann D.,Dikic I.;
Science 333:228-233(2011).
Cited for: PHOSPHORYLATION AT SER-177 BY TBK1.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-170; SER-171; SER-173AND SER-174, AND MASS SPECTROMETRY.

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