TBC17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBC17_HUMAN
• UniProt AC: Q9HA65
• Protein Name: TBC1 domain family member 17
• Gene Name: TBC1D17
• Organism: Homo sapiens (Human).
• Sequence Length: 648
• Subcellular Localization: Cytoplasmic vesicle, autophagosome .
• Protein Description: Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known..
• Protein Sequence: MEGAGYRVVFEKGGVYLHTSAKKYQDRDSLIAGVIRVVEKDNDVLLHWAPVEEAGDSTQILFSKKDSSGGDSCASEEEPTFDPDYEPDWAVISTVRPQLCHSEPTRGAEPSCPQGSWAFSVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSPQDSRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQPQPEGAASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELPHNVQEILGLAPPAEPHSPSPTASPLPLSPTRAPPTPPPSTDTAPQPDSSLEILPEEEDEGADS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	VFEKGGVYLHTSAKK EEEECCEEEECCCCH	8.95	23312004
19	Phosphorylation	KGGVYLHTSAKKYQD ECCEEEECCCCHHCC	27.99	20068231
20	Phosphorylation	GGVYLHTSAKKYQDR CCEEEECCCCHHCCH	27.61	25159151
22	Ubiquitination	VYLHTSAKKYQDRDS EEEECCCCHHCCHHH	52.35	22817900
23	Ubiquitination	YLHTSAKKYQDRDSL EEECCCCHHCCHHHH	48.11	21890473
23	Ubiquitination	YLHTSAKKYQDRDSL EEECCCCHHCCHHHH	48.11	21890473
23	Ubiquitination	YLHTSAKKYQDRDSL EEECCCCHHCCHHHH	48.11	22817900
24	Phosphorylation	LHTSAKKYQDRDSLI EECCCCHHCCHHHHH	18.23	24275569
29	Phosphorylation	KKYQDRDSLIAGVIR CHHCCHHHHHHEEEE	23.67	29214152
31	Ubiquitination	YQDRDSLIAGVIRVV HCCHHHHHHEEEEEE	3.48	32015554
63	Phosphorylation	DSTQILFSKKDSSGG CCCEEEEECCCCCCC	35.04	24719451
64	Ubiquitination	STQILFSKKDSSGGD CCEEEEECCCCCCCC	53.95	32015554
65	Ubiquitination	TQILFSKKDSSGGDS CEEEEECCCCCCCCC	62.74	-
191	Phosphorylation	YLVFPHDSSALSNSF EEEEECCHHHHHCCC	17.93	28857561
192	Phosphorylation	LVFPHDSSALSNSFH EEEECCHHHHHCCCE	39.01	28857561
197	Phosphorylation	DSSALSNSFHHLQLF CHHHHHCCCEEEEEE	23.68	28857561
221	Phosphorylation	RFLQDPYSTTFSSFS HHHCCCCCCCCHHHH	26.76	28348404
222	Phosphorylation	FLQDPYSTTFSSFSR HHCCCCCCCCHHHHH	26.47	28857561
223	Phosphorylation	LQDPYSTTFSSFSRV HCCCCCCCCHHHHHH	18.64	28857561
225	Phosphorylation	DPYSTTFSSFSRVTN CCCCCCCHHHHHHHH	28.51	24719451
226	Phosphorylation	PYSTTFSSFSRVTNF CCCCCCHHHHHHHHH	24.05	28857561
228	Phosphorylation	STTFSSFSRVTNFFR CCCCHHHHHHHHHHC	27.99	28857561
270	Ubiquitination	VISCVELGPRPTVER EEEEEEECCCCCCCC	11.58	33845483
303	Ubiquitination	LQQVPELKNRIFSGG HHCCHHHHHHHHCCC	42.38	33845483
308	Phosphorylation	ELKNRIFSGGLSPSL HHHHHHHCCCCCHHH	29.58	-
310	Ubiquitination	KNRIFSGGLSPSLRR HHHHHCCCCCHHHHH	23.06	29967540
314	Phosphorylation	FSGGLSPSLRREAWK HCCCCCHHHHHHHHH	31.00	-
343	Ubiquitination	HKAHIRKKTDEYFRM HHHHHHHHCHHHHHH	51.89	29967540
347	Phosphorylation	IRKKTDEYFRMKLQW HHHHCHHHHHHHHEE	10.17	22817900
351	Ubiquitination	TDEYFRMKLQWKSVS CHHHHHHHHEEECCC	33.02	-
366	Phosphorylation	PEQERRNSLLHGYRS HHHHHHHHHHHHHHH	30.42	29214152
455	Phosphorylation	VQGNFEESQETMKRQ HCCCHHHCHHHHHHH	26.56	-
569	Phosphorylation	LSVEDVLTRAEALHR CCHHHHHHHHHHHHH	27.90	20068231
579	Phosphorylation	EALHRQLTACPELPH HHHHHHHHCCCCCCC	20.20	30278072
602	Phosphorylation	APPAEPHSPSPTASP CCCCCCCCCCCCCCC	37.48	30278072
604	Phosphorylation	PAEPHSPSPTASPLP CCCCCCCCCCCCCCC	37.59	30278072
606	Phosphorylation	EPHSPSPTASPLPLS CCCCCCCCCCCCCCC	44.07	30278072
608	Phosphorylation	HSPSPTASPLPLSPT CCCCCCCCCCCCCCC	29.46	30278072
613	Phosphorylation	TASPLPLSPTRAPPT CCCCCCCCCCCCCCC	23.45	28348404
615	Phosphorylation	SPLPLSPTRAPPTPP CCCCCCCCCCCCCCC	35.77	22854040
620	Phosphorylation	SPTRAPPTPPPSTDT CCCCCCCCCCCCCCC	47.57	30576142
624	Phosphorylation	APPTPPPSTDTAPQP CCCCCCCCCCCCCCC	44.69	30242111
625	Phosphorylation	PPTPPPSTDTAPQPD CCCCCCCCCCCCCCC	43.04	30242111
627	Phosphorylation	TPPPSTDTAPQPDSS CCCCCCCCCCCCCCC	40.08	30242111
633	Phosphorylation	DTAPQPDSSLEILPE CCCCCCCCCCCCCCH	43.43	28270605
634	Phosphorylation	TAPQPDSSLEILPEE CCCCCCCCCCCCCHH	37.08	24275569
648	Phosphorylation	EEDEGADS------- HCCCCCCC-------	41.40	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBC17_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBC17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBC17_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CACO1_HUMAN	CALCOCO1	physical	16169070
TAXB1_HUMAN	TAX1BP1	physical	16169070
TF3C1_HUMAN	GTF3C1	physical	16169070
RAB5A_HUMAN	RAB5A	physical	16923123
RAB5B_HUMAN	RAB5B	physical	16923123
RAB5C_HUMAN	RAB5C	physical	16923123
PARVA_HUMAN	PARVA	physical	22863883
RAB8A_HUMAN	RAB8A	physical	22854040
UBXN8_HUMAN	UBXN8	physical	26389662

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.